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The map label for this gene is dut [H]

Identifier: 116493242

GI number: 116493242

Start: 1472199

End: 1472732

Strand: Reverse

Name: dut [H]

Synonym: PEPE_1504

Alternate gene names: 116493242

Gene position: 1472732-1472199 (Counterclockwise)

Preceding gene: 116493246

Following gene: 116493241

Centisome position: 80.37

GC content: 37.08

Gene sequence:

>534_bases
ATGAGTAGAGGATTTGAAATTATTAGTAAGTATCAAAATCAAGGATTACATTTACCCCAACGACAAACAAAAGCAGCCGC
TGGATATGACTTTGAAGCGGCAGAAGATTTTGTGTTACCAAGTATTTGGAAATTGAATTTTGTGAAGGTTTTGTGGGCCC
TACGTCATCAAGAAAATGTAACAGACGAAGTATTAGATGCGGCTCGAGCAGAATTAAAACCATATTTAGTACCAACGGGT
ATTAAAGCATATATGGAAGATGATGAGTATTTAATGTTGGCCAATCGTTCTAGTAACCCTCTAAAACGTAGTTTAATTTT
ACCTAATGGGGTAGGAATTGTGGACGCGGACTACTACAATAATGAAAGCAATGAAGGGGCTATTTTTCTCCAACTTGTAA
ATTATGGAATTACAGATGTAAAAATCAAAAAGGGCGAACGAATTGGTCAGGGAATTTTTATGAAATATTTAGTAGCTGAC
AACGAAACGGCCTCAGAACAAAAGCGAACTGGTGGGTTTGGTTCGACTAAGTAG

Upstream 100 bases:

>100_bases
CAAGAAAGCGCATAAAGTCAATTGCTTCAACAGATTTCCGTTTACAAAGTGGGTCAATAAAAGGATAATAAAATAAATGA
TTATTAGGAGGGAAACCGTA

Downstream 100 bases:

>100_bases
TCATTAAAAATCAATAAAGGTCAAACTAATTTTGATTAAATTATAGAAATAAATGCTATCCTAATTGTACGAATTTAAAG
TTGAGGGGGAATTTAAAGCT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSRGFEIISKYQNQGLHLPQRQTKAAAGYDFEAAEDFVLPSIWKLNFVKVLWALRHQENVTDEVLDAARAELKPYLVPTG
IKAYMEDDEYLMLANRSSNPLKRSLILPNGVGIVDADYYNNESNEGAIFLQLVNYGITDVKIKKGERIGQGIFMKYLVAD
NETASEQKRTGGFGSTK

Sequences:

>Translated_177_residues
MSRGFEIISKYQNQGLHLPQRQTKAAAGYDFEAAEDFVLPSIWKLNFVKVLWALRHQENVTDEVLDAARAELKPYLVPTG
IKAYMEDDEYLMLANRSSNPLKRSLILPNGVGIVDADYYNNESNEGAIFLQLVNYGITDVKIKKGERIGQGIFMKYLVAD
NETASEQKRTGGFGSTK
>Mature_176_residues
SRGFEIISKYQNQGLHLPQRQTKAAAGYDFEAAEDFVLPSIWKLNFVKVLWALRHQENVTDEVLDAARAELKPYLVPTGI
KAYMEDDEYLMLANRSSNPLKRSLILPNGVGIVDADYYNNESNEGAIFLQLVNYGITDVKIKKGERIGQGIFMKYLVADN
ETASEQKRTGGFGSTK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19912; Mature: 19781

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGFEIISKYQNQGLHLPQRQTKAAAGYDFEAAEDFVLPSIWKLNFVKVLWALRHQENV
CCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
TDEVLDAARAELKPYLVPTGIKAYMEDDEYLMLANRSSNPLKRSLILPNGVGIVDADYYN
HHHHHHHHHHHCCCEECCCCCEEEECCCCEEEEECCCCCCCCCEEECCCCCCEEECCCCC
NESNEGAIFLQLVNYGITDVKIKKGERIGQGIFMKYLVADNETASEQKRTGGFGSTK
CCCCCCEEEEEEECCCCCEEEEECCCCCCCHHEEEEEECCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
SRGFEIISKYQNQGLHLPQRQTKAAAGYDFEAAEDFVLPSIWKLNFVKVLWALRHQENV
CCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
TDEVLDAARAELKPYLVPTGIKAYMEDDEYLMLANRSSNPLKRSLILPNGVGIVDADYYN
HHHHHHHHHHHCCCEECCCCCEEEECCCCEEEEECCCCCCCCCEEECCCCCCEEECCCCC
NESNEGAIFLQLVNYGITDVKIKKGERIGQGIFMKYLVADNETASEQKRTGGFGSTK
CCCCCCEEEEEEECCCCCEEEEECCCCCCCHHEEEEEECCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]