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The map label for this gene is nisP [H]

Identifier: 116515961

GI number: 116515961

Start: 1747182

End: 1748921

Strand: Direct

Name: nisP [H]

Synonym: SPD_1753

Alternate gene names: 116515961

Gene position: 1747182-1748921 (Clockwise)

Preceding gene: 116516806

Following gene: 116517021

Centisome position: 85.39

GC content: 29.48

Gene sequence:

>1740_bases
ATGAAGATTATGAAAAAAAAATATTGGACTTTAGCGATATTATTCTTTTGTTTGTTCAATAATTCTGTTACTGCTCAAGA
AATACCTAAAAATCTTGATGGCAATATAACTCACACTCAGACTAGCGAAAGTTTTTCTGAATCTGATGAAAAACAGGTTG
ACTATTCTAATAAAAATCAAGAAGAAGTAGACCAAAATAAATTTCGTATTCAAATCGATAAGACAGAATTATTTGTAACA
ACAGATAAACATTTAGAAAAAAACTGTTGTAAATTGGAACTTGAACCACAAATAAATAACGATATTGTTAACTCTGAAAG
TAATAATTTACTAGGCGAAGATAATTTAGATAATAAAATTAAGGAAAATGTTTCTCATCTAGATAATAGAGGAGGAAATA
TAGAGCATGACAAAGATAACTTAGAATCGTCGATTGTAAGAAAATATGAATGGGATATAGATAAAGTTACTGGTGGAGGC
GAAAGTTATAAATTATATTCTAAAAGTAATTCTAAAGTTTCAATTGCTATTTTAGATTCAGGAGTCGATTTACAAAATAC
TGGATTACTGAAAAATCTTTCAAATCACTCAAAAAACTATGTCCCCAATAAAGGATATTTAGGAAAAGAGGAGGGAGAGG
AAGGAATAATATCAGATATTCAAGATAGATTAGGTCATGGTACGGCTGTTGTAGCTCAAATTGTAGGGGATGACAATATT
AATGGAGTAAATCCTCACGTTAATATTAACGTCTATAGAATATTTGGTAAGTCGTCAGCTAGTCCAGATTGGATTGTAAA
AGCAATTTTTGATGCTGTAGATGATGGCAATGATATTATCAATCTTAGTACTGGACAATATTTAATGATTGATGGAGAAT
ATGAGGACGGAACAAATGATTTTGAAACATTTTTGAAGTATAAAAAGGCTATTGATTACGCGAATCAAAAAGGAGTAATT
ATAGTAGCTGCATTAGGGAATGACTCCCTAAATGTATCAAATCAGTCAGATTTATTGAAACTTATTAGTTCACGCAAAAA
AGTAAGAAAACCAGGATTAGTAGTTGATGTTCCAAGTTATTTCTCATCTACAATTTCGGTCGGAGGCATAGATCGCTTAG
GTAATTTATCAGATTTTAGCAATAAAGGGGATTCTGATGCAATATATGCGCCTGCAGGCTCAACATTATCTCTTTCAGAA
TTAGGACTTAATAACTTTATTAATGCAGAAAAATATAAAGAAGATTGGATTTTTTCGGCAACACTAGGAGGATATACGTA
TCTTTATGGAAACTCATTTGCTGCTCCTAAAGTTTCTGGTGCGATTGCAATGATTATTGATAAATACAAATTAAAAGATC
AGCCCTATAATTATATGTTTGTAAAAAAAATTCTGGAAGAAACATTACCAGTAAAAAATGGTATAAAAGTGTTAAATATA
CCAAACGTATTGAGATATGATTTGAATATGTTACAATTAGAATATAAAAATGAACAAAGTTGGGATAGTTTCATAGATAA
TGTTAATTTAATTGAGTTGGAAGAGAGAATTCAAACTACTATTGGAATTAAACAAATAAACACACACAATATTATTACTA
TTGCCCGAGAAGGGTACTCTCAAAATTATTTACCTAACACTTCAGAAAATACATATAATTCATTACAAGTCAGTTTAGTT
GGAGTATTACTACTTTTTATAAGTATGGTAAATATTTTATGGGCTAAAAAAAGTAAATGA

Upstream 100 bases:

>100_bases
AAATTGTAGAGATTGGGACCCATAGAGAACTTCTTGAACTAGGAGGCATTTATAAGCAATTGTATTCAAATAATTAGTTT
TTGATTAAAAGGGTAAATTT

Downstream 100 bases:

>100_bases
AAATAAAATTTGGAGCCCTCTGAAAAAGTAAGTCCTACAGTTCAACTAAAATGAGTCAAAAGATGAATCACCTTGATGTA
GGGGAGTTTGTCTTATTGCT

Product: serine protease, subtilase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVT
TDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGG
ESYKLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDNI
NGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVI
IVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSE
LGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKILEETLPVKNGIKVLNI
PNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERIQTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLV
GVLLLFISMVNILWAKKSK

Sequences:

>Translated_579_residues
MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVT
TDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGG
ESYKLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDNI
NGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVI
IVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSE
LGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKILEETLPVKNGIKVLNI
PNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERIQTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLV
GVLLLFISMVNILWAKKSK
>Mature_579_residues
MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVT
TDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGG
ESYKLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDNI
NGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVI
IVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSE
LGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKILEETLPVKNGIKVLNI
PNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERIQTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLV
GVLLLFISMVNILWAKKSK

Specific function: Cleaves the lantibiotic nisin precursor peptide [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019931
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR008357
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 64922; Mature: 64922

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQ
CCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEECCCCCHHHCCCHHHCCCCCCCH
EEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKI
HHHCCCCEEEEEECEEEEEEECHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHH
KENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESYKLYSKSNSKVSIAILDS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCEEEEECCCCEEEEEEEEC
GVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDNI
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
NGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTND
CCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCHH
FETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSY
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECHHH
FSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSELGLNNFINAEKYKEDWIFSA
HHHHCCCCCCHHCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCHHCCCCHHHHCCEEEEE
TLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKILEETLPVKNGIKVLNI
ECCCEEEEECCCCCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHCCHHCCEEEEEC
PNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERIQTTIGIKQINTHNIITIAREGYS
CHHHHHCCEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHCCEEECCCCEEEEEECCCC
QNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAKKSK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQ
CCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEECCCCCHHHCCCHHHCCCCCCCH
EEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKI
HHHCCCCEEEEEECEEEEEEECHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHH
KENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESYKLYSKSNSKVSIAILDS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCEEEEECCCCEEEEEEEEC
GVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDNI
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
NGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTND
CCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCHH
FETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSY
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECHHH
FSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSELGLNNFINAEKYKEDWIFSA
HHHHCCCCCCHHCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCHHCCCCHHHHCCEEEEE
TLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKILEETLPVKNGIKVLNI
ECCCEEEEECCCCCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHCCHHCCEEEEEC
PNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERIQTTIGIKQINTHNIITIAREGYS
CHHHHHCCEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHCCEEECCCCEEEEEECCCC
QNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAKKSK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8478324; 8161176; 7630881 [H]