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The map label for this gene is uvrB

Identifier: 116494463

GI number: 116494463

Start: 935523

End: 937538

Strand: Direct

Name: uvrB

Synonym: LSEI_0956

Alternate gene names: 116494463

Gene position: 935523-937538 (Clockwise)

Preceding gene: 116494462

Following gene: 116494464

Centisome position: 32.31

GC content: 46.28

Gene sequence:

>2016_bases
ATGATCGAACGAATAGCCGATCGTAAATTTGATCTGGTTTCACCTTACCAACCAGCTGGTGATCAGCCACAGGCCATTGC
CAAGTTGACAAAGGGCTTTGAAGAGGGTAAGAAAGAACAGATCTTGTTGGGTGCAACTGGGACTGGGAAGACCTTTACGA
TGAGCAACATCATCGCCAACTTGAACAAGCCGACCTTGATTTTGTCTCACAACAAAACATTGGCCGGGCAGCTTTATGGT
GAATTCAAGGAATTCTTCCCGCATAACGCGGTTGAGTATTTTGTTTCCTACTATGATTATTATCAACCTGAAGCCTATGT
CCCGAGTACCGACACGTATATCGAAAAAGATAGTGCGATTAACGACGAAATTGATAAACTGCGGCACAGCGCCACCAGTG
CGTTGTTGGAACGAAATGATGTCATCGTGGTGGCCTCAGTGTCGTCAATCTTTGGTTTAGGTGATCCGCATGAATACAAG
AATCATGTGCTGTCATTGCGAACTGGCATGACGATTGATCGTAATACACTGTTACGCCAACTTGTAGATATTCAATTTGA
TCGAAACGACATTGATTTTCAACGTGGTCGCTTTCGAGTTCGCGGCGATGTCGTTGAAATTTTCCCGGCCAGTCGTGATG
ACCATGCGATTCGAGTCGAGTTTTTCGGTGATGAAATTGATCGGATTACCGAAGTCGACGCATTGACCGGCGAAGTCATC
GGGACACGTGATCATGTGGCAATTTTCCCGGCAACGCATTTCATGACCAGCGATGAACAGATGCAGCGAGCGATTAAGAG
CATTGCTGCTGAGTTAGAGGCACAATTGAAAGTCCTGCGCAGTGAAAACAAACTGTTGGAGGCGCAACGGTTAGAGCAGC
GGACGAACTATGATATCGAAATGATGCGGGAAATGGGTTTCACCAGCGGCATTGAAAACTATTCACGCCATATGGATGGC
CGTAAGCCTGGTGAACCACCGTATACACTGCTGGACTTTTTCCCGAAAGACTTCAACATTATGGTGGATGAAAGTCATGT
CACCATGCCGCAAATTCGCGGGATGTACAATGGCGACCGAGCGCGGAAGCAAATGCTGGTCAACTACGGTTTCCGTTTAC
CAAGTGCTTTGGACAACCGGCCATTGAAAATCAATGAATTTGAACAACATGTCCATCGTATTTTGTATGTGAGTGCTACT
CCTGGTCCTTATGAACTGGATCGGGTTCCTAAAGACGATATTGCTGAGCAGATCATTCGGCCAACCGGGTTATTGGATCC
GAAGATCGAGGTTCGACCGGTCATGGGTCAAATTGATGATCTTGTTGGTGAAATTAACAAACGGGTTGATGCTCACGAAC
GTGTTTTCATCACCACCTTGACCAAGAAAATGGCTGAAGATCTGACTGACTACCTGAAAGACATGGGCATCAAGGTTCGC
TACTTGCATAGTGACATCAAGACACTTGAACGGACGCAGATTATTCGTGATCTGCGACTTGGCAAGTTTGATGTGCTGAT
TGGGATTAACCTTTTGCGTGAAGGAATCGATGTCCCTGAAGTTTCGTTGATTGCAATCTTGGATGCTGACAAGGAAGGCT
TTTTGCGTGCCGAACGTTCCTTGATTCAAACCATTGGGCGGGCTTCACGTAACGAGCATGGCAAAGTCATCATGTATGCT
GATAAGGTGACAGATTCCATGAAGGCTGCCATTGATGAAACCCAACGTCGACGGACGATTCAGGAGAAGTTCAACGAAGA
ACATCACATCACGCCAAAGACCATTATCAAACCGATTCGGGCAGCTATTTCCAGCTATGAACAATCAGATGATGATAAAG
CCGAGGCCAAGAAGACTTTTGCTGAAGTTGATTATGAGGATATGAGCAAGGCTGATAAGAAGGAGTTAGTAGCAAACCTG
CGCTCACAAATGCAGGCGGCGGCTAAGAAGCTTGATTTCGAGCAGGCAGCGTCATTACGCGACACAATTCTTGAATTGCA
GGCTGATATGTCTTAA

Upstream 100 bases:

>100_bases
ATGCGTTCACTGGGGCTTTTTTCCTGCACGGATTGACACGTGTTCACCTTGTATTCGGAATGAATGATGCCCATGTGATT
GTTTTATAGGAGGCATGTCG

Downstream 100 bases:

>100_bases
TCAGATCGCACTTGCACGATGGTACCAAGTCAGCCATGATTGCTTTGAACAGATTCGGTGAGCGCGAACCAGCCCGGTTA
GAAACCGGAGCATAAGTGGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MIERIADRKFDLVSPYQPAGDQPQAIAKLTKGFEEGKKEQILLGATGTGKTFTMSNIIANLNKPTLILSHNKTLAGQLYG
EFKEFFPHNAVEYFVSYYDYYQPEAYVPSTDTYIEKDSAINDEIDKLRHSATSALLERNDVIVVASVSSIFGLGDPHEYK
NHVLSLRTGMTIDRNTLLRQLVDIQFDRNDIDFQRGRFRVRGDVVEIFPASRDDHAIRVEFFGDEIDRITEVDALTGEVI
GTRDHVAIFPATHFMTSDEQMQRAIKSIAAELEAQLKVLRSENKLLEAQRLEQRTNYDIEMMREMGFTSGIENYSRHMDG
RKPGEPPYTLLDFFPKDFNIMVDESHVTMPQIRGMYNGDRARKQMLVNYGFRLPSALDNRPLKINEFEQHVHRILYVSAT
PGPYELDRVPKDDIAEQIIRPTGLLDPKIEVRPVMGQIDDLVGEINKRVDAHERVFITTLTKKMAEDLTDYLKDMGIKVR
YLHSDIKTLERTQIIRDLRLGKFDVLIGINLLREGIDVPEVSLIAILDADKEGFLRAERSLIQTIGRASRNEHGKVIMYA
DKVTDSMKAAIDETQRRRTIQEKFNEEHHITPKTIIKPIRAAISSYEQSDDDKAEAKKTFAEVDYEDMSKADKKELVANL
RSQMQAAAKKLDFEQAASLRDTILELQADMS

Sequences:

>Translated_671_residues
MIERIADRKFDLVSPYQPAGDQPQAIAKLTKGFEEGKKEQILLGATGTGKTFTMSNIIANLNKPTLILSHNKTLAGQLYG
EFKEFFPHNAVEYFVSYYDYYQPEAYVPSTDTYIEKDSAINDEIDKLRHSATSALLERNDVIVVASVSSIFGLGDPHEYK
NHVLSLRTGMTIDRNTLLRQLVDIQFDRNDIDFQRGRFRVRGDVVEIFPASRDDHAIRVEFFGDEIDRITEVDALTGEVI
GTRDHVAIFPATHFMTSDEQMQRAIKSIAAELEAQLKVLRSENKLLEAQRLEQRTNYDIEMMREMGFTSGIENYSRHMDG
RKPGEPPYTLLDFFPKDFNIMVDESHVTMPQIRGMYNGDRARKQMLVNYGFRLPSALDNRPLKINEFEQHVHRILYVSAT
PGPYELDRVPKDDIAEQIIRPTGLLDPKIEVRPVMGQIDDLVGEINKRVDAHERVFITTLTKKMAEDLTDYLKDMGIKVR
YLHSDIKTLERTQIIRDLRLGKFDVLIGINLLREGIDVPEVSLIAILDADKEGFLRAERSLIQTIGRASRNEHGKVIMYA
DKVTDSMKAAIDETQRRRTIQEKFNEEHHITPKTIIKPIRAAISSYEQSDDDKAEAKKTFAEVDYEDMSKADKKELVANL
RSQMQAAAKKLDFEQAASLRDTILELQADMS
>Mature_671_residues
MIERIADRKFDLVSPYQPAGDQPQAIAKLTKGFEEGKKEQILLGATGTGKTFTMSNIIANLNKPTLILSHNKTLAGQLYG
EFKEFFPHNAVEYFVSYYDYYQPEAYVPSTDTYIEKDSAINDEIDKLRHSATSALLERNDVIVVASVSSIFGLGDPHEYK
NHVLSLRTGMTIDRNTLLRQLVDIQFDRNDIDFQRGRFRVRGDVVEIFPASRDDHAIRVEFFGDEIDRITEVDALTGEVI
GTRDHVAIFPATHFMTSDEQMQRAIKSIAAELEAQLKVLRSENKLLEAQRLEQRTNYDIEMMREMGFTSGIENYSRHMDG
RKPGEPPYTLLDFFPKDFNIMVDESHVTMPQIRGMYNGDRARKQMLVNYGFRLPSALDNRPLKINEFEQHVHRILYVSAT
PGPYELDRVPKDDIAEQIIRPTGLLDPKIEVRPVMGQIDDLVGEINKRVDAHERVFITTLTKKMAEDLTDYLKDMGIKVR
YLHSDIKTLERTQIIRDLRLGKFDVLIGINLLREGIDVPEVSLIAILDADKEGFLRAERSLIQTIGRASRNEHGKVIMYA
DKVTDSMKAAIDETQRRRTIQEKFNEEHHITPKTIIKPIRAAISSYEQSDDDKAEAKKTFAEVDYEDMSKADKKELVANL
RSQMQAAAKKLDFEQAASLRDTILELQADMS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=58.0451127819549, Blast_Score=776, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_LACC3 (Q03AL7)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806197.1
- ProteinModelPortal:   Q03AL7
- SMR:   Q03AL7
- STRING:   Q03AL7
- GeneID:   4419353
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0956
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q03AL7
- ProtClustDB:   PRK05298
- BioCyc:   LCAS321967:LSEI_0956-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76716; Mature: 76716

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERIADRKFDLVSPYQPAGDQPQAIAKLTKGFEEGKKEQILLGATGTGKTFTMSNIIAN
CCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHC
LNKPTLILSHNKTLAGQLYGEFKEFFPHNAVEYFVSYYDYYQPEAYVPSTDTYIEKDSAI
CCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDEIDKLRHSATSALLERNDVIVVASVSSIFGLGDPHEYKNHVLSLRTGMTIDRNTLLRQ
HHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCEECHHHHHHH
LVDIQFDRNDIDFQRGRFRVRGDVVEIFPASRDDHAIRVEFFGDEIDRITEVDALTGEVI
HHHCCCCCCCCCHHCCCEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHCCCC
GTRDHVAIFPATHFMTSDEQMQRAIKSIAAELEAQLKVLRSENKLLEAQRLEQRTNYDIE
CCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MMREMGFTSGIENYSRHMDGRKPGEPPYTLLDFFPKDFNIMVDESHVTMPQIRGMYNGDR
HHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHCCCCCCHH
ARKQMLVNYGFRLPSALDNRPLKINEFEQHVHRILYVSATPGPYELDRVPKDDIAEQIIR
HHHHHHHHHCCCCCHHHCCCCCEECHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHC
PTGLLDPKIEVRPVMGQIDDLVGEINKRVDAHERVFITTLTKKMAEDLTDYLKDMGIKVR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHHCCCEEE
YLHSDIKTLERTQIIRDLRLGKFDVLIGINLLREGIDVPEVSLIAILDADKEGFLRAERS
EHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHH
LIQTIGRASRNEHGKVIMYADKVTDSMKAAIDETQRRRTIQEKFNEEHHITPKTIIKPIR
HHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AAISSYEQSDDDKAEAKKTFAEVDYEDMSKADKKELVANLRSQMQAAAKKLDFEQAASLR
HHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DTILELQADMS
HHHHHHHHCCC
>Mature Secondary Structure
MIERIADRKFDLVSPYQPAGDQPQAIAKLTKGFEEGKKEQILLGATGTGKTFTMSNIIAN
CCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHC
LNKPTLILSHNKTLAGQLYGEFKEFFPHNAVEYFVSYYDYYQPEAYVPSTDTYIEKDSAI
CCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDEIDKLRHSATSALLERNDVIVVASVSSIFGLGDPHEYKNHVLSLRTGMTIDRNTLLRQ
HHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCEECHHHHHHH
LVDIQFDRNDIDFQRGRFRVRGDVVEIFPASRDDHAIRVEFFGDEIDRITEVDALTGEVI
HHHCCCCCCCCCHHCCCEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHCCCC
GTRDHVAIFPATHFMTSDEQMQRAIKSIAAELEAQLKVLRSENKLLEAQRLEQRTNYDIE
CCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MMREMGFTSGIENYSRHMDGRKPGEPPYTLLDFFPKDFNIMVDESHVTMPQIRGMYNGDR
HHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHCCCCCCHH
ARKQMLVNYGFRLPSALDNRPLKINEFEQHVHRILYVSATPGPYELDRVPKDDIAEQIIR
HHHHHHHHHCCCCCHHHCCCCCEECHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHC
PTGLLDPKIEVRPVMGQIDDLVGEINKRVDAHERVFITTLTKKMAEDLTDYLKDMGIKVR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHHCCCEEE
YLHSDIKTLERTQIIRDLRLGKFDVLIGINLLREGIDVPEVSLIAILDADKEGFLRAERS
EHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHH
LIQTIGRASRNEHGKVIMYADKVTDSMKAAIDETQRRRTIQEKFNEEHHITPKTIIKPIR
HHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AAISSYEQSDDDKAEAKKTFAEVDYEDMSKADKKELVANLRSQMQAAAKKLDFEQAASLR
HHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DTILELQADMS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA