Click here to switch to the map view.

The map label for this gene is ykgC [H]

Identifier: 116492325

GI number: 116492325

Start: 581988

End: 583346

Strand: Direct

Name: ykgC [H]

Synonym: PEPE_0528

Alternate gene names: 116492325

Gene position: 581988-583346 (Clockwise)

Preceding gene: 116492324

Following gene: 116492326

Centisome position: 31.76

GC content: 38.56

Gene sequence:

>1359_bases
ATGATTAAAGCTAAGAATGTATATATTGGTTTTGGAAAAGCGGCTAAGACACTTGCTTTTCGTCAAGCACAACGCGGTGA
ATCAGTCGTAGTAATCGAGGAATCTGATCAGATGTACGGTGGAACATGTATCAATATTGCATGTATTCCATCTAAGCTGT
TGTATGAATTATCTGACAAGCCACAGGTTGGTGGTTTAAAAGATAACTACAAAATGGCAATTACTAAAAAAAGAAGTGTC
ATTGGCAAATTAAGGTATAGTAATTTTCATAAATTAGCTGATCAAAAGACGGTTAAAGTTTTGAATGGATCGGCTTCGTT
TATTGACCAACATACGTTAAACGTTAAATATTTGAATGGAGCGACAGAAGAAGTAGTAGGCGAAAGAATTTTTATTAATA
CCGGTGCTACATCTACAATCCCAGATATCCCGGGATTAAAAGAAAGTTCAAGAACCGTTACTAGCACGGATTTATTAGAT
CAAGATCACTTTCCCCAATCTTTAGCCATTATTGGTGGTGGGTATATTGGAATGGAATTTGCAACAACGTATAGTCAATT
TGGTTCCAAAGTGACGATGATTAATCGCAATGCAGAATTTATGCGTGGAATGGACCAAGATGTTTCCCAAGCGGTAAAAC
AAAACTTTGATAAAGCCGGAATTGAAGTGCTTCAGTCAGCCGAAGTGATTCGAGTGCAAGATCAAGGTTCACACGCCGTA
TTGACTGTTGCTTCTGATGGAAGTGAATCACAAATAATGGTTGATATGATTCTCGTTGCCACTGGACGAAAGCCTAATAT
CCAAGGTTTAAATTTAGAACAAGCAGGAATTCGTTATACCGAAGCCGGAGTTGCAGTCGATGATCATCTTAGAACCAATG
TTCAAAACATTTGGGCAATGGGTGACGTTCGAGGCGGAGCACAGTTTACCTTCCTCTCCTTGGATGATTATCGAATTGTT
TATAATCAGTTATACGCTAGTGGAACGAAGACAACTGAGGAGCAAGTAATTGTTCCAAAAACAATCTTTTTAATGCCGCC
ATTATCTCAAATTGGCATGTCTGAAAGGGAAGCACTTGATAAAAAAATAGAATATCGTACGGGAAAGGTTGCCGTTGCTG
GAATGCCCAAAGCACATATTTTAGGCCATCCGAACGGATTTTATAAAGTACTTATAGATAAAGAAGATCATATCCTAGGA
GCCACGATCTATGCTCCAGAAGCACATGAAATTATCAACATCATCAGTTTGGCGATGCATGCCAATTTGCCTTACCAAAT
GTTAAGAGATCAGATTTATTCTCACCCCACGATGGCGGAAGGATTAAATGATCTGTTCGAAACGATTGGTATGAACTAA

Upstream 100 bases:

>100_bases
TTTGCTACAGGTTTAACTTATTTTAAATAAGCAAATTATTTGATATTGTTTAGTCGTAAACCTATACTCTGTTTATCATG
GTTTTATAGTGGGGGATAAA

Downstream 100 bases:

>100_bases
AGGTGATTGGATTTGTCGGAATTATTATTTTTCATGTTTTGAACAAAAGTTATTTAATTGATTGCTAAAACGCAGATGCT
ACTAGATTCTGTTTTGGCTG

Product: pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, related enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MIKAKNVYIGFGKAAKTLAFRQAQRGESVVVIEESDQMYGGTCINIACIPSKLLYELSDKPQVGGLKDNYKMAITKKRSV
IGKLRYSNFHKLADQKTVKVLNGSASFIDQHTLNVKYLNGATEEVVGERIFINTGATSTIPDIPGLKESSRTVTSTDLLD
QDHFPQSLAIIGGGYIGMEFATTYSQFGSKVTMINRNAEFMRGMDQDVSQAVKQNFDKAGIEVLQSAEVIRVQDQGSHAV
LTVASDGSESQIMVDMILVATGRKPNIQGLNLEQAGIRYTEAGVAVDDHLRTNVQNIWAMGDVRGGAQFTFLSLDDYRIV
YNQLYASGTKTTEEQVIVPKTIFLMPPLSQIGMSEREALDKKIEYRTGKVAVAGMPKAHILGHPNGFYKVLIDKEDHILG
ATIYAPEAHEIINIISLAMHANLPYQMLRDQIYSHPTMAEGLNDLFETIGMN

Sequences:

>Translated_452_residues
MIKAKNVYIGFGKAAKTLAFRQAQRGESVVVIEESDQMYGGTCINIACIPSKLLYELSDKPQVGGLKDNYKMAITKKRSV
IGKLRYSNFHKLADQKTVKVLNGSASFIDQHTLNVKYLNGATEEVVGERIFINTGATSTIPDIPGLKESSRTVTSTDLLD
QDHFPQSLAIIGGGYIGMEFATTYSQFGSKVTMINRNAEFMRGMDQDVSQAVKQNFDKAGIEVLQSAEVIRVQDQGSHAV
LTVASDGSESQIMVDMILVATGRKPNIQGLNLEQAGIRYTEAGVAVDDHLRTNVQNIWAMGDVRGGAQFTFLSLDDYRIV
YNQLYASGTKTTEEQVIVPKTIFLMPPLSQIGMSEREALDKKIEYRTGKVAVAGMPKAHILGHPNGFYKVLIDKEDHILG
ATIYAPEAHEIINIISLAMHANLPYQMLRDQIYSHPTMAEGLNDLFETIGMN
>Mature_452_residues
MIKAKNVYIGFGKAAKTLAFRQAQRGESVVVIEESDQMYGGTCINIACIPSKLLYELSDKPQVGGLKDNYKMAITKKRSV
IGKLRYSNFHKLADQKTVKVLNGSASFIDQHTLNVKYLNGATEEVVGERIFINTGATSTIPDIPGLKESSRTVTSTDLLD
QDHFPQSLAIIGGGYIGMEFATTYSQFGSKVTMINRNAEFMRGMDQDVSQAVKQNFDKAGIEVLQSAEVIRVQDQGSHAV
LTVASDGSESQIMVDMILVATGRKPNIQGLNLEQAGIRYTEAGVAVDDHLRTNVQNIWAMGDVRGGAQFTFLSLDDYRIV
YNQLYASGTKTTEEQVIVPKTIFLMPPLSQIGMSEREALDKKIEYRTGKVAVAGMPKAHILGHPNGFYKVLIDKEDHILG
ATIYAPEAHEIINIISLAMHANLPYQMLRDQIYSHPTMAEGLNDLFETIGMN

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=467, Percent_Identity=27.4089935760171, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50301238, Length=449, Percent_Identity=24.0534521158129, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI291045266, Length=433, Percent_Identity=24.9422632794457, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=25, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=25, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=25, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=25, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=25, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI22035672, Length=460, Percent_Identity=26.0869565217391, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=23.4883720930233, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=42.350332594235, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=27.0562770562771, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=24.6575342465753, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=25.4817987152034, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789065, Length=187, Percent_Identity=28.3422459893048, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=27.6086956521739, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=25.531914893617, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=354, Percent_Identity=25.4237288135593, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=354, Percent_Identity=25.4237288135593, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=454, Percent_Identity=23.568281938326, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=242, Percent_Identity=26.8595041322314, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=26.963906581741, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325166, Length=449, Percent_Identity=25.3897550111359, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=22.6694915254237, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=29.3478260869565, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24640549, Length=429, Percent_Identity=27.972027972028, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24640553, Length=429, Percent_Identity=27.972027972028, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24640551, Length=429, Percent_Identity=27.7389277389277, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=27.2151898734177, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 49782; Mature: 49782

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKAKNVYIGFGKAAKTLAFRQAQRGESVVVIEESDQMYGGTCINIACIPSKLLYELSDK
CCEECEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHCCCC
PQVGGLKDNYKMAITKKRSVIGKLRYSNFHKLADQKTVKVLNGSASFIDQHTLNVKYLNG
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCEEEEEEEECC
ATEEVVGERIFINTGATSTIPDIPGLKESSRTVTSTDLLDQDHFPQSLAIIGGGYIGMEF
CHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCEEEEEECCEEEHHH
ATTYSQFGSKVTMINRNAEFMRGMDQDVSQAVKQNFDKAGIEVLQSAEVIRVQDQGSHAV
HHHHHHHCCEEEEEECCHHHHCCCCHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCEEE
LTVASDGSESQIMVDMILVATGRKPNIQGLNLEQAGIRYTEAGVAVDDHLRTNVQNIWAM
EEEECCCCCCEEEEEEEEEECCCCCCCCCCCCHHCCCEEEECCCEEHHHHHHCHHHHEEE
GDVRGGAQFTFLSLDDYRIVYNQLYASGTKTTEEQVIVPKTIFLMPPLSQIGMSEREALD
CCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEECEEEEECCCHHHHCCCHHHHHH
KKIEYRTGKVAVAGMPKAHILGHPNGFYKVLIDKEDHILGATIYAPEAHEIINIISLAMH
HHHHCCCCCEEEECCCCCEEEECCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
ANLPYQMLRDQIYSHPTMAEGLNDLFETIGMN
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKAKNVYIGFGKAAKTLAFRQAQRGESVVVIEESDQMYGGTCINIACIPSKLLYELSDK
CCEECEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHCCCC
PQVGGLKDNYKMAITKKRSVIGKLRYSNFHKLADQKTVKVLNGSASFIDQHTLNVKYLNG
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCEEEEEEEECC
ATEEVVGERIFINTGATSTIPDIPGLKESSRTVTSTDLLDQDHFPQSLAIIGGGYIGMEF
CHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCEEEEEECCEEEHHH
ATTYSQFGSKVTMINRNAEFMRGMDQDVSQAVKQNFDKAGIEVLQSAEVIRVQDQGSHAV
HHHHHHHCCEEEEEECCHHHHCCCCHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCEEE
LTVASDGSESQIMVDMILVATGRKPNIQGLNLEQAGIRYTEAGVAVDDHLRTNVQNIWAM
EEEECCCCCCEEEEEEEEEECCCCCCCCCCCCHHCCCEEEECCCEEHHHHHHCHHHHEEE
GDVRGGAQFTFLSLDDYRIVYNQLYASGTKTTEEQVIVPKTIFLMPPLSQIGMSEREALD
CCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEECEEEEECCCHHHHCCCHHHHHH
KKIEYRTGKVAVAGMPKAHILGHPNGFYKVLIDKEDHILGATIYAPEAHEIINIISLAMH
HHHHCCCCCEEEECCCCCEEEECCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
ANLPYQMLRDQIYSHPTMAEGLNDLFETIGMN
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]