Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 116493142

GI number: 116493142

Start: 1381990

End: 1382649

Strand: Reverse

Name: adk [H]

Synonym: PEPE_1397

Alternate gene names: 116493142

Gene position: 1382649-1381990 (Counterclockwise)

Preceding gene: 116493143

Following gene: 116493141

Centisome position: 75.46

GC content: 37.88

Gene sequence:

>660_bases
ATGAGTAAATTAAACCTCGTTTTGATGGGTCTTCCAGGTGCTGGTAAAGGTACACAGGCTCAGAGAATTATTGAGGATTT
CAAAATTCCACATATTTCAACTGGTGACATTTTCCGTGAAGCTATGAAAAATGAAACCGAAATGGGTGTGGAAGCAAAGA
AGTTCATTGATAAGGGTGAACTTGTTCCCGATAGTGTAACTAACGGGATCGTCGAAGATCGTCTTGCAATGGACGATGTC
AACGATGGTTTTATGCTTGATGGTTTTCCTAGAAATATCGATCAAGCTAAGGCGCTAGATGAAATGACATCTCGTTTAAA
CAAACCACTTACAGCAGTGATTAACATTCATGTTGATCCTGAAGTTTTGGTTGAAAGACTATCTGGCAGATTTATTTGTA
AAAATTGTGGAGCTACTTATCATAAGCTTTACAATCCACCAAAGGTTGAAGGAACTTGTGATGTTTGCGGACATCACGAA
TTCTTCCAACGTGAGGACGACAAGCCAGAAACTGTAAAAAATCGCATTGCTGTTAATACTAAACTTAACACTCCGTTGAT
TTCTTACTATGAAGAAAAGCATCTCCTTTACAACATTAATGGCGATCAGGATATCAACGATGTTTATTCTGAAGTCAAAA
AAGTATTAGAGGCTCTCTAA

Upstream 100 bases:

>100_bases
TCGAGTTGGCAAATCAACTTGAAGGGTTAATGATGAAACGAGAATACGTTGGATTCATTCGAAAATAATTCGTTAGTTTA
ACAATGAAGGAGAATTTCAA

Downstream 100 bases:

>100_bases
TTTCGTGCTTGTTGGTACTATAGATAACGTTCATTGTTTGCAAATAGTTTTTTCGTATGGTAAGCTAATTCAGGTTTAGC
TTCGAAATACATATTTTGAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSKLNLVLMGLPGAGKGTQAQRIIEDFKIPHISTGDIFREAMKNETEMGVEAKKFIDKGELVPDSVTNGIVEDRLAMDDV
NDGFMLDGFPRNIDQAKALDEMTSRLNKPLTAVINIHVDPEVLVERLSGRFICKNCGATYHKLYNPPKVEGTCDVCGHHE
FFQREDDKPETVKNRIAVNTKLNTPLISYYEEKHLLYNINGDQDINDVYSEVKKVLEAL

Sequences:

>Translated_219_residues
MSKLNLVLMGLPGAGKGTQAQRIIEDFKIPHISTGDIFREAMKNETEMGVEAKKFIDKGELVPDSVTNGIVEDRLAMDDV
NDGFMLDGFPRNIDQAKALDEMTSRLNKPLTAVINIHVDPEVLVERLSGRFICKNCGATYHKLYNPPKVEGTCDVCGHHE
FFQREDDKPETVKNRIAVNTKLNTPLISYYEEKHLLYNINGDQDINDVYSEVKKVLEAL
>Mature_218_residues
SKLNLVLMGLPGAGKGTQAQRIIEDFKIPHISTGDIFREAMKNETEMGVEAKKFIDKGELVPDSVTNGIVEDRLAMDDVN
DGFMLDGFPRNIDQAKALDEMTSRLNKPLTAVINIHVDPEVLVERLSGRFICKNCGATYHKLYNPPKVEGTCDVCGHHEF
FQREDDKPETVKNRIAVNTKLNTPLISYYEEKHLLYNINGDQDINDVYSEVKKVLEAL

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI19923437, Length=219, Percent_Identity=39.2694063926941, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=34.9282296650718, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=34.9282296650718, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI310110345, Length=213, Percent_Identity=37.5586854460094, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI53832003, Length=213, Percent_Identity=37.5586854460094, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI8051579, Length=213, Percent_Identity=37.5586854460094, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI53832001, Length=213, Percent_Identity=37.5586854460094, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=27.4418604651163, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI28144899, Length=216, Percent_Identity=24.537037037037, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI28144897, Length=216, Percent_Identity=24.537037037037, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI7706497, Length=222, Percent_Identity=26.5765765765766, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=27.7511961722488, Blast_Score=84, Evalue=8e-17,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=40.3669724770642, Blast_Score=170, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=32.8638497652582, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=32.5581395348837, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=207, Percent_Identity=26.5700483091787, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=25.5813953488372, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=26.046511627907, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=38.0952380952381, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.5329949238579, Blast_Score=131, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=26.7281105990783, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=35.981308411215, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=38.5786802030457, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=38.5786802030457, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24652; Mature: 24521

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLNLVLMGLPGAGKGTQAQRIIEDFKIPHISTGDIFREAMKNETEMGVEAKKFIDKGE
CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCHHHHHHCCCC
LVPDSVTNGIVEDRLAMDDVNDGFMLDGFPRNIDQAKALDEMTSRLNKPLTAVINIHVDP
CCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCH
EVLVERLSGRFICKNCGATYHKLYNPPKVEGTCDVCGHHEFFQREDDKPETVKNRIAVNT
HHHHHHHCCCEEEHHCCHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHEEEEC
KLNTPLISYYEEKHLLYNINGDQDINDVYSEVKKVLEAL
CCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SKLNLVLMGLPGAGKGTQAQRIIEDFKIPHISTGDIFREAMKNETEMGVEAKKFIDKGE
CCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCHHHHHHCCCC
LVPDSVTNGIVEDRLAMDDVNDGFMLDGFPRNIDQAKALDEMTSRLNKPLTAVINIHVDP
CCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCH
EVLVERLSGRFICKNCGATYHKLYNPPKVEGTCDVCGHHEFFQREDDKPETVKNRIAVNT
HHHHHHHCCCEEEHHCCHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHEEEEC
KLNTPLISYYEEKHLLYNINGDQDINDVYSEVKKVLEAL
CCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA