| Definition | Lactobacillus casei ATCC 334, complete genome. |
|---|---|
| Accession | NC_008526 |
| Length | 2,895,264 |
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The map label for this gene is yvgN [H]
Identifier: 116493796
GI number: 116493796
Start: 220430
End: 221290
Strand: Direct
Name: yvgN [H]
Synonym: LSEI_0225
Alternate gene names: 116493796
Gene position: 220430-221290 (Clockwise)
Preceding gene: 116493795
Following gene: 116493798
Centisome position: 7.61
GC content: 46.23
Gene sequence:
>861_bases TTGGCACATTTAACCAAATTGACCGACACATATACATTAAGTAATGGTGTTAAGATTCCGATCGTCGGGTTCGGCACTTG GCAGACCCCTGATGGCGACGTTGCCAAGCATAGTGTCGAAGCGGCATTGGCTGCAGGCTATCGCCATATTGACACGGCGG CTGCTTACGGTAACGAAGAAAGCGTTGGTGCAGGTTTGCGCGCATCCGGCGTACCTCGCGATCAGATCTTCTTAACCACT AAGCTTTGGAATGGTGATCACGGTTACGAGGCGACTAAAGCAGTGCTAGATAAATCACTCAAGAAACTGGGCGTTGATTA TGTGGATCTATATTTAATTCATTGGCCAAACCCAATTAAGTTCCGTGATAATTGGGAAGAAACTAATGCAGGGTCATGGA AGGCCATGGAAGAAGCGTACAAAGCCGGCAAAGTTCGAGCAATTGGGGTTTCAAACTTCCGCGCCAAGCACATTGACGCT TTGCTAAAAACAGCTACTGTCAAGCCAATGGTTAACCAGATTTTCTTGAATCCAAGTGATTTGCAGCCAGAAGTTGTGGC GTATAATGACGCCCATGATATTTTAAGTGAAGCGTACAGCCCACTTGGCACAGGCAAAATTTTCCAAGTTGATGCCTTAA AGAAAATTGCCGCACGCTATCACAAGAGTGTTGCTCAGATCGTCCTCCGCTGGTCATTGCAACATGGTTTCTTACCATTG CCAAAATCCGTTCATGACGATCGGATTAAGGAAAACACCGAGTTGTTCGACTTTGAACTGAGCCATCATGATATGACCTT GATTGATGCTTTGCACGGTGAAGCCGGCTTAGCAACTGACCCAGATACAACGGATTTCTAA
Upstream 100 bases:
>100_bases TTTTGACTGATGCAAGTGTGACGCTGGGCTGCTAACACATTCAATCAACTACTTACTTGTGGTAAGCTTATAGTAGTACC CAGTAAAGGAGATGCTCATT
Downstream 100 bases:
>100_bases GGCAAAATCAGCGATATTAGGTTTTTAGTTTTTTCCATGAGAAAAGCATCTGCCATGAGGTTGCGGCAGATGCTTTTTTA TATACTTTGAAAGATTGAGC
Product: aldo/keto reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 286; Mature: 285
Protein sequence:
>286_residues MAHLTKLTDTYTLSNGVKIPIVGFGTWQTPDGDVAKHSVEAALAAGYRHIDTAAAYGNEESVGAGLRASGVPRDQIFLTT KLWNGDHGYEATKAVLDKSLKKLGVDYVDLYLIHWPNPIKFRDNWEETNAGSWKAMEEAYKAGKVRAIGVSNFRAKHIDA LLKTATVKPMVNQIFLNPSDLQPEVVAYNDAHDILSEAYSPLGTGKIFQVDALKKIAARYHKSVAQIVLRWSLQHGFLPL PKSVHDDRIKENTELFDFELSHHDMTLIDALHGEAGLATDPDTTDF
Sequences:
>Translated_286_residues MAHLTKLTDTYTLSNGVKIPIVGFGTWQTPDGDVAKHSVEAALAAGYRHIDTAAAYGNEESVGAGLRASGVPRDQIFLTT KLWNGDHGYEATKAVLDKSLKKLGVDYVDLYLIHWPNPIKFRDNWEETNAGSWKAMEEAYKAGKVRAIGVSNFRAKHIDA LLKTATVKPMVNQIFLNPSDLQPEVVAYNDAHDILSEAYSPLGTGKIFQVDALKKIAARYHKSVAQIVLRWSLQHGFLPL PKSVHDDRIKENTELFDFELSHHDMTLIDALHGEAGLATDPDTTDF >Mature_285_residues AHLTKLTDTYTLSNGVKIPIVGFGTWQTPDGDVAKHSVEAALAAGYRHIDTAAAYGNEESVGAGLRASGVPRDQIFLTTK LWNGDHGYEATKAVLDKSLKKLGVDYVDLYLIHWPNPIKFRDNWEETNAGSWKAMEEAYKAGKVRAIGVSNFRAKHIDAL LKTATVKPMVNQIFLNPSDLQPEVVAYNDAHDILSEAYSPLGTGKIFQVDALKKIAARYHKSVAQIVLRWSLQHGFLPLP KSVHDDRIKENTELFDFELSHHDMTLIDALHGEAGLATDPDTTDF
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=287, Percent_Identity=37.6306620209059, Blast_Score=200, Evalue=1e-51, Organism=Homo sapiens, GI5174391, Length=287, Percent_Identity=37.6306620209059, Blast_Score=200, Evalue=1e-51, Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=38.2252559726962, Blast_Score=189, Evalue=3e-48, Organism=Homo sapiens, GI223468663, Length=284, Percent_Identity=36.6197183098592, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI93277124, Length=309, Percent_Identity=35.5987055016181, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI4502049, Length=284, Percent_Identity=38.3802816901408, Blast_Score=172, Evalue=3e-43, Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=37.6811594202899, Blast_Score=172, Evalue=3e-43, Organism=Homo sapiens, GI24497583, Length=290, Percent_Identity=34.1379310344828, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI310109920, Length=291, Percent_Identity=33.6769759450172, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI45446745, Length=291, Percent_Identity=33.6769759450172, Blast_Score=168, Evalue=4e-42, Organism=Homo sapiens, GI4503285, Length=291, Percent_Identity=33.6769759450172, Blast_Score=168, Evalue=4e-42, Organism=Homo sapiens, GI5453543, Length=291, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=5e-42, Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=5e-42, Organism=Homo sapiens, GI310109922, Length=279, Percent_Identity=34.7670250896057, Blast_Score=168, Evalue=6e-42, Organism=Homo sapiens, GI300116271, Length=280, Percent_Identity=35.7142857142857, Blast_Score=149, Evalue=2e-36, Organism=Homo sapiens, GI291291012, Length=262, Percent_Identity=32.824427480916, Blast_Score=144, Evalue=8e-35, Organism=Homo sapiens, GI310109926, Length=128, Percent_Identity=40.625, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI207028673, Length=128, Percent_Identity=40.625, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI310109924, Length=150, Percent_Identity=30.6666666666667, Blast_Score=82, Evalue=7e-16, Organism=Escherichia coli, GI87082198, Length=272, Percent_Identity=42.6470588235294, Blast_Score=208, Evalue=3e-55, Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=36.6141732283465, Blast_Score=150, Evalue=7e-38, Organism=Escherichia coli, GI1788081, Length=273, Percent_Identity=30.03663003663, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI1788070, Length=308, Percent_Identity=25.6493506493506, Blast_Score=82, Evalue=4e-17, Organism=Caenorhabditis elegans, GI71998625, Length=272, Percent_Identity=41.1764705882353, Blast_Score=207, Evalue=5e-54, Organism=Caenorhabditis elegans, GI17564128, Length=301, Percent_Identity=36.2126245847176, Blast_Score=177, Evalue=8e-45, Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=31.5436241610738, Blast_Score=167, Evalue=6e-42, Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=35.9322033898305, Blast_Score=164, Evalue=5e-41, Organism=Caenorhabditis elegans, GI17550248, Length=293, Percent_Identity=34.4709897610922, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17537075, Length=308, Percent_Identity=35.7142857142857, Blast_Score=162, Evalue=3e-40, Organism=Caenorhabditis elegans, GI17566692, Length=289, Percent_Identity=35.2941176470588, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17561298, Length=269, Percent_Identity=33.8289962825279, Blast_Score=155, Evalue=3e-38, Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=30.7692307692308, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17538386, Length=282, Percent_Identity=32.2695035460993, Blast_Score=148, Evalue=4e-36, Organism=Caenorhabditis elegans, GI17562292, Length=254, Percent_Identity=31.496062992126, Blast_Score=129, Evalue=2e-30, Organism=Caenorhabditis elegans, GI17561300, Length=250, Percent_Identity=30, Blast_Score=128, Evalue=4e-30, Organism=Saccharomyces cerevisiae, GI6320576, Length=297, Percent_Identity=39.7306397306397, Blast_Score=204, Evalue=1e-53, Organism=Saccharomyces cerevisiae, GI6324694, Length=295, Percent_Identity=39.6610169491525, Blast_Score=196, Evalue=3e-51, Organism=Saccharomyces cerevisiae, GI6322556, Length=285, Percent_Identity=39.2982456140351, Blast_Score=191, Evalue=1e-49, Organism=Saccharomyces cerevisiae, GI6320079, Length=296, Percent_Identity=39.1891891891892, Blast_Score=162, Evalue=5e-41, Organism=Saccharomyces cerevisiae, GI6321896, Length=309, Percent_Identity=32.6860841423948, Blast_Score=162, Evalue=6e-41, Organism=Saccharomyces cerevisiae, GI6319625, Length=285, Percent_Identity=34.3859649122807, Blast_Score=144, Evalue=1e-35, Organism=Drosophila melanogaster, GI24657054, Length=284, Percent_Identity=39.7887323943662, Blast_Score=193, Evalue=1e-49, Organism=Drosophila melanogaster, GI24663317, Length=292, Percent_Identity=38.013698630137, Blast_Score=192, Evalue=2e-49, Organism=Drosophila melanogaster, GI24662789, Length=301, Percent_Identity=34.5514950166113, Blast_Score=177, Evalue=5e-45, Organism=Drosophila melanogaster, GI21356425, Length=282, Percent_Identity=36.5248226950355, Blast_Score=177, Evalue=8e-45, Organism=Drosophila melanogaster, GI24644950, Length=301, Percent_Identity=35.5481727574751, Blast_Score=176, Evalue=2e-44, Organism=Drosophila melanogaster, GI20129731, Length=289, Percent_Identity=35.9861591695502, Blast_Score=175, Evalue=3e-44, Organism=Drosophila melanogaster, GI221378297, Length=321, Percent_Identity=33.9563862928349, Blast_Score=168, Evalue=3e-42, Organism=Drosophila melanogaster, GI45553081, Length=284, Percent_Identity=35.2112676056338, Blast_Score=165, Evalue=3e-41, Organism=Drosophila melanogaster, GI24662781, Length=275, Percent_Identity=38.5454545454545, Blast_Score=164, Evalue=6e-41, Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=38.0952380952381, Blast_Score=159, Evalue=2e-39, Organism=Drosophila melanogaster, GI281366140, Length=244, Percent_Identity=35.2459016393443, Blast_Score=144, Evalue=9e-35,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31650; Mature: 31519
Theoretical pI: Translated: 6.45; Mature: 6.45
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.4 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAHLTKLTDTYTLSNGVKIPIVGFGTWQTPDGDVAKHSVEAALAAGYRHIDTAAAYGNEE CCCCHHCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCH SVGAGLRASGVPRDQIFLTTKLWNGDHGYEATKAVLDKSLKKLGVDYVDLYLIHWPNPIK HCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCC FRDNWEETNAGSWKAMEEAYKAGKVRAIGVSNFRAKHIDALLKTATVKPMVNQIFLNPSD CCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC LQPEVVAYNDAHDILSEAYSPLGTGKIFQVDALKKIAARYHKSVAQIVLRWSLQHGFLPL CCCCEEEECCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC PKSVHDDRIKENTELFDFELSHHDMTLIDALHGEAGLATDPDTTDF CCCCCHHHHHCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCC >Mature Secondary Structure AHLTKLTDTYTLSNGVKIPIVGFGTWQTPDGDVAKHSVEAALAAGYRHIDTAAAYGNEE CCCHHCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCH SVGAGLRASGVPRDQIFLTTKLWNGDHGYEATKAVLDKSLKKLGVDYVDLYLIHWPNPIK HCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCC FRDNWEETNAGSWKAMEEAYKAGKVRAIGVSNFRAKHIDALLKTATVKPMVNQIFLNPSD CCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC LQPEVVAYNDAHDILSEAYSPLGTGKIFQVDALKKIAARYHKSVAQIVLRWSLQHGFLPL CCCCEEEECCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC PKSVHDDRIKENTELFDFELSHHDMTLIDALHGEAGLATDPDTTDF CCCCCHHHHHCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]