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The map label for this gene is gor [H]

Identifier: 116491967

GI number: 116491967

Start: 180274

End: 181608

Strand: Reverse

Name: gor [H]

Synonym: PEPE_0153

Alternate gene names: 116491967

Gene position: 181608-180274 (Counterclockwise)

Preceding gene: 116491968

Following gene: 116491966

Centisome position: 9.91

GC content: 44.94

Gene sequence:

>1335_bases
ATGACTGAAAGTTATCAATTTGATGTTTTGTACTTAGGCGCGGGGCATGGTGCCTTCGACGGGGCGGTTCCACTAGCTAA
TAGTGGTAAAAAAGTCGCCATCGTCGAAGCGGACAAAATCGGGGGAACTTGTCCAAACCGTGGATGCAACGCGAAAATTA
CGCTGGACAACCCGGTTCAACTTTTACGCCACCAAGAACGCCTTGATGGCATTGTAAATGGTGACTTAAAACTGGATTGG
ACTGCCAATGTAGAACATGAACACGAAGTCATCGACGGCTTGCCGGACATGATTACTGGTCTACTCGACTCTGTTGACAT
CGAAATTATTCACGGTCGTGGAAAATTTGTTGATGCTCACACCATCGAAGTGGATCAACAGCGCTACACCGCTGACAAAA
TCGTGATTGCAACGGGGCTACGTCCCCACCATCTAGATGTTATGGGATCAGAACTTACGCATGACAGTACTGATTTTATG
AACCTCAAGCATCTTCCTGAAAATATCGTAATTATTGGCGCGGGCTATATTGGCATGGAATTTGCCACGATTGCCAATGC
TGCCGGCGCGAACGTCACTGTACTTTTACGCCATAATCGGGCGTTGCGCAAGTTTAATCAAGATTACGTAAAACAAGTCA
TTGCCGACCTCGAAAAACGAGGGGTGAAGTTCATTTACAACGCTCAGGTGGATCGTTTTGAGGAAGACGGTTCTCATTTT
ACCGTGTCTTATAACGATCACGAAACCCTCACCACCGACTGGATTTTGGATGCTACCGGACGAATTCCTAATATCGAAAA
CATCGGATTAGACGAAGTAGGCGTTAGTTACAATGCTAACGGGATCGAAGTTAACGATCATCTCCAAACTAACATTGATA
ACATCTATGCTTCTGGTGATGTGCTTGATAAAGAACAGCCTAAGCTCACCCCGACTGCGATCTTTGAATCTAGTTATTTA
ACCCAACTTTTCACAGGAAAGACTACTGACGCAATCAATTATCCGGCCATCCCAACCATTGTCTTTACCTCGCCACAAAT
CGCACAGGTTGGTATGAGCGTCGAAGAAGCTCAGCAAAATCCTGATTACACCATTAAAACTAATCATCTTCCTGACGGAT
GGTTCCGCCAAGTTGATAAGGAAACAATTGGTAATAACACCTTGATTTACGATCAAGACCATCATCTTGTAGGAGCAGCT
GAAGTTAGTGAACATGCTGCCGATGCAATTAACGTTTTATTACCAGCAATTGAGTTCCAATATACAGCTGAACAACTAGG
ACGCATCGTACCCCTCTTCCCTACTTTGGGAGCGGACGTCTGGTCACAGATTTAA

Upstream 100 bases:

>100_bases
TCCCAGTTGCAATCGCTTGCAACTCGCCCCTATCCTCTGCTATGCTCGTGCCAACAATGGTAATTGTTTATTCACCTAAA
TTTAGGATGGAGGTAATTAA

Downstream 100 bases:

>100_bases
AAAAAACGCTGAGCCTTTCTGAAAGAGGTTCAGTGTTTTTATTTTCTACAATTAAAAAAAGTGAAAAATATTTTTACGTC
TACTGCCGAAGATGATTAAC

Product: pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, related enzyme

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTESYQFDVLYLGAGHGAFDGAVPLANSGKKVAIVEADKIGGTCPNRGCNAKITLDNPVQLLRHQERLDGIVNGDLKLDW
TANVEHEHEVIDGLPDMITGLLDSVDIEIIHGRGKFVDAHTIEVDQQRYTADKIVIATGLRPHHLDVMGSELTHDSTDFM
NLKHLPENIVIIGAGYIGMEFATIANAAGANVTVLLRHNRALRKFNQDYVKQVIADLEKRGVKFIYNAQVDRFEEDGSHF
TVSYNDHETLTTDWILDATGRIPNIENIGLDEVGVSYNANGIEVNDHLQTNIDNIYASGDVLDKEQPKLTPTAIFESSYL
TQLFTGKTTDAINYPAIPTIVFTSPQIAQVGMSVEEAQQNPDYTIKTNHLPDGWFRQVDKETIGNNTLIYDQDHHLVGAA
EVSEHAADAINVLLPAIEFQYTAEQLGRIVPLFPTLGADVWSQI

Sequences:

>Translated_444_residues
MTESYQFDVLYLGAGHGAFDGAVPLANSGKKVAIVEADKIGGTCPNRGCNAKITLDNPVQLLRHQERLDGIVNGDLKLDW
TANVEHEHEVIDGLPDMITGLLDSVDIEIIHGRGKFVDAHTIEVDQQRYTADKIVIATGLRPHHLDVMGSELTHDSTDFM
NLKHLPENIVIIGAGYIGMEFATIANAAGANVTVLLRHNRALRKFNQDYVKQVIADLEKRGVKFIYNAQVDRFEEDGSHF
TVSYNDHETLTTDWILDATGRIPNIENIGLDEVGVSYNANGIEVNDHLQTNIDNIYASGDVLDKEQPKLTPTAIFESSYL
TQLFTGKTTDAINYPAIPTIVFTSPQIAQVGMSVEEAQQNPDYTIKTNHLPDGWFRQVDKETIGNNTLIYDQDHHLVGAA
EVSEHAADAINVLLPAIEFQYTAEQLGRIVPLFPTLGADVWSQI
>Mature_443_residues
TESYQFDVLYLGAGHGAFDGAVPLANSGKKVAIVEADKIGGTCPNRGCNAKITLDNPVQLLRHQERLDGIVNGDLKLDWT
ANVEHEHEVIDGLPDMITGLLDSVDIEIIHGRGKFVDAHTIEVDQQRYTADKIVIATGLRPHHLDVMGSELTHDSTDFMN
LKHLPENIVIIGAGYIGMEFATIANAAGANVTVLLRHNRALRKFNQDYVKQVIADLEKRGVKFIYNAQVDRFEEDGSHFT
VSYNDHETLTTDWILDATGRIPNIENIGLDEVGVSYNANGIEVNDHLQTNIDNIYASGDVLDKEQPKLTPTAIFESSYLT
QLFTGKTTDAINYPAIPTIVFTSPQIAQVGMSVEEAQQNPDYTIKTNHLPDGWFRQVDKETIGNNTLIYDQDHHLVGAAE
VSEHAADAINVLLPAIEFQYTAEQLGRIVPLFPTLGADVWSQI

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=370, Percent_Identity=33.5135135135135, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI291045266, Length=347, Percent_Identity=32.5648414985591, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=27.2727272727273, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI33519430, Length=338, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519428, Length=338, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519426, Length=338, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI148277065, Length=338, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI148277071, Length=338, Percent_Identity=30.7692307692308, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI22035672, Length=367, Percent_Identity=28.8828337874659, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI291045268, Length=322, Percent_Identity=32.2981366459627, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1789915, Length=344, Percent_Identity=34.0116279069767, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=28.5714285714286, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082354, Length=429, Percent_Identity=26.5734265734266, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87081717, Length=369, Percent_Identity=28.7262872628726, Blast_Score=115, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17557007, Length=384, Percent_Identity=28.3854166666667, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=342, Percent_Identity=30.1169590643275, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=342, Percent_Identity=30.1169590643275, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=26.9565217391304, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=371, Percent_Identity=28.3018867924528, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17559934, Length=185, Percent_Identity=29.7297297297297, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=380, Percent_Identity=26.8421052631579, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=25.3763440860215, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325240, Length=378, Percent_Identity=24.3386243386243, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640549, Length=386, Percent_Identity=30.8290155440415, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24640553, Length=386, Percent_Identity=30.8290155440415, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24640551, Length=386, Percent_Identity=30.8290155440415, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=27.4122807017544, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17737741, Length=389, Percent_Identity=28.5347043701799, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49019; Mature: 48888

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESYQFDVLYLGAGHGAFDGAVPLANSGKKVAIVEADKIGGTCPNRGCNAKITLDNPVQ
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCHHH
LLRHQERLDGIVNGDLKLDWTANVEHEHEVIDGLPDMITGLLDSVDIEIIHGRGKFVDAH
HHHHHHHHCCEECCCEEEEEEECCCHHHHHHCCCHHHHHHHHCCCCEEEEECCCCEEEEE
TIEVDQQRYTADKIVIATGLRPHHLDVMGSELTHDSTDFMNLKHLPENIVIIGAGYIGME
EEEECCHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHCCCCCEEEEECCHHHHH
FATIANAAGANVTVLLRHNRALRKFNQDYVKQVIADLEKRGVKFIYNAQVDRFEEDGSHF
HHHHHCCCCCCEEEEEECCHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCHHHCCCCCEE
TVSYNDHETLTTDWILDATGRIPNIENIGLDEVGVSYNANGIEVNDHLQTNIDNIYASGD
EEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEECCCCEEECCCHHCCCCCEEECCC
VLDKEQPKLTPTAIFESSYLTQLFTGKTTDAINYPAIPTIVFTSPQIAQVGMSVEEAQQN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHCCCHHHHHCC
PDYTIKTNHLPDGWFRQVDKETIGNNTLIYDQDHHLVGAAEVSEHAADAINVLLPAIEFQ
CCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHEE
YTAEQLGRIVPLFPTLGADVWSQI
ECHHHHCCEEEECCCCCHHHHHCC
>Mature Secondary Structure 
TESYQFDVLYLGAGHGAFDGAVPLANSGKKVAIVEADKIGGTCPNRGCNAKITLDNPVQ
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCHHH
LLRHQERLDGIVNGDLKLDWTANVEHEHEVIDGLPDMITGLLDSVDIEIIHGRGKFVDAH
HHHHHHHHCCEECCCEEEEEEECCCHHHHHHCCCHHHHHHHHCCCCEEEEECCCCEEEEE
TIEVDQQRYTADKIVIATGLRPHHLDVMGSELTHDSTDFMNLKHLPENIVIIGAGYIGME
EEEECCHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHCCCCCEEEEECCHHHHH
FATIANAAGANVTVLLRHNRALRKFNQDYVKQVIADLEKRGVKFIYNAQVDRFEEDGSHF
HHHHHCCCCCCEEEEEECCHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCHHHCCCCCEE
TVSYNDHETLTTDWILDATGRIPNIENIGLDEVGVSYNANGIEVNDHLQTNIDNIYASGD
EEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEECCCCEEECCCHHCCCCCEEECCC
VLDKEQPKLTPTAIFESSYLTQLFTGKTTDAINYPAIPTIVFTSPQIAQVGMSVEEAQQN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHCCCHHHHHCC
PDYTIKTNHLPDGWFRQVDKETIGNNTLIYDQDHHLVGAAEVSEHAADAINVLLPAIEFQ
CCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHEE
YTAEQLGRIVPLFPTLGADVWSQI
ECHHHHCCEEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]