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The map label for this gene is yqeC [H]

Identifier: 116493798

GI number: 116493798

Start: 222562

End: 223467

Strand: Direct

Name: yqeC [H]

Synonym: LSEI_0227

Alternate gene names: 116493798

Gene position: 222562-223467 (Clockwise)

Preceding gene: 116493796

Following gene: 116493799

Centisome position: 7.69

GC content: 49.89

Gene sequence:

>906_bases
ATGCATATTGGCATGGTTGGTTTAGGAAAAATGGGTATGAATCTGGTCGCAAATATGCGCGATCATGATATTGAAGTGAC
AGCATTTGATTTGAACGACAAAGCGCGAGAAGAGGTAGGGCAATATGGGGCCAAGGCAGTGGCAAGCCTGGATGCCTTGG
TTATGAGCTTGGCATCTCCGCGGATCATCTGGAGCATGGTGCCTGCTGGCAAACCGACAGAAGCCACGATTAGTCAGCTA
GCTAAACTGTTGCGGCCAGATGATATTGTGATTGATGGCGGCAACTCCTATTATCAGGATTCAATCGCACACGGAAAGCT
GCTAGCTGCTGAGGGAATTCATTTCTTTGATGTCGGCACTTCAGGCGGCATGGCCGGTGCACGCGCCGATGGCAATTTCA
TGATTGGTGGCGACAAGGCGATCTTTAACAAGATTGAGCCGCTGTTCAAGGCGATCGCTGCAAAAGGTGGCTATCTGTAT
ACTGGCCCAGCTGGATCTGGTCACTATTTGAAAATGATTCACAACGGTATTGAATATGGGATGATGCAGGCGATTGGTGA
AGGCTTCGATGTGTTAGCCCACAGTCCGTATGACTACGACAATGCGGCGGTTGCCAACATGTGGAACAATGGCTCGGTGA
TTCGCAGCTGGCTGATGGATTTGGCCGCCAATGCCTTTACCGAGGATGCGAACCTTGAAAAGATTCAGGGTATCATGCAC
AGCTCGGGTGAAGGTGCTTGGACCGTTGAAGAAGCCTTACGTCTACATGTTGCAACGCCGGTGATTGCCAGTTCGTTGAT
GATGCGCTATCGCTCTGAAGAAGCAGATACGATGACGGGTAAAGTGGTCGCTGCCTTGCGTAATCAGTTTGGCGGCCATG
CGGTTGATCCAATTAAGTCAAAATAA

Upstream 100 bases:

>100_bases
TACATACAATGGCATCAGGATATAAGATAACCATCACAGAAGCGGTTTGTTTTTTAGAAAACGGATGGTCACAGGGTCAA
ATAACGAGGAGGCAGCAAAC

Downstream 100 bases:

>100_bases
CTTGCAGAACCATCGTGATATCGCCATTTTAATAACTAAGTCAAAAATTGATTAAGTAAAGGAGATAAGCATGGCAATCA
AATATATGATTGGCGTTGAT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MHIGMVGLGKMGMNLVANMRDHDIEVTAFDLNDKAREEVGQYGAKAVASLDALVMSLASPRIIWSMVPAGKPTEATISQL
AKLLRPDDIVIDGGNSYYQDSIAHGKLLAAEGIHFFDVGTSGGMAGARADGNFMIGGDKAIFNKIEPLFKAIAAKGGYLY
TGPAGSGHYLKMIHNGIEYGMMQAIGEGFDVLAHSPYDYDNAAVANMWNNGSVIRSWLMDLAANAFTEDANLEKIQGIMH
SSGEGAWTVEEALRLHVATPVIASSLMMRYRSEEADTMTGKVVAALRNQFGGHAVDPIKSK

Sequences:

>Translated_301_residues
MHIGMVGLGKMGMNLVANMRDHDIEVTAFDLNDKAREEVGQYGAKAVASLDALVMSLASPRIIWSMVPAGKPTEATISQL
AKLLRPDDIVIDGGNSYYQDSIAHGKLLAAEGIHFFDVGTSGGMAGARADGNFMIGGDKAIFNKIEPLFKAIAAKGGYLY
TGPAGSGHYLKMIHNGIEYGMMQAIGEGFDVLAHSPYDYDNAAVANMWNNGSVIRSWLMDLAANAFTEDANLEKIQGIMH
SSGEGAWTVEEALRLHVATPVIASSLMMRYRSEEADTMTGKVVAALRNQFGGHAVDPIKSK
>Mature_301_residues
MHIGMVGLGKMGMNLVANMRDHDIEVTAFDLNDKAREEVGQYGAKAVASLDALVMSLASPRIIWSMVPAGKPTEATISQL
AKLLRPDDIVIDGGNSYYQDSIAHGKLLAAEGIHFFDVGTSGGMAGARADGNFMIGGDKAIFNKIEPLFKAIAAKGGYLY
TGPAGSGHYLKMIHNGIEYGMMQAIGEGFDVLAHSPYDYDNAAVANMWNNGSVIRSWLMDLAANAFTEDANLEKIQGIMH
SSGEGAWTVEEALRLHVATPVIASSLMMRYRSEEADTMTGKVVAALRNQFGGHAVDPIKSK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=312, Percent_Identity=35.2564102564103, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1788341, Length=318, Percent_Identity=35.8490566037736, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=34.4827586206897, Blast_Score=151, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=35.1724137931034, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321977, Length=286, Percent_Identity=34.965034965035, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24639279, Length=288, Percent_Identity=34.375, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32241; Mature: 32241

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGMVGLGKMGMNLVANMRDHDIEVTAFDLNDKAREEVGQYGAKAVASLDALVMSLASP
CCCCCEECCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RIIWSMVPAGKPTEATISQLAKLLRPDDIVIDGGNSYYQDSIAHGKLLAAEGIHFFDVGT
CEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCEEEECCEEEEECCC
SGGMAGARADGNFMIGGDKAIFNKIEPLFKAIAAKGGYLYTGPAGSGHYLKMIHNGIEYG
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
MMQAIGEGFDVLAHSPYDYDNAAVANMWNNGSVIRSWLMDLAANAFTEDANLEKIQGIMH
HHHHHCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SSGEGAWTVEEALRLHVATPVIASSLMMRYRSEEADTMTGKVVAALRNQFGGHAVDPIKS
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
K
C
>Mature Secondary Structure
MHIGMVGLGKMGMNLVANMRDHDIEVTAFDLNDKAREEVGQYGAKAVASLDALVMSLASP
CCCCCEECCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RIIWSMVPAGKPTEATISQLAKLLRPDDIVIDGGNSYYQDSIAHGKLLAAEGIHFFDVGT
CEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCEEEECCEEEEECCC
SGGMAGARADGNFMIGGDKAIFNKIEPLFKAIAAKGGYLYTGPAGSGHYLKMIHNGIEYG
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
MMQAIGEGFDVLAHSPYDYDNAAVANMWNNGSVIRSWLMDLAANAFTEDANLEKIQGIMH
HHHHHCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SSGEGAWTVEEALRLHVATPVIASSLMMRYRSEEADTMTGKVVAALRNQFGGHAVDPIKS
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]