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The map label for this gene is hepT [H]

Identifier: 116495752

GI number: 116495752

Start: 2298530

End: 2299492

Strand: Direct

Name: hepT [H]

Synonym: LSEI_2300

Alternate gene names: 116495752

Gene position: 2298530-2299492 (Clockwise)

Preceding gene: 116495751

Following gene: 116495756

Centisome position: 79.39

GC content: 50.88

Gene sequence:

>963_bases
ATGTGGCATGAATACCCAACGTTAGCGCCGGAGCTGGCTTCAGCGCTAGCCATGATCGAAAAACAGATCACGACCAACAA
CACACCGGTCGCCAAGGCAATCATGGAGATGATCAATGGCGGCGGCAAACTGTTGCGTCCCGCTTACTGTCTGCTTTTTT
CACGGTTTCAAGACGTTGATCGCGAGAAGATGATCGCCTTGGCAGCGGCCATTGAAACCCTGCACACAGCGACCTTGATT
CACGATGACATCATTGACAAATCGCCCACCCGCCGCAATCAGGTCACCATCCAGAAGCAATTCGGACCAGACACAGCGGT
CTATGCCGGCGACTACCTTTTCGTTGTCTGCTTCAAGTTACTGTCGCATTATGCGTCAAGCTTACGCAGCATTCAGCAAG
ACAGCGGCAGCATGGAAAAGATTCTTAAAGGTGAACTGGATCAAATGGCCACCCGCTACCAAACCAAGATTACCATCGAC
GACTATCTTAAACAGGTTTCCGGTAAGACTGGCCAACTTTTCGCCCTCAGCTGCTTCATCGGTGCCTACGAAAGCGGCAG
CAGTCCCACCTTTGCTAAAAACGCTGAAAAAATCGGCATGAACATTGGGATTGCTTTCCAACTACTAGATGACATCCTCG
ATTACACCAGTGATGACGACACTCTCGGTAAACCAGTGTGCGAAGATGTTCGCAGTGGCGTCTACTCTGCACCCTTGATC
CTGGCCATGCAACGCAATCGGCAAGCTTTCTTGCCACTGCTAGCAAAAAAAGATCAGATCACCGATGCGGAAATGAATGA
ACTGCGCCAGCTCGTCATTCACCATCAAGGCGTTGAGCAAGCTTACGCCATGGCCCAGAAACGAACTGAACAGGCCATCG
CCGGTTTGCAAAAACTACCAGCAGGCGCTGCGCAGGATGATTTGATTCGCTTGACGCAGAGCTTGTTGAATCGGAAAGCT
TAA

Upstream 100 bases:

>100_bases
GCAGCCAACTTTCTTTTTGAACACATCGATATCTTGCGGCGACTGCGCTACGACCGAACCAAGCGCCGCAAAAAAGGAGC
TACACATGAAAATTCATCCC

Downstream 100 bases:

>100_bases
TTGAACTGGCGTGATCGTCGCTGATGGATCGTAATTCCTGTACTGAACTCGTGACTCATTAGAATCCGCGTAATCTAGTA
AAGGTCTAAACTATAGAATC

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MWHEYPTLAPELASALAMIEKQITTNNTPVAKAIMEMINGGGKLLRPAYCLLFSRFQDVDREKMIALAAAIETLHTATLI
HDDIIDKSPTRRNQVTIQKQFGPDTAVYAGDYLFVVCFKLLSHYASSLRSIQQDSGSMEKILKGELDQMATRYQTKITID
DYLKQVSGKTGQLFALSCFIGAYESGSSPTFAKNAEKIGMNIGIAFQLLDDILDYTSDDDTLGKPVCEDVRSGVYSAPLI
LAMQRNRQAFLPLLAKKDQITDAEMNELRQLVIHHQGVEQAYAMAQKRTEQAIAGLQKLPAGAAQDDLIRLTQSLLNRKA

Sequences:

>Translated_320_residues
MWHEYPTLAPELASALAMIEKQITTNNTPVAKAIMEMINGGGKLLRPAYCLLFSRFQDVDREKMIALAAAIETLHTATLI
HDDIIDKSPTRRNQVTIQKQFGPDTAVYAGDYLFVVCFKLLSHYASSLRSIQQDSGSMEKILKGELDQMATRYQTKITID
DYLKQVSGKTGQLFALSCFIGAYESGSSPTFAKNAEKIGMNIGIAFQLLDDILDYTSDDDTLGKPVCEDVRSGVYSAPLI
LAMQRNRQAFLPLLAKKDQITDAEMNELRQLVIHHQGVEQAYAMAQKRTEQAIAGLQKLPAGAAQDDLIRLTQSLLNRKA
>Mature_320_residues
MWHEYPTLAPELASALAMIEKQITTNNTPVAKAIMEMINGGGKLLRPAYCLLFSRFQDVDREKMIALAAAIETLHTATLI
HDDIIDKSPTRRNQVTIQKQFGPDTAVYAGDYLFVVCFKLLSHYASSLRSIQQDSGSMEKILKGELDQMATRYQTKITID
DYLKQVSGKTGQLFALSCFIGAYESGSSPTFAKNAEKIGMNIGIAFQLLDDILDYTSDDDTLGKPVCEDVRSGVYSAPLI
LAMQRNRQAFLPLLAKKDQITDAEMNELRQLVIHHQGVEQAYAMAQKRTEQAIAGLQKLPAGAAQDDLIRLTQSLLNRKA

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=309, Percent_Identity=29.4498381877023, Blast_Score=138, Evalue=5e-33,
Organism=Escherichia coli, GI1789578, Length=314, Percent_Identity=28.9808917197452, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17505681, Length=310, Percent_Identity=28.7096774193548, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319475, Length=300, Percent_Identity=28.6666666666667, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325188, Length=228, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651612, Length=291, Percent_Identity=28.1786941580756, Blast_Score=114, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35494; Mature: 35494

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWHEYPTLAPELASALAMIEKQITTNNTPVAKAIMEMINGGGKLLRPAYCLLFSRFQDVD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
REKMIALAAAIETLHTATLIHDDIIDKSPTRRNQVTIQKQFGPDTAVYAGDYLFVVCFKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
LSHYASSLRSIQQDSGSMEKILKGELDQMATRYQTKITIDDYLKQVSGKTGQLFALSCFI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEHHHHH
GAYESGSSPTFAKNAEKIGMNIGIAFQLLDDILDYTSDDDTLGKPVCEDVRSGVYSAPLI
HHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHCHHH
LAMQRNRQAFLPLLAKKDQITDAEMNELRQLVIHHQGVEQAYAMAQKRTEQAIAGLQKLP
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGAAQDDLIRLTQSLLNRKA
CCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWHEYPTLAPELASALAMIEKQITTNNTPVAKAIMEMINGGGKLLRPAYCLLFSRFQDVD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
REKMIALAAAIETLHTATLIHDDIIDKSPTRRNQVTIQKQFGPDTAVYAGDYLFVVCFKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
LSHYASSLRSIQQDSGSMEKILKGELDQMATRYQTKITIDDYLKQVSGKTGQLFALSCFI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEHHHHH
GAYESGSSPTFAKNAEKIGMNIGIAFQLLDDILDYTSDDDTLGKPVCEDVRSGVYSAPLI
HHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHCHHH
LAMQRNRQAFLPLLAKKDQITDAEMNELRQLVIHHQGVEQAYAMAQKRTEQAIAGLQKLP
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGAAQDDLIRLTQSLLNRKA
CCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]