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The map label for this gene is ygcA [C]

Identifier: 116495254

GI number: 116495254

Start: 1768656

End: 1770023

Strand: Direct

Name: ygcA [C]

Synonym: LSEI_1774

Alternate gene names: 116495254

Gene position: 1768656-1770023 (Clockwise)

Preceding gene: 116495252

Following gene: 116495256

Centisome position: 61.09

GC content: 48.54

Gene sequence:

>1368_bases
ATGGCAGTCACTGTCAAAATCGGTCAGCGTTTTCCCCTGACCATCAAGCGTCTAGACATTAATGGCGCAGGTATCGGTTA
TTATCAACGGAAAATTACGTTTGTTACCGGTGCACTACCTCAAGAGGTCGTCGTCGCAGAGGTTACTGGGATTCACGACC
GTTATCTTGAGGCCAAAGTTCATAAAATTCGGACGGCGTCACCAAATCGCGTAACCCCGGCAGAACCGCTATTTGGACAA
ATCGGCGGGGTCGAACTCAATCATCTCGCTTATCCGGCGCAATTGCGATTTAAGCGAGATGTCGTCGCACAATCGCTTGC
CAAATTTAAACCGACTGGCTGGACCCATTATGATTTGCGGCCGACGATTGGCATGGCACAACCAACGCACTATCGAAACA
AGGCCCAATTTCCTGTTCGGGTCATTGATGGTCACGTACGCGCAGGTCTTTATGCTCCAAACTCACATCATCTCATCCCT
TTAACCAAGTTTCTGACCCAAGCACCGCTGACAATGAAAGTCGTGACAACCTTGTGTCAGATTCTCGAACAGCTTCAGAT
CCCGATCTATAACGAGAAAAAGCGCTCCGGAATTGTCAAAACATTGGTTGTTCGCGAATCATTTGCAACGAAAGAAGTCC
AGGTCACGTTCATCACGAACAGTCCAAAATTACCGCACGAAGGCGAATTGCTCAATGGCATCGCCACTCAGCTTCCCATG
GTGGTCAGCATCGCCCAGAATATCAATCCTGGCGAAACATCCTTAATTTGGGGCAAAGAAAGTCGCCTGCTGGCAGGTCT
CCCTTATATCCAAGAAACACTGTTAGGCCGGACTTTTCAACTCTCACCACAAGCATTTCTCCAACTGAACCCAAAACAAA
CAGAGACACTTTATACATTGGCCGCAAAAGCACTTGATTTAGGGCCGCACGACACCTTAATTGATGCGTACTGTGGGATC
GGAACAGTCGGCATCAGTTTAGCAAAAGGCAATCAACCTATTTACGGAATGGACACCATTGCGGAAGGCATTGCCGATGC
CAAGGCAAATGCTAAAGCAAATGGCCTCACCAATGCCCATTATTCAGTGGGCAAGGCTGAAGACATTTTTCCAAAATGGG
TTCAGGAAGGCATGAAACCAGACGCGGTCATCGTTGACCCGCCACGAGCTGGACTAGAGCGTGCCTTCATCGACGCCCTC
CTTGAACTCGATCCACCCAAATTTGTCTACATTTCCTGCAACCCTTCCACCTTGGCCCGTGATCTCGTTTTCCTCACTAA
ACGCTACAAAGTCGACTGGATTCAAAGCATCGACATGTTTCCACAAACAGCACGATGCGAAGCAGTGGTAAAATTTACAA
GAGCGTGA

Upstream 100 bases:

>100_bases
GTATTCGAATAATTGATTTTCACATTAAATCCTCCCGATGATTCATTATACTAAACATTCTTAAGCCTCGTCACCATTTC
TCAAAGCAAAGGAGCATTTC

Downstream 100 bases:

>100_bases
ACAGCTGCGTTTAGGAACCGTAACATAAGCGGCCTCAAGCTGTAACCAGCCGGGCTTTGGCTGGTTACGGCTTGAGGTCC
TTATGTGCAGGTTTCTGCGG

Product: tRNA (uracil-5-)-methyltransferase related enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MAVTVKIGQRFPLTIKRLDINGAGIGYYQRKITFVTGALPQEVVVAEVTGIHDRYLEAKVHKIRTASPNRVTPAEPLFGQ
IGGVELNHLAYPAQLRFKRDVVAQSLAKFKPTGWTHYDLRPTIGMAQPTHYRNKAQFPVRVIDGHVRAGLYAPNSHHLIP
LTKFLTQAPLTMKVVTTLCQILEQLQIPIYNEKKRSGIVKTLVVRESFATKEVQVTFITNSPKLPHEGELLNGIATQLPM
VVSIAQNINPGETSLIWGKESRLLAGLPYIQETLLGRTFQLSPQAFLQLNPKQTETLYTLAAKALDLGPHDTLIDAYCGI
GTVGISLAKGNQPIYGMDTIAEGIADAKANAKANGLTNAHYSVGKAEDIFPKWVQEGMKPDAVIVDPPRAGLERAFIDAL
LELDPPKFVYISCNPSTLARDLVFLTKRYKVDWIQSIDMFPQTARCEAVVKFTRA

Sequences:

>Translated_455_residues
MAVTVKIGQRFPLTIKRLDINGAGIGYYQRKITFVTGALPQEVVVAEVTGIHDRYLEAKVHKIRTASPNRVTPAEPLFGQ
IGGVELNHLAYPAQLRFKRDVVAQSLAKFKPTGWTHYDLRPTIGMAQPTHYRNKAQFPVRVIDGHVRAGLYAPNSHHLIP
LTKFLTQAPLTMKVVTTLCQILEQLQIPIYNEKKRSGIVKTLVVRESFATKEVQVTFITNSPKLPHEGELLNGIATQLPM
VVSIAQNINPGETSLIWGKESRLLAGLPYIQETLLGRTFQLSPQAFLQLNPKQTETLYTLAAKALDLGPHDTLIDAYCGI
GTVGISLAKGNQPIYGMDTIAEGIADAKANAKANGLTNAHYSVGKAEDIFPKWVQEGMKPDAVIVDPPRAGLERAFIDAL
LELDPPKFVYISCNPSTLARDLVFLTKRYKVDWIQSIDMFPQTARCEAVVKFTRA
>Mature_454_residues
AVTVKIGQRFPLTIKRLDINGAGIGYYQRKITFVTGALPQEVVVAEVTGIHDRYLEAKVHKIRTASPNRVTPAEPLFGQI
GGVELNHLAYPAQLRFKRDVVAQSLAKFKPTGWTHYDLRPTIGMAQPTHYRNKAQFPVRVIDGHVRAGLYAPNSHHLIPL
TKFLTQAPLTMKVVTTLCQILEQLQIPIYNEKKRSGIVKTLVVRESFATKEVQVTFITNSPKLPHEGELLNGIATQLPMV
VSIAQNINPGETSLIWGKESRLLAGLPYIQETLLGRTFQLSPQAFLQLNPKQTETLYTLAAKALDLGPHDTLIDAYCGIG
TVGISLAKGNQPIYGMDTIAEGIADAKANAKANGLTNAHYSVGKAEDIFPKWVQEGMKPDAVIVDPPRAGLERAFIDALL
ELDPPKFVYISCNPSTLARDLVFLTKRYKVDWIQSIDMFPQTARCEAVVKFTRA

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=357, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI51173878, Length=357, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI269784680, Length=210, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI269784676, Length=210, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI20149688, Length=210, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI269784678, Length=210, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789148, Length=456, Percent_Identity=27.8508771929825, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787083, Length=363, Percent_Identity=27.8236914600551, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790403, Length=167, Percent_Identity=29.3413173652695, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997438, Length=169, Percent_Identity=32.5443786982249, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322909, Length=148, Percent_Identity=35.1351351351351, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24666579, Length=427, Percent_Identity=28.3372365339578, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 50309; Mature: 50178

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50926 TRAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTVKIGQRFPLTIKRLDINGAGIGYYQRKITFVTGALPQEVVVAEVTGIHDRYLEAKV
CEEEEEECCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHCCHHHHHHHHH
HKIRTASPNRVTPAEPLFGQIGGVELNHLAYPAQLRFKRDVVAQSLAKFKPTGWTHYDLR
HHHCCCCCCCCCCCCCHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECC
PTIGMAQPTHYRNKAQFPVRVIDGHVRAGLYAPNSHHLIPLTKFLTQAPLTMKVVTTLCQ
CCCCCCCCCCCCCCCCCCEEEECCCEEECEECCCCCCEEHHHHHHHCCCCHHHHHHHHHH
ILEQLQIPIYNEKKRSGIVKTLVVRESFATKEVQVTFITNSPKLPHEGELLNGIATQLPM
HHHHHCCCCCCCHHHCCHHHHEEHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHH
VVSIAQNINPGETSLIWGKESRLLAGLPYIQETLLGRTFQLSPQAFLQLNPKQTETLYTL
HHHHHHCCCCCCCEEEECCCCCEEECCHHHHHHHCCCEEEECCHHEEEECCCHHHHHHHH
AAKALDLGPHDTLIDAYCGIGTVGISLAKGNQPIYGMDTIAEGIADAKANAKANGLTNAH
HHHHHCCCCCHHHHHHHHCCCHHEEEEECCCCCEECHHHHHHHHHHCCCCCCCCCCCCCC
YSVGKAEDIFPKWVQEGMKPDAVIVDPPRAGLERAFIDALLELDPPKFVYISCNPSTLAR
CCCCCCHHCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHH
DLVFLTKRYKVDWIQSIDMFPQTARCEAVVKFTRA
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHEECC
>Mature Secondary Structure 
AVTVKIGQRFPLTIKRLDINGAGIGYYQRKITFVTGALPQEVVVAEVTGIHDRYLEAKV
EEEEEECCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHCCHHHHHHHHH
HKIRTASPNRVTPAEPLFGQIGGVELNHLAYPAQLRFKRDVVAQSLAKFKPTGWTHYDLR
HHHCCCCCCCCCCCCCHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECC
PTIGMAQPTHYRNKAQFPVRVIDGHVRAGLYAPNSHHLIPLTKFLTQAPLTMKVVTTLCQ
CCCCCCCCCCCCCCCCCCEEEECCCEEECEECCCCCCEEHHHHHHHCCCCHHHHHHHHHH
ILEQLQIPIYNEKKRSGIVKTLVVRESFATKEVQVTFITNSPKLPHEGELLNGIATQLPM
HHHHHCCCCCCCHHHCCHHHHEEHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHH
VVSIAQNINPGETSLIWGKESRLLAGLPYIQETLLGRTFQLSPQAFLQLNPKQTETLYTL
HHHHHHCCCCCCCEEEECCCCCEEECCHHHHHHHCCCEEEECCHHEEEECCCHHHHHHHH
AAKALDLGPHDTLIDAYCGIGTVGISLAKGNQPIYGMDTIAEGIADAKANAKANGLTNAH
HHHHHCCCCCHHHHHHHHCCCHHEEEEECCCCCEECHHHHHHHHHHCCCCCCCCCCCCCC
YSVGKAEDIFPKWVQEGMKPDAVIVDPPRAGLERAFIDALLELDPPKFVYISCNPSTLAR
CCCCCCHHCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHH
DLVFLTKRYKVDWIQSIDMFPQTARCEAVVKFTRA
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]