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The map label for this gene is gntK [H]

Identifier: 116493799

GI number: 116493799

Start: 223538

End: 225106

Strand: Direct

Name: gntK [H]

Synonym: LSEI_0228

Alternate gene names: 116493799

Gene position: 223538-225106 (Clockwise)

Preceding gene: 116493798

Following gene: 116493800

Centisome position: 7.72

GC content: 48.76

Gene sequence:

>1569_bases
ATGGCAATCAAATATATGATTGGCGTTGATCTGGGCACTACTAGCACAAAGGTCGTTTTGTTTGATCTCAAGGGTCACGC
AATTGCAACCGCCAATAATCCCTACCCGTTATATCAAGATACGCCCGACATGGCTGAGGAAGATCCGGAAGAGATTTTTG
CAGCGACAGTTGGCGGTTTAACTGAAGTGATGCATCGCGGTAATGTCCAACCCGATGAACTTGGCGGGGTTTCCTTTTCC
GCAGCGATGCACAGTCTGATTTTGATGGACGAAAATGATAAGCCGCTGACGCGCGTCATCACGTGGGCTGATAACCGAGC
AGCAGCCTATGCAACGAAGCTGAAGCAAAGCGATTTAGGGATGACACTGTTTAAAAACACAGGTGTGCCGACGCACCCGA
TGTCCCCATTGGTTAAATTGCTTTGGTTGAGTGCCGAACATCCAGAATTGGTCGCTCAGACTTCCCACTTTATTGGCATT
AAAGACTTTATTTTGTTCCGCTTCTTTGGCCGATATGTGCAGGATTACTCGCTGGCTAACGCAACTGGGCTCTTTAATAT
TCACACCATGGATTGGGATGACCGTGCACTTGATGTTGCCAATGTTCGGCGCGATCAATTGCCAGAACTGGTCGACACCA
GTTATCAGTTGACAGGATTAAATGCCAACTATGCGGCGGTGACCGGTATTGATGCTAAAACGCCTTTCATTCTCGGTGCC
AGTGATGGGACATTGAGCAACCTTGGCGTTGGCGCGATTGATCCTGGTGTCTTGGCGGTGACCATTGGTACGTCAGGTGC
AGTACGGGTTGTGACTGACAAGCCGGTAGTTGATCCGCAAGGGCGCCTGTTCACTTACTACCTGTCACCGAATCACTGGG
TTGTTGGCGGTCCAGTTAACAACGGTGGTATTGTCTTCCGCTGGGTTCGTGATCAACTTTTTGCACCAGAGAAATTAACG
GCCGAACAACTGCAAGTTGATTCCTATGAAATTCTGACAGAAATTGCTAGCAAGATACCCGCTGGGGCTGATGGCTTACT
TTTCCATCCATATTTAGGCGGAGAACGGGCACCGATTTGGGATGCCAATGCTCGTGGCAGTTTCTTTGGCTTAACCCGGC
AGCATACACGTGCGCATATGGTGCGAGCAGCACTTGAAGGGATCGTTTACAACCTATATATGGTGATGCTGATGATCGAA
GGTATTACTGGCAAACCAAAAGCCATCCAGGCTACTGGCGGATTTGCGCGCAGTGCACTGTGGCGCCAGATGTTGGCTGA
CGTTTTTGAACAGGAAGTCAATATTCCGGAAAGCTTTGAAAGTTCAGCCTTGGGAGCAGTTGTTTTGGGAATGAAGTCAC
TGGGACTGATTGACGATTTGAACGTGGTTAAAGATATGATTGGTGTCACCAATACCCATGAACCCAATGCTGACAATTTT
CAAGCTTATCGTGAGTTGTTGCCAATCTGGATTCGATTGACGCGTAAACTTGGCAGCGAGTATCAAGCAATTGCCGACTA
TCAGCGGGCGCATCCAGATCCGAATGCCCATATAGCCGCTGAGGATTAG

Upstream 100 bases:

>100_bases
CATGCGGTTGATCCAATTAAGTCAAAATAACTTGCAGAACCATCGTGATATCGCCATTTTAATAACTAAGTCAAAAATTG
ATTAAGTAAAGGAGATAAGC

Downstream 100 bases:

>100_bases
TCGCCAGCACTGCGCCTGTTGTCCGTGCTAAGACGGAATATGCTGGTTCGATGGGAAAATAGCGAGAATGAAGCAACCGG
GTACACAGATCAAACGACAT

Product: gluconate kinase

Products: NA

Alternate protein names: Gluconate kinase [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MAIKYMIGVDLGTTSTKVVLFDLKGHAIATANNPYPLYQDTPDMAEEDPEEIFAATVGGLTEVMHRGNVQPDELGGVSFS
AAMHSLILMDENDKPLTRVITWADNRAAAYATKLKQSDLGMTLFKNTGVPTHPMSPLVKLLWLSAEHPELVAQTSHFIGI
KDFILFRFFGRYVQDYSLANATGLFNIHTMDWDDRALDVANVRRDQLPELVDTSYQLTGLNANYAAVTGIDAKTPFILGA
SDGTLSNLGVGAIDPGVLAVTIGTSGAVRVVTDKPVVDPQGRLFTYYLSPNHWVVGGPVNNGGIVFRWVRDQLFAPEKLT
AEQLQVDSYEILTEIASKIPAGADGLLFHPYLGGERAPIWDANARGSFFGLTRQHTRAHMVRAALEGIVYNLYMVMLMIE
GITGKPKAIQATGGFARSALWRQMLADVFEQEVNIPESFESSALGAVVLGMKSLGLIDDLNVVKDMIGVTNTHEPNADNF
QAYRELLPIWIRLTRKLGSEYQAIADYQRAHPDPNAHIAAED

Sequences:

>Translated_522_residues
MAIKYMIGVDLGTTSTKVVLFDLKGHAIATANNPYPLYQDTPDMAEEDPEEIFAATVGGLTEVMHRGNVQPDELGGVSFS
AAMHSLILMDENDKPLTRVITWADNRAAAYATKLKQSDLGMTLFKNTGVPTHPMSPLVKLLWLSAEHPELVAQTSHFIGI
KDFILFRFFGRYVQDYSLANATGLFNIHTMDWDDRALDVANVRRDQLPELVDTSYQLTGLNANYAAVTGIDAKTPFILGA
SDGTLSNLGVGAIDPGVLAVTIGTSGAVRVVTDKPVVDPQGRLFTYYLSPNHWVVGGPVNNGGIVFRWVRDQLFAPEKLT
AEQLQVDSYEILTEIASKIPAGADGLLFHPYLGGERAPIWDANARGSFFGLTRQHTRAHMVRAALEGIVYNLYMVMLMIE
GITGKPKAIQATGGFARSALWRQMLADVFEQEVNIPESFESSALGAVVLGMKSLGLIDDLNVVKDMIGVTNTHEPNADNF
QAYRELLPIWIRLTRKLGSEYQAIADYQRAHPDPNAHIAAED
>Mature_521_residues
AIKYMIGVDLGTTSTKVVLFDLKGHAIATANNPYPLYQDTPDMAEEDPEEIFAATVGGLTEVMHRGNVQPDELGGVSFSA
AMHSLILMDENDKPLTRVITWADNRAAAYATKLKQSDLGMTLFKNTGVPTHPMSPLVKLLWLSAEHPELVAQTSHFIGIK
DFILFRFFGRYVQDYSLANATGLFNIHTMDWDDRALDVANVRRDQLPELVDTSYQLTGLNANYAAVTGIDAKTPFILGAS
DGTLSNLGVGAIDPGVLAVTIGTSGAVRVVTDKPVVDPQGRLFTYYLSPNHWVVGGPVNNGGIVFRWVRDQLFAPEKLTA
EQLQVDSYEILTEIASKIPAGADGLLFHPYLGGERAPIWDANARGSFFGLTRQHTRAHMVRAALEGIVYNLYMVMLMIEG
ITGKPKAIQATGGFARSALWRQMLADVFEQEVNIPESFESSALGAVVLGMKSLGLIDDLNVVKDMIGVTNTHEPNADNFQ
AYRELLPIWIRLTRKLGSEYQAIADYQRAHPDPNAHIAAED

Specific function: Unknown

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=446, Percent_Identity=24.8878923766816, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI41393575, Length=449, Percent_Identity=25.3897550111359, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI189409120, Length=458, Percent_Identity=25.1091703056769, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4504007, Length=445, Percent_Identity=25.1685393258427, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI88196792, Length=529, Percent_Identity=21.5500945179584, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI164663828, Length=549, Percent_Identity=23.4972677595628, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI164663830, Length=573, Percent_Identity=22.8621291448517, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789987, Length=499, Percent_Identity=28.4569138276553, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1787789, Length=503, Percent_Identity=28.0318091451292, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790361, Length=485, Percent_Identity=27.8350515463918, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790005, Length=500, Percent_Identity=25.4, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1789168, Length=473, Percent_Identity=23.4672304439746, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789138, Length=493, Percent_Identity=23.3265720081136, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17535599, Length=462, Percent_Identity=23.8095238095238, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=437, Percent_Identity=23.3409610983982, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24656367, Length=527, Percent_Identity=23.3396584440228, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357867, Length=540, Percent_Identity=23.8888888888889, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17864214, Length=475, Percent_Identity=24.4210526315789, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656372, Length=344, Percent_Identity=26.1627906976744, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24654573, Length=406, Percent_Identity=25.1231527093596, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24655555, Length=430, Percent_Identity=24.4186046511628, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24655560, Length=430, Percent_Identity=24.4186046511628, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24655570, Length=430, Percent_Identity=24.4186046511628, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24655574, Length=430, Percent_Identity=24.4186046511628, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24655565, Length=430, Percent_Identity=24.4186046511628, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24657106, Length=544, Percent_Identity=23.3455882352941, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24657102, Length=544, Percent_Identity=23.3455882352941, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24652871, Length=486, Percent_Identity=20.3703703703704, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922058, Length=486, Percent_Identity=20.3703703703704, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45552909, Length=247, Percent_Identity=25.9109311740891, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR006002 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.12 [H]

Molecular weight: Translated: 57190; Mature: 57059

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKYMIGVDLGTTSTKVVLFDLKGHAIATANNPYPLYQDTPDMAEEDPEEIFAATVGGL
CEEEEEEEEEECCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TEVMHRGNVQPDELGGVSFSAAMHSLILMDENDKPLTRVITWADNRAAAYATKLKQSDLG
HHHHHCCCCCCHHCCCEEHHHHHCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCC
MTLFKNTGVPTHPMSPLVKLLWLSAEHPELVAQTSHFIGIKDFILFRFFGRYVQDYSLAN
EEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
ATGLFNIHTMDWDDRALDVANVRRDQLPELVDTSYQLTGLNANYAAVTGIDAKTPFILGA
CCCEEEEEEECCCCCHHHHHHCCHHHCHHHHCCCEEEEECCCCCEEEECCCCCCCEEEEC
SDGTLSNLGVGAIDPGVLAVTIGTSGAVRVVTDKPVVDPQGRLFTYYLSPNHWVVGGPVN
CCCCHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCEEEECCCC
NGGIVFRWVRDQLFAPEKLTAEQLQVDSYEILTEIASKIPAGADGLLFHPYLGGERAPIW
CCCEEEEEEHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
DANARGSFFGLTRQHTRAHMVRAALEGIVYNLYMVMLMIEGITGKPKAIQATGGFARSAL
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
WRQMLADVFEQEVNIPESFESSALGAVVLGMKSLGLIDDLNVVKDMIGVTNTHEPNADNF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHH
QAYRELLPIWIRLTRKLGSEYQAIADYQRAHPDPNAHIAAED
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
AIKYMIGVDLGTTSTKVVLFDLKGHAIATANNPYPLYQDTPDMAEEDPEEIFAATVGGL
EEEEEEEEEECCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TEVMHRGNVQPDELGGVSFSAAMHSLILMDENDKPLTRVITWADNRAAAYATKLKQSDLG
HHHHHCCCCCCHHCCCEEHHHHHCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCC
MTLFKNTGVPTHPMSPLVKLLWLSAEHPELVAQTSHFIGIKDFILFRFFGRYVQDYSLAN
EEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
ATGLFNIHTMDWDDRALDVANVRRDQLPELVDTSYQLTGLNANYAAVTGIDAKTPFILGA
CCCEEEEEEECCCCCHHHHHHCCHHHCHHHHCCCEEEEECCCCCEEEECCCCCCCEEEEC
SDGTLSNLGVGAIDPGVLAVTIGTSGAVRVVTDKPVVDPQGRLFTYYLSPNHWVVGGPVN
CCCCHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCEEEECCCC
NGGIVFRWVRDQLFAPEKLTAEQLQVDSYEILTEIASKIPAGADGLLFHPYLGGERAPIW
CCCEEEEEEHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
DANARGSFFGLTRQHTRAHMVRAALEGIVYNLYMVMLMIEGITGKPKAIQATGGFARSAL
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
WRQMLADVFEQEVNIPESFESSALGAVVLGMKSLGLIDDLNVVKDMIGVTNTHEPNADNF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHH
QAYRELLPIWIRLTRKLGSEYQAIADYQRAHPDPNAHIAAED
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8535972 [H]