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The map label for this gene is lldD [C]

Identifier: 116492687

GI number: 116492687

Start: 922326

End: 923435

Strand: Direct

Name: lldD [C]

Synonym: PEPE_0922

Alternate gene names: 116492687

Gene position: 922326-923435 (Clockwise)

Preceding gene: 116492685

Following gene: 116492688

Centisome position: 50.33

GC content: 40.0

Gene sequence:

>1110_bases
ATGACAATGATTAATGGTTATGAACAAAGTGATCGTGAAGAAAAAATTGACATTTTAAATTTGGAGTCTTTGGAAGAAAG
AGCCGAAAAGATTATTCCAACTGGTGGGTTTGGATATATCTCTGGTGGTTCTGAAGATGAATGGACTCTCCGACAAAATC
GAACTGCATTCCAGCATCGACAAATCGCGCCCAAAGCTTTGAGTGGAATTGAAAAACCAGAACTAAATACAGAAATCTTT
GGAATTCCATTGAATACTCCAGTGATGATGGCGCCAGCTGCAGCTCAAGGCTTAGCACATTCACAAGGTGAAAAAGATAC
AGCTAGAGGTCTTGCCGCAGTAGGAGGCTTAATGGCACAAAGCACATATTCATCAGTTTCTATTGCTGATACGGCAGCTG
CTGGTGAAGGTGCTCCTCAATTTTTCCAGCTTTACATGAGTAAGGACTGGAATTTTAATGAGAGCTTGCTAGATGAGGCT
AAAAAAGCTCATGTTAAAGCAATTATTTTGACCGTAGATGCCACTGTTGATGGTTATCGAGAAGCTGATATTAAAAATAA
GTTTGCATTTCCACTTCCAATGGCTAACTTAACTAAGTTTTCCGAGGGTGATGGTCAAGGAAAAGGAATTGAAGAAATCT
ACGCTTCTGCAGCTCAAAATATAAGACCGGAAGATGTTAGAAGAATTGCTGATTACACACAATTACCCGTAATTGTTAAA
GGAATTCAAACTCCTGAGGATGCTATTCGAGCAATTGATGCTGGGGCAGCCGGCATTTATGTATCAAACCATGGAGGTCG
TCAGCTAAACGGGGGACCTGGATCTTTTGATGTTTTGGAAGATATCGCTACCTCCGTTAATAAGCAGGTGCCAATTATCT
TTGATAGTGGTGTACGTCGTGGTTCAGATGTATTTAAAGCTTTGGCTAGTGGCGCAGACATCGTGGCTTTGGGTCGTCCA
GTAATTTATGGATTAGCTTTAGGTGGTGCCAAAGGGGTTCAATCTGTATTTGAACATATAGACCATGAACTTGAAATTGT
GATGCAACTAGCAGGTACTAAAACCATTGATGATATTAAAAATAACCCACTACTAAACATCAAATATTAA

Upstream 100 bases:

>100_bases
ATAGCAAGTAGAAATCTGTTACTATTCTGTTCTTTGCTATCAGTAAATTTTAGAATAGTTAATCTTAAAATTAGTAGTGA
TTTGGATGGGGGCATATATT

Downstream 100 bases:

>100_bases
TTGATAAAATCCTCCAATTCTGGGGGATTTTTTAGATATCGAGGAACTTTTTTGATATGTCGGCTACTAGATACTGATGG
GTATTTATTGACTTAATAGA

Product: L-lactate dehydrogenase (FMN-dependent) related alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTMINGYEQSDREEKIDILNLESLEERAEKIIPTGGFGYISGGSEDEWTLRQNRTAFQHRQIAPKALSGIEKPELNTEIF
GIPLNTPVMMAPAAAQGLAHSQGEKDTARGLAAVGGLMAQSTYSSVSIADTAAAGEGAPQFFQLYMSKDWNFNESLLDEA
KKAHVKAIILTVDATVDGYREADIKNKFAFPLPMANLTKFSEGDGQGKGIEEIYASAAQNIRPEDVRRIADYTQLPVIVK
GIQTPEDAIRAIDAGAAGIYVSNHGGRQLNGGPGSFDVLEDIATSVNKQVPIIFDSGVRRGSDVFKALASGADIVALGRP
VIYGLALGGAKGVQSVFEHIDHELEIVMQLAGTKTIDDIKNNPLLNIKY

Sequences:

>Translated_369_residues
MTMINGYEQSDREEKIDILNLESLEERAEKIIPTGGFGYISGGSEDEWTLRQNRTAFQHRQIAPKALSGIEKPELNTEIF
GIPLNTPVMMAPAAAQGLAHSQGEKDTARGLAAVGGLMAQSTYSSVSIADTAAAGEGAPQFFQLYMSKDWNFNESLLDEA
KKAHVKAIILTVDATVDGYREADIKNKFAFPLPMANLTKFSEGDGQGKGIEEIYASAAQNIRPEDVRRIADYTQLPVIVK
GIQTPEDAIRAIDAGAAGIYVSNHGGRQLNGGPGSFDVLEDIATSVNKQVPIIFDSGVRRGSDVFKALASGADIVALGRP
VIYGLALGGAKGVQSVFEHIDHELEIVMQLAGTKTIDDIKNNPLLNIKY
>Mature_368_residues
TMINGYEQSDREEKIDILNLESLEERAEKIIPTGGFGYISGGSEDEWTLRQNRTAFQHRQIAPKALSGIEKPELNTEIFG
IPLNTPVMMAPAAAQGLAHSQGEKDTARGLAAVGGLMAQSTYSSVSIADTAAAGEGAPQFFQLYMSKDWNFNESLLDEAK
KAHVKAIILTVDATVDGYREADIKNKFAFPLPMANLTKFSEGDGQGKGIEEIYASAAQNIRPEDVRRIADYTQLPVIVKG
IQTPEDAIRAIDAGAAGIYVSNHGGRQLNGGPGSFDVLEDIATSVNKQVPIIFDSGVRRGSDVFKALASGADIVALGRPV
IYGLALGGAKGVQSVFEHIDHELEIVMQLAGTKTIDDIKNNPLLNIKY

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=36.8421052631579, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI54234014, Length=348, Percent_Identity=32.4712643678161, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI7705393, Length=348, Percent_Identity=32.4712643678161, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1790033, Length=368, Percent_Identity=32.6086956521739, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI193208036, Length=356, Percent_Identity=34.8314606741573, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32566217, Length=264, Percent_Identity=34.8484848484849, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323587, Length=358, Percent_Identity=32.6815642458101, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI78707188, Length=352, Percent_Identity=35.2272727272727, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI281363140, Length=352, Percent_Identity=35.2272727272727, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI78707190, Length=352, Percent_Identity=35.2272727272727, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 39692; Mature: 39561

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMINGYEQSDREEKIDILNLESLEERAEKIIPTGGFGYISGGSEDEWTLRQNRTAFQHR
CCCCCCCCCCCHHHCCCEECHHHHHHHHHHCCCCCCCEECCCCCCCCEEHHHCCHHHHHH
QIAPKALSGIEKPELNTEIFGIPLNTPVMMAPAAAQGLAHSQGEKDTARGLAAVGGLMAQ
HCCHHHHCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
STYSSVSIADTAAAGEGAPQFFQLYMSKDWNFNESLLDEAKKAHVKAIILTVDATVDGYR
CCCCCEEEHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEEEEEECCCCCCH
EADIKNKFAFPLPMANLTKFSEGDGQGKGIEEIYASAAQNIRPEDVRRIADYTQLPVIVK
HCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHEE
GIQTPEDAIRAIDAGAAGIYVSNHGGRQLNGGPGSFDVLEDIATSVNKQVPIIFDSGVRR
CCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCC
GSDVFKALASGADIVALGRPVIYGLALGGAKGVQSVFEHIDHELEIVMQLAGTKTIDDIK
HHHHHHHHHCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHC
NNPLLNIKY
CCCEEEEEC
>Mature Secondary Structure 
TMINGYEQSDREEKIDILNLESLEERAEKIIPTGGFGYISGGSEDEWTLRQNRTAFQHR
CCCCCCCCCCHHHCCCEECHHHHHHHHHHCCCCCCCEECCCCCCCCEEHHHCCHHHHHH
QIAPKALSGIEKPELNTEIFGIPLNTPVMMAPAAAQGLAHSQGEKDTARGLAAVGGLMAQ
HCCHHHHCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
STYSSVSIADTAAAGEGAPQFFQLYMSKDWNFNESLLDEAKKAHVKAIILTVDATVDGYR
CCCCCEEEHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEEEEEECCCCCCH
EADIKNKFAFPLPMANLTKFSEGDGQGKGIEEIYASAAQNIRPEDVRRIADYTQLPVIVK
HCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHEE
GIQTPEDAIRAIDAGAAGIYVSNHGGRQLNGGPGSFDVLEDIATSVNKQVPIIFDSGVRR
CCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCC
GSDVFKALASGADIVALGRPVIYGLALGGAKGVQSVFEHIDHELEIVMQLAGTKTIDDIK
HHHHHHHHHCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHC
NNPLLNIKY
CCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]