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The map label for this gene is recQ [H]

Identifier: 116492357

GI number: 116492357

Start: 616919

End: 618673

Strand: Direct

Name: recQ [H]

Synonym: PEPE_0562

Alternate gene names: 116492357

Gene position: 616919-618673 (Clockwise)

Preceding gene: 116492356

Following gene: 116492358

Centisome position: 33.67

GC content: 46.21

Gene sequence:

>1755_bases
ATGAATCCACAGGCAGTTTTGAAATCAAATTTTGGATATGATGCGTTTCGACCAGGGCAGGAGCGAGCCATCAACGCAGT
TTTGGACCACCAAAACGTTTTGGCCGTCATGCCAACGGGCGGAGGGAAATCACTGTGTTATCAAATTCCAGCCTTGATGC
AGGCGGGACTAACCTTAGTTATTTCGCCTTTGATTTCTTTGATGAAAGATCAAGTTGATGCTCTAGCAGCCAACGGAATT
GACGCCACCTTCATCAATAGCTCCTTAGATTATGCGGAAATCAACGAGCGGTTTAGCCAAGCGCGCCAGGGTGCGGTGAA
GCTGCTTTATATTTCACCAGAACGCCTCGATTCCGAATACTTTGATCGCTTAGCAGAACTACCGATTGATTTGATTGCCA
TCGATGAAGCCCACTGTATTTCACAGTGGGGGCATGATTTTCGACCGAGCTACCTAAAATTAACGGATATCATCCATCAT
CTTCCAACTCGACCAACGATTATCGCTCTCACCGCTACGGCGACGCCTCGGGTAGCTGAGGATATTAAGCAACGCTTAGC
CATCCAACAGGAAGTTCAAACTGGATTTGCTCGACCTAACCTTTCATTTAAAGTCGTCAAGGATCAAGACAGCGACCGTT
TTTTGATCGACTACTTGAAATTGAATCCAGATCAATCGGGCATTATCTACGCCAGTACCGTGAAAGAGGTCGAACGGCTC
CATCGCCTTTTAACTAAAAAGCATTTCCAAGTGGCCATGTATCATGGACAACTTTCGAAAGAAGAACGTCGGCAAAATCA
AGACGACTTTCTGTATGATCGAGTGCTAGTTATGATTGCAACCAACGCGTTTGGGATGGGGATTGATAAGAGTAACGTGC
GCTTTGTCATCCACGACCAGATTCCGGGCAGTATCGAATCCTACTATCAAGAAGCGGGGCGTGCAGGGCGAGACGGTCTA
CCGAGTGAAGCCATCTTGTTATACAAATTGCGCGACGTTCAGATTCAGCACTACTATATCGAACAATCCGAACGAGACGA
AGCCAGCATGACGATGGAATACCAAAAGCTACAGGCGATGAGTCAGTATGGTAATACGCAAAAGTGTTTACAGCGCTACA
TTCTAAATTACTTCAATGAAGATGCTCCAGACTGTGGGCAATGTAGTAACTGTTTGGATACGCGAGCTCTACAAGACGTG
ACGATTGAGGCTCAGCAAGTGTTGTCTTGTATCCGGCGGATGGGGGAACGTTTTGGAAAAGAAATGGTCGCCCTCGTACT
GACGGGTTCGAAAAATCAGCGGGTAAAACAGTTGCACTATGAAAAATTATCGACATACGGTTTAATGCAGCAGCGGACCA
AGAAGAGCGTGACCGAATTAATCGATTTTCTCACAGCGGCTGGATACATCGCCCCAGACGGCGGCCAGTTTCCCGTCTTG
AAAATCACCGAGGAGGGCTTACGCGTTCTTTTAGGTCAGCAAAAAGTGGCTCGAAAAGTGGCACTTAAGGCAAATAAGTC
TTTACCAGAAAACGACGCGTTGTTTGAAGAATTGCGGGCGCTTCGTCGGGAACTAGCTGAAAAACAAAACGTTCCTCCGT
TTGTCATCTTTTCCGATCAAACTTTGCACGATATGTGCACAGTCATGCCAGACACGCTCGATGAAATGTTAGACGTGAAA
GGAATCGGGGAAAGCAAACTCCAAAAATATGGTGAACAGTTCTTCCAAATTTTACGAAATTATCAAGAAGCTTAG

Upstream 100 bases:

>100_bases
AAGTAAATAGGTGACGAATTTAAGAGGAGGTGACTTAATTGTCAGACTCCTTTTATTATTTACCCGTCATTAACATCCCA
AAGAGAAGAAGAGGAATTAC

Downstream 100 bases:

>100_bases
TATTTGTTAAAGTGCTGAGCTTTTTTTGTTAGAATTTATAAGGATAGGTATAAAATGTTGCTACTGCCAATGAGTGAGGA
GAATGCTACTTGCGAATCAG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MNPQAVLKSNFGYDAFRPGQERAINAVLDHQNVLAVMPTGGGKSLCYQIPALMQAGLTLVISPLISLMKDQVDALAANGI
DATFINSSLDYAEINERFSQARQGAVKLLYISPERLDSEYFDRLAELPIDLIAIDEAHCISQWGHDFRPSYLKLTDIIHH
LPTRPTIIALTATATPRVAEDIKQRLAIQQEVQTGFARPNLSFKVVKDQDSDRFLIDYLKLNPDQSGIIYASTVKEVERL
HRLLTKKHFQVAMYHGQLSKEERRQNQDDFLYDRVLVMIATNAFGMGIDKSNVRFVIHDQIPGSIESYYQEAGRAGRDGL
PSEAILLYKLRDVQIQHYYIEQSERDEASMTMEYQKLQAMSQYGNTQKCLQRYILNYFNEDAPDCGQCSNCLDTRALQDV
TIEAQQVLSCIRRMGERFGKEMVALVLTGSKNQRVKQLHYEKLSTYGLMQQRTKKSVTELIDFLTAAGYIAPDGGQFPVL
KITEEGLRVLLGQQKVARKVALKANKSLPENDALFEELRALRRELAEKQNVPPFVIFSDQTLHDMCTVMPDTLDEMLDVK
GIGESKLQKYGEQFFQILRNYQEA

Sequences:

>Translated_584_residues
MNPQAVLKSNFGYDAFRPGQERAINAVLDHQNVLAVMPTGGGKSLCYQIPALMQAGLTLVISPLISLMKDQVDALAANGI
DATFINSSLDYAEINERFSQARQGAVKLLYISPERLDSEYFDRLAELPIDLIAIDEAHCISQWGHDFRPSYLKLTDIIHH
LPTRPTIIALTATATPRVAEDIKQRLAIQQEVQTGFARPNLSFKVVKDQDSDRFLIDYLKLNPDQSGIIYASTVKEVERL
HRLLTKKHFQVAMYHGQLSKEERRQNQDDFLYDRVLVMIATNAFGMGIDKSNVRFVIHDQIPGSIESYYQEAGRAGRDGL
PSEAILLYKLRDVQIQHYYIEQSERDEASMTMEYQKLQAMSQYGNTQKCLQRYILNYFNEDAPDCGQCSNCLDTRALQDV
TIEAQQVLSCIRRMGERFGKEMVALVLTGSKNQRVKQLHYEKLSTYGLMQQRTKKSVTELIDFLTAAGYIAPDGGQFPVL
KITEEGLRVLLGQQKVARKVALKANKSLPENDALFEELRALRRELAEKQNVPPFVIFSDQTLHDMCTVMPDTLDEMLDVK
GIGESKLQKYGEQFFQILRNYQEA
>Mature_584_residues
MNPQAVLKSNFGYDAFRPGQERAINAVLDHQNVLAVMPTGGGKSLCYQIPALMQAGLTLVISPLISLMKDQVDALAANGI
DATFINSSLDYAEINERFSQARQGAVKLLYISPERLDSEYFDRLAELPIDLIAIDEAHCISQWGHDFRPSYLKLTDIIHH
LPTRPTIIALTATATPRVAEDIKQRLAIQQEVQTGFARPNLSFKVVKDQDSDRFLIDYLKLNPDQSGIIYASTVKEVERL
HRLLTKKHFQVAMYHGQLSKEERRQNQDDFLYDRVLVMIATNAFGMGIDKSNVRFVIHDQIPGSIESYYQEAGRAGRDGL
PSEAILLYKLRDVQIQHYYIEQSERDEASMTMEYQKLQAMSQYGNTQKCLQRYILNYFNEDAPDCGQCSNCLDTRALQDV
TIEAQQVLSCIRRMGERFGKEMVALVLTGSKNQRVKQLHYEKLSTYGLMQQRTKKSVTELIDFLTAAGYIAPDGGQFPVL
KITEEGLRVLLGQQKVARKVALKANKSLPENDALFEELRALRRELAEKQNVPPFVIFSDQTLHDMCTVMPDTLDEMLDVK
GIGESKLQKYGEQFFQILRNYQEA

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=636, Percent_Identity=32.3899371069182, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI110735439, Length=539, Percent_Identity=33.2096474953618, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI169218196, Length=539, Percent_Identity=33.2096474953618, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI14591902, Length=487, Percent_Identity=34.7022587268994, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI14591904, Length=487, Percent_Identity=34.7022587268994, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI148612816, Length=426, Percent_Identity=36.6197183098592, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI51242947, Length=352, Percent_Identity=40.9090909090909, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI51242943, Length=352, Percent_Identity=40.9090909090909, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI284005309, Length=346, Percent_Identity=39.0173410404624, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI262118318, Length=345, Percent_Identity=25.2173913043478, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI262231852, Length=345, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI216548263, Length=345, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI13518015, Length=345, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI13514831, Length=391, Percent_Identity=22.7621483375959, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31542656, Length=397, Percent_Identity=23.6775818639798, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI20149629, Length=338, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI7661920, Length=359, Percent_Identity=21.7270194986072, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI4758138, Length=342, Percent_Identity=24.8538011695906, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI48994977, Length=589, Percent_Identity=42.6146010186757, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI87082221, Length=352, Percent_Identity=23.0113636363636, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787016, Length=343, Percent_Identity=24.4897959183673, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=646, Percent_Identity=31.2693498452012, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI71987997, Length=488, Percent_Identity=35.4508196721311, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71987993, Length=488, Percent_Identity=35.4508196721311, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI32564293, Length=493, Percent_Identity=33.2657200811359, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17552866, Length=416, Percent_Identity=32.6923076923077, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71995724, Length=366, Percent_Identity=24.0437158469945, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17507121, Length=373, Percent_Identity=23.8605898123324, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17555296, Length=353, Percent_Identity=22.9461756373938, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71987143, Length=354, Percent_Identity=22.5988700564972, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=552, Percent_Identity=33.5144927536232, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320224, Length=356, Percent_Identity=26.123595505618, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321360, Length=339, Percent_Identity=25.6637168141593, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321856, Length=348, Percent_Identity=23.8505747126437, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324217, Length=340, Percent_Identity=23.8235294117647, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646066, Length=633, Percent_Identity=32.7014218009479, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24664226, Length=423, Percent_Identity=35.2245862884161, Blast_Score=235, Evalue=6e-62,
Organism=Drosophila melanogaster, GI62472181, Length=423, Percent_Identity=35.2245862884161, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24664230, Length=423, Percent_Identity=35.2245862884161, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21358123, Length=352, Percent_Identity=36.6477272727273, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24645031, Length=371, Percent_Identity=22.3719676549865, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642822, Length=352, Percent_Identity=23.8636363636364, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574962, Length=332, Percent_Identity=24.0963855421687, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66312; Mature: 66312

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQAVLKSNFGYDAFRPGQERAINAVLDHQNVLAVMPTGGGKSLCYQIPALMQAGLTLV
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
ISPLISLMKDQVDALAANGIDATFINSSLDYAEINERFSQARQGAVKLLYISPERLDSEY
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCHHH
FDRLAELPIDLIAIDEAHCISQWGHDFRPSYLKLTDIIHHLPTRPTIIALTATATPRVAE
HHHHHHCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
DIKQRLAIQQEVQTGFARPNLSFKVVKDQDSDRFLIDYLKLNPDQSGIIYASTVKEVERL
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCEEEHHHHHHHHHH
HRLLTKKHFQVAMYHGQLSKEERRQNQDDFLYDRVLVMIATNAFGMGIDKSNVRFVIHDQ
HHHHHHHHHHEEEHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
IPGSIESYYQEAGRAGRDGLPSEAILLYKLRDVQIQHYYIEQSERDEASMTMEYQKLQAM
CCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHH
SQYGNTQKCLQRYILNYFNEDAPDCGQCSNCLDTRALQDVTIEAQQVLSCIRRMGERFGK
HHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMVALVLTGSKNQRVKQLHYEKLSTYGLMQQRTKKSVTELIDFLTAAGYIAPDGGQFPVL
HHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
KITEEGLRVLLGQQKVARKVALKANKSLPENDALFEELRALRRELAEKQNVPPFVIFSDQ
EECHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCC
TLHDMCTVMPDTLDEMLDVKGIGESKLQKYGEQFFQILRNYQEA
HHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPQAVLKSNFGYDAFRPGQERAINAVLDHQNVLAVMPTGGGKSLCYQIPALMQAGLTLV
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
ISPLISLMKDQVDALAANGIDATFINSSLDYAEINERFSQARQGAVKLLYISPERLDSEY
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCHHH
FDRLAELPIDLIAIDEAHCISQWGHDFRPSYLKLTDIIHHLPTRPTIIALTATATPRVAE
HHHHHHCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
DIKQRLAIQQEVQTGFARPNLSFKVVKDQDSDRFLIDYLKLNPDQSGIIYASTVKEVERL
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCEEEHHHHHHHHHH
HRLLTKKHFQVAMYHGQLSKEERRQNQDDFLYDRVLVMIATNAFGMGIDKSNVRFVIHDQ
HHHHHHHHHHEEEHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
IPGSIESYYQEAGRAGRDGLPSEAILLYKLRDVQIQHYYIEQSERDEASMTMEYQKLQAM
CCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHH
SQYGNTQKCLQRYILNYFNEDAPDCGQCSNCLDTRALQDVTIEAQQVLSCIRRMGERFGK
HHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMVALVLTGSKNQRVKQLHYEKLSTYGLMQQRTKKSVTELIDFLTAAGYIAPDGGQFPVL
HHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
KITEEGLRVLLGQQKVARKVALKANKSLPENDALFEELRALRRELAEKQNVPPFVIFSDQ
EECHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCC
TLHDMCTVMPDTLDEMLDVKGIGESKLQKYGEQFFQILRNYQEA
HHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]