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The map label for this gene is yqgN [H]

Identifier: 116492497

GI number: 116492497

Start: 769102

End: 769665

Strand: Direct

Name: yqgN [H]

Synonym: PEPE_0729

Alternate gene names: 116492497

Gene position: 769102-769665 (Clockwise)

Preceding gene: 116492496

Following gene: 116492498

Centisome position: 41.97

GC content: 37.23

Gene sequence:

>564_bases
ATGAATAAAAATATCTTTAGGCAAACTCAAATTAAACGCTTAAATCAAATTGATATAACGTCTAAAAGAGCTAAAGAGGC
GTTAATTTTAGAAAGTTTTTTCGATCAACATGAAGTAAAAAATGCTCGAAAATTAGCGATAACCATGAGTCACGGCTTTG
AGCTAGACACAGCACCCATCATTCAACGGCTAATTGAAAATGGTAAATGTGTCTATGTCCCACGGACCTTGCCAGAACGA
CAGATGGAGTTCGTCGAATATAATTTAAATACACCCATGCAACCAAAGTTCCAAGGAATTTTAGAACCAGTAGGGGGGAA
TGTGGTTCGTCCCGAAGCATTGGATCTAATAATTGTCCCTGGTCTAGCTTATGAAGTTTCGAATGGTTATCGGTTGGGAT
TTGGGGGAGGATATTACGATCGTTACTTGAAAAAAACGCCAGCCTCGAAAATAGTTTTAGCTTTTTCAGAACAAATTTAT
TCAGATCCTCAGTGGGATGTAGAACCTTTTGATGTACCATTAGAAAAAATTATTACAGAAGAAGGGGTTCAATTTGAACG
TTAG

Upstream 100 bases:

>100_bases
ACACAAGGAAACAAAATAATCGTAATTAAGGCTGGAAGACTGCAATTTGCTGTCGCTTCTAGCTTTTTTTATATATTTAA
ATGTAACTATGGGGGATAAA

Downstream 100 bases:

>100_bases
ATGATTCGGTTTGAAAAGGAAGGTTCTTAATGAGTGATCAAAAACAACTTTTAAAGCGTCTATACGAAGGCCCATTCGTT
ACACAAACAATCGTGGGAAT

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MNKNIFRQTQIKRLNQIDITSKRAKEALILESFFDQHEVKNARKLAITMSHGFELDTAPIIQRLIENGKCVYVPRTLPER
QMEFVEYNLNTPMQPKFQGILEPVGGNVVRPEALDLIIVPGLAYEVSNGYRLGFGGGYYDRYLKKTPASKIVLAFSEQIY
SDPQWDVEPFDVPLEKIITEEGVQFER

Sequences:

>Translated_187_residues
MNKNIFRQTQIKRLNQIDITSKRAKEALILESFFDQHEVKNARKLAITMSHGFELDTAPIIQRLIENGKCVYVPRTLPER
QMEFVEYNLNTPMQPKFQGILEPVGGNVVRPEALDLIIVPGLAYEVSNGYRLGFGGGYYDRYLKKTPASKIVLAFSEQIY
SDPQWDVEPFDVPLEKIITEEGVQFER
>Mature_187_residues
MNKNIFRQTQIKRLNQIDITSKRAKEALILESFFDQHEVKNARKLAITMSHGFELDTAPIIQRLIENGKCVYVPRTLPER
QMEFVEYNLNTPMQPKFQGILEPVGGNVVRPEALDLIIVPGLAYEVSNGYRLGFGGGYYDRYLKKTPASKIVLAFSEQIY
SDPQWDVEPFDVPLEKIITEEGVQFER

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=185, Percent_Identity=28.1081081081081, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1789278, Length=150, Percent_Identity=31.3333333333333, Blast_Score=60, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161077430, Length=161, Percent_Identity=32.9192546583851, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 21510; Mature: 21510

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNIFRQTQIKRLNQIDITSKRAKEALILESFFDQHEVKNARKLAITMSHGFELDTAPI
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
IQRLIENGKCVYVPRTLPERQMEFVEYNLNTPMQPKFQGILEPVGGNVVRPEALDLIIVP
HHHHHHCCCEEEECCCCCHHHHHHHEECCCCCCCHHHHHHHHHCCCCEECCCCCCEEEEC
GLAYEVSNGYRLGFGGGYYDRYLKKTPASKIVLAFSEQIYSDPQWDVEPFDVPLEKIITE
CEEEECCCCEEECCCCCHHHHHHHHCCCHHEEHEEHHHHHCCCCCCCCCCCCCHHHHHHH
EGVQFER
CCCCCCC
>Mature Secondary Structure
MNKNIFRQTQIKRLNQIDITSKRAKEALILESFFDQHEVKNARKLAITMSHGFELDTAPI
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
IQRLIENGKCVYVPRTLPERQMEFVEYNLNTPMQPKFQGILEPVGGNVVRPEALDLIIVP
HHHHHHCCCEEEECCCCCHHHHHHHEECCCCCCCHHHHHHHHHCCCCEECCCCCCEEEEC
GLAYEVSNGYRLGFGGGYYDRYLKKTPASKIVLAFSEQIYSDPQWDVEPFDVPLEKIITE
CEEEECCCCEEECCCCCHHHHHHHHCCCHHEEHEEHHHHHCCCCCCCCCCCCCHHHHHHH
EGVQFER
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]