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The map label for this gene is pbuX [H]

Identifier: 116493561

GI number: 116493561

Start: 1818151

End: 1819476

Strand: Direct

Name: pbuX [H]

Synonym: PEPE_1835

Alternate gene names: 116493561

Gene position: 1818151-1819476 (Clockwise)

Preceding gene: 116493556

Following gene: 116493562

Centisome position: 99.22

GC content: 41.55

Gene sequence:

>1326_bases
ATGAAAACAACTGAATCAAGTTACACCGAAGTTCCTGTAACTGAAATTAAACCACAATTAACTGAAGGAAAAGCTGCTAT
TTTAGGCTTTCAACACCTTTTAGCCATGTACTCTGGCGATGTTATTGTTCCTCTTTTAATCGGTGGTTTTTTACATTTTA
CAGCCGCTCAAATGACTTATTTAGTCTCTGTTGATATTTTCATGTGTGGTATCGCTACGCTCTTACAAATTAAACGCACT
CCTCTAACTGGGATTGGTCTCCCAGTCGTTTTAGGTTGCGCCGTGCAAGCCGTCCAACCCCTCCAGCAAATCGGAGGGAC
TCTAGGGGTCACCGCCATGTACGGAGCAATTATCGCTTCTGGTGTCTTTGTATTTCTAGTTGGTGGACTTTTCTCTAAAA
TTAAAGGACTTTTCCCACCAATCGTAACCGGCTCAATTATTACCGTAATTGGCTTTACTTTAATTCCTGTGGCCTTTCAA
GATATTGGCGGTGGAAATGTTGCTGCTAAAAGTTTTGGAGATCCCCGTAATCTATTAGTAGGCTTAATCACCGTTTTGAT
TATTGTAGGTATTAATGTGTGGGCTCGCGGTTTTTTCCGTTCTATCGCCATCTTAATTGGTATTTTAATCGGCACCATCC
TTGCTAGTTTTATGGGCATGGTTTCGTTATCGCCCATTGCTGAAGCTAGTTGGTTTCGAATTCCTCAACCTTTCTATTTT
GGAGTTCCTACCTTTAATCTTTCCGCTATTCTAACCATGATTATGGTTACTTTAACTACAATGATTGAATCGACAGGGGT
CTTTTTCGCATTAGGTGATCTGGTAGGTAAAGAAATTACCCAAGACGATTTAAAACGTGGATACCGTTCAGAAGGAATTG
CAGCCATCCTTGGAGGGATCTTTAATACATTTCCCTACTCAACTTTTTCGGAAAATGTAGGTGTTCTCCAGCTTTCAGGC
GTTAAAAGCCGTAAACCTTTATATTATGCAGCTGGTTTCCTTATTGTTTTAGGGTTACTTCCTAAGGCTGGTGCCACTGC
CACCATTGTGCCGACCAGCGTCCTCGGGGGAGCTATGTTGGTAATGTTCGGAATTGTCGGGGTTCAAGGGGTCCGTATCT
TACAACAAGTCAACTTCAACCAGACTAAAAACATTCTAATCGTTTCGCTATCAGTTGGTATGGGACTTGGCTCAACCATT
TATCCTCAACTTTACCAAGCCCTTCCCGCTACTATTAAAATGCTACTTACCAACGGCATCGTGATTGCTAGTATCACTGC
TGTCGTTCTTAATTTGTTATTTAATGGCTACGATCGGGATATGTAA

Upstream 100 bases:

>100_bases
TGTATTATGATGGCTTGAGACTTTTTGTCTTGAGCTTTTTTAGTTTTATAGGCTCGATTTCATATTGATTTGAAAATTAT
GAAAACGAGGATGAGAATTC

Downstream 100 bases:

>100_bases
GATGTGCTAAAATTGAATTAATTAAACTAATGTTTTTAATTACCCTTTCAAAGGGAGTTAAAAGCATTTTTATTTAGAAT
TGGAGAATGCAAAATGAACA

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKTTESSYTEVPVTEIKPQLTEGKAAILGFQHLLAMYSGDVIVPLLIGGFLHFTAAQMTYLVSVDIFMCGIATLLQIKRT
PLTGIGLPVVLGCAVQAVQPLQQIGGTLGVTAMYGAIIASGVFVFLVGGLFSKIKGLFPPIVTGSIITVIGFTLIPVAFQ
DIGGGNVAAKSFGDPRNLLVGLITVLIIVGINVWARGFFRSIAILIGILIGTILASFMGMVSLSPIAEASWFRIPQPFYF
GVPTFNLSAILTMIMVTLTTMIESTGVFFALGDLVGKEITQDDLKRGYRSEGIAAILGGIFNTFPYSTFSENVGVLQLSG
VKSRKPLYYAAGFLIVLGLLPKAGATATIVPTSVLGGAMLVMFGIVGVQGVRILQQVNFNQTKNILIVSLSVGMGLGSTI
YPQLYQALPATIKMLLTNGIVIASITAVVLNLLFNGYDRDM

Sequences:

>Translated_441_residues
MKTTESSYTEVPVTEIKPQLTEGKAAILGFQHLLAMYSGDVIVPLLIGGFLHFTAAQMTYLVSVDIFMCGIATLLQIKRT
PLTGIGLPVVLGCAVQAVQPLQQIGGTLGVTAMYGAIIASGVFVFLVGGLFSKIKGLFPPIVTGSIITVIGFTLIPVAFQ
DIGGGNVAAKSFGDPRNLLVGLITVLIIVGINVWARGFFRSIAILIGILIGTILASFMGMVSLSPIAEASWFRIPQPFYF
GVPTFNLSAILTMIMVTLTTMIESTGVFFALGDLVGKEITQDDLKRGYRSEGIAAILGGIFNTFPYSTFSENVGVLQLSG
VKSRKPLYYAAGFLIVLGLLPKAGATATIVPTSVLGGAMLVMFGIVGVQGVRILQQVNFNQTKNILIVSLSVGMGLGSTI
YPQLYQALPATIKMLLTNGIVIASITAVVLNLLFNGYDRDM
>Mature_441_residues
MKTTESSYTEVPVTEIKPQLTEGKAAILGFQHLLAMYSGDVIVPLLIGGFLHFTAAQMTYLVSVDIFMCGIATLLQIKRT
PLTGIGLPVVLGCAVQAVQPLQQIGGTLGVTAMYGAIIASGVFVFLVGGLFSKIKGLFPPIVTGSIITVIGFTLIPVAFQ
DIGGGNVAAKSFGDPRNLLVGLITVLIIVGINVWARGFFRSIAILIGILIGTILASFMGMVSLSPIAEASWFRIPQPFYF
GVPTFNLSAILTMIMVTLTTMIESTGVFFALGDLVGKEITQDDLKRGYRSEGIAAILGGIFNTFPYSTFSENVGVLQLSG
VKSRKPLYYAAGFLIVLGLLPKAGATATIVPTSVLGGAMLVMFGIVGVQGVRILQQVNFNQTKNILIVSLSVGMGLGSTI
YPQLYQALPATIKMLLTNGIVIASITAVVLNLLFNGYDRDM

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=459, Percent_Identity=26.3616557734205, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI44680143, Length=463, Percent_Identity=26.3498920086393, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI44680148, Length=481, Percent_Identity=23.0769230769231, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI40316845, Length=481, Percent_Identity=23.0769230769231, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI87082181, Length=440, Percent_Identity=40, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1790087, Length=437, Percent_Identity=33.1807780320366, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87082178, Length=441, Percent_Identity=29.9319727891156, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788843, Length=371, Percent_Identity=30.7277628032345, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI87081818, Length=414, Percent_Identity=28.5024154589372, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87081750, Length=429, Percent_Identity=23.5431235431235, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=231, Percent_Identity=27.7056277056277, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17542262, Length=183, Percent_Identity=28.9617486338798, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=215, Percent_Identity=28.8372093023256, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17542260, Length=190, Percent_Identity=25.2631578947368, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356175, Length=422, Percent_Identity=25.1184834123223, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46675; Mature: 46675

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]