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The map label for this gene is pepB [H]

Identifier: 116493361

GI number: 116493361

Start: 1616503

End: 1618302

Strand: Reverse

Name: pepB [H]

Synonym: PEPE_1633

Alternate gene names: 116493361

Gene position: 1618302-1616503 (Counterclockwise)

Preceding gene: 116493362

Following gene: 116493359

Centisome position: 88.32

GC content: 37.11

Gene sequence:

>1800_bases
ATGGCAAAAAAACAACTAACACGGGCAGAGGTTCCGGAAGCGTTAACTTGGAACGTCACCGATATTTTTACAACTGAAGC
AGATTTTAAAAAGGCCATTCAACAAGTTGAAAAACAAATTGTTGAAATTCAGGCCAATTCTAAACATATGACCGAGAGTG
CTACACAGTTATTAACATTAACTGAATTACTTTATGAGAGTGAAGAACTCCTTATGAAAGTTTATGGATATGCGGCTCGG
GTTAATGATGGCGATACTGCTGACCCACATGGGAACGATTTGATGAATCAAGCATTATTAATTGTTAATAAGTGGGAAGC
AGCCGTATCATTTTATGATCCTAAAATAACGCAACTATCAGCAGCGCAATTAGATCAATTTTTAGATGATAAGCCAGAAT
TAAAACGATATGAATTTAATTTACGTCGAATTCAAGAGCAAGCTGCCCATACCCTTACTCCTGCTGAAGAAAAATTGTTG
GCTCAACTTCAACCGGCGATTGATGATGCTTCAGACATTTCTTCGAAATTAGATGACGCTGATTTAGATTTTGGAATGAT
TAAAGATGAAAATGGCGAAGAAGTTCAATTAACTAATGCTACAGCCAGCGAATTTGCTACTTCAGCAGATCAGGACATGC
GAATGCGTGCTAGTAAACAAGTTGCTAAGGCGTACCGTTCAATGCGGAATACCTTTGGTGCTACCCTTAAAAGCCACGTT
CATGCCCAAAATATTTTAGCCACAATTAGGCATTTTGATAGTGCACGTCAGATGAATTTGGCTGATCAAAAAATTCCAGA
AGCCGTTTACGATACGTTGATTAATACGACACATGAACATCTGGATTTGATGCATGATTATTATGCTTTCCGAAAAGCAT
ACTTAGGATTAGATCATATGTATCAATTTGATCGACATGTTCCTTTGGTTGCAGATGCTAAGTTAAGTTTGGCATTTGAA
GAAGGCAAAAAGGTTACGATGGCAGCCTTGGCTCCGTTAGGCAAAGATTATCAAAATTATTTGCAAGAGGAATTTGAACA
ACGTTGGATTGATGCAGCTGAAAATAAAGGGAAACGTAGTGGGGGCTATGAGGACGACGTTTATGGAGTGCATCCATATA
TCTTACTAAATTGGAATGATATTTATGATAGTACTTCAACGTTAGCCCATGAATCGGGCCACGCACTTCAGAGTGTTTAC
ACGGATAAGGCCCAACCTTTCTGGTATTCACAATATCCAATCTTTATTGCTGAAATTGCTTCAACTTTAAACGAAAGCTT
ATTAAACCATTATATGTTAGAAAAATATGCTGATGATCCTCAAATTAAAGCATTTATTTTAACACAAGATGTGGACAACT
TTATTGGCACGGTTTATCGTCAAACTCTTTTTGCGGAATTTGAGCATTTTATTTATACAGAAGATGCCAAAGGAACGACC
CTTACCCCCGATTTGATGGCTGATAAATTTAACGGATTGTTTAAAGAATATAATGGAGATGCTGTAACAGATTTACCTTG
GAAAGACGATACTTGGGCGCAAATTCCTCATTTCTATTACGATTATTATGTTTACCAATACGCTACATCTAAAGCCATCG
CAACCGCTTTAGCCGATGATATTATTTCTGGTAAACCTGGTGCATTGGAAAACTATAAGAAATTCTTATCAGCTGGAGCA
AGCAATTATCCAGTCGAAATAGTTAAACAGGCTGGGGTAGATGTAACTAAACGTGACTATCTTGATCAAGCATTTAAAAT
ATTTGGTGAAGAAGTCGAAGAATTAAAGCGAATTTTATAA

Upstream 100 bases:

>100_bases
CAACACAATGCACGCCCCTTATCAGTTAATTAAGTGCCTTAAGTTGTGTATAGTTTCGGAAGTTGTAAAATAAAAGGCAA
TAGTATTAGGAGGATTTTAC

Downstream 100 bases:

>100_bases
TATTTAAACTAAGACATTGGAATTAAAGTCATAAAAAAACTCCCCGAGTTAAAATGGGGAGCATCTAGTTTTGTACATTC
AATTTAGGCATGATACTTGT

Product: oligopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MAKKQLTRAEVPEALTWNVTDIFTTEADFKKAIQQVEKQIVEIQANSKHMTESATQLLTLTELLYESEELLMKVYGYAAR
VNDGDTADPHGNDLMNQALLIVNKWEAAVSFYDPKITQLSAAQLDQFLDDKPELKRYEFNLRRIQEQAAHTLTPAEEKLL
AQLQPAIDDASDISSKLDDADLDFGMIKDENGEEVQLTNATASEFATSADQDMRMRASKQVAKAYRSMRNTFGATLKSHV
HAQNILATIRHFDSARQMNLADQKIPEAVYDTLINTTHEHLDLMHDYYAFRKAYLGLDHMYQFDRHVPLVADAKLSLAFE
EGKKVTMAALAPLGKDYQNYLQEEFEQRWIDAAENKGKRSGGYEDDVYGVHPYILLNWNDIYDSTSTLAHESGHALQSVY
TDKAQPFWYSQYPIFIAEIASTLNESLLNHYMLEKYADDPQIKAFILTQDVDNFIGTVYRQTLFAEFEHFIYTEDAKGTT
LTPDLMADKFNGLFKEYNGDAVTDLPWKDDTWAQIPHFYYDYYVYQYATSKAIATALADDIISGKPGALENYKKFLSAGA
SNYPVEIVKQAGVDVTKRDYLDQAFKIFGEEVEELKRIL

Sequences:

>Translated_599_residues
MAKKQLTRAEVPEALTWNVTDIFTTEADFKKAIQQVEKQIVEIQANSKHMTESATQLLTLTELLYESEELLMKVYGYAAR
VNDGDTADPHGNDLMNQALLIVNKWEAAVSFYDPKITQLSAAQLDQFLDDKPELKRYEFNLRRIQEQAAHTLTPAEEKLL
AQLQPAIDDASDISSKLDDADLDFGMIKDENGEEVQLTNATASEFATSADQDMRMRASKQVAKAYRSMRNTFGATLKSHV
HAQNILATIRHFDSARQMNLADQKIPEAVYDTLINTTHEHLDLMHDYYAFRKAYLGLDHMYQFDRHVPLVADAKLSLAFE
EGKKVTMAALAPLGKDYQNYLQEEFEQRWIDAAENKGKRSGGYEDDVYGVHPYILLNWNDIYDSTSTLAHESGHALQSVY
TDKAQPFWYSQYPIFIAEIASTLNESLLNHYMLEKYADDPQIKAFILTQDVDNFIGTVYRQTLFAEFEHFIYTEDAKGTT
LTPDLMADKFNGLFKEYNGDAVTDLPWKDDTWAQIPHFYYDYYVYQYATSKAIATALADDIISGKPGALENYKKFLSAGA
SNYPVEIVKQAGVDVTKRDYLDQAFKIFGEEVEELKRIL
>Mature_598_residues
AKKQLTRAEVPEALTWNVTDIFTTEADFKKAIQQVEKQIVEIQANSKHMTESATQLLTLTELLYESEELLMKVYGYAARV
NDGDTADPHGNDLMNQALLIVNKWEAAVSFYDPKITQLSAAQLDQFLDDKPELKRYEFNLRRIQEQAAHTLTPAEEKLLA
QLQPAIDDASDISSKLDDADLDFGMIKDENGEEVQLTNATASEFATSADQDMRMRASKQVAKAYRSMRNTFGATLKSHVH
AQNILATIRHFDSARQMNLADQKIPEAVYDTLINTTHEHLDLMHDYYAFRKAYLGLDHMYQFDRHVPLVADAKLSLAFEE
GKKVTMAALAPLGKDYQNYLQEEFEQRWIDAAENKGKRSGGYEDDVYGVHPYILLNWNDIYDSTSTLAHESGHALQSVYT
DKAQPFWYSQYPIFIAEIASTLNESLLNHYMLEKYADDPQIKAFILTQDVDNFIGTVYRQTLFAEFEHFIYTEDAKGTTL
TPDLMADKFNGLFKEYNGDAVTDLPWKDDTWAQIPHFYYDYYVYQYATSKAIATALADDIISGKPGALENYKKFLSAGAS
NYPVEIVKQAGVDVTKRDYLDQAFKIFGEEVEELKRIL

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 68299; Mature: 68168

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKQLTRAEVPEALTWNVTDIFTTEADFKKAIQQVEKQIVEIQANSKHMTESATQLLTL
CCCCCCCHHHCCCCEEECCHHEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TELLYESEELLMKVYGYAARVNDGDTADPHGNDLMNQALLIVNKWEAAVSFYDPKITQLS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEHHHHHHHHCCCCHHHHH
AAQLDQFLDDKPELKRYEFNLRRIQEQAAHTLTPAEEKLLAQLQPAIDDASDISSKLDDA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
DLDFGMIKDENGEEVQLTNATASEFATSADQDMRMRASKQVAKAYRSMRNTFGATLKSHV
CCCCCEEECCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAQNILATIRHFDSARQMNLADQKIPEAVYDTLINTTHEHLDLMHDYYAFRKAYLGLDHM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHH
YQFDRHVPLVADAKLSLAFEEGKKVTMAALAPLGKDYQNYLQEEFEQRWIDAAENKGKRS
HHHHCCCCEEECCCEEEEHHCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GGYEDDVYGVHPYILLNWNDIYDSTSTLAHESGHALQSVYTDKAQPFWYSQYPIFIAEIA
CCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCHHHHHHHHCCCCCCEECCCCHHHHHHH
STLNESLLNHYMLEKYADDPQIKAFILTQDVDNFIGTVYRQTLFAEFEHFIYTEDAKGTT
HHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
LTPDLMADKFNGLFKEYNGDAVTDLPWKDDTWAQIPHFYYDYYVYQYATSKAIATALADD
CCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IISGKPGALENYKKFLSAGASNYPVEIVKQAGVDVTKRDYLDQAFKIFGEEVEELKRIL
HHCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKKQLTRAEVPEALTWNVTDIFTTEADFKKAIQQVEKQIVEIQANSKHMTESATQLLTL
CCCCCCHHHCCCCEEECCHHEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TELLYESEELLMKVYGYAARVNDGDTADPHGNDLMNQALLIVNKWEAAVSFYDPKITQLS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEHHHHHHHHCCCCHHHHH
AAQLDQFLDDKPELKRYEFNLRRIQEQAAHTLTPAEEKLLAQLQPAIDDASDISSKLDDA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
DLDFGMIKDENGEEVQLTNATASEFATSADQDMRMRASKQVAKAYRSMRNTFGATLKSHV
CCCCCEEECCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAQNILATIRHFDSARQMNLADQKIPEAVYDTLINTTHEHLDLMHDYYAFRKAYLGLDHM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHH
YQFDRHVPLVADAKLSLAFEEGKKVTMAALAPLGKDYQNYLQEEFEQRWIDAAENKGKRS
HHHHCCCCEEECCCEEEEHHCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GGYEDDVYGVHPYILLNWNDIYDSTSTLAHESGHALQSVYTDKAQPFWYSQYPIFIAEIA
CCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCHHHHHHHHCCCCCCEECCCCHHHHHHH
STLNESLLNHYMLEKYADDPQIKAFILTQDVDNFIGTVYRQTLFAEFEHFIYTEDAKGTT
HHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
LTPDLMADKFNGLFKEYNGDAVTDLPWKDDTWAQIPHFYYDYYVYQYATSKAIATALADD
CCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IISGKPGALENYKKFLSAGASNYPVEIVKQAGVDVTKRDYLDQAFKIFGEEVEELKRIL
HHCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]