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The map label for this gene is yrkA [H]

Identifier: 116495682

GI number: 116495682

Start: 2221325

End: 2222716

Strand: Direct

Name: yrkA [H]

Synonym: LSEI_2229

Alternate gene names: 116495682

Gene position: 2221325-2222716 (Clockwise)

Preceding gene: 116495678

Following gene: 116495683

Centisome position: 76.72

GC content: 43.25

Gene sequence:

>1392_bases
ATGGAAAGTGGCCAAATCGTCCCCAATTTATTGGTGATGCTCGTCACCTTTTTATTCGCGGCATTTTTTGTCGCGTGTGA
ATTTGCTCTGGTGCAAAGTCGTCCAAGTGCCTTGGAAGAAATGATTGATAATGGTACTGGCCGTAAAGCTAAAGTCGAGC
GGGCTTTACGAATGGTGCATAATCTAAACGAGTATCTCTCAACGACACAGGTTGGTGTTTCGCTTGCTGGCATTATCCTT
GGTTGGATCGGGGAAACAACCGTTGAGTTTTTGTTGGTTGATCTTTTTGGCTTGACCCACCTGAGCTTGCCTAATGGTAG
TCTGCACGCAGTTGGCGCGATTTTAGGCGTGATTATTTTAACCTACTTAGAAGTCGTGTTAACCGAAATTGTTCCAAAAA
ACATCTCGATTGATTATCCGATCAAAACCTTGATGCTGGTTGTAACACCGCTACATTATTTCCATATTTTGTTCTATCCT
TTTGTTTGGCTGCTGAATGTCAGTGCCACCGGGATTGTCAAAATGATGGGGATGAAGCCCGCAGACGAAGGCAACGAAGC
CTTTTCGCAAGCTGAGATTCTGAGTCTGAGTAAAAATGCCGTCACAACTGGTGACATGGAACAAAATGATGTTATCTACA
TGCAGCGGGCATTTGAACTGAATGACAAGACCGCCAAAGACATCATGGTGGATCGAACCAGCTTGTTTGTCATTGATATC
ACCACCACCGTCAAAGAAGCTTTGCGGGATTACTTAACGCAAGGTTACAGCCGATTCCCGGTTGTTGCGAATGGCGATAA
GGATAAGATTCTCGGGTATGTTTACATCTATGACTTGGTCAAGCAAGGTCAAGTCGACCCGTCTGTGAAGGTCTCTAAGC
TGTTACGTTCCATCATTAATGTGCCTGAAGTAACACCGATTCATAGTATTCTGGCACAAATGATCAAGAAACAGACGCCA
ATTGTTGTGGTCGTTGACGAGTATGGTGGTACTAGTGGGATTGTCACCGATAAGGATATTTACGAAGAACTATTTGGTAC
CGTCAAGGATGAAATTGATGATGTCTCTGATGAATACATTCGGCAAACGGATGATCCAAAGGTCTTCCGAGTCAGTGGCA
AAACAACCTTGTGGGATTTTGAACGTTACTTCCACACCAATATTAAAGCCTTCACTGATTCAGAAATCATCACCATTGCT
GGTTTTATCATGGAAGATCACCCTGATTTGAAACTGCACGATAAGGTCAAGATTGATCATTTCAACTTCACCGTTGCTGA
TTTTTCCCGCGGCTTTGCTAACTGGTTTGATGTCACACAAGATCCAAAACCAGTTAAACAAACGGTTGCTGAAGAGGTTA
AAGAAGCTAAAAACGACGATAACAAGCATTAA

Upstream 100 bases:

>100_bases
CAAGCATAACATAGAAGCAAAGTGATGGAATTATCGGTCATCTTTGTCATTCAATGTTAAAATTAACTTTGTACGATACA
TGAAATGAGGAATGGAATAC

Downstream 100 bases:

>100_bases
TCAGGATCAAGCTAAACTTTCAAAAACGTGGTACTCGTTGAGGGGATCACGTTTTTTTATCGTAATCTATTTTTGTGCAA
TACCGCTAGGCGCAACTACC

Product: hemolysin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MESGQIVPNLLVMLVTFLFAAFFVACEFALVQSRPSALEEMIDNGTGRKAKVERALRMVHNLNEYLSTTQVGVSLAGIIL
GWIGETTVEFLLVDLFGLTHLSLPNGSLHAVGAILGVIILTYLEVVLTEIVPKNISIDYPIKTLMLVVTPLHYFHILFYP
FVWLLNVSATGIVKMMGMKPADEGNEAFSQAEILSLSKNAVTTGDMEQNDVIYMQRAFELNDKTAKDIMVDRTSLFVIDI
TTTVKEALRDYLTQGYSRFPVVANGDKDKILGYVYIYDLVKQGQVDPSVKVSKLLRSIINVPEVTPIHSILAQMIKKQTP
IVVVVDEYGGTSGIVTDKDIYEELFGTVKDEIDDVSDEYIRQTDDPKVFRVSGKTTLWDFERYFHTNIKAFTDSEIITIA
GFIMEDHPDLKLHDKVKIDHFNFTVADFSRGFANWFDVTQDPKPVKQTVAEEVKEAKNDDNKH

Sequences:

>Translated_463_residues
MESGQIVPNLLVMLVTFLFAAFFVACEFALVQSRPSALEEMIDNGTGRKAKVERALRMVHNLNEYLSTTQVGVSLAGIIL
GWIGETTVEFLLVDLFGLTHLSLPNGSLHAVGAILGVIILTYLEVVLTEIVPKNISIDYPIKTLMLVVTPLHYFHILFYP
FVWLLNVSATGIVKMMGMKPADEGNEAFSQAEILSLSKNAVTTGDMEQNDVIYMQRAFELNDKTAKDIMVDRTSLFVIDI
TTTVKEALRDYLTQGYSRFPVVANGDKDKILGYVYIYDLVKQGQVDPSVKVSKLLRSIINVPEVTPIHSILAQMIKKQTP
IVVVVDEYGGTSGIVTDKDIYEELFGTVKDEIDDVSDEYIRQTDDPKVFRVSGKTTLWDFERYFHTNIKAFTDSEIITIA
GFIMEDHPDLKLHDKVKIDHFNFTVADFSRGFANWFDVTQDPKPVKQTVAEEVKEAKNDDNKH
>Mature_463_residues
MESGQIVPNLLVMLVTFLFAAFFVACEFALVQSRPSALEEMIDNGTGRKAKVERALRMVHNLNEYLSTTQVGVSLAGIIL
GWIGETTVEFLLVDLFGLTHLSLPNGSLHAVGAILGVIILTYLEVVLTEIVPKNISIDYPIKTLMLVVTPLHYFHILFYP
FVWLLNVSATGIVKMMGMKPADEGNEAFSQAEILSLSKNAVTTGDMEQNDVIYMQRAFELNDKTAKDIMVDRTSLFVIDI
TTTVKEALRDYLTQGYSRFPVVANGDKDKILGYVYIYDLVKQGQVDPSVKVSKLLRSIINVPEVTPIHSILAQMIKKQTP
IVVVVDEYGGTSGIVTDKDIYEELFGTVKDEIDDVSDEYIRQTDDPKVFRVSGKTTLWDFERYFHTNIKAFTDSEIITIA
GFIMEDHPDLKLHDKVKIDHFNFTVADFSRGFANWFDVTQDPKPVKQTVAEEVKEAKNDDNKH

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=402, Percent_Identity=34.5771144278607, Blast_Score=241, Evalue=8e-64,
Organism=Escherichia coli, GI145693175, Length=435, Percent_Identity=23.2183908045977, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790664, Length=425, Percent_Identity=23.0588235294118, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786879, Length=243, Percent_Identity=28.3950617283951, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082033, Length=193, Percent_Identity=27.979274611399, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 52007; Mature: 52007

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGQIVPNLLVMLVTFLFAAFFVACEFALVQSRPSALEEMIDNGTGRKAKVERALRMVH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHH
NLNEYLSTTQVGVSLAGIILGWIGETTVEFLLVDLFGLTHLSLPNGSLHAVGAILGVIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
TYLEVVLTEIVPKNISIDYPIKTLMLVVTPLHYFHILFYPFVWLLNVSATGIVKMMGMKP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
ADEGNEAFSQAEILSLSKNAVTTGDMEQNDVIYMQRAFELNDKTAKDIMVDRTSLFVIDI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHCCCCCHHHHHEEECCEEEEEEE
TTTVKEALRDYLTQGYSRFPVVANGDKDKILGYVYIYDLVKQGQVDPSVKVSKLLRSIIN
HHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
VPEVTPIHSILAQMIKKQTPIVVVVDEYGGTSGIVTDKDIYEELFGTVKDEIDDVSDEYI
CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
RQTDDPKVFRVSGKTTLWDFERYFHTNIKAFTDSEIITIAGFIMEDHPDLKLHDKVKIDH
HCCCCCCEEEEECCCCHHHHHHHHHCCCCEECCCCEEEEEHHHHCCCCCCEEECEEEEEE
FNFTVADFSRGFANWFDVTQDPKPVKQTVAEEVKEAKNDDNKH
EEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MESGQIVPNLLVMLVTFLFAAFFVACEFALVQSRPSALEEMIDNGTGRKAKVERALRMVH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHH
NLNEYLSTTQVGVSLAGIILGWIGETTVEFLLVDLFGLTHLSLPNGSLHAVGAILGVIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
TYLEVVLTEIVPKNISIDYPIKTLMLVVTPLHYFHILFYPFVWLLNVSATGIVKMMGMKP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
ADEGNEAFSQAEILSLSKNAVTTGDMEQNDVIYMQRAFELNDKTAKDIMVDRTSLFVIDI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHCCCCCHHHHHEEECCEEEEEEE
TTTVKEALRDYLTQGYSRFPVVANGDKDKILGYVYIYDLVKQGQVDPSVKVSKLLRSIIN
HHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
VPEVTPIHSILAQMIKKQTPIVVVVDEYGGTSGIVTDKDIYEELFGTVKDEIDDVSDEYI
CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
RQTDDPKVFRVSGKTTLWDFERYFHTNIKAFTDSEIITIAGFIMEDHPDLKLHDKVKIDH
HCCCCCCEEEEECCCCHHHHHHHHHCCCCEECCCCEEEEEHHHHCCCCCCEEECEEEEEE
FNFTVADFSRGFANWFDVTQDPKPVKQTVAEEVKEAKNDDNKH
EEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]