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The map label for this gene is gluP [H]

Identifier: 116492498

GI number: 116492498

Start: 769695

End: 770384

Strand: Direct

Name: gluP [H]

Synonym: PEPE_0730

Alternate gene names: 116492498

Gene position: 769695-770384 (Clockwise)

Preceding gene: 116492497

Following gene: 116492499

Centisome position: 42.01

GC content: 36.67

Gene sequence:

>690_bases
ATGAGTGATCAAAAACAACTTTTAAAGCGTCTATACGAAGGCCCATTCGTTACACAAACAATCGTGGGAATTAATATTTT
AGTTTTTCTTTGGTTGACGCTAATCGGCGGAAGCACGAATATTTCAGTCCTAGTTACCCACGGTGCTTTGGTACCGGTGC
TGGTACAAAACGGTCAGGGACTGTGGACAATATTTACATCGATGTTTATTCATATTGGATTTGAACATATCTTGTTTAAT
ATGATTGCGTTATACTTTATTGGTAGGCTTTTGGAACGAATGATTGGTCATTGGAAATTTGTATTAATATATATTTTTTC
AGGTCTTTTTGCTAATTTAGCAAGTTTGGCTCTCTCAAACCCTAATAGTATTTCTGCCGGTGCAAGTGGGGCTATTTTTG
GGATTATCGGTGTATGGCTGATGATGGCAGAACAGTATCGAGAGTACCCCGCATTAATCGATATGGGTAAACAAATGCTA
TTATTTAGCGTTTTGGGCTTGATAAGTGGACTGTTGGGTACTAACATGAATATTATTGCGCATTTAGGTGGTTTAGTTTC
TGGATTTTTAATAGCGTATGTAATCGGATTCCCTAAATTTGGTAAGGTTCCAACTTGGAAACGTATTGGTAGTGCAATTT
TAATCGTTCTTATGATGATAGCGTTTTGTAAATTAGCGTTTACATCATAA

Upstream 100 bases:

>100_bases
GGGATGTAGAACCTTTTGATGTACCATTAGAAAAAATTATTACAGAAGAAGGGGTTCAATTTGAACGTTAGATGATTCGG
TTTGAAAAGGAAGGTTCTTA

Downstream 100 bases:

>100_bases
CAATAATCTGGTAAATTAGTTGAGATGGTATTATGAAAACACTTTATGATGTGCAACAACTTTTAAAGCAATTCGGAATA
TTTGTTTACGTTGGAAAACG

Product: membrane-associated serine protease

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSDQKQLLKRLYEGPFVTQTIVGINILVFLWLTLIGGSTNISVLVTHGALVPVLVQNGQGLWTIFTSMFIHIGFEHILFN
MIALYFIGRLLERMIGHWKFVLIYIFSGLFANLASLALSNPNSISAGASGAIFGIIGVWLMMAEQYREYPALIDMGKQML
LFSVLGLISGLLGTNMNIIAHLGGLVSGFLIAYVIGFPKFGKVPTWKRIGSAILIVLMMIAFCKLAFTS

Sequences:

>Translated_229_residues
MSDQKQLLKRLYEGPFVTQTIVGINILVFLWLTLIGGSTNISVLVTHGALVPVLVQNGQGLWTIFTSMFIHIGFEHILFN
MIALYFIGRLLERMIGHWKFVLIYIFSGLFANLASLALSNPNSISAGASGAIFGIIGVWLMMAEQYREYPALIDMGKQML
LFSVLGLISGLLGTNMNIIAHLGGLVSGFLIAYVIGFPKFGKVPTWKRIGSAILIVLMMIAFCKLAFTS
>Mature_228_residues
SDQKQLLKRLYEGPFVTQTIVGINILVFLWLTLIGGSTNISVLVTHGALVPVLVQNGQGLWTIFTSMFIHIGFEHILFNM
IALYFIGRLLERMIGHWKFVLIYIFSGLFANLASLALSNPNSISAGASGAIFGIIGVWLMMAEQYREYPALIDMGKQMLL
FSVLGLISGLLGTNMNIIAHLGGLVSGFLIAYVIGFPKFGKVPTWKRIGSAILIVLMMIAFCKLAFTS

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI93352558, Length=169, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI301069362, Length=169, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 25164; Mature: 25033

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQKQLLKRLYEGPFVTQTIVGINILVFLWLTLIGGSTNISVLVTHGALVPVLVQNGQG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCH
LWTIFTSMFIHIGFEHILFNMIALYFIGRLLERMIGHWKFVLIYIFSGLFANLASLALSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNSISAGASGAIFGIIGVWLMMAEQYREYPALIDMGKQMLLFSVLGLISGLLGTNMNIIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLGGLVSGFLIAYVIGFPKFGKVPTWKRIGSAILIVLMMIAFCKLAFTS
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDQKQLLKRLYEGPFVTQTIVGINILVFLWLTLIGGSTNISVLVTHGALVPVLVQNGQG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCH
LWTIFTSMFIHIGFEHILFNMIALYFIGRLLERMIGHWKFVLIYIFSGLFANLASLALSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNSISAGASGAIFGIIGVWLMMAEQYREYPALIDMGKQMLLFSVLGLISGLLGTNMNIIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLGGLVSGFLIAYVIGFPKFGKVPTWKRIGSAILIVLMMIAFCKLAFTS
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]