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The map label for this gene is cls [H]

Identifier: 116494950

GI number: 116494950

Start: 1456703

End: 1458172

Strand: Direct

Name: cls [H]

Synonym: LSEI_1464

Alternate gene names: 116494950

Gene position: 1456703-1458172 (Clockwise)

Preceding gene: 116494948

Following gene: 116494953

Centisome position: 50.31

GC content: 45.92

Gene sequence:

>1470_bases
ATGTCGCTGATTACCTGGCTTATTCTTATTATTTTGGTTTTAAACACCTTCGGGGCAATCTTCACGGTTCTACGCGAGGT
CCGAGATATCTCAACGACTTGGGCGTGGTTGCTAGTGCTTATTTTTTTACCGATCGTCGGGTTTGGTTTTTATTTATTTG
CTGGCCGCGGCTTATCAACGAAAAAATTGCAACGGATTCAACACGAATATGAGTCTGGCGTAAAAGCATTTGTCTCACTA
CAAAAGCACGAAAACGCCCGGAATAAGTTATTGCCACCGACTGATTACACGCCAGCGGCCAAGGCTTTAACCGCCTTTTT
TCTGAATACCGCGCAAGCACCGGTCCTTGCCCATAACCAAGTGCAACTTTACACGGATGGCGAGAAAAAGTTTGCGGCGT
TATTCCGCGATATTGAGGCCGCTAAAGATTATATCTATGTTGAGTACTACACCATTTACAATGATGAATTAGGCAATCAA
TTCCAGCAACTGCTGATCAAGAAAGCTAAGGAAGGCGTTGTTGTAAAGGTCCTATATGACGCTTGGGGTTCCATGGGCGC
TACAGCAAAGTGGTGGCGCCGGCTGACCGACGTTGGCGGGCAAGCCGAAAGTTACTTTAGTTCCAAGCATCCCATCACTG
ACTTTCGTTTGAACTATCGTGATCATCGCAAGATCGTTGTCATTGACGACCACGTCGGGTATATCGGCGGGTTTAATGTT
GGTGACCAATACGTCTCCCGCAAACCTAAGTTCGGTTATTGGCGCGACACACATTTGCGCATTATCGGCAATACGATTTA
CGCTTTAAAAATTCGCTTCACCATGGATTGGAATGCAACAGTCAGCAAAAAAGACGAAATTGCTTATAGTGTTGAACAAG
ATAGTGCCGATAGTGTCACTGCCGACAGTTTGACAGCCGGTGCAACGCCTATCCAGATCGTTGCTTCCGGACCTGACCGC
CCAACGCAACAAATTAAGTTGGGATACACCAAGTTAATCACCAGTGCCACCAAATCTGTTTGGATTCAAAGTCCTTATTT
GGTGCCAGATGATACTGTGATCGACGCTTTAGTATCCGCTGCCATGTCAGGGATTGATGTTCGCATCATGATTCCTGACA
TGCCTGATCACCCGTTCATTTTCCGCGCGACACAATACTATGCGAATTATCTGACTCGCGCTGGCGTGAAAATCTACCAT
TACGAACACGGCTTTATGCATGCGAAAACGGTGGTTGTCGACAATGCCATCGCCAGCGTTGGCTCGGCAAATTTCGATAT
CCGTAGTTTTAAGCTGAATTTTGAAATTAATGCGTTTATTTATGATCGTAAAGTGGCCAGTAGCTTGGGCCAGATTTTCG
AGGCTGATATGGCGCGCAGTTACTTACTGACGCCTGAGCTAATCGCCAAACAAAGCAGTTGGCTTCGGTTTAAACAAGAC
TTCTCGCGGTTATTATCACCTATTCTTTAA

Upstream 100 bases:

>100_bases
CTCCTACCCAAATATTTCGCAAATCCTCCTATTTGCCCCTCCAACGTGACAGCCTCGCTTCGCTTGAGTACAATGAACTT
ATTCTTCTTGGAGGTGCGGT

Downstream 100 bases:

>100_bases
GTAAAAACTGGCGCTTTATTCTGAATGATGTCAGAATAAAGCGCCAGTTTTTACTATATAAAGCTTCATTAACGTTGCCA
GTCGTCCAAGACTTTGGTGT

Product: phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase-like protein

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSLITWLILIILVLNTFGAIFTVLREVRDISTTWAWLLVLIFLPIVGFGFYLFAGRGLSTKKLQRIQHEYESGVKAFVSL
QKHENARNKLLPPTDYTPAAKALTAFFLNTAQAPVLAHNQVQLYTDGEKKFAALFRDIEAAKDYIYVEYYTIYNDELGNQ
FQQLLIKKAKEGVVVKVLYDAWGSMGATAKWWRRLTDVGGQAESYFSSKHPITDFRLNYRDHRKIVVIDDHVGYIGGFNV
GDQYVSRKPKFGYWRDTHLRIIGNTIYALKIRFTMDWNATVSKKDEIAYSVEQDSADSVTADSLTAGATPIQIVASGPDR
PTQQIKLGYTKLITSATKSVWIQSPYLVPDDTVIDALVSAAMSGIDVRIMIPDMPDHPFIFRATQYYANYLTRAGVKIYH
YEHGFMHAKTVVVDNAIASVGSANFDIRSFKLNFEINAFIYDRKVASSLGQIFEADMARSYLLTPELIAKQSSWLRFKQD
FSRLLSPIL

Sequences:

>Translated_489_residues
MSLITWLILIILVLNTFGAIFTVLREVRDISTTWAWLLVLIFLPIVGFGFYLFAGRGLSTKKLQRIQHEYESGVKAFVSL
QKHENARNKLLPPTDYTPAAKALTAFFLNTAQAPVLAHNQVQLYTDGEKKFAALFRDIEAAKDYIYVEYYTIYNDELGNQ
FQQLLIKKAKEGVVVKVLYDAWGSMGATAKWWRRLTDVGGQAESYFSSKHPITDFRLNYRDHRKIVVIDDHVGYIGGFNV
GDQYVSRKPKFGYWRDTHLRIIGNTIYALKIRFTMDWNATVSKKDEIAYSVEQDSADSVTADSLTAGATPIQIVASGPDR
PTQQIKLGYTKLITSATKSVWIQSPYLVPDDTVIDALVSAAMSGIDVRIMIPDMPDHPFIFRATQYYANYLTRAGVKIYH
YEHGFMHAKTVVVDNAIASVGSANFDIRSFKLNFEINAFIYDRKVASSLGQIFEADMARSYLLTPELIAKQSSWLRFKQD
FSRLLSPIL
>Mature_488_residues
SLITWLILIILVLNTFGAIFTVLREVRDISTTWAWLLVLIFLPIVGFGFYLFAGRGLSTKKLQRIQHEYESGVKAFVSLQ
KHENARNKLLPPTDYTPAAKALTAFFLNTAQAPVLAHNQVQLYTDGEKKFAALFRDIEAAKDYIYVEYYTIYNDELGNQF
QQLLIKKAKEGVVVKVLYDAWGSMGATAKWWRRLTDVGGQAESYFSSKHPITDFRLNYRDHRKIVVIDDHVGYIGGFNVG
DQYVSRKPKFGYWRDTHLRIIGNTIYALKIRFTMDWNATVSKKDEIAYSVEQDSADSVTADSLTAGATPIQIVASGPDRP
TQQIKLGYTKLITSATKSVWIQSPYLVPDDTVIDALVSAAMSGIDVRIMIPDMPDHPFIFRATQYYANYLTRAGVKIYHY
EHGFMHAKTVVVDNAIASVGSANFDIRSFKLNFEINAFIYDRKVASSLGQIFEADMARSYLLTPELIAKQSSWLRFKQDF
SRLLSPIL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=494, Percent_Identity=28.1376518218623, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1787007, Length=369, Percent_Identity=26.2872628726287, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 55469; Mature: 55338

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLITWLILIILVLNTFGAIFTVLREVRDISTTWAWLLVLIFLPIVGFGFYLFAGRGLST
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
KKLQRIQHEYESGVKAFVSLQKHENARNKLLPPTDYTPAAKALTAFFLNTAQAPVLAHNQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCE
VQLYTDGEKKFAALFRDIEAAKDYIYVEYYTIYNDELGNQFQQLLIKKAKEGVVVKVLYD
EEEEECCHHHHHHHHHHHHHHCCEEEEEEEEEECHHHHHHHHHHHHHHHCCCEEEEEEEC
AWGSMGATAKWWRRLTDVGGQAESYFSSKHPITDFRLNYRDHRKIVVIDDHVGYIGGFNV
CCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCEECCCCC
GDQYVSRKPKFGYWRDTHLRIIGNTIYALKIRFTMDWNATVSKKDEIAYSVEQDSADSVT
CHHHHCCCCCCCCCCCCEEEEEECEEEEEEEEEEEECCCCCCCCCCEEEEECCCCCCCCC
ADSLTAGATPIQIVASGPDRPTQQIKLGYTKLITSATKSVWIQSPYLVPDDTVIDALVSA
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
AMSGIDVRIMIPDMPDHPFIFRATQYYANYLTRAGVKIYHYEHGFMHAKTVVVDNAIASV
HHCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEEEEECCCEEEEEEEEHHHHHHC
GSANFDIRSFKLNFEINAFIYDRKVASSLGQIFEADMARSYLLTPELIAKQSSWLRFKQD
CCCCCEEEEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHH
FSRLLSPIL
HHHHHHCCC
>Mature Secondary Structure 
SLITWLILIILVLNTFGAIFTVLREVRDISTTWAWLLVLIFLPIVGFGFYLFAGRGLST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
KKLQRIQHEYESGVKAFVSLQKHENARNKLLPPTDYTPAAKALTAFFLNTAQAPVLAHNQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCE
VQLYTDGEKKFAALFRDIEAAKDYIYVEYYTIYNDELGNQFQQLLIKKAKEGVVVKVLYD
EEEEECCHHHHHHHHHHHHHHCCEEEEEEEEEECHHHHHHHHHHHHHHHCCCEEEEEEEC
AWGSMGATAKWWRRLTDVGGQAESYFSSKHPITDFRLNYRDHRKIVVIDDHVGYIGGFNV
CCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCEECCCCC
GDQYVSRKPKFGYWRDTHLRIIGNTIYALKIRFTMDWNATVSKKDEIAYSVEQDSADSVT
CHHHHCCCCCCCCCCCCEEEEEECEEEEEEEEEEEECCCCCCCCCCEEEEECCCCCCCCC
ADSLTAGATPIQIVASGPDRPTQQIKLGYTKLITSATKSVWIQSPYLVPDDTVIDALVSA
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
AMSGIDVRIMIPDMPDHPFIFRATQYYANYLTRAGVKIYHYEHGFMHAKTVVVDNAIASV
HHCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEEEEECCCEEEEEEEEHHHHHHC
GSANFDIRSFKLNFEINAFIYDRKVASSLGQIFEADMARSYLLTPELIAKQSSWLRFKQD
CCCCCEEEEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHH
FSRLLSPIL
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]