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The map label for this gene is nhaK [H]

Identifier: 116494508

GI number: 116494508

Start: 988069

End: 990177

Strand: Direct

Name: nhaK [H]

Synonym: LSEI_1004

Alternate gene names: 116494508

Gene position: 988069-990177 (Clockwise)

Preceding gene: 116494507

Following gene: 116494509

Centisome position: 34.13

GC content: 48.17

Gene sequence:

>2109_bases
ATGCATTTAGTCGAAGCCGTTTTGTTCTTGATGGCACTTGTCATCGTCTCAAACGTGCTCAGTCACTACATTGTGGCTGT
CCCGGTCTCCTTGATTCAAGTCGCGCTGGGATTAGGCGCGGCTTTGTTTTTTCATTTGGAGATCAATTTAGCGACAGACT
GGTTCATGCTGTTGTTCATTGCTCCGCTGCTATTTTATGACGGGCGTAATTTTCCGCGGCGCGAGTTATGGGAACTGCGT
GGTCCGATTATCGGAAACGCGATTTTTCTGGTGTTTGTCACGATGCTGGTCGGTGGGTATCTGATTCACTTTTTGATTCC
GCCGATGCCGTTGCCCGCAAGTTTTGCCTTGGCAGCGATTCTCAGCCCGACTGATCCGATCGCGGTGCAGAGTCTAGCTA
AGCGCGTTCATCTACCAAAAGGTGTGCTGCATTTGGTGAGCGGCGAGAGCTTGATCAACGATGCCAGCGGGCTGATCGGT
TTTAAATATGGCATTGCGGCGACCATGACAGGTACATTTGTCCTTGGCAACGCCGTTCGGGATTTCTTTTATGTGGCAAT
TGTCGGTGCCTTGGCTGGACTGGTGTTAATCAGTTTAATCAACCTAAGTCGCAAATGGCTGCTGCAGCAAGGGATTAACG
ATGTCATTTTGCATACTATCTTGCAGGTGCTAACACCTTTCTTCATCTATCTCGTGGTGGACGAGTTCATGCATGCGTCG
GGTGTCATTGCAGTCGTTGTGGCGGGGTTGCTTAGTAATACTCGCTACAACCGTTACATTGCTGCCTTGCCAGAACTTAG
AATTGTTTCGGAACGTACTTGGGACATTATTGTCTATACACTTAACGGGATTATTTTTCTCATTCTCGGCATTGAATTGC
CGGTTGCGATGACCGACACGATTGCTGATCATGAGGTCAGCACGTTTCAGGCGCTCGGCTTTGTGGTTGTCGTTTACCTG
GGCATTTTAATTGTTCGAACGCTATGGATTTACGGTTACATGCTGCTGGCAAAACGTTCCAAAGAAGGCAAAGCTTCATG
GCGAGCAGCTCTTTTGAGTGGTATTTCTGGCGTGCGCGGCGCGATTACATTAGTCGGGGTGCTTGCCGTCCCAGCAGCTT
TGAGCAACGGTGATGCATTTCCGGAGCGTAGTTTAATGTTGTTCATCGCGGCTGGTGTGGTGGTGCTAAGTTTAATCGTC
GCCATTATCGCTTTGCCGTTAGTTACCCGTTCAGTGGCACCACTGCAAACGCGTGGATCCACGATTGTAACTGACGACAG
TGGCGATCAAGATGATGATGACAGCAACGATATTCGTATCATTTCGCTGAGTCAGGCACAAACCTTTGTCTTTCAAATGG
CGGTTCGCCGAGTTGAGTCGGAGCGCCGTGAGACGAATCAAAAAGCCGCTTTGGACTTGATTGCGGAATATCAGTACCTG
ATTCGCCGGTTAGAACTCGCTGAAGATACCGGTGCTGCCATTCCACCGCTCATTCAGGATGAACTGGATCTGCGAAAAGT
CGGGGTTCAAGGCGAGCTATATGCTTTAGACGATCTATGGCGCGACAACAAAATTATGTCCAAAAGTTACGCTAAAGCCC
GCAAACAATTGCAACACCGCCTGAATGATCTGGACTCAATGGCCAAACGCTCCGGCCGACCAACTTTCCGCATGTTGTTC
GAACGTTCCGCCTTACGCTTATCGCATTGGTGGTACACCGTGGCCAGCGAGCAAAATCGTTCGCACCGATTCTTCAACGA
GCGCTTATTTATTGAAAAAGAAACCGCAAAAGGCGGACTTAAATATTTATCGCAGTTTTTACGACAAAAGGAGAACAAAG
CCCACAATTATAACCGCCAAGTTATTTATGCTTTGATTGTCCAATATCGAAATCGAATTGCTTCGGTGAAGGCTTTGAAC
ACGCACAAATCAACTCAATATGAGCAGGAACTCGGGCGCTTGCGAGCTATTGCGTTTGCAGCTGAACGGGCCGCTATCCA
CGATCTGACAGAAAAAGGGTATATCACGATGACGATGGCGCAAAAACTGAATCAAAATGTTAATTTCACTGAAAATGCGG
CTACCTTAACGTCACTTGAAGAGGTTTAA

Upstream 100 bases:

>100_bases
AAAAACAGTGAAAGCTAAATTTGATGTTGATCTGGAAACTGAGGTTCGAATTATCGGTGAACCTGGTCAACCAAAATAGA
CCTTAGGAAGGGGCGACACA

Downstream 100 bases:

>100_bases
GGGCCGCTGCGGACAAGTCATGCCTGTTCCAAAAGAGCGTTTGGTTGGGTTGAATCAGTTGATTTTTGCTTTTTAAAACA
GACGTTAATTGACAACGGTA

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 702; Mature: 702

Protein sequence:

>702_residues
MHLVEAVLFLMALVIVSNVLSHYIVAVPVSLIQVALGLGAALFFHLEINLATDWFMLLFIAPLLFYDGRNFPRRELWELR
GPIIGNAIFLVFVTMLVGGYLIHFLIPPMPLPASFALAAILSPTDPIAVQSLAKRVHLPKGVLHLVSGESLINDASGLIG
FKYGIAATMTGTFVLGNAVRDFFYVAIVGALAGLVLISLINLSRKWLLQQGINDVILHTILQVLTPFFIYLVVDEFMHAS
GVIAVVVAGLLSNTRYNRYIAALPELRIVSERTWDIIVYTLNGIIFLILGIELPVAMTDTIADHEVSTFQALGFVVVVYL
GILIVRTLWIYGYMLLAKRSKEGKASWRAALLSGISGVRGAITLVGVLAVPAALSNGDAFPERSLMLFIAAGVVVLSLIV
AIIALPLVTRSVAPLQTRGSTIVTDDSGDQDDDDSNDIRIISLSQAQTFVFQMAVRRVESERRETNQKAALDLIAEYQYL
IRRLELAEDTGAAIPPLIQDELDLRKVGVQGELYALDDLWRDNKIMSKSYAKARKQLQHRLNDLDSMAKRSGRPTFRMLF
ERSALRLSHWWYTVASEQNRSHRFFNERLFIEKETAKGGLKYLSQFLRQKENKAHNYNRQVIYALIVQYRNRIASVKALN
THKSTQYEQELGRLRAIAFAAERAAIHDLTEKGYITMTMAQKLNQNVNFTENAATLTSLEEV

Sequences:

>Translated_702_residues
MHLVEAVLFLMALVIVSNVLSHYIVAVPVSLIQVALGLGAALFFHLEINLATDWFMLLFIAPLLFYDGRNFPRRELWELR
GPIIGNAIFLVFVTMLVGGYLIHFLIPPMPLPASFALAAILSPTDPIAVQSLAKRVHLPKGVLHLVSGESLINDASGLIG
FKYGIAATMTGTFVLGNAVRDFFYVAIVGALAGLVLISLINLSRKWLLQQGINDVILHTILQVLTPFFIYLVVDEFMHAS
GVIAVVVAGLLSNTRYNRYIAALPELRIVSERTWDIIVYTLNGIIFLILGIELPVAMTDTIADHEVSTFQALGFVVVVYL
GILIVRTLWIYGYMLLAKRSKEGKASWRAALLSGISGVRGAITLVGVLAVPAALSNGDAFPERSLMLFIAAGVVVLSLIV
AIIALPLVTRSVAPLQTRGSTIVTDDSGDQDDDDSNDIRIISLSQAQTFVFQMAVRRVESERRETNQKAALDLIAEYQYL
IRRLELAEDTGAAIPPLIQDELDLRKVGVQGELYALDDLWRDNKIMSKSYAKARKQLQHRLNDLDSMAKRSGRPTFRMLF
ERSALRLSHWWYTVASEQNRSHRFFNERLFIEKETAKGGLKYLSQFLRQKENKAHNYNRQVIYALIVQYRNRIASVKALN
THKSTQYEQELGRLRAIAFAAERAAIHDLTEKGYITMTMAQKLNQNVNFTENAATLTSLEEV
>Mature_702_residues
MHLVEAVLFLMALVIVSNVLSHYIVAVPVSLIQVALGLGAALFFHLEINLATDWFMLLFIAPLLFYDGRNFPRRELWELR
GPIIGNAIFLVFVTMLVGGYLIHFLIPPMPLPASFALAAILSPTDPIAVQSLAKRVHLPKGVLHLVSGESLINDASGLIG
FKYGIAATMTGTFVLGNAVRDFFYVAIVGALAGLVLISLINLSRKWLLQQGINDVILHTILQVLTPFFIYLVVDEFMHAS
GVIAVVVAGLLSNTRYNRYIAALPELRIVSERTWDIIVYTLNGIIFLILGIELPVAMTDTIADHEVSTFQALGFVVVVYL
GILIVRTLWIYGYMLLAKRSKEGKASWRAALLSGISGVRGAITLVGVLAVPAALSNGDAFPERSLMLFIAAGVVVLSLIV
AIIALPLVTRSVAPLQTRGSTIVTDDSGDQDDDDSNDIRIISLSQAQTFVFQMAVRRVESERRETNQKAALDLIAEYQYL
IRRLELAEDTGAAIPPLIQDELDLRKVGVQGELYALDDLWRDNKIMSKSYAKARKQLQHRLNDLDSMAKRSGRPTFRMLF
ERSALRLSHWWYTVASEQNRSHRFFNERLFIEKETAKGGLKYLSQFLRQKENKAHNYNRQVIYALIVQYRNRIASVKALN
THKSTQYEQELGRLRAIAFAAERAAIHDLTEKGYITMTMAQKLNQNVNFTENAATLTSLEEV

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=414, Percent_Identity=24.6376811594203, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790501, Length=425, Percent_Identity=35.0588235294118, Blast_Score=226, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI25150332, Length=400, Percent_Identity=23.75, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221473212, Length=365, Percent_Identity=24.1095890410959, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221473215, Length=365, Percent_Identity=24.1095890410959, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281364513, Length=365, Percent_Identity=24.1095890410959, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221473222, Length=365, Percent_Identity=24.1095890410959, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 78284; Mature: 78284

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLVEAVLFLMALVIVSNVLSHYIVAVPVSLIQVALGLGAALFFHLEINLATDWFMLLFI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHH
APLLFYDGRNFPRRELWELRGPIIGNAIFLVFVTMLVGGYLIHFLIPPMPLPASFALAAI
HHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LSPTDPIAVQSLAKRVHLPKGVLHLVSGESLINDASGLIGFKYGIAATMTGTFVLGNAVR
CCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DFFYVAIVGALAGLVLISLINLSRKWLLQQGINDVILHTILQVLTPFFIYLVVDEFMHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVIAVVVAGLLSNTRYNRYIAALPELRIVSERTWDIIVYTLNGIIFLILGIELPVAMTDT
CHHHHHHHHHHHCCCHHHHHHHCCCHHEECCCCCEEEEEHHHHHHHHHHHCCCCHHHHHH
IADHEVSTFQALGFVVVVYLGILIVRTLWIYGYMLLAKRSKEGKASWRAALLSGISGVRG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
AITLVGVLAVPAALSNGDAFPERSLMLFIAAGVVVLSLIVAIIALPLVTRSVAPLQTRGS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCC
TIVTDDSGDQDDDDSNDIRIISLSQAQTFVFQMAVRRVESERRETNQKAALDLIAEYQYL
EEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRLELAEDTGAAIPPLIQDELDLRKVGVQGELYALDDLWRDNKIMSKSYAKARKQLQHR
HHHHHHHHCCCCCCCCHHHCCHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHH
LNDLDSMAKRSGRPTFRMLFERSALRLSHWWYTVASEQNRSHRFFNERLFIEKETAKGGL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHEEEEEHHHHHHH
KYLSQFLRQKENKAHNYNRQVIYALIVQYRNRIASVKALNTHKSTQYEQELGRLRAIAFA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AERAAIHDLTEKGYITMTMAQKLNQNVNFTENAATLTSLEEV
HHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MHLVEAVLFLMALVIVSNVLSHYIVAVPVSLIQVALGLGAALFFHLEINLATDWFMLLFI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHH
APLLFYDGRNFPRRELWELRGPIIGNAIFLVFVTMLVGGYLIHFLIPPMPLPASFALAAI
HHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LSPTDPIAVQSLAKRVHLPKGVLHLVSGESLINDASGLIGFKYGIAATMTGTFVLGNAVR
CCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DFFYVAIVGALAGLVLISLINLSRKWLLQQGINDVILHTILQVLTPFFIYLVVDEFMHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVIAVVVAGLLSNTRYNRYIAALPELRIVSERTWDIIVYTLNGIIFLILGIELPVAMTDT
CHHHHHHHHHHHCCCHHHHHHHCCCHHEECCCCCEEEEEHHHHHHHHHHHCCCCHHHHHH
IADHEVSTFQALGFVVVVYLGILIVRTLWIYGYMLLAKRSKEGKASWRAALLSGISGVRG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
AITLVGVLAVPAALSNGDAFPERSLMLFIAAGVVVLSLIVAIIALPLVTRSVAPLQTRGS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCC
TIVTDDSGDQDDDDSNDIRIISLSQAQTFVFQMAVRRVESERRETNQKAALDLIAEYQYL
EEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRLELAEDTGAAIPPLIQDELDLRKVGVQGELYALDDLWRDNKIMSKSYAKARKQLQHR
HHHHHHHHCCCCCCCCHHHCCHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHH
LNDLDSMAKRSGRPTFRMLFERSALRLSHWWYTVASEQNRSHRFFNERLFIEKETAKGGL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHEEEEEHHHHHHH
KYLSQFLRQKENKAHNYNRQVIYALIVQYRNRIASVKALNTHKSTQYEQELGRLRAIAFA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AERAAIHDLTEKGYITMTMAQKLNQNVNFTENAATLTSLEEV
HHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]