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The map label for this gene is msbA [H]

Identifier: 116493678

GI number: 116493678

Start: 99140

End: 100768

Strand: Direct

Name: msbA [H]

Synonym: LSEI_0106

Alternate gene names: 116493678

Gene position: 99140-100768 (Clockwise)

Preceding gene: 116493677

Following gene: 116493679

Centisome position: 3.42

GC content: 34.93

Gene sequence:

>1629_bases
ATGAACCCAATTATAATAAGAACGCTAAAAAAGCATGGCGTTGCTTTTACGTTACTAGTAATATTTACGATTATAAGTAC
AGCACTGATCACTGGGAATACATATTTAGAAGGTAGATTGTTAGACAGTTTGGTTTATAGTCATAGACCGACACTTTTTA
TAACATTCTTTGTGCTTATGCTGGGGATTGGAATTCTTAGACTGTTTTTTTCGTTTTTTACAAGTCACATACAAATACTA
ACCAAACAAGAGACGGTGCTTGAGTTAAATAGAAAAATATTTTTTGAATTATTTAAGAAGGACACTCTTAGTATACTTAA
ATGGAGTCCAACCACCTTGAGTTCTCGTATTAATGATGATGTGACCGAGATAGTTTCCTTTTTCTCAGATACACTTGTTA
AGCTGTGTTCCGTGATTGTATCCACGATCACGATCTCTGCATATGTATTCAGTGCAGATCCGAAGATATTCATCATAATG
ATTATCTTCATACCTATCTACTTTTTAATTTACATTGTGTTTCGTCCCAAAATATACAGTATAAACTTAACGATGGAAAA
TAAGCAAAACGAATACTATACGACGAGAAATGATTTCGTTGGTAGGTATATTGAAATCAAAGGATCTGGTAATTTTTCCA
GTGAGAAGAAAAGGCTGCGCACAGTTGAGGATGGTTTACTTAAAACGTTTGTCAAAAGTTTTTGGGTACGATACTGGATG
TCGACATCTCAAATAGTGATGCAATTAGTCTTTCAAGCCGTATTTTTCATTGTCGGAGGCTTGGCAGTACTACGGGGAAA
TATCACAATTGGCTTTTTCTCTATAGTTCTTCAGTATTTCGGACAACTTCTTAATTCAGTAGATCAGATTTTTGGAATTG
CAATTGGAACCGAGAAATATCATGCGTCGCTTACGAGGATGAAAAGGATTTTCGACATTGCGGCAGATAAAAATGGAGAC
AGGCCTATTAGCAGTGTGAGAGCAATTGATATTAACAATTTTAATATAAAAATGTTTCCAGAAAGCAAGAAAGATTCAAA
GATGTTCTATTCTCAAGATTTGTCGTGTTCATTCGAAAATCCAGGACTGTACGTTATTTCAGGCGATAATGGTATTGGAA
AAAGTACATTCGTACGGACAATCACAAGAATTTACCAGCCTAAACTAAGGGGCAGTGTTTTGATCAATGGACTGGATGTA
AATAAAATAGATATGGATGCATTGAGACAAAAAGAAATGGGATTCCTGTTTCAGGATGTGCCATCGCCTCATATTACCGT
GAGAGAATACTTATCTGATTTAGAAAGAAATGGTTTCTTGAATGATTTAAAAGAATCAAGACCTTTTTTAAATGTGTACT
TTTCAGATGTATTCAATTTGGCTGATATTTATGAAAAAAAAGTAGATGTACTGTCAAGTGGTGAGTTACAGCTTGTTCGA
TTGCTTGCTGCATTGGGCAAAAAAGATGCCAGTATGTATATTTTGGATGAGCCTACCGCGAATATTTACCCACAAATTCG
GTCTGCCGTGATTTGTTTGTTACAAGAATTAGGTAAAAGCAAATTGATTATAACCATATCGCATGACGAACATTTGATAG
GCCTTGGTAAGTCAATTGTAATGGAATAG

Upstream 100 bases:

>100_bases
TGCTATAGGCGTTGAATTACGGCAGATGTTATTGCTTTTCTAGAAGTTTTCTAGACGATAATAGCTGCTTTTTTGGAATT
TCTTGGAGATGATCTGACTG

Downstream 100 bases:

>100_bases
CAATGAAGAATCATTGAATATATGGTGAGATAATTCAATGGTTCAGTTATTTCTGAAGTGAAAGTACTGATATAAAGTGA
GCTCATTCTAAGCTAGTTCT

Product: ABC-type multidrug transport system, ATPase and permease component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MNPIIIRTLKKHGVAFTLLVIFTIISTALITGNTYLEGRLLDSLVYSHRPTLFITFFVLMLGIGILRLFFSFFTSHIQIL
TKQETVLELNRKIFFELFKKDTLSILKWSPTTLSSRINDDVTEIVSFFSDTLVKLCSVIVSTITISAYVFSADPKIFIIM
IIFIPIYFLIYIVFRPKIYSINLTMENKQNEYYTTRNDFVGRYIEIKGSGNFSSEKKRLRTVEDGLLKTFVKSFWVRYWM
STSQIVMQLVFQAVFFIVGGLAVLRGNITIGFFSIVLQYFGQLLNSVDQIFGIAIGTEKYHASLTRMKRIFDIAADKNGD
RPISSVRAIDINNFNIKMFPESKKDSKMFYSQDLSCSFENPGLYVISGDNGIGKSTFVRTITRIYQPKLRGSVLINGLDV
NKIDMDALRQKEMGFLFQDVPSPHITVREYLSDLERNGFLNDLKESRPFLNVYFSDVFNLADIYEKKVDVLSSGELQLVR
LLAALGKKDASMYILDEPTANIYPQIRSAVICLLQELGKSKLIITISHDEHLIGLGKSIVME

Sequences:

>Translated_542_residues
MNPIIIRTLKKHGVAFTLLVIFTIISTALITGNTYLEGRLLDSLVYSHRPTLFITFFVLMLGIGILRLFFSFFTSHIQIL
TKQETVLELNRKIFFELFKKDTLSILKWSPTTLSSRINDDVTEIVSFFSDTLVKLCSVIVSTITISAYVFSADPKIFIIM
IIFIPIYFLIYIVFRPKIYSINLTMENKQNEYYTTRNDFVGRYIEIKGSGNFSSEKKRLRTVEDGLLKTFVKSFWVRYWM
STSQIVMQLVFQAVFFIVGGLAVLRGNITIGFFSIVLQYFGQLLNSVDQIFGIAIGTEKYHASLTRMKRIFDIAADKNGD
RPISSVRAIDINNFNIKMFPESKKDSKMFYSQDLSCSFENPGLYVISGDNGIGKSTFVRTITRIYQPKLRGSVLINGLDV
NKIDMDALRQKEMGFLFQDVPSPHITVREYLSDLERNGFLNDLKESRPFLNVYFSDVFNLADIYEKKVDVLSSGELQLVR
LLAALGKKDASMYILDEPTANIYPQIRSAVICLLQELGKSKLIITISHDEHLIGLGKSIVME
>Mature_542_residues
MNPIIIRTLKKHGVAFTLLVIFTIISTALITGNTYLEGRLLDSLVYSHRPTLFITFFVLMLGIGILRLFFSFFTSHIQIL
TKQETVLELNRKIFFELFKKDTLSILKWSPTTLSSRINDDVTEIVSFFSDTLVKLCSVIVSTITISAYVFSADPKIFIIM
IIFIPIYFLIYIVFRPKIYSINLTMENKQNEYYTTRNDFVGRYIEIKGSGNFSSEKKRLRTVEDGLLKTFVKSFWVRYWM
STSQIVMQLVFQAVFFIVGGLAVLRGNITIGFFSIVLQYFGQLLNSVDQIFGIAIGTEKYHASLTRMKRIFDIAADKNGD
RPISSVRAIDINNFNIKMFPESKKDSKMFYSQDLSCSFENPGLYVISGDNGIGKSTFVRTITRIYQPKLRGSVLINGLDV
NKIDMDALRQKEMGFLFQDVPSPHITVREYLSDLERNGFLNDLKESRPFLNVYFSDVFNLADIYEKKVDVLSSGELQLVR
LLAALGKKDASMYILDEPTANIYPQIRSAVICLLQELGKSKLIITISHDEHLIGLGKSIVME

Specific function: Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787143, Length=499, Percent_Identity=22.2444889779559, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789032, Length=185, Percent_Identity=31.3513513513514, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR011917
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 61901; Mature: 61901

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIIIRTLKKHGVAFTLLVIFTIISTALITGNTYLEGRLLDSLVYSHRPTLFITFFVLM
CCCEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHHHHHH
LGIGILRLFFSFFTSHIQILTKQETVLELNRKIFFELFKKDTLSILKWSPTTLSSRINDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCC
VTEIVSFFSDTLVKLCSVIVSTITISAYVFSADPKIFIIMIIFIPIYFLIYIVFRPKIYS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEE
INLTMENKQNEYYTTRNDFVGRYIEIKGSGNFSSEKKRLRTVEDGLLKTFVKSFWVRYWM
EEEEEECCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
STSQIVMQLVFQAVFFIVGGLAVLRGNITIGFFSIVLQYFGQLLNSVDQIFGIAIGTEKY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHH
HASLTRMKRIFDIAADKNGDRPISSVRAIDINNFNIKMFPESKKDSKMFYSQDLSCSFEN
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCHHHCCCCCCEECC
PGLYVISGDNGIGKSTFVRTITRIYQPKLRGSVLINGLDVNKIDMDALRQKEMGFLFQDV
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCC
PSPHITVREYLSDLERNGFLNDLKESRPFLNVYFSDVFNLADIYEKKVDVLSSGELQLVR
CCCCEEHHHHHHHHHHCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LLAALGKKDASMYILDEPTANIYPQIRSAVICLLQELGKSKLIITISHDEHLIGLGKSIV
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHH
ME
CC
>Mature Secondary Structure
MNPIIIRTLKKHGVAFTLLVIFTIISTALITGNTYLEGRLLDSLVYSHRPTLFITFFVLM
CCCEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHHHHHH
LGIGILRLFFSFFTSHIQILTKQETVLELNRKIFFELFKKDTLSILKWSPTTLSSRINDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCC
VTEIVSFFSDTLVKLCSVIVSTITISAYVFSADPKIFIIMIIFIPIYFLIYIVFRPKIYS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEE
INLTMENKQNEYYTTRNDFVGRYIEIKGSGNFSSEKKRLRTVEDGLLKTFVKSFWVRYWM
EEEEEECCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
STSQIVMQLVFQAVFFIVGGLAVLRGNITIGFFSIVLQYFGQLLNSVDQIFGIAIGTEKY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHH
HASLTRMKRIFDIAADKNGDRPISSVRAIDINNFNIKMFPESKKDSKMFYSQDLSCSFEN
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCHHHCCCCCCEECC
PGLYVISGDNGIGKSTFVRTITRIYQPKLRGSVLINGLDVNKIDMDALRQKEMGFLFQDV
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCC
PSPHITVREYLSDLERNGFLNDLKESRPFLNVYFSDVFNLADIYEKKVDVLSSGELQLVR
CCCCEEHHHHHHHHHHCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LLAALGKKDASMYILDEPTANIYPQIRSAVICLLQELGKSKLIITISHDEHLIGLGKSIV
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHH
ME
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA