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The map label for this gene is gcp

Identifier: 116493210

GI number: 116493210

Start: 1445582

End: 1446619

Strand: Reverse

Name: gcp

Synonym: PEPE_1472

Alternate gene names: 116493210

Gene position: 1446619-1445582 (Counterclockwise)

Preceding gene: 116493211

Following gene: 116493209

Centisome position: 78.95

GC content: 39.79

Gene sequence:

>1038_bases
GTGGATCAAACTAGTTTAATTTTAGCAATCGAATCAAGTTGTGATGAAACTAGTGTTGCAGTTATTAAAAATGGTGACAT
TATTTTATCTAACATAATTGCAACACAAATTAATAGCCATCAGCGCTTTGGCGGGGTGGTTCCGGAAGTTGCCAGTCGCC
ATCATATCGAGCAAATTACCATCTGCATTGAACAAGCCTTAAAGCAAGCTGAAGTACGTAAAGAGGACCTCGATGCTGTA
GCAGTTACGTATGGACCCGGATTAGTTGGGGCACTTTTAGTGGGCGTTTCAGCTGCTAAAGCTTTTGCTTTTGCAAATGA
ATTACCATTAATCCCAGTTAATCACATGATTGGACATATCTACGCTGCACGTTTTGTAAAACCCATTGTTTTTCCAGCCT
TAGCTCTCCTTGTTTCGGGGGGTCATACAGAACTAGTATATATGCCAACCGAAAATGAATTTAAAATTATCGGTGAGACT
CGTGATGATGCAGCCGGTGAAGCCTATGATAAAGTGGGGCGCGTAATGGGTTTGAAGTATCCAGCGGGTAAAGCAATCGA
CGAACTTGCTCACCAAGGCGAAGACATCTTCAAGTTCCCACGAGCAATGGAACACGAAGATAATTTTGATTTTAGTTTCA
GTGGTTTGAAGAGTGCTTTTATTAATACAGTGCATCATGCAGATCAAATTAATGAAGAACTTAGTAAAAAAGATTTAGCA
GCAAGCTTCCAACAAAGCGTGATAGATGTTATCACGGCTAAAACGGTTCGGGCTTGCGAGCAGTTAGAAATAAAACAATT
AATTTTAGCTGGAGGAGTTGCAGCTAACCGTGGTTTACGGGATACTTTAGATAAAGAACTTGGCGAAAAATTTAATCATT
TAGATTTCGTTAAGGCACCTTTGGATCTTTGTGGTGATAATGGAGCAATGATTGGTGCTGCTGGTGAAATGTTAATGCGA
CACCAAGTTTTTGCTGATATGACGTTAAATGCTGATCCAAGTTTAGAATTTGATTGGGAACCAGAAGCAATTAAGTAA

Upstream 100 bases:

>100_bases
GGTTTTGAAAAGACAGGAATCAAGAAGAGGTATTATTTCGGCGATCATGAAGATGCAATTGATATGACATTAGATTTGTC
GAAGTGGCGAGGAGGATATC

Downstream 100 bases:

>100_bases
AGAGTGGGTGAATAAATATGACTGAGCAAATGTATCAAGTTCATCAAGTTATTAAAAAGGAAATTGAAAATCATAATATT
TATGGTGCTTCCTATAGCTT

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDQTSLILAIESSCDETSVAVIKNGDIILSNIIATQINSHQRFGGVVPEVASRHHIEQITICIEQALKQAEVRKEDLDAV
AVTYGPGLVGALLVGVSAAKAFAFANELPLIPVNHMIGHIYAARFVKPIVFPALALLVSGGHTELVYMPTENEFKIIGET
RDDAAGEAYDKVGRVMGLKYPAGKAIDELAHQGEDIFKFPRAMEHEDNFDFSFSGLKSAFINTVHHADQINEELSKKDLA
ASFQQSVIDVITAKTVRACEQLEIKQLILAGGVAANRGLRDTLDKELGEKFNHLDFVKAPLDLCGDNGAMIGAAGEMLMR
HQVFADMTLNADPSLEFDWEPEAIK

Sequences:

>Translated_345_residues
MDQTSLILAIESSCDETSVAVIKNGDIILSNIIATQINSHQRFGGVVPEVASRHHIEQITICIEQALKQAEVRKEDLDAV
AVTYGPGLVGALLVGVSAAKAFAFANELPLIPVNHMIGHIYAARFVKPIVFPALALLVSGGHTELVYMPTENEFKIIGET
RDDAAGEAYDKVGRVMGLKYPAGKAIDELAHQGEDIFKFPRAMEHEDNFDFSFSGLKSAFINTVHHADQINEELSKKDLA
ASFQQSVIDVITAKTVRACEQLEIKQLILAGGVAANRGLRDTLDKELGEKFNHLDFVKAPLDLCGDNGAMIGAAGEMLMR
HQVFADMTLNADPSLEFDWEPEAIK
>Mature_345_residues
MDQTSLILAIESSCDETSVAVIKNGDIILSNIIATQINSHQRFGGVVPEVASRHHIEQITICIEQALKQAEVRKEDLDAV
AVTYGPGLVGALLVGVSAAKAFAFANELPLIPVNHMIGHIYAARFVKPIVFPALALLVSGGHTELVYMPTENEFKIIGET
RDDAAGEAYDKVGRVMGLKYPAGKAIDELAHQGEDIFKFPRAMEHEDNFDFSFSGLKSAFINTVHHADQINEELSKKDLA
ASFQQSVIDVITAKTVRACEQLEIKQLILAGGVAANRGLRDTLDKELGEKFNHLDFVKAPLDLCGDNGAMIGAAGEMLMR
HQVFADMTLNADPSLEFDWEPEAIK

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=344, Percent_Identity=33.1395348837209, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI8923380, Length=320, Percent_Identity=31.875, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1789445, Length=339, Percent_Identity=41.0029498525074, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=33.434650455927, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71995670, Length=322, Percent_Identity=32.6086956521739, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6320099, Length=337, Percent_Identity=32.0474777448071, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322891, Length=351, Percent_Identity=27.9202279202279, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20129063, Length=340, Percent_Identity=30.8823529411765, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21357207, Length=328, Percent_Identity=29.8780487804878, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_PEDPA (Q03E69)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804945.1
- ProteinModelPortal:   Q03E69
- SMR:   Q03E69
- STRING:   Q03E69
- MEROPS:   M22.001
- GeneID:   4417323
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1472
- NMPDR:   fig|278197.10.peg.1296
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q03E69
- BioCyc:   PPEN278197:PEPE_1472-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37565; Mature: 37565

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQTSLILAIESSCDETSVAVIKNGDIILSNIIATQINSHQRFGGVVPEVASRHHIEQIT
CCCCEEEEEEECCCCCCEEEEEECCCEEEHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
ICIEQALKQAEVRKEDLDAVAVTYGPGLVGALLVGVSAAKAFAFANELPLIPVNHMIGHI
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
YAARFVKPIVFPALALLVSGGHTELVYMPTENEFKIIGETRDDAAGEAYDKVGRVMGLKY
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
PAGKAIDELAHQGEDIFKFPRAMEHEDNFDFSFSGLKSAFINTVHHADQINEELSKKDLA
CCCHHHHHHHHCCCHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFQQSVIDVITAKTVRACEQLEIKQLILAGGVAANRGLRDTLDKELGEKFNHLDFVKAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCHHHHHHHH
LDLCGDNGAMIGAAGEMLMRHQVFADMTLNADPSLEFDWEPEAIK
HHHCCCCCCEEEHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDQTSLILAIESSCDETSVAVIKNGDIILSNIIATQINSHQRFGGVVPEVASRHHIEQIT
CCCCEEEEEEECCCCCCEEEEEECCCEEEHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
ICIEQALKQAEVRKEDLDAVAVTYGPGLVGALLVGVSAAKAFAFANELPLIPVNHMIGHI
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
YAARFVKPIVFPALALLVSGGHTELVYMPTENEFKIIGETRDDAAGEAYDKVGRVMGLKY
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
PAGKAIDELAHQGEDIFKFPRAMEHEDNFDFSFSGLKSAFINTVHHADQINEELSKKDLA
CCCHHHHHHHHCCCHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFQQSVIDVITAKTVRACEQLEIKQLILAGGVAANRGLRDTLDKELGEKFNHLDFVKAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCHHHHHHHH
LDLCGDNGAMIGAAGEMLMRHQVFADMTLNADPSLEFDWEPEAIK
HHHCCCCCCEEEHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA