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The map label for this gene is gpsA

Identifier: 116494454

GI number: 116494454

Start: 925211

End: 926266

Strand: Direct

Name: gpsA

Synonym: LSEI_0947

Alternate gene names: 116494454

Gene position: 925211-926266 (Clockwise)

Preceding gene: 116494453

Following gene: 116494455

Centisome position: 31.96

GC content: 48.58

Gene sequence:

>1056_bases
GTGCCAACGAAAATAGCAGTGTTAGGTGCTGGTTCTTGGGGCACCGTGCTAGCCAATTTATTAACTGAAAATGGTCATGA
AGTTGATTTGTGGAGTCACAATCCGGATCAGGTAGCCTTGATGAAGCGGACCCATCAAAATGAACACTATCTTGGTGCTG
AGTTTACATTACAGCCGGCTTTGCATGTGACTGCTGACCTTGGCCAAGCCTTGGATCAAGCGGCGGTCATTTTGTTTGTT
GTTCCAACCAATGCGATTCGCAGCGTGGCCGAGCAAGTTAAACCAATTCTGCAAGCTCATAAAGGGCGCGGTGAACAACC
GATTATTGTTCATGCTGCTAAAGGACTTGAACGTGGCAGTGAGTTGCGCATCTCGCAAGTGCTCGCAGAAGTCTTGCCGA
AGGAATTAATTCAAGGTATTGTTGTGATTTCCGGCCCGAGTCACGCCGAAGATGTCGCCACCCACGATATTACAACGTTA
ACCGCCGCTTCCGATGATTTGAAGTTGGCAGAAAAAGTGCAGAAGCTGTTCATGAATGATTATTTTCGGTTGTATACCAA
CACAGACGTCATTGGCGTTGAAATTGGTGCCGCTCTGAAAAACGTGATTGCCATTGGCGCTGGTGCCTTGCACGGTCTCG
GCTATGGCGACAACACCAAAGCGGCCTTGATGACTCGCGGTTTAGCTGAAATCAGTCGGGTCGGCGTGAAGCTAGGTGCC
GAACCGTTGACTTTCATCGGCTTATCCGGTGTCGGTGATCTGATTGTGACCTGTACCTCGGTCCACAGTCGTAACTGGCG
AGCCGGCAACGCACTTGGAAAAGGTGAAAAGTTGCCGGATGTGTTGAAAAATATGGGGATGGTGGTTGAAGGTGTCTCAA
CGACCAAAGTTGCCCATCAAATGGCCCGTGAACTTGACGTTGACATGCCAATCACAGACGCGATTTATCAAGTGCTCTAC
GAAAACGCGCCGATTCGTACTGTCATTACTGACTTGATGAAGCGTTCTGGTAAACCGGAATTCGATTTTGACAATGCGAG
TTTACAAAAACCATAA

Upstream 100 bases:

>100_bases
GTTGCAGCGGCTGGCTTAGTTTGGTATCGGCGGCGGCAAGGAAATGTGGCATGGTATTTAGACGGCAATCCGCTTAAAGC
GGTGGAATAGGAGTGATTTT

Downstream 100 bases:

>100_bases
AACCATGTATATTAAACAGTATAGCTTACTAATTGTAAGCAATATGGGAAAAGGAGAGACTGCCCATGGCAAAAAAATAT
GATGTAATCGTGATCGGTGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MPTKIAVLGAGSWGTVLANLLTENGHEVDLWSHNPDQVALMKRTHQNEHYLGAEFTLQPALHVTADLGQALDQAAVILFV
VPTNAIRSVAEQVKPILQAHKGRGEQPIIVHAAKGLERGSELRISQVLAEVLPKELIQGIVVISGPSHAEDVATHDITTL
TAASDDLKLAEKVQKLFMNDYFRLYTNTDVIGVEIGAALKNVIAIGAGALHGLGYGDNTKAALMTRGLAEISRVGVKLGA
EPLTFIGLSGVGDLIVTCTSVHSRNWRAGNALGKGEKLPDVLKNMGMVVEGVSTTKVAHQMARELDVDMPITDAIYQVLY
ENAPIRTVITDLMKRSGKPEFDFDNASLQKP

Sequences:

>Translated_351_residues
MPTKIAVLGAGSWGTVLANLLTENGHEVDLWSHNPDQVALMKRTHQNEHYLGAEFTLQPALHVTADLGQALDQAAVILFV
VPTNAIRSVAEQVKPILQAHKGRGEQPIIVHAAKGLERGSELRISQVLAEVLPKELIQGIVVISGPSHAEDVATHDITTL
TAASDDLKLAEKVQKLFMNDYFRLYTNTDVIGVEIGAALKNVIAIGAGALHGLGYGDNTKAALMTRGLAEISRVGVKLGA
EPLTFIGLSGVGDLIVTCTSVHSRNWRAGNALGKGEKLPDVLKNMGMVVEGVSTTKVAHQMARELDVDMPITDAIYQVLY
ENAPIRTVITDLMKRSGKPEFDFDNASLQKP
>Mature_350_residues
PTKIAVLGAGSWGTVLANLLTENGHEVDLWSHNPDQVALMKRTHQNEHYLGAEFTLQPALHVTADLGQALDQAAVILFVV
PTNAIRSVAEQVKPILQAHKGRGEQPIIVHAAKGLERGSELRISQVLAEVLPKELIQGIVVISGPSHAEDVATHDITTLT
AASDDLKLAEKVQKLFMNDYFRLYTNTDVIGVEIGAALKNVIAIGAGALHGLGYGDNTKAALMTRGLAEISRVGVKLGAE
PLTFIGLSGVGDLIVTCTSVHSRNWRAGNALGKGEKLPDVLKNMGMVVEGVSTTKVAHQMARELDVDMPITDAIYQVLYE
NAPIRTVITDLMKRSGKPEFDFDNASLQKP

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=349, Percent_Identity=28.3667621776504, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI24307999, Length=353, Percent_Identity=26.628895184136, Blast_Score=121, Evalue=9e-28,
Organism=Escherichia coli, GI1790037, Length=338, Percent_Identity=41.7159763313609, Blast_Score=251, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI32564399, Length=342, Percent_Identity=28.6549707602339, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193210136, Length=356, Percent_Identity=28.0898876404494, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564403, Length=356, Percent_Identity=28.0898876404494, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17507425, Length=339, Percent_Identity=26.2536873156342, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI193210134, Length=213, Percent_Identity=32.8638497652582, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320181, Length=357, Percent_Identity=28.8515406162465, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324513, Length=351, Percent_Identity=28.7749287749288, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136202, Length=338, Percent_Identity=27.810650887574, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136200, Length=338, Percent_Identity=27.810650887574, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136204, Length=338, Percent_Identity=27.810650887574, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI22026922, Length=357, Percent_Identity=23.5294117647059, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_LACC3 (Q03AM6)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806188.1
- ProteinModelPortal:   Q03AM6
- SMR:   Q03AM6
- STRING:   Q03AM6
- GeneID:   4419344
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0947
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q03AM6
- ProtClustDB:   PRK00094
- BioCyc:   LCAS321967:LSEI_0947-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 37706; Mature: 37575

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 200-200 BINDING 114-114 BINDING 114-114 BINDING 149-149 BINDING 264-264 BINDING 290-290

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKIAVLGAGSWGTVLANLLTENGHEVDLWSHNPDQVALMKRTHQNEHYLGAEFTLQPA
CCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEECCEEEECCH
LHVTADLGQALDQAAVILFVVPTNAIRSVAEQVKPILQAHKGRGEQPIIVHAAKGLERGS
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
ELRISQVLAEVLPKELIQGIVVISGPSHAEDVATHDITTLTAASDDLKLAEKVQKLFMND
HHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHH
YFRLYTNTDVIGVEIGAALKNVIAIGAGALHGLGYGDNTKAALMTRGLAEISRVGVKLGA
HHEEEECCCEEEEEHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
EPLTFIGLSGVGDLIVTCTSVHSRNWRAGNALGKGEKLPDVLKNMGMVVEGVSTTKVAHQ
CCEEEEECCCCCHHHHEEHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEECCHHHHHHHH
MARELDVDMPITDAIYQVLYENAPIRTVITDLMKRSGKPEFDFDNASLQKP
HHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTKIAVLGAGSWGTVLANLLTENGHEVDLWSHNPDQVALMKRTHQNEHYLGAEFTLQPA
CCEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEECCEEEECCH
LHVTADLGQALDQAAVILFVVPTNAIRSVAEQVKPILQAHKGRGEQPIIVHAAKGLERGS
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
ELRISQVLAEVLPKELIQGIVVISGPSHAEDVATHDITTLTAASDDLKLAEKVQKLFMND
HHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHH
YFRLYTNTDVIGVEIGAALKNVIAIGAGALHGLGYGDNTKAALMTRGLAEISRVGVKLGA
HHEEEECCCEEEEEHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
EPLTFIGLSGVGDLIVTCTSVHSRNWRAGNALGKGEKLPDVLKNMGMVVEGVSTTKVAHQ
CCEEEEECCCCCHHHHEEHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEECCHHHHHHHH
MARELDVDMPITDAIYQVLYENAPIRTVITDLMKRSGKPEFDFDNASLQKP
HHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA