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The map label for this gene is bmr [H]

Identifier: 116493363

GI number: 116493363

Start: 1618984

End: 1620159

Strand: Reverse

Name: bmr [H]

Synonym: PEPE_1635

Alternate gene names: 116493363

Gene position: 1620159-1618984 (Counterclockwise)

Preceding gene: 116493364

Following gene: 116493362

Centisome position: 88.42

GC content: 38.01

Gene sequence:

>1176_bases
ATGAGTGAAAAAAACAGAAAGACATTATATATCTTAATTGCTGGAAACTTCTTAATTTGTTTGGGGATTGGTCTAGTCAT
ACCCGTCACACCATTTATTAAGAATCATTACGGTTATACTACTACTCAAATGGGAATTATGACGGCATTGTTTGCTTTCT
CGCAATTTATCGCTTCTCCATTAGTTGGACGAGTTTCAGATAAAATTGGACGTAAGCCACTGATTGTAGCGGGATTATTT
TTCTACGCCGTTTCGGAAGTAATCTTTGCTTTATCAAATTCGTTATTACTATTTAACGTATCCAGAGTTGTTGGTGGCAT
TTCAGCCGCTTTGTTTATTCCAACGTCGATGGCTTTAGCATCTGATGTTACCACTACGGCGCAAAGGGCTAAGGTAATTG
GTTGGATTTCAGCCGCATTTAGTGGGGGACTAATTTTAGGACCAGGGCTCGGTGGTGTATTAGCAAATATCCATTATAAA
GTGCCGTTTTGGGCGGCTGCAGCCTTAGGGCTGGTTTCAACATTATTTACGTATTTGGTAATGCCGAAGACTGAAGTGAA
AATAGAAGAAACGGAAATGACCAAGTTTACTAAGCCGAATGCTTTGAAAAGTGTCATGACGGCGCCACTAGTAATTCTAT
TTACGATGATTTTTGTAGCAGCCTTTGGGTTACAGGGATTCGAAAGTATTTATAGCATCTACGTTAACCAAGTCTTCAAT
TTTAGTTTAGGAACGATTGCACTAGTATTGACTTTTAATGGGATTTTCTCGTTGATTTTGCAAGTGTTTATCTTTGATTT
CTTGGTGCGGAAAATGGGTGAAGTGAGACTGATTGGGGCATGCTTCTTAATTGGAGCAATTTTTGTTTTTTGGATTACCC
AAGCTCATACTCAAATTGAAGTAATCATTGCTACATTAGTAGTTTTCTCTGCCTTCGATGTTTTACGTCCGGCCATCACC
ACCTTATTAACTAAGGAAGGTAAAGACAATCAAGGCTTAATTAATGGATTAAACATGTCTTTAACTAGTGTGGGGAACGT
CATCGGACCAATTATTGCCGGAATGTTGATGGATTACAATACTCACATTCCATATATGATTGTCGCTGTAATTTTATTCA
TATCTTATGGAATTACTTTCATCGTAGGACATGTGATGAAAAAAGAAACACGGTAG

Upstream 100 bases:

>100_bases
ATTATGGTCTCCGTAAGATATAGGTAATGAGCTTGAGCTTTTTTATTCATTGAGTGTTATCATGAAAGAATGTATCAGAT
AACGAAGGAGATGAATTACA

Downstream 100 bases:

>100_bases
ATGATAAAAAACTGTAGCGGGGCGATCAAGCTCGGCTACAGTTTTTTGTTTGATATAGTTTGGAAAGTTTCATATTAAGA
TAGTTATTCCTTGAAAATGT

Product: major facilitator superfamily permease

Products: NA

Alternate protein names: Multidrug-efflux transporter 1 [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSEKNRKTLYILIAGNFLICLGIGLVIPVTPFIKNHYGYTTTQMGIMTALFAFSQFIASPLVGRVSDKIGRKPLIVAGLF
FYAVSEVIFALSNSLLLFNVSRVVGGISAALFIPTSMALASDVTTTAQRAKVIGWISAAFSGGLILGPGLGGVLANIHYK
VPFWAAAALGLVSTLFTYLVMPKTEVKIEETEMTKFTKPNALKSVMTAPLVILFTMIFVAAFGLQGFESIYSIYVNQVFN
FSLGTIALVLTFNGIFSLILQVFIFDFLVRKMGEVRLIGACFLIGAIFVFWITQAHTQIEVIIATLVVFSAFDVLRPAIT
TLLTKEGKDNQGLINGLNMSLTSVGNVIGPIIAGMLMDYNTHIPYMIVAVILFISYGITFIVGHVMKKETR

Sequences:

>Translated_391_residues
MSEKNRKTLYILIAGNFLICLGIGLVIPVTPFIKNHYGYTTTQMGIMTALFAFSQFIASPLVGRVSDKIGRKPLIVAGLF
FYAVSEVIFALSNSLLLFNVSRVVGGISAALFIPTSMALASDVTTTAQRAKVIGWISAAFSGGLILGPGLGGVLANIHYK
VPFWAAAALGLVSTLFTYLVMPKTEVKIEETEMTKFTKPNALKSVMTAPLVILFTMIFVAAFGLQGFESIYSIYVNQVFN
FSLGTIALVLTFNGIFSLILQVFIFDFLVRKMGEVRLIGACFLIGAIFVFWITQAHTQIEVIIATLVVFSAFDVLRPAIT
TLLTKEGKDNQGLINGLNMSLTSVGNVIGPIIAGMLMDYNTHIPYMIVAVILFISYGITFIVGHVMKKETR
>Mature_390_residues
SEKNRKTLYILIAGNFLICLGIGLVIPVTPFIKNHYGYTTTQMGIMTALFAFSQFIASPLVGRVSDKIGRKPLIVAGLFF
YAVSEVIFALSNSLLLFNVSRVVGGISAALFIPTSMALASDVTTTAQRAKVIGWISAAFSGGLILGPGLGGVLANIHYKV
PFWAAAALGLVSTLFTYLVMPKTEVKIEETEMTKFTKPNALKSVMTAPLVILFTMIFVAAFGLQGFESIYSIYVNQVFNF
SLGTIALVLTFNGIFSLILQVFIFDFLVRKMGEVRLIGACFLIGAIFVFWITQAHTQIEVIIATLVVFSAFDVLRPAITT
LLTKEGKDNQGLINGLNMSLTSVGNVIGPIIAGMLMDYNTHIPYMIVAVILFISYGITFIVGHVMKKETR

Specific function: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally div

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=326, Percent_Identity=23.6196319018405, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI94721311, Length=336, Percent_Identity=24.702380952381, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI225703104, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI225703102, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI217416366, Length=412, Percent_Identity=21.1165048543689, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081738, Length=379, Percent_Identity=27.4406332453826, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17738085, Length=338, Percent_Identity=25.7396449704142, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42523; Mature: 42392

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKNRKTLYILIAGNFLICLGIGLVIPVTPFIKNHYGYTTTQMGIMTALFAFSQFIASP
CCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LVGRVSDKIGRKPLIVAGLFFYAVSEVIFALSNSLLLFNVSRVVGGISAALFIPTSMALA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHH
SDVTTTAQRAKVIGWISAAFSGGLILGPGLGGVLANIHYKVPFWAAAALGLVSTLFTYLV
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHEEECCHHHHHHHHHHHHHHHHHHH
MPKTEVKIEETEMTKFTKPNALKSVMTAPLVILFTMIFVAAFGLQGFESIYSIYVNQVFN
CCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
FSLGTIALVLTFNGIFSLILQVFIFDFLVRKMGEVRLIGACFLIGAIFVFWITQAHTQIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIIATLVVFSAFDVLRPAITTLLTKEGKDNQGLINGLNMSLTSVGNVIGPIIAGMLMDYN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCC
THIPYMIVAVILFISYGITFIVGHVMKKETR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEKNRKTLYILIAGNFLICLGIGLVIPVTPFIKNHYGYTTTQMGIMTALFAFSQFIASP
CCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LVGRVSDKIGRKPLIVAGLFFYAVSEVIFALSNSLLLFNVSRVVGGISAALFIPTSMALA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHH
SDVTTTAQRAKVIGWISAAFSGGLILGPGLGGVLANIHYKVPFWAAAALGLVSTLFTYLV
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHEEECCHHHHHHHHHHHHHHHHHHH
MPKTEVKIEETEMTKFTKPNALKSVMTAPLVILFTMIFVAAFGLQGFESIYSIYVNQVFN
CCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
FSLGTIALVLTFNGIFSLILQVFIFDFLVRKMGEVRLIGACFLIGAIFVFWITQAHTQIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIIATLVVFSAFDVLRPAITTLLTKEGKDNQGLINGLNMSLTSVGNVIGPIIAGMLMDYN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCC
THIPYMIVAVILFISYGITFIVGHVMKKETR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1675788; 7961792; 8969508; 9384377 [H]