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The map label for this gene is pncB [H]

Identifier: 116493262

GI number: 116493262

Start: 1494153

End: 1495616

Strand: Reverse

Name: pncB [H]

Synonym: PEPE_1525

Alternate gene names: 116493262

Gene position: 1495616-1494153 (Counterclockwise)

Preceding gene: 116493264

Following gene: 116493261

Centisome position: 81.62

GC content: 38.05

Gene sequence:

>1464_bases
ATGGTAAAAGAGTTTCCAGATGACACATTAACTTTGCATACAGATGCGTATCAAATCAATATGATCCAAACCTATTGGAA
TAAAGGAATTCACAACAAGACGGCGATCTTTGAAGTGTTTTTCAGAAATATGCCATTTGATAATGGGTATGCTGTTTTTG
CTGGATTAGACCGCATTATTGATTATATCAGTAACTTACATTTTTCAGAGAGCGATATTGAATATTTAAAGGATGTGGCT
GGTTATCCAGACGATTTTTTAGCTTACCTTAAAGATTTTCATTTTAGAGGTACAATTCGTTCTGCAGTTGAAGGCGACCT
AGTTTTCAACAACGAACCTATTTTACAAGTCGAAGGGCCACTTGCCGACTGTCAATTAATTGAAACAGCGTTATTGAATA
TTGTCAATTACCAAACCTTAATTGCTACAAAAGCGGCTCGCATTAAGTCGGTAGTTGGTTCAGACAAGTTACTTGAATTT
GGTACTCGGCGTGCGCAAGAAATGGATGCTGCCCTTTGGGGAACTCGCGCTGCTTACATTGGTGGCTTCGATGCTACCAG
TAATGTACGGGCCGGTAAGAAATTTGGAATTCCAGTAAGTGGGACACACGCGCATGCATTGGTTCAATATTACATGAATG
ATTATGATGCTTTCAAAGCGTATGCGACAACTCACCGTGATTGTGTTTTTCTAGTAGATACATTTGATACATTAAAAAGT
GGGGTACCTAATGCTATTCGCGTAGCAAAAGAAATGGGCGATAAGATTAATTTCTTAGGAGTTCGAATTGACAGTGGTGA
CATGGCCTATTTATCGAAACGTGTTCGTGAACAATTAGATGAAGCAGGTTTCCCTAATGCTAAAATTTTTGCATCGAATG
ATTTAGATGAAAAAACAATCCAAAACTTGAAGATGCAGGGAGCTAAGATTGAAGTTTGGGGCGTTGGTACTAAGTTGATT
ACGGCATATGATCAACCAGCGCTAGGTGCAGTTTATAAGATGGTGTCAATTGAACGTGACGGTAAAATGGTGGATACCAT
CAAATTATCAAATAATGCTGAGAAAGTTTCTACTCCAGGTAAAAAACAAGTTTGGCGTATTTCAAGAAACTCAGATGGAA
AATCGGAAGGTGACTATATCACTCTTTGGGATGAAGATCCTCGAGTAGAAGAGTCTCTATACATGTTCCATCCGAACTAC
ACGTATATTAATAAAACGGTCACTGATTTTAAAGCTCGTCCAGTTTTACAAACCATTTTTGAAGATGGTAAATTAGTTTA
TGATCGACCAAGTTTGGCTGAGATTAAAGAATTTGCTCGTCGTAGTTTGGATTCTCTGTGGGATGAGTACAAACGGGATT
TAAATCCACAAGATTATCCGGTGGATCTTTCACAAGATTGCTACGACAATAAAGTTGCTATTATCAAGCGAGTCCGTGAA
TATGTTGGGAAACTAAAATTTTAA

Upstream 100 bases:

>100_bases
TCCTAGATTAAAAATTGCGATTTAATGTATAAATGATAAAATTAAAACAACTGTATTGTTAGATTAAATAAAAACATAAA
AGAGTAGGAGCATAATCATC

Downstream 100 bases:

>100_bases
CAAACTAGGTGATAAAATTGCGAGAATTACAAAAAGAGATTATTGAAACTTTAAAGGTTCAACCGACGATTGACCCAAAA
CAGGAAATTCGTCGTAGTGT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MVKEFPDDTLTLHTDAYQINMIQTYWNKGIHNKTAIFEVFFRNMPFDNGYAVFAGLDRIIDYISNLHFSESDIEYLKDVA
GYPDDFLAYLKDFHFRGTIRSAVEGDLVFNNEPILQVEGPLADCQLIETALLNIVNYQTLIATKAARIKSVVGSDKLLEF
GTRRAQEMDAALWGTRAAYIGGFDATSNVRAGKKFGIPVSGTHAHALVQYYMNDYDAFKAYATTHRDCVFLVDTFDTLKS
GVPNAIRVAKEMGDKINFLGVRIDSGDMAYLSKRVREQLDEAGFPNAKIFASNDLDEKTIQNLKMQGAKIEVWGVGTKLI
TAYDQPALGAVYKMVSIERDGKMVDTIKLSNNAEKVSTPGKKQVWRISRNSDGKSEGDYITLWDEDPRVEESLYMFHPNY
TYINKTVTDFKARPVLQTIFEDGKLVYDRPSLAEIKEFARRSLDSLWDEYKRDLNPQDYPVDLSQDCYDNKVAIIKRVRE
YVGKLKF

Sequences:

>Translated_487_residues
MVKEFPDDTLTLHTDAYQINMIQTYWNKGIHNKTAIFEVFFRNMPFDNGYAVFAGLDRIIDYISNLHFSESDIEYLKDVA
GYPDDFLAYLKDFHFRGTIRSAVEGDLVFNNEPILQVEGPLADCQLIETALLNIVNYQTLIATKAARIKSVVGSDKLLEF
GTRRAQEMDAALWGTRAAYIGGFDATSNVRAGKKFGIPVSGTHAHALVQYYMNDYDAFKAYATTHRDCVFLVDTFDTLKS
GVPNAIRVAKEMGDKINFLGVRIDSGDMAYLSKRVREQLDEAGFPNAKIFASNDLDEKTIQNLKMQGAKIEVWGVGTKLI
TAYDQPALGAVYKMVSIERDGKMVDTIKLSNNAEKVSTPGKKQVWRISRNSDGKSEGDYITLWDEDPRVEESLYMFHPNY
TYINKTVTDFKARPVLQTIFEDGKLVYDRPSLAEIKEFARRSLDSLWDEYKRDLNPQDYPVDLSQDCYDNKVAIIKRVRE
YVGKLKF
>Mature_487_residues
MVKEFPDDTLTLHTDAYQINMIQTYWNKGIHNKTAIFEVFFRNMPFDNGYAVFAGLDRIIDYISNLHFSESDIEYLKDVA
GYPDDFLAYLKDFHFRGTIRSAVEGDLVFNNEPILQVEGPLADCQLIETALLNIVNYQTLIATKAARIKSVVGSDKLLEF
GTRRAQEMDAALWGTRAAYIGGFDATSNVRAGKKFGIPVSGTHAHALVQYYMNDYDAFKAYATTHRDCVFLVDTFDTLKS
GVPNAIRVAKEMGDKINFLGVRIDSGDMAYLSKRVREQLDEAGFPNAKIFASNDLDEKTIQNLKMQGAKIEVWGVGTKLI
TAYDQPALGAVYKMVSIERDGKMVDTIKLSNNAEKVSTPGKKQVWRISRNSDGKSEGDYITLWDEDPRVEESLYMFHPNY
TYINKTVTDFKARPVLQTIFEDGKLVYDRPSLAEIKEFARRSLDSLWDEYKRDLNPQDYPVDLSQDCYDNKVAIIKRVRE
YVGKLKF

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=517, Percent_Identity=33.0754352030948, Blast_Score=269, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71997947, Length=524, Percent_Identity=37.2137404580153, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71997952, Length=524, Percent_Identity=37.2137404580153, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71997955, Length=203, Percent_Identity=48.7684729064039, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24581587, Length=517, Percent_Identity=37.137330754352, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI161076680, Length=229, Percent_Identity=44.1048034934498, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24581595, Length=229, Percent_Identity=44.1048034934498, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI28574709, Length=229, Percent_Identity=44.1048034934498, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24581593, Length=229, Percent_Identity=44.1048034934498, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24581591, Length=229, Percent_Identity=44.1048034934498, Blast_Score=174, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55406; Mature: 55406

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKEFPDDTLTLHTDAYQINMIQTYWNKGIHNKTAIFEVFFRNMPFDNGYAVFAGLDRII
CCCCCCCCCEEEEECCEEEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHH
DYISNLHFSESDIEYLKDVAGYPDDFLAYLKDFHFRGTIRSAVEGDLVFNNEPILQVEGP
HHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCCEEECCCCEEEECCC
LADCQLIETALLNIVNYQTLIATKAARIKSVVGSDKLLEFGTRRAQEMDAALWGTRAAYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEE
GGFDATSNVRAGKKFGIPVSGTHAHALVQYYMNDYDAFKAYATTHRDCVFLVDTFDTLKS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHH
GVPNAIRVAKEMGDKINFLGVRIDSGDMAYLSKRVREQLDEAGFPNAKIFASNDLDEKTI
CCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
QNLKMQGAKIEVWGVGTKLITAYDQPALGAVYKMVSIERDGKMVDTIKLSNNAEKVSTPG
HHHHHCCCEEEEEECCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEEECCCCHHCCCCC
KKQVWRISRNSDGKSEGDYITLWDEDPRVEESLYMFHPNYTYINKTVTDFKARPVLQTIF
HHHEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEECCCEEEECCCHHHHHCHHHHHHHH
EDGKLVYDRPSLAEIKEFARRSLDSLWDEYKRDLNPQDYPVDLSQDCYDNKVAIIKRVRE
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YVGKLKF
HHHCCCC
>Mature Secondary Structure
MVKEFPDDTLTLHTDAYQINMIQTYWNKGIHNKTAIFEVFFRNMPFDNGYAVFAGLDRII
CCCCCCCCCEEEEECCEEEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHH
DYISNLHFSESDIEYLKDVAGYPDDFLAYLKDFHFRGTIRSAVEGDLVFNNEPILQVEGP
HHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCCEEECCCCEEEECCC
LADCQLIETALLNIVNYQTLIATKAARIKSVVGSDKLLEFGTRRAQEMDAALWGTRAAYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEE
GGFDATSNVRAGKKFGIPVSGTHAHALVQYYMNDYDAFKAYATTHRDCVFLVDTFDTLKS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHH
GVPNAIRVAKEMGDKINFLGVRIDSGDMAYLSKRVREQLDEAGFPNAKIFASNDLDEKTI
CCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
QNLKMQGAKIEVWGVGTKLITAYDQPALGAVYKMVSIERDGKMVDTIKLSNNAEKVSTPG
HHHHHCCCEEEEEECCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEEECCCCHHCCCCC
KKQVWRISRNSDGKSEGDYITLWDEDPRVEESLYMFHPNYTYINKTVTDFKARPVLQTIF
HHHEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEECCCEEEECCCHHHHHCHHHHHHHH
EDGKLVYDRPSLAEIKEFARRSLDSLWDEYKRDLNPQDYPVDLSQDCYDNKVAIIKRVRE
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YVGKLKF
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]