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The map label for this gene is fabF [H]

Identifier: 116492625

GI number: 116492625

Start: 862406

End: 863632

Strand: Direct

Name: fabF [H]

Synonym: PEPE_0859

Alternate gene names: 116492625

Gene position: 862406-863632 (Clockwise)

Preceding gene: 116492624

Following gene: 116492626

Centisome position: 47.06

GC content: 39.53

Gene sequence:

>1227_bases
ATGGGTAGACGAGTAGTAGTAACAGGCATGGGAGCTTTGACTCCTCTTGGAAATGATCGAGAATCCTTCATTCAAGGACT
AAATAGTTCAAAAGTTGGAATCGATAAAATTACACATTTTGATGCCGAACTAACAGGTATCACGGTTGCCGGTGAGGTTA
AGGACTTTGATCCAACTGTTAGAATTGAAAGAAAAATTGCGAAACGGATGGATGCATTTTCTCAATATGCTCTGTATTCT
GCCGTTGAAGCAATGGAACAAGCTGATTTTAAAGAAGGCGAGTTAGATCCTTACCAAGTCGGTGTAATTTATGGTTCAGG
AATTGGTGGATTAACTACCATCCAAGAACAAGTCATTAAAATGGATCATAAAGGGCCAAGACGGGTTTCACCATTATTTG
TAACTAACTCAATTACTAACATGGCAGCTGGGAACATTTCAATGTATTTCAATGCAAAAAATACCAGTCAAGCAATCGTT
ACTGCTTGTGCTAGCGCAAATAATGCAATTGGAAATGCATTCCACCATATCAAAAATGGTTACGCAGATGTTATGATTAC
AGGTGGTTCAGAATCATCAATTAATGAAATTGGAATCGCTGGTTTCGCTTCATTAACTGCATTAACTGCATCAGAAGATC
GTTTACGTGCCTCAATTCCATTTGATAAGGATCGCAATGGTTTTGTAATGGGTGAAGGAGCAGCTACTTTAATCCTTGAA
GACTACGACCATGCTAAAGCACGTGGTGCTAATATTTTAGCTGAAATCGTTGGTTACGGTATGACAAGTGATGCTTTCCA
TATGACCCAACCAGATCCTGAAGGTCGCGGTGCCATTCGTGCAATGCAAATGGCAATGGACGAAGGTGGCATTAAAGCCA
ATGATATTGATTATATCAATGCTCATGGTACCAGTACGCATGCTAACGATAGTGCAGAATCAAAAGCTATCGAAAGCATC
TTTACTGAAAACGACCATTATAAGGTAAGTAGTACTAAGTCAATGACTGGTCATTTGCTTGGTGCGGCTGGAGCAATTGA
AGCTGTTGCAACTATTGCAGCACTTCAAAATGGTATTATGCCGGTTAACGTAGGTTTAGAAACTAAAGACCCTGAAGTTA
ACATTCCATTAGTTACAGAAGATAACCGTAAGGCTTCTGTTAACTATGCCTTGAGTAATTCATTTGGTTTTGGTGGACAT
AACGCTGTATTAGCATTCAAGAGGTGA

Upstream 100 bases:

>100_bases
TTCTTCAACAGTAGCCTTTTTACTTGAAAATGATTATATAACTGGTCAAGTACTTACCGTTGACGGTGGAATGACCCTTT
AGGTTTTTGAGGAGGAAAAA

Downstream 100 bases:

>100_bases
AAATGTTGACTGAAATAGATTTAGAAAAGTTATTAACCAAATTAGATAAATCATCATTCACGTCATTCGAAATGACGGAA
GGTGATTTTAGCATTAAAGT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MGRRVVVTGMGALTPLGNDRESFIQGLNSSKVGIDKITHFDAELTGITVAGEVKDFDPTVRIERKIAKRMDAFSQYALYS
AVEAMEQADFKEGELDPYQVGVIYGSGIGGLTTIQEQVIKMDHKGPRRVSPLFVTNSITNMAAGNISMYFNAKNTSQAIV
TACASANNAIGNAFHHIKNGYADVMITGGSESSINEIGIAGFASLTALTASEDRLRASIPFDKDRNGFVMGEGAATLILE
DYDHAKARGANILAEIVGYGMTSDAFHMTQPDPEGRGAIRAMQMAMDEGGIKANDIDYINAHGTSTHANDSAESKAIESI
FTENDHYKVSSTKSMTGHLLGAAGAIEAVATIAALQNGIMPVNVGLETKDPEVNIPLVTEDNRKASVNYALSNSFGFGGH
NAVLAFKR

Sequences:

>Translated_408_residues
MGRRVVVTGMGALTPLGNDRESFIQGLNSSKVGIDKITHFDAELTGITVAGEVKDFDPTVRIERKIAKRMDAFSQYALYS
AVEAMEQADFKEGELDPYQVGVIYGSGIGGLTTIQEQVIKMDHKGPRRVSPLFVTNSITNMAAGNISMYFNAKNTSQAIV
TACASANNAIGNAFHHIKNGYADVMITGGSESSINEIGIAGFASLTALTASEDRLRASIPFDKDRNGFVMGEGAATLILE
DYDHAKARGANILAEIVGYGMTSDAFHMTQPDPEGRGAIRAMQMAMDEGGIKANDIDYINAHGTSTHANDSAESKAIESI
FTENDHYKVSSTKSMTGHLLGAAGAIEAVATIAALQNGIMPVNVGLETKDPEVNIPLVTEDNRKASVNYALSNSFGFGGH
NAVLAFKR
>Mature_407_residues
GRRVVVTGMGALTPLGNDRESFIQGLNSSKVGIDKITHFDAELTGITVAGEVKDFDPTVRIERKIAKRMDAFSQYALYSA
VEAMEQADFKEGELDPYQVGVIYGSGIGGLTTIQEQVIKMDHKGPRRVSPLFVTNSITNMAAGNISMYFNAKNTSQAIVT
ACASANNAIGNAFHHIKNGYADVMITGGSESSINEIGIAGFASLTALTASEDRLRASIPFDKDRNGFVMGEGAATLILED
YDHAKARGANILAEIVGYGMTSDAFHMTQPDPEGRGAIRAMQMAMDEGGIKANDIDYINAHGTSTHANDSAESKAIESIF
TENDHYKVSSTKSMTGHLLGAAGAIEAVATIAALQNGIMPVNVGLETKDPEVNIPLVTEDNRKASVNYALSNSFGFGGHN
AVLAFKR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=39.1826923076923, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=45.8904109589041, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI41872631, Length=417, Percent_Identity=26.378896882494, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=45.9657701711491, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=37.1764705882353, Blast_Score=212, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=37.7403846153846, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=253, Percent_Identity=42.6877470355731, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=361, Percent_Identity=26.5927977839335, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=355, Percent_Identity=27.0422535211268, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=36.784140969163, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=39.7129186602871, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI221330659, Length=427, Percent_Identity=26.6978922716628, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920632, Length=427, Percent_Identity=26.6978922716628, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43425; Mature: 43294

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRVVVTGMGALTPLGNDRESFIQGLNSSKVGIDKITHFDAELTGITVAGEVKDFDPTV
CCCEEEEECCCCCCCCCCCHHHHHHCCCCCCCCHHHHEECCCEEEEEEEECCCCCCCCCH
RIERKIAKRMDAFSQYALYSAVEAMEQADFKEGELDPYQVGVIYGSGIGGLTTIQEQVIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
MDHKGPRRVSPLFVTNSITNMAAGNISMYFNAKNTSQAIVTACASANNAIGNAFHHIKNG
HCCCCCCCCCCEEEECCHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCC
YADVMITGGSESSINEIGIAGFASLTALTASEDRLRASIPFDKDRNGFVMGEGAATLILE
CEEEEEECCCCCCCHHHCCHHHHHHHEEECCCCCEEEECCCCCCCCCEEEECCCEEEEEE
DYDHAKARGANILAEIVGYGMTSDAFHMTQPDPEGRGAIRAMQMAMDEGGIKANDIDYIN
CCCCHHHCCHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCEECCCCEEE
AHGTSTHANDSAESKAIESIFTENDHYKVSSTKSMTGHLLGAAGAIEAVATIAALQNGIM
CCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
PVNVGLETKDPEVNIPLVTEDNRKASVNYALSNSFGFGGHNAVLAFKR
EEEECCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEEEC
>Mature Secondary Structure 
GRRVVVTGMGALTPLGNDRESFIQGLNSSKVGIDKITHFDAELTGITVAGEVKDFDPTV
CCEEEEECCCCCCCCCCCHHHHHHCCCCCCCCHHHHEECCCEEEEEEEECCCCCCCCCH
RIERKIAKRMDAFSQYALYSAVEAMEQADFKEGELDPYQVGVIYGSGIGGLTTIQEQVIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
MDHKGPRRVSPLFVTNSITNMAAGNISMYFNAKNTSQAIVTACASANNAIGNAFHHIKNG
HCCCCCCCCCCEEEECCHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCC
YADVMITGGSESSINEIGIAGFASLTALTASEDRLRASIPFDKDRNGFVMGEGAATLILE
CEEEEEECCCCCCCHHHCCHHHHHHHEEECCCCCEEEECCCCCCCCCEEEECCCEEEEEE
DYDHAKARGANILAEIVGYGMTSDAFHMTQPDPEGRGAIRAMQMAMDEGGIKANDIDYIN
CCCCHHHCCHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCEECCCCEEE
AHGTSTHANDSAESKAIESIFTENDHYKVSSTKSMTGHLLGAAGAIEAVATIAALQNGIM
CCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
PVNVGLETKDPEVNIPLVTEDNRKASVNYALSNSFGFGGHNAVLAFKR
EEEECCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]