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The map label for this gene is comEB [H]

Identifier: 116492911

GI number: 116492911

Start: 1150743

End: 1151225

Strand: Reverse

Name: comEB [H]

Synonym: PEPE_1150

Alternate gene names: 116492911

Gene position: 1151225-1150743 (Counterclockwise)

Preceding gene: 116492912

Following gene: 116492910

Centisome position: 62.83

GC content: 38.1

Gene sequence:

>483_bases
ATGGACAATAGAATTGATTGGGATCAATATTTTATGACACAGGCAACCCTGTTATCACTCAGAAGTACGTGCACGCGGCT
TTCAGTGGGGGCAGTTATTGTTAGAGACCGGCGAGTAATAGCTGGGGGCTATAATGGTTCAGTTTCTGGAGACGTACATT
GTATTGACGAGGGATGCTATTTAGTAGAGGGACACTGCGTTCGTACGATACACGCGGAAATGAATGCGGTTCTGCAATGT
GCTAAGTTTGGTGTTGCAACGGATGGCGCAGAAGTTTATGTAACGGATTTTCCCTGTTTACAGTGTACAAAAATGTTGTT
ACAGTCCGGAATTATTAAAATTAATTATCTTAGAAATTACCATAATGACCAATATGCCGTAGAGCTTTTAAAAAGAAAGA
ATGTCGAAATTAAGCAGATTAAATTCTCAGAGGATGATTTAGATAAAATTAATATTAATCATATTTTAAGAGAAGGTGAA
TGA

Upstream 100 bases:

>100_bases
TAAATCCATTGAAGATTTAAAGCAAGTACAGGGGATTGGTGATAAAATTTTTGAAGGACTACAAGATGCAATTACTGTAT
AAATTAAGGATGGAAATGAT

Downstream 100 bases:

>100_bases
GGTTTCTTTTATATGGGCAACAGTAGCTGTTTTTTTACTGTCTGGATTAATCTTTACCAGAGCTAAAATATTTTTATTAT
TATTAATAATTTGGTTAATT

Product: deoxycytidylate deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MDNRIDWDQYFMTQATLLSLRSTCTRLSVGAVIVRDRRVIAGGYNGSVSGDVHCIDEGCYLVEGHCVRTIHAEMNAVLQC
AKFGVATDGAEVYVTDFPCLQCTKMLLQSGIIKINYLRNYHNDQYAVELLKRKNVEIKQIKFSEDDLDKININHILREGE

Sequences:

>Translated_160_residues
MDNRIDWDQYFMTQATLLSLRSTCTRLSVGAVIVRDRRVIAGGYNGSVSGDVHCIDEGCYLVEGHCVRTIHAEMNAVLQC
AKFGVATDGAEVYVTDFPCLQCTKMLLQSGIIKINYLRNYHNDQYAVELLKRKNVEIKQIKFSEDDLDKININHILREGE
>Mature_160_residues
MDNRIDWDQYFMTQATLLSLRSTCTRLSVGAVIVRDRRVIAGGYNGSVSGDVHCIDEGCYLVEGHCVRTIHAEMNAVLQC
AKFGVATDGAEVYVTDFPCLQCTKMLLQSGIIKINYLRNYHNDQYAVELLKRKNVEIKQIKFSEDDLDKININHILREGE

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI61742821, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321938, Length=148, Percent_Identity=36.4864864864865, Blast_Score=100, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24667298, Length=138, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667302, Length=138, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 18148; Mature: 18148

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRIDWDQYFMTQATLLSLRSTCTRLSVGAVIVRDRRVIAGGYNGSVSGDVHCIDEGCY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEECCCCCCCCCCEEEEECCEE
LVEGHCVRTIHAEMNAVLQCAKFGVATDGAEVYVTDFPCLQCTKMLLQSGIIKINYLRNY
EEECCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECC
HNDQYAVELLKRKNVEIKQIKFSEDDLDKININHILREGE
CCCHHHHHHHHHCCCEEEEEEECCCCCCEECHHHHEECCC
>Mature Secondary Structure
MDNRIDWDQYFMTQATLLSLRSTCTRLSVGAVIVRDRRVIAGGYNGSVSGDVHCIDEGCY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEECCCCCCCCCCEEEEECCEE
LVEGHCVRTIHAEMNAVLQCAKFGVATDGAEVYVTDFPCLQCTKMLLQSGIIKINYLRNY
EEECCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECC
HNDQYAVELLKRKNVEIKQIKFSEDDLDKININHILREGE
CCCHHHHHHHHHCCCEEEEEEECCCCCCEECHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]