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The map label for this gene is lytS [H]

Identifier: 116492463

GI number: 116492463

Start: 737548

End: 739287

Strand: Direct

Name: lytS [H]

Synonym: PEPE_0695

Alternate gene names: 116492463

Gene position: 737548-739287 (Clockwise)

Preceding gene: 116492462

Following gene: 116492464

Centisome position: 40.25

GC content: 36.09

Gene sequence:

>1740_bases
ATGTTAAATTTAACCGTACTTTTGTTTGAAAGAGCTGGATTAATTATTATTTTGGCTTTTTTTCTAGTAAATATTCCTCA
ATTTAGGAAATTACTTTTTCGAAAAGATTGGTCAACAACTTTCCAATTATTTGCGATTTTTTCTATTTTTACGATTGTAG
CAAATTTAATTGGTGTTGAACTTCGACCTGATAATAGCATTCAATTCAAATCCCTTCTGCAGAATGTTACCCCTGGAGAT
TCTGTAGCTAATATTCGAATTTTAACGGTTACAGTTTCAGGAATTATTGGCGGGCCGCTGGTTGGGGGTGGAGTAGGCTT
AGTCGCTGGACTTCACCGAATGTTGCAAGAGTCGCTAACAACCGACGCCCTTTTTTATATTCCCAGTTCGATGATAATTG
GAATTTTAGCCGGTTTTTTTGCTAAGAAAAAACAACATCGCTTTGCAACAATGAAAGTGTTTGATGGTTTTTTAGTAGGA
CTTTTAATGGAAGCAATCCAAATGCTGTTTATTTTACTATTTAGTCCGACAGGTTGGACTTTGGTAAAATATATTGCAAT
ACCAATGATGCTAGTAGGTGCTTTAGGGACTTCGGTTTTCTTATCAATTATCACGCTTTACTTTCGGCAGGAAGTTGATA
CTCAAGCTACCCAAACTAAATCAATTTTTCAGTTAGCTTTAAAAACTTTGCCAGTTTTTCGTCAAGGGTTAAATCAAGAA
GCCGCTAAAAAGGCTGCTAGTTTAATATTGGAATATACAAATTTTGATGCGGTTGGTATTACAGATGAATCTAAGATTCT
GGCTTTTGCGGGGATGGGAAGTGATCACCATATCACAGGTGCTTCTATCTTGACGGAATTATCTGAAGAGGCGGTTAAAT
TGGGTGAAGTTCAAATTGGAAATAATGCTCATGAGATTAATTGCCCTGTAAAAAGTTGTCCATTACACTCGGCCGTCGTA
GTACCTTTAATCATTAAAGGTAAAGCAGTAGGTAGTTTGAAACTCTACTATGTAGAAGAATGGCGATTAAGTCCAGTGGA
AATTCAATTAGGAACAGGGCTGGGAGAAATATTAGCAATGCAGATAATGTTAGGAGAAATCGAGCATCAATCAGAATTAG
TGCGGGATGCCGAAATAAAATCTCTCCAATCGCAAGTCAATCCGCACTTTTTCTTTAATGCGATAAATACAATTGTGGCA
GTTATGCGGTACGACAGTGACCAAGCACGTGAATTACTGATCCAACTCAGTACTTATTTTAGGGCAAATTTAACGGGGAT
TAGAGAAACAACCATTCCGTTGTATCAAGAATTCAAACATGTTAAAGCCTATTTAATGCTTGAACAAACACGTTTTCCAA
ATCGATTTGAAATTTTGTTTCACCAGAAGGTTTCGGAAAATGTAATGATACCTCCATTTAGCATCCAAATTATTGTTGAA
AATGCCCTTAAGCATGCCTTTAATAGTCGAAAAAAGGGCAATATAGTTTCAATTAATGTTGAACAGATTAAACAAAGACT
TAAAATTGAAATTACTGACAATGGGCAAGGGATTGATAAAAGTATTATTGATAAATTAGGAAAACAGACGGTAAGTTCTG
TAAGTGGGAGTGGAACGGCATTACAAAATCTTAATGTGCGCTTGATGGGTCTTTATGGTAAAGATGCCGAACTAAAAATA
AGCAGTGATCAAAATGGAACCCAGGTGGTAATCCAAATTCCATATAAGGAACAGGTGTAA

Upstream 100 bases:

>100_bases
ATTTTTTTGTAGGCTTTAATAAGGGATGACCGTTGAAAGGCTTATAATTATATTGTGATTAAGAATGGTAGTTTTAGAAT
GATTAATGTAAGGAGTAGGC

Downstream 100 bases:

>100_bases
AGATAGTGAAGATATTAATTGTTGATGATGAGCCCCTAGCTCGAAGTGAACTTGATTTTTTATTGAGGAATAATCCGTTA
GTAGATAGCGTTAGTGAAGC

Product: membrane signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MLNLTVLLFERAGLIIILAFFLVNIPQFRKLLFRKDWSTTFQLFAIFSIFTIVANLIGVELRPDNSIQFKSLLQNVTPGD
SVANIRILTVTVSGIIGGPLVGGGVGLVAGLHRMLQESLTTDALFYIPSSMIIGILAGFFAKKKQHRFATMKVFDGFLVG
LLMEAIQMLFILLFSPTGWTLVKYIAIPMMLVGALGTSVFLSIITLYFRQEVDTQATQTKSIFQLALKTLPVFRQGLNQE
AAKKAASLILEYTNFDAVGITDESKILAFAGMGSDHHITGASILTELSEEAVKLGEVQIGNNAHEINCPVKSCPLHSAVV
VPLIIKGKAVGSLKLYYVEEWRLSPVEIQLGTGLGEILAMQIMLGEIEHQSELVRDAEIKSLQSQVNPHFFFNAINTIVA
VMRYDSDQARELLIQLSTYFRANLTGIRETTIPLYQEFKHVKAYLMLEQTRFPNRFEILFHQKVSENVMIPPFSIQIIVE
NALKHAFNSRKKGNIVSINVEQIKQRLKIEITDNGQGIDKSIIDKLGKQTVSSVSGSGTALQNLNVRLMGLYGKDAELKI
SSDQNGTQVVIQIPYKEQV

Sequences:

>Translated_579_residues
MLNLTVLLFERAGLIIILAFFLVNIPQFRKLLFRKDWSTTFQLFAIFSIFTIVANLIGVELRPDNSIQFKSLLQNVTPGD
SVANIRILTVTVSGIIGGPLVGGGVGLVAGLHRMLQESLTTDALFYIPSSMIIGILAGFFAKKKQHRFATMKVFDGFLVG
LLMEAIQMLFILLFSPTGWTLVKYIAIPMMLVGALGTSVFLSIITLYFRQEVDTQATQTKSIFQLALKTLPVFRQGLNQE
AAKKAASLILEYTNFDAVGITDESKILAFAGMGSDHHITGASILTELSEEAVKLGEVQIGNNAHEINCPVKSCPLHSAVV
VPLIIKGKAVGSLKLYYVEEWRLSPVEIQLGTGLGEILAMQIMLGEIEHQSELVRDAEIKSLQSQVNPHFFFNAINTIVA
VMRYDSDQARELLIQLSTYFRANLTGIRETTIPLYQEFKHVKAYLMLEQTRFPNRFEILFHQKVSENVMIPPFSIQIIVE
NALKHAFNSRKKGNIVSINVEQIKQRLKIEITDNGQGIDKSIIDKLGKQTVSSVSGSGTALQNLNVRLMGLYGKDAELKI
SSDQNGTQVVIQIPYKEQV
>Mature_579_residues
MLNLTVLLFERAGLIIILAFFLVNIPQFRKLLFRKDWSTTFQLFAIFSIFTIVANLIGVELRPDNSIQFKSLLQNVTPGD
SVANIRILTVTVSGIIGGPLVGGGVGLVAGLHRMLQESLTTDALFYIPSSMIIGILAGFFAKKKQHRFATMKVFDGFLVG
LLMEAIQMLFILLFSPTGWTLVKYIAIPMMLVGALGTSVFLSIITLYFRQEVDTQATQTKSIFQLALKTLPVFRQGLNQE
AAKKAASLILEYTNFDAVGITDESKILAFAGMGSDHHITGASILTELSEEAVKLGEVQIGNNAHEINCPVKSCPLHSAVV
VPLIIKGKAVGSLKLYYVEEWRLSPVEIQLGTGLGEILAMQIMLGEIEHQSELVRDAEIKSLQSQVNPHFFFNAINTIVA
VMRYDSDQARELLIQLSTYFRANLTGIRETTIPLYQEFKHVKAYLMLEQTRFPNRFEILFHQKVSENVMIPPFSIQIIVE
NALKHAFNSRKKGNIVSINVEQIKQRLKIEITDNGQGIDKSIIDKLGKQTVSSVSGSGTALQNLNVRLMGLYGKDAELKI
SSDQNGTQVVIQIPYKEQV

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=581, Percent_Identity=30.4647160068847, Blast_Score=286, Evalue=4e-78,
Organism=Escherichia coli, GI1788446, Length=590, Percent_Identity=32.7118644067797, Blast_Score=244, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64266; Mature: 64266

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLTVLLFERAGLIIILAFFLVNIPQFRKLLFRKDWSTTFQLFAIFSIFTIVANLIGVE
CCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEE
LRPDNSIQFKSLLQNVTPGDSVANIRILTVTVSGIIGGPLVGGGVGLVAGLHRMLQESLT
ECCCCCHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
TDALFYIPSSMIIGILAGFFAKKKQHRFATMKVFDGFLVGLLMEAIQMLFILLFSPTGWT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LVKYIAIPMMLVGALGTSVFLSIITLYFRQEVDTQATQTKSIFQLALKTLPVFRQGLNQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHH
AAKKAASLILEYTNFDAVGITDESKILAFAGMGSDHHITGASILTELSEEAVKLGEVQIG
HHHHHHHHHHEECCCCEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEC
NNAHEINCPVKSCPLHSAVVVPLIIKGKAVGSLKLYYVEEWRLSPVEIQLGTGLGEILAM
CCCEEEECCHHCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHH
QIMLGEIEHQSELVRDAEIKSLQSQVNPHFFFNAINTIVAVMRYDSDQARELLIQLSTYF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RANLTGIRETTIPLYQEFKHVKAYLMLEQTRFPNRFEILFHQKVSENVMIPPFSIQIIVE
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCEECCCCEEEHHHH
NALKHAFNSRKKGNIVSINVEQIKQRLKIEITDNGQGIDKSIIDKLGKQTVSSVSGSGTA
HHHHHHHCCCCCCCEEEEEHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCE
LQNLNVRLMGLYGKDAELKISSDQNGTQVVIQIPYKEQV
EECCCEEEEEEECCCCEEEEECCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MLNLTVLLFERAGLIIILAFFLVNIPQFRKLLFRKDWSTTFQLFAIFSIFTIVANLIGVE
CCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEE
LRPDNSIQFKSLLQNVTPGDSVANIRILTVTVSGIIGGPLVGGGVGLVAGLHRMLQESLT
ECCCCCHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
TDALFYIPSSMIIGILAGFFAKKKQHRFATMKVFDGFLVGLLMEAIQMLFILLFSPTGWT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LVKYIAIPMMLVGALGTSVFLSIITLYFRQEVDTQATQTKSIFQLALKTLPVFRQGLNQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHH
AAKKAASLILEYTNFDAVGITDESKILAFAGMGSDHHITGASILTELSEEAVKLGEVQIG
HHHHHHHHHHEECCCCEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEC
NNAHEINCPVKSCPLHSAVVVPLIIKGKAVGSLKLYYVEEWRLSPVEIQLGTGLGEILAM
CCCEEEECCHHCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHH
QIMLGEIEHQSELVRDAEIKSLQSQVNPHFFFNAINTIVAVMRYDSDQARELLIQLSTYF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RANLTGIRETTIPLYQEFKHVKAYLMLEQTRFPNRFEILFHQKVSENVMIPPFSIQIIVE
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCEECCCCEEEHHHH
NALKHAFNSRKKGNIVSINVEQIKQRLKIEITDNGQGIDKSIIDKLGKQTVSSVSGSGTA
HHHHHHHCCCCCCCEEEEEHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCE
LQNLNVRLMGLYGKDAELKISSDQNGTQVVIQIPYKEQV
EECCCEEEEEEECCCCEEEEECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]