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The map label for this gene is mdtG [H]

Identifier: 116493295

GI number: 116493295

Start: 1535796

End: 1537025

Strand: Direct

Name: mdtG [H]

Synonym: PEPE_1567

Alternate gene names: 116493295

Gene position: 1535796-1537025 (Clockwise)

Preceding gene: 116493284

Following gene: 116493302

Centisome position: 83.81

GC content: 39.76

Gene sequence:

>1230_bases
ATGATGTTTTTCAATCGAAAAGGACAATCTAGAAAGAAACGTGAACCTTGGGAACAAAATCTTTTTGTGCTTTGGTTCGG
AACCTTCATAGCCGGGGTCGCATTTAGTGAGATTATGCCGTTTTTGTCGCTTTATGTCAACACACTCGGTGACTTCTCAA
AATCGCAACTATCTTTTTATAGTGGTCTAACTTATTCTTCTACTTTCTTAATTTTAGCAATTATTTCTCCAATTTGGGGA
AAAATTGCGGATAAGCGTGGAAGAAAAGTAATGATTTTAAGAGCTTCACTCGGAATGGCTTTCGTCTTAGGCGCAATGGG
CCTTGTTCAAAACGTCTTTCAACTGATTGGCCTTCGTTTATTACAAGGTGTTTTTGCAGGTTATATTAGTAACTCCAATG
CACTCATCGCTACCGAAACTCCTAAAGAAAAAAGTGGTTATGCACTTGGTATTTTATCTACTGGTCCTGTATCCGGATCT
CTACTAGGTCCCCTCATTGGTGGTGCACTAGCTTCTATTTTTTCATATCGAGTAACTTTCTTTATTACAGGTGGTTTATT
ACTAATCGTCTTTTTCCTAAGTTTCTTCTTGGTACATGAACACTTCGTTCCCGTAGAAAGTGAATCTGGTTCGCTTTCTG
CTCGAGAGGTAATTGGTAAACTAAATCAGCCTAAGGCCGTATTCGGCATGTTTATCACAACGATGATTATTCAAGCATCT
AATAATTCAATCGCGCCGATTATTAGTTTATACGTTAAAGAATTAATGCATAATGGGGCTGGTGTAACAATGGTTGCTGG
TTTAATTGCTGCAATTCCGGGAATTGCTAACATGTTAGCGGCTCCGCGCTTAGGAGAACTTGGGGACCAGATTGGAACCG
AAAAAGTTCTTTCCGTGGCCTTTCTCTTCGCCATGGTATTCTACATTCCAATGGCCTTTGTTCCTTCTATTTTTTGGCTA
GGAGTTTTCCGCTTCTTTATCGGAATTTCTGATGGAGCGATGCTACCAGCGGTTCAGAGTATTTTATCTAAACGAACACC
TGCTGCGGTAACTGGGCGTGTATTTAGTTGGAACCAGTCTTTCCAAGCACTCGGAAATATGATTGGCCCATTACTAGGCT
CTGCAGTCTCTGGTTTATTTGACTATAACGCTGTCTTTATTGCTACTTCTGTATTAGTTTTAATTAACTTTATCTTATTC
CGTTGGTTAAACGGACGATCAGTAGCATAA

Upstream 100 bases:

>100_bases
CCAATTTTTTAGTTTTTTACTCATTGACTTTTGCTCCATTACTATTTTTAATTTTTATGGTATTGTATATTGGTATATCT
TTTTTGAAAGAGGGCTTTTT

Downstream 100 bases:

>100_bases
ATCAAGTTAGTAACGCTGTGTTATGTTGATTACTGAGAAGCAATCCTAAACTATATTTCAGACCACAAAAAAAGAGGTAC
CACTGATAAATTCAGCGGTG

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MMFFNRKGQSRKKREPWEQNLFVLWFGTFIAGVAFSEIMPFLSLYVNTLGDFSKSQLSFYSGLTYSSTFLILAIISPIWG
KIADKRGRKVMILRASLGMAFVLGAMGLVQNVFQLIGLRLLQGVFAGYISNSNALIATETPKEKSGYALGILSTGPVSGS
LLGPLIGGALASIFSYRVTFFITGGLLLIVFFLSFFLVHEHFVPVESESGSLSAREVIGKLNQPKAVFGMFITTMIIQAS
NNSIAPIISLYVKELMHNGAGVTMVAGLIAAIPGIANMLAAPRLGELGDQIGTEKVLSVAFLFAMVFYIPMAFVPSIFWL
GVFRFFIGISDGAMLPAVQSILSKRTPAAVTGRVFSWNQSFQALGNMIGPLLGSAVSGLFDYNAVFIATSVLVLINFILF
RWLNGRSVA

Sequences:

>Translated_409_residues
MMFFNRKGQSRKKREPWEQNLFVLWFGTFIAGVAFSEIMPFLSLYVNTLGDFSKSQLSFYSGLTYSSTFLILAIISPIWG
KIADKRGRKVMILRASLGMAFVLGAMGLVQNVFQLIGLRLLQGVFAGYISNSNALIATETPKEKSGYALGILSTGPVSGS
LLGPLIGGALASIFSYRVTFFITGGLLLIVFFLSFFLVHEHFVPVESESGSLSAREVIGKLNQPKAVFGMFITTMIIQAS
NNSIAPIISLYVKELMHNGAGVTMVAGLIAAIPGIANMLAAPRLGELGDQIGTEKVLSVAFLFAMVFYIPMAFVPSIFWL
GVFRFFIGISDGAMLPAVQSILSKRTPAAVTGRVFSWNQSFQALGNMIGPLLGSAVSGLFDYNAVFIATSVLVLINFILF
RWLNGRSVA
>Mature_409_residues
MMFFNRKGQSRKKREPWEQNLFVLWFGTFIAGVAFSEIMPFLSLYVNTLGDFSKSQLSFYSGLTYSSTFLILAIISPIWG
KIADKRGRKVMILRASLGMAFVLGAMGLVQNVFQLIGLRLLQGVFAGYISNSNALIATETPKEKSGYALGILSTGPVSGS
LLGPLIGGALASIFSYRVTFFITGGLLLIVFFLSFFLVHEHFVPVESESGSLSAREVIGKLNQPKAVFGMFITTMIIQAS
NNSIAPIISLYVKELMHNGAGVTMVAGLIAAIPGIANMLAAPRLGELGDQIGTEKVLSVAFLFAMVFYIPMAFVPSIFWL
GVFRFFIGISDGAMLPAVQSILSKRTPAAVTGRVFSWNQSFQALGNMIGPLLGSAVSGLFDYNAVFIATSVLVLINFILF
RWLNGRSVA

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=386, Percent_Identity=49.2227979274611, Blast_Score=376, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44337; Mature: 44337

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFFNRKGQSRKKREPWEQNLFVLWFGTFIAGVAFSEIMPFLSLYVNTLGDFSKSQLSFY
CCCCCCCCCCCCCCCCHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SGLTYSSTFLILAIISPIWGKIADKRGRKVMILRASLGMAFVLGAMGLVQNVFQLIGLRL
HCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LQGVFAGYISNSNALIATETPKEKSGYALGILSTGPVSGSLLGPLIGGALASIFSYRVTF
HHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FITGGLLLIVFFLSFFLVHEHFVPVESESGSLSAREVIGKLNQPKAVFGMFITTMIIQAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCC
NNSIAPIISLYVKELMHNGAGVTMVAGLIAAIPGIANMLAAPRLGELGDQIGTEKVLSVA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FLFAMVFYIPMAFVPSIFWLGVFRFFIGISDGAMLPAVQSILSKRTPAAVTGRVFSWNQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHCCCCEECCHH
FQALGNMIGPLLGSAVSGLFDYNAVFIATSVLVLINFILFRWLNGRSVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMFFNRKGQSRKKREPWEQNLFVLWFGTFIAGVAFSEIMPFLSLYVNTLGDFSKSQLSFY
CCCCCCCCCCCCCCCCHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SGLTYSSTFLILAIISPIWGKIADKRGRKVMILRASLGMAFVLGAMGLVQNVFQLIGLRL
HCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LQGVFAGYISNSNALIATETPKEKSGYALGILSTGPVSGSLLGPLIGGALASIFSYRVTF
HHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FITGGLLLIVFFLSFFLVHEHFVPVESESGSLSAREVIGKLNQPKAVFGMFITTMIIQAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCC
NNSIAPIISLYVKELMHNGAGVTMVAGLIAAIPGIANMLAAPRLGELGDQIGTEKVLSVA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FLFAMVFYIPMAFVPSIFWLGVFRFFIGISDGAMLPAVQSILSKRTPAAVTGRVFSWNQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHCCCCEECCHH
FQALGNMIGPLLGSAVSGLFDYNAVFIATSVLVLINFILFRWLNGRSVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA