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The map label for this gene is 116492179

Identifier: 116492179

GI number: 116492179

Start: 421858

End: 422232

Strand: Reverse

Name: 116492179

Synonym: PEPE_0376

Alternate gene names: NA

Gene position: 422232-421858 (Counterclockwise)

Preceding gene: 116492181

Following gene: 116492174

Centisome position: 23.04

GC content: 40.0

Gene sequence:

>375_bases
ATGAATATTCGTGAAATTGATCATATTACGCTAACTGTATCTGATATCGCTCGTAGCGAACGCTTTTATCATGAAGTTTT
CGATATGCCGATTCTAATCGATGCTCCATTCGCGGGGGTTCGCGCTGGCAAACAACGAATTTACTTCGTTACTCCAGACC
AACAACCCCAATTTGCTCCAGCTCAGGCTACTACTGGTAGCATTGCCCTTTCCGTTGTTGCTAAAAATCCAATGGAAGAA
ATTGTTAACCATCTCAAAAGTTATTTCATCGAAATTATCGACGATCCTAAAACTCGCCAAGGAACTCATGGCGATGTTCA
ATCACTCTTAATTAAAGATCCTGATGGTAATCTGATTGAAATCGCTAATTACTAA

Upstream 100 bases:

>100_bases
CTAAAATAACTAATAACCACCGTAGCATGAATTTATACAAATCGTCAATCCAATTTGCCTATGCTATACTTAATCTCGTT
ATTAGGAGGACTTACATACA

Downstream 100 bases:

>100_bases
AATAATGATTAGGATGTAACCATTTTAGCATCAAAAACAAAAGGAAGTCTCGACTAAAAAAGTCAAGGCTTCCTTTTTTG
CTTCTACAAATACTTAGCAT

Product: lactoylglutathione lyase related lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MNIREIDHITLTVSDIARSERFYHEVFDMPILIDAPFAGVRAGKQRIYFVTPDQQPQFAPAQATTGSIALSVVAKNPMEE
IVNHLKSYFIEIIDDPKTRQGTHGDVQSLLIKDPDGNLIEIANY

Sequences:

>Translated_124_residues
MNIREIDHITLTVSDIARSERFYHEVFDMPILIDAPFAGVRAGKQRIYFVTPDQQPQFAPAQATTGSIALSVVAKNPMEE
IVNHLKSYFIEIIDDPKTRQGTHGDVQSLLIKDPDGNLIEIANY
>Mature_124_residues
MNIREIDHITLTVSDIARSERFYHEVFDMPILIDAPFAGVRAGKQRIYFVTPDQQPQFAPAQATTGSIALSVVAKNPMEE
IVNHLKSYFIEIIDDPKTRQGTHGDVQSLLIKDPDGNLIEIANY

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=123, Percent_Identity=30.0813008130081, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: NA

Molecular weight: Translated: 13939; Mature: 13939

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIREIDHITLTVSDIARSERFYHEVFDMPILIDAPFAGVRAGKQRIYFVTPDQQPQFAP
CCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCC
AQATTGSIALSVVAKNPMEEIVNHLKSYFIEIIDDPKTRQGTHGDVQSLLIKDPDGNLIE
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEE
IANY
EECC
>Mature Secondary Structure
MNIREIDHITLTVSDIARSERFYHEVFDMPILIDAPFAGVRAGKQRIYFVTPDQQPQFAP
CCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCC
AQATTGSIALSVVAKNPMEEIVNHLKSYFIEIIDDPKTRQGTHGDVQSLLIKDPDGNLIE
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEE
IANY
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]