Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 116493071

GI number: 116493071

Start: 1311147

End: 1311863

Strand: Reverse

Name: atpB

Synonym: PEPE_1323

Alternate gene names: 116493071

Gene position: 1311863-1311147 (Counterclockwise)

Preceding gene: 116493072

Following gene: 116493070

Centisome position: 71.59

GC content: 36.68

Gene sequence:

>717_bases
GTGAGTGGTGAATCAATTTCAACTTTTCAGTTTCTTGGTTTGACATTTAATACGACTAACTTAATTTCAGGTTTAGTAAG
TGCACTAATTGTTTTTTGTGTAGTGTTTGCTTTATCTCGTAATTTGAAGTTAAAGCCGACTGGTAAGCAAAATATTTTGG
AGTGGATCGTTGATTTTACCAATGGTATCCTCCGCGATTCAGTGGATGAAGAGGAAGAAAAGAATTTTGGTCTATATGCT
TTCACATTATTCCTATTTATTTTTGTTTCTAACCAAATCGGTCTATTCCTGCAAATCGCATGGAATGATGTTTCGTATCT
AAGAAGCCCAACAGCTGATCCGATTGTCACTTTAACATTGTCGTTGATCACAATGATGTTAGCGCACTATTCAGGTGTTG
CAAAATTTGGCTTTAAAAAATATTTTGAAAAAACATATTTATCGCCATTTAAAGTTTGGTTACCGATTGGTGTTTTTACA
GAATTCATTGATTTCTTGACCCTTGGGCTACGTATCTACGGTGTTATTTTTGCCGGCGAAATGCTTCTTAAGATGATCGG
AGGAATTGCATTCTCGGGTGGCATCGTCAATATGATTGTCGCCATCCCACTTGCCTTGATTTGGCAAGGATTTTCCGTAT
TTTTGGGAAGTATTCAGGCGTTCGTGTTTGTAACACTAACATCCGTTTACATTTCTCATAAGGTCGAAGACGAATAA

Upstream 100 bases:

>100_bases
AGACGGAAAATACTGTCTTTTGTTCAAGTTTATGACTTAGATTATTGTCAATTTTTGGCTTTGGTTTAGGTACACTTAGG
TAGAAAAGAGGTGATATTCT

Downstream 100 bases:

>100_bases
TAATATATTTTTAGGTAGGAGGAACAACTATTATGGGTGCTATTGCAGCTGGAATTGCTATGTTTGGAGCCGCTATTGGT
GGTGGTATCGGTGACGGTAT

Product: F0F1-type ATP synthase, subunit a

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSGESISTFQFLGLTFNTTNLISGLVSALIVFCVVFALSRNLKLKPTGKQNILEWIVDFTNGILRDSVDEEEEKNFGLYA
FTLFLFIFVSNQIGLFLQIAWNDVSYLRSPTADPIVTLTLSLITMMLAHYSGVAKFGFKKYFEKTYLSPFKVWLPIGVFT
EFIDFLTLGLRIYGVIFAGEMLLKMIGGIAFSGGIVNMIVAIPLALIWQGFSVFLGSIQAFVFVTLTSVYISHKVEDE

Sequences:

>Translated_238_residues
MSGESISTFQFLGLTFNTTNLISGLVSALIVFCVVFALSRNLKLKPTGKQNILEWIVDFTNGILRDSVDEEEEKNFGLYA
FTLFLFIFVSNQIGLFLQIAWNDVSYLRSPTADPIVTLTLSLITMMLAHYSGVAKFGFKKYFEKTYLSPFKVWLPIGVFT
EFIDFLTLGLRIYGVIFAGEMLLKMIGGIAFSGGIVNMIVAIPLALIWQGFSVFLGSIQAFVFVTLTSVYISHKVEDE
>Mature_237_residues
SGESISTFQFLGLTFNTTNLISGLVSALIVFCVVFALSRNLKLKPTGKQNILEWIVDFTNGILRDSVDEEEEKNFGLYAF
TLFLFIFVSNQIGLFLQIAWNDVSYLRSPTADPIVTLTLSLITMMLAHYSGVAKFGFKKYFEKTYLSPFKVWLPIGVFTE
FIDFLTLGLRIYGVIFAGEMLLKMIGGIAFSGGIVNMIVAIPLALIWQGFSVFLGSIQAFVFVTLTSVYISHKVEDE

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=209, Percent_Identity=29.1866028708134, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_PEDPA (Q03EK8)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804806.1
- ProteinModelPortal:   Q03EK8
- SMR:   Q03EK8
- STRING:   Q03EK8
- GeneID:   4417010
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1323
- NMPDR:   fig|278197.10.peg.1161
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   NIFAGEM
- PhylomeDB:   Q03EK8
- ProtClustDB:   CLSK778186
- BioCyc:   PPEN278197:PEPE_1323-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26604; Mature: 26472

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1805878c)-; HASH(0x17fe2954)-; HASH(0x185482ac)-; HASH(0x18487240)-; HASH(0x17ca8958)-; HASH(0x13f12f68)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGESISTFQFLGLTFNTTNLISGLVSALIVFCVVFALSRNLKLKPTGKQNILEWIVDFT
CCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHH
NGILRDSVDEEEEKNFGLYAFTLFLFIFVSNQIGLFLQIAWNDVSYLRSPTADPIVTLTL
HHHHHCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCCHHHHHHH
SLITMMLAHYSGVAKFGFKKYFEKTYLSPFKVWLPIGVFTEFIDFLTLGLRIYGVIFAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLKMIGGIAFSGGIVNMIVAIPLALIWQGFSVFLGSIQAFVFVTLTSVYISHKVEDE
HHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
SGESISTFQFLGLTFNTTNLISGLVSALIVFCVVFALSRNLKLKPTGKQNILEWIVDFT
CCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHH
NGILRDSVDEEEEKNFGLYAFTLFLFIFVSNQIGLFLQIAWNDVSYLRSPTADPIVTLTL
HHHHHCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCCHHHHHHH
SLITMMLAHYSGVAKFGFKKYFEKTYLSPFKVWLPIGVFTEFIDFLTLGLRIYGVIFAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLKMIGGIAFSGGIVNMIVAIPLALIWQGFSVFLGSIQAFVFVTLTSVYISHKVEDE
HHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA