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The map label for this gene is pip [H]

Identifier: 116492182

GI number: 116492182

Start: 424922

End: 425836

Strand: Reverse

Name: pip [H]

Synonym: PEPE_0379

Alternate gene names: 116492182

Gene position: 425836-424922 (Counterclockwise)

Preceding gene: 116492183

Following gene: 116492181

Centisome position: 23.24

GC content: 39.13

Gene sequence:

>915_bases
TTGAAACAAGGAACAACAATTTTAACACTAGATAATGGATACCATTTATGGTCTCACACTGATGGTGACGACGATTCAAT
CCATCTATTAGCTCTTCACGGTGGCCCTGGTGGAAACCATGAATATTGGGAAAACTTCCACGATGAACTTTTAAAGCAAG
GCTTGAACGTCCAAGTACATTACTATGACCAACTGGGCTCATGGTATTCTGATCAACCAGATTACTCCGATCCTGAAATC
GCCGAAAAATATCTATCATATGATTACTTCTTAGACGAAGTTGAAGAAGTTCGTCAAAAACTTGGAATTGATCATTTCTA
CCTTATCGGTCAATCATGGGGTGGCGCATTAACAATGATGTATGCTCTTAAATATGGTCAACATCTTAAGGGTGCTATCA
TTTCATCCATGGTCGATAACATTGACGAATATTTGGAACATCAAGATGCAATCCGTGATGAAGCTCTTGCTCCTGAAGAT
GCTCAATTCATGCGTGACTGCGAAAAATCTGGTGACTGGGACAACGAACGTTACCAAAAATTAGTTGACATTTTGAATGC
TGGTTACGTTGATCGTAAACAACCAGTTGCAATCCGTCATTTAGTACCAACTATGGCTACTCCGGTTTATAATGCTTTCC
AAGGCGATAACGAATTCGTTGTTACTGGAAAACTTAACGAATGGGATGTTCGTGACCAAATTAAAAATATCAATGTTCCA
ACCTTATTGACATTTGGTGAACATGAAACTATGCCGCTAGATTCAGCACGTCGTATGGCTGAAGTTATTCCTAACGCTAA
GTTAGTTACAACGCCTAATGGTGGCCATCATCACATGATTGATAATGCACCAGTTTACTTCAAACATCTTGCAGATTATC
TTCGTGAAGTTGAAGCTGGAACTTTCAATAAGTAA

Upstream 100 bases:

>100_bases
TTTATTATTGATTAAACCAATGGTAAATCAATATGGGTTCTGGTCAGTTTCCTTCAAATCTGATATTATAAGCTTAAATT
TAAGAAACTAGGTGAGTGTT

Downstream 100 bases:

>100_bases
TCTAAATAAGTCATATTTAAAAAGGACTAACTAATTTTTAGTTAGTCCTTTTTACTAGCTTACCGCCTGTAAAAGCGCTA
TTATTAATATAGTTTATTGG

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP; Tricorn protease-interacting factor F1 [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKQGTTILTLDNGYHLWSHTDGDDDSIHLLALHGGPGGNHEYWENFHDELLKQGLNVQVHYYDQLGSWYSDQPDYSDPEI
AEKYLSYDYFLDEVEEVRQKLGIDHFYLIGQSWGGALTMMYALKYGQHLKGAIISSMVDNIDEYLEHQDAIRDEALAPED
AQFMRDCEKSGDWDNERYQKLVDILNAGYVDRKQPVAIRHLVPTMATPVYNAFQGDNEFVVTGKLNEWDVRDQIKNINVP
TLLTFGEHETMPLDSARRMAEVIPNAKLVTTPNGGHHHMIDNAPVYFKHLADYLREVEAGTFNK

Sequences:

>Translated_304_residues
MKQGTTILTLDNGYHLWSHTDGDDDSIHLLALHGGPGGNHEYWENFHDELLKQGLNVQVHYYDQLGSWYSDQPDYSDPEI
AEKYLSYDYFLDEVEEVRQKLGIDHFYLIGQSWGGALTMMYALKYGQHLKGAIISSMVDNIDEYLEHQDAIRDEALAPED
AQFMRDCEKSGDWDNERYQKLVDILNAGYVDRKQPVAIRHLVPTMATPVYNAFQGDNEFVVTGKLNEWDVRDQIKNINVP
TLLTFGEHETMPLDSARRMAEVIPNAKLVTTPNGGHHHMIDNAPVYFKHLADYLREVEAGTFNK
>Mature_304_residues
MKQGTTILTLDNGYHLWSHTDGDDDSIHLLALHGGPGGNHEYWENFHDELLKQGLNVQVHYYDQLGSWYSDQPDYSDPEI
AEKYLSYDYFLDEVEEVRQKLGIDHFYLIGQSWGGALTMMYALKYGQHLKGAIISSMVDNIDEYLEHQDAIRDEALAPED
AQFMRDCEKSGDWDNERYQKLVDILNAGYVDRKQPVAIRHLVPTMATPVYNAFQGDNEFVVTGKLNEWDVRDQIKNINVP
TLLTFGEHETMPLDSARRMAEVIPNAKLVTTPNGGHHHMIDNAPVYFKHLADYLREVEAGTFNK

Specific function: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome) yi

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34865; Mature: 34865

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQGTTILTLDNGYHLWSHTDGDDDSIHLLALHGGPGGNHEYWENFHDELLKQGLNVQVH
CCCCCEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEE
YYDQLGSWYSDQPDYSDPEIAEKYLSYDYFLDEVEEVRQKLGIDHFYLIGQSWGGALTMM
EEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHH
YALKYGQHLKGAIISSMVDNIDEYLEHQDAIRDEALAPEDAQFMRDCEKSGDWDNERYQK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
LVDILNAGYVDRKQPVAIRHLVPTMATPVYNAFQGDNEFVVTGKLNEWDVRDQIKNINVP
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCC
TLLTFGEHETMPLDSARRMAEVIPNAKLVTTPNGGHHHMIDNAPVYFKHLADYLREVEAG
EEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TFNK
CCCC
>Mature Secondary Structure
MKQGTTILTLDNGYHLWSHTDGDDDSIHLLALHGGPGGNHEYWENFHDELLKQGLNVQVH
CCCCCEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEE
YYDQLGSWYSDQPDYSDPEIAEKYLSYDYFLDEVEEVRQKLGIDHFYLIGQSWGGALTMM
EEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHH
YALKYGQHLKGAIISSMVDNIDEYLEHQDAIRDEALAPEDAQFMRDCEKSGDWDNERYQK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
LVDILNAGYVDRKQPVAIRHLVPTMATPVYNAFQGDNEFVVTGKLNEWDVRDQIKNINVP
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCC
TLLTFGEHETMPLDSARRMAEVIPNAKLVTTPNGGHHHMIDNAPVYFKHLADYLREVEAG
EEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TFNK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946961; 11029001; 12374735 [H]