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The map label for this gene is upp

Identifier: 116494655

GI number: 116494655

Start: 1144426

End: 1145055

Strand: Direct

Name: upp

Synonym: LSEI_1159

Alternate gene names: 116494655

Gene position: 1144426-1145055 (Clockwise)

Preceding gene: 116494654

Following gene: 116494656

Centisome position: 39.53

GC content: 48.57

Gene sequence:

>630_bases
ATGGGCAAATTTACAGTTTTGAATCACCCGTTGATTCAGCATAAGCTGACCCTGATTCGGGACAAGCATGCTGGAACCAA
GGAGTTCCGCGAAATCGCCAATGAAATCGCGGAATTAATGGTGTATGAAATCACACGGGATCTGCCACTTGAAAGTATCG
AAATTGAGACACCGATGGGTAAAACTATCCAAAAACAGCTTGCTGGCAAGAAGCTTGCGGTTGTCCCAATTTTGCGCGCG
GGTTTAGGGATGGTTGATGGTGTTTTGCGGCTGATTCCAGCCGCAAAAGTCGGTCACATTGGCATGTATCGCGATGAGAA
GACCCTTAAACCGCATGAATACTTTGTTAAAATGCCGCCGGATATTGAACAACGGGATTTGATCATTGTCGATCCAATGC
TGGCAACTGGCGGATCAGCTAACATGGCCATTGAGGCACTCAAGAAGCGCGGTGCCACATCAATGCGGCTAGTTGTCTTG
GTGGCAGCGCCGGAGGGTGTTAAAGCCGTCCAGGCGGCCAATCCAGATGTCGATATCTATGCGGCAGCGTTAGATGATCA
TTTGAACGAAAATGGCTATATTGTGCCGGGTCTTGGAGATGCAGGCGACAGACTTTTTGGGACAAAATGA

Upstream 100 bases:

>100_bases
CTATCAGAGGGCTTAGGACGTGATGCTCACGGTAGCACATGGCGACTAAGACCTTTATATAGCGGTTTCTAGGATGAAGA
ATGCGTTTAGGAGGCGCCAA

Downstream 100 bases:

>100_bases
CATTCTTTGGCATGTGTAAAAGCACGTGCCTTTTTCATATTTCTTCAAAAGAATTTTCATAGCCGCAAAAATAGATGGTC
AAAAGCCGCCCAAAGCCATG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGKFTVLNHPLIQHKLTLIRDKHAGTKEFREIANEIAELMVYEITRDLPLESIEIETPMGKTIQKQLAGKKLAVVPILRA
GLGMVDGVLRLIPAAKVGHIGMYRDEKTLKPHEYFVKMPPDIEQRDLIIVDPMLATGGSANMAIEALKKRGATSMRLVVL
VAAPEGVKAVQAANPDVDIYAAALDDHLNENGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MGKFTVLNHPLIQHKLTLIRDKHAGTKEFREIANEIAELMVYEITRDLPLESIEIETPMGKTIQKQLAGKKLAVVPILRA
GLGMVDGVLRLIPAAKVGHIGMYRDEKTLKPHEYFVKMPPDIEQRDLIIVDPMLATGGSANMAIEALKKRGATSMRLVVL
VAAPEGVKAVQAANPDVDIYAAALDDHLNENGYIVPGLGDAGDRLFGTK
>Mature_208_residues
GKFTVLNHPLIQHKLTLIRDKHAGTKEFREIANEIAELMVYEITRDLPLESIEIETPMGKTIQKQLAGKKLAVVPILRAG
LGMVDGVLRLIPAAKVGHIGMYRDEKTLKPHEYFVKMPPDIEQRDLIIVDPMLATGGSANMAIEALKKRGATSMRLVVLV
AAPEGVKAVQAANPDVDIYAAALDDHLNENGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=31.1881188118812, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=31.1881188118812, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI21450816, Length=165, Percent_Identity=29.6969696969697, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=53.6231884057971, Blast_Score=234, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17539892, Length=207, Percent_Identity=26.5700483091787, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17539894, Length=207, Percent_Identity=26.5700483091787, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.0625, Blast_Score=132, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45550449, Length=208, Percent_Identity=32.6923076923077, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=32.0197044334975, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=32.0197044334975, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=32.0197044334975, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358379, Length=171, Percent_Identity=25.1461988304094, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_LACC3 (Q03A25)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806389.1
- ProteinModelPortal:   Q03A25
- SMR:   Q03A25
- STRING:   Q03A25
- GeneID:   4421616
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1159
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   Q03A25
- ProtClustDB:   PRK00129
- BioCyc:   LCAS321967:LSEI_1159-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22809; Mature: 22678

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKFTVLNHPLIQHKLTLIRDKHAGTKEFREIANEIAELMVYEITRDLPLESIEIETPMG
CCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
KTIQKQLAGKKLAVVPILRAGLGMVDGVLRLIPAAKVGHIGMYRDEKTLKPHEYFVKMPP
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCCCCCCCCEEEECCC
DIEQRDLIIVDPMLATGGSANMAIEALKKRGATSMRLVVLVAAPEGVKAVQAANPDVDIY
CCCCCCEEEECCHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHCCCCCCEEE
AAALDDHLNENGYIVPGLGDAGDRLFGTK
EEEHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKFTVLNHPLIQHKLTLIRDKHAGTKEFREIANEIAELMVYEITRDLPLESIEIETPMG
CCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
KTIQKQLAGKKLAVVPILRAGLGMVDGVLRLIPAAKVGHIGMYRDEKTLKPHEYFVKMPP
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCCCCCCCCEEEECCC
DIEQRDLIIVDPMLATGGSANMAIEALKKRGATSMRLVVLVAAPEGVKAVQAANPDVDIY
CCCCCCEEEECCHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHCCCCCCEEE
AAALDDHLNENGYIVPGLGDAGDRLFGTK
EEEHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA