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The map label for this gene is mntH [H]

Identifier: 116491863

GI number: 116491863

Start: 41901

End: 43502

Strand: Direct

Name: mntH [H]

Synonym: PEPE_0045

Alternate gene names: 116491863

Gene position: 41901-43502 (Clockwise)

Preceding gene: 116491862

Following gene: 116491864

Centisome position: 2.29

GC content: 40.7

Gene sequence:

>1602_bases
ATGATTTTGATGAGTAATGAGATCAAGAACCCAAAGAAACGTCGCAAATTAGTGGAATACGCTAATGGACGATCATTGGA
AGAAATAAATGGGACAGTTAAGGTGCCTAAGAATATTGGTTTTTGGAAGGCACTGTTTATGTATTCGGGTCCGGGAGCAT
TAGTTGCTGTTGGTTATATGGACCCTGGTAATTGGTCAACATCAATCACTGGGGGTCAAAACTTCCAGTACATGCTAATG
TCGATTATCTTGATTTCGAGTTTAATCGCGATGTTGTTACAATATATGGCGGCTAAACTGGGAATTGTGAGTCAAATGGA
CTTAGCGCAGGCAATTCGCGCTAGAACAAGTAAGTCATTGGGAATTGTATTATGGATTTTAACGGAATTGGCAATTATGG
CGACTGATATCGCTGAAGTAATTGGTGCTGCAATTGCGCTGTATTTGTTGTTCCATATTCCGCTAGCCATCGCGGTTTTC
ATTACCGTTTTGGATGTACTGCTATTACTGTTATTGACTAAGATTGGTTTTAGAAAAATTGAAGCCATTGTGGTGTGTTT
AATCATGGTTATTTTAGTGGTTTTCGTCTACCAAGTTGCTTTATCAAATCCAAATTGGGGTGCGGTATTTAGCGGCTTAG
TACCAACCACTAAAGCATTTGAAACTTCACCAACAATTGGCGGAATGACTCCTTTAAGTGGGTCACTAGGAATTATTGGT
GCGACAGTTATGCCTCATAACTTGTACTTGCACTCAGCGGTTTCACAAACGCGTGAAATTGATCATAACGATGAAGAAGA
CGTAGCAAGAACGCTACGCTTCTCAACTTGGGATTCAAATATTCAGCTATCATTCGCATTTATCGTTAATTCACTTCTAT
TGGTGATGGGAGTTGCCGTATTTAAGTCCGGCGCTGTCCAAGATCCATCATTCTTTGGTCTATTCCATGCGTTAAATGAT
ACTTCAACTTTGAGTAACGGAATTTTGATTGGAGTTGCCAAAACTGGGGTACTTTCGACATTATTTGCGGTAGCTTTGTT
GGCTTCTGGTCAAAATTCAACCATCACGGGAACGTTAACCGGCCAGGTTATCATGGAAGGGTTCATTCACATGCGAATGC
CACTTTGGGCACGGCGTTTGATTACCCGTTTGATTTCAGTTGTACCAGTTTTGATTTGTGTCATGATTACCAGCGGTAAA
GGTGATCTTCAAGAACACGAAGCCCTAAATCAGTTGATGAATAACTCTCAAGTATTTTTGGCTTTTGCATTACCATTCTC
AATGATTCCATTGTTGATGATGACGGATAGTCGCGTTGAAATGGGTGATCGATTTAAGAATAGTTGGGCGGTCAAAATTT
TAGGTTGGATTTCGGTTATTTTCCTAACCTACCTCAATATGACTGGTTTACCAAATTCAATTACGGCCTTCTTTGGAGCT
AATCCAAGTGCTGGTGAAGTAGAGCTGGCGCACATAATTGCCTATATGCTAGTGGCAGTAGTTCTAGCACTCCTAGCTTG
GACAGTCTTTGAACTCCATAAAGGTAACCAACGTTACGAATTGGAAATGCGAAGTAAAGCAGAAGCTAAGGAGGAAGCAT
AA

Upstream 100 bases:

>100_bases
AATCATTGAAGCCACAAATGCCCGTCTAACGGCAATAAAAAGAGTTTGCGCATCGTGAACAATATGTTACGATAGCCGTG
GTTCAAGATTGAGGAAAGGA

Downstream 100 bases:

>100_bases
TGACCTTTGATGTTAAGAGAATATTAGTTGGTGTAGATGATTCGGAAGATGCCGTTTTAGCCTTTGATTATGCAATTAAT
CTGGCTAAAAAATCGGGTTC

Product: manganese transporter NRAMP

Products: NA

Alternate protein names: Hop-inducible cation transporter [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MILMSNEIKNPKKRRKLVEYANGRSLEEINGTVKVPKNIGFWKALFMYSGPGALVAVGYMDPGNWSTSITGGQNFQYMLM
SIILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIALYLLFHIPLAIAVF
ITVLDVLLLLLLTKIGFRKIEAIVVCLIMVILVVFVYQVALSNPNWGAVFSGLVPTTKAFETSPTIGGMTPLSGSLGIIG
ATVMPHNLYLHSAVSQTREIDHNDEEDVARTLRFSTWDSNIQLSFAFIVNSLLLVMGVAVFKSGAVQDPSFFGLFHALND
TSTLSNGILIGVAKTGVLSTLFAVALLASGQNSTITGTLTGQVIMEGFIHMRMPLWARRLITRLISVVPVLICVMITSGK
GDLQEHEALNQLMNNSQVFLAFALPFSMIPLLMMTDSRVEMGDRFKNSWAVKILGWISVIFLTYLNMTGLPNSITAFFGA
NPSAGEVELAHIIAYMLVAVVLALLAWTVFELHKGNQRYELEMRSKAEAKEEA

Sequences:

>Translated_533_residues
MILMSNEIKNPKKRRKLVEYANGRSLEEINGTVKVPKNIGFWKALFMYSGPGALVAVGYMDPGNWSTSITGGQNFQYMLM
SIILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIALYLLFHIPLAIAVF
ITVLDVLLLLLLTKIGFRKIEAIVVCLIMVILVVFVYQVALSNPNWGAVFSGLVPTTKAFETSPTIGGMTPLSGSLGIIG
ATVMPHNLYLHSAVSQTREIDHNDEEDVARTLRFSTWDSNIQLSFAFIVNSLLLVMGVAVFKSGAVQDPSFFGLFHALND
TSTLSNGILIGVAKTGVLSTLFAVALLASGQNSTITGTLTGQVIMEGFIHMRMPLWARRLITRLISVVPVLICVMITSGK
GDLQEHEALNQLMNNSQVFLAFALPFSMIPLLMMTDSRVEMGDRFKNSWAVKILGWISVIFLTYLNMTGLPNSITAFFGA
NPSAGEVELAHIIAYMLVAVVLALLAWTVFELHKGNQRYELEMRSKAEAKEEA
>Mature_533_residues
MILMSNEIKNPKKRRKLVEYANGRSLEEINGTVKVPKNIGFWKALFMYSGPGALVAVGYMDPGNWSTSITGGQNFQYMLM
SIILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIALYLLFHIPLAIAVF
ITVLDVLLLLLLTKIGFRKIEAIVVCLIMVILVVFVYQVALSNPNWGAVFSGLVPTTKAFETSPTIGGMTPLSGSLGIIG
ATVMPHNLYLHSAVSQTREIDHNDEEDVARTLRFSTWDSNIQLSFAFIVNSLLLVMGVAVFKSGAVQDPSFFGLFHALND
TSTLSNGILIGVAKTGVLSTLFAVALLASGQNSTITGTLTGQVIMEGFIHMRMPLWARRLITRLISVVPVLICVMITSGK
GDLQEHEALNQLMNNSQVFLAFALPFSMIPLLMMTDSRVEMGDRFKNSWAVKILGWISVIFLTYLNMTGLPNSITAFFGA
NPSAGEVELAHIIAYMLVAVVLALLAWTVFELHKGNQRYELEMRSKAEAKEEA

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI295293167, Length=444, Percent_Identity=33.7837837837838, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI295293175, Length=482, Percent_Identity=32.5726141078838, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI295293173, Length=482, Percent_Identity=32.5726141078838, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI10835169, Length=482, Percent_Identity=32.5726141078838, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI295293178, Length=482, Percent_Identity=32.5726141078838, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI295293171, Length=482, Percent_Identity=32.5726141078838, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI295293169, Length=482, Percent_Identity=32.5726141078838, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI109255241, Length=409, Percent_Identity=32.518337408313, Blast_Score=209, Evalue=6e-54,
Organism=Escherichia coli, GI1788736, Length=429, Percent_Identity=31.7016317016317, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI193210616, Length=518, Percent_Identity=31.8532818532818, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71999499, Length=538, Percent_Identity=31.0408921933086, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17569473, Length=396, Percent_Identity=33.5858585858586, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71993856, Length=276, Percent_Identity=35.8695652173913, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321841, Length=431, Percent_Identity=36.6589327146172, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6324450, Length=433, Percent_Identity=33.4872979214781, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323062, Length=411, Percent_Identity=35.2798053527981, Blast_Score=206, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24648607, Length=442, Percent_Identity=31.9004524886878, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI281362176, Length=442, Percent_Identity=31.9004524886878, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24648609, Length=442, Percent_Identity=31.9004524886878, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI45553443, Length=431, Percent_Identity=31.7865429234339, Blast_Score=230, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 58260; Mature: 58260

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMSNEIKNPKKRRKLVEYANGRSLEEINGTVKVPKNIGFWKALFMYSGPGALVAVGYM
CEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCEECCCCCCHHHHHHHCCCCCCEEEEEEC
DPGNWSTSITGGQNFQYMLMSIILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIVLWILTELAIMATDIAEVIGAAIALYLLFHIPLAIAVFITVLDVLLLLLLTKIGFRKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAIVVCLIMVILVVFVYQVALSNPNWGAVFSGLVPTTKAFETSPTIGGMTPLSGSLGIIG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ATVMPHNLYLHSAVSQTREIDHNDEEDVARTLRFSTWDSNIQLSFAFIVNSLLLVMGVAV
EEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHH
FKSGAVQDPSFFGLFHALNDTSTLSNGILIGVAKTGVLSTLFAVALLASGQNSTITGTLT
HCCCCCCCCHHHHHHHHHCCCCHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEH
GQVIMEGFIHMRMPLWARRLITRLISVVPVLICVMITSGKGDLQEHEALNQLMNNSQVFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEE
AFALPFSMIPLLMMTDSRVEMGDRFKNSWAVKILGWISVIFLTYLNMTGLPNSITAFFGA
EEHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECC
NPSAGEVELAHIIAYMLVAVVLALLAWTVFELHKGNQRYELEMRSKAEAKEEA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCC
>Mature Secondary Structure
MILMSNEIKNPKKRRKLVEYANGRSLEEINGTVKVPKNIGFWKALFMYSGPGALVAVGYM
CEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCEECCCCCCHHHHHHHCCCCCCEEEEEEC
DPGNWSTSITGGQNFQYMLMSIILISSLIAMLLQYMAAKLGIVSQMDLAQAIRARTSKSL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIVLWILTELAIMATDIAEVIGAAIALYLLFHIPLAIAVFITVLDVLLLLLLTKIGFRKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAIVVCLIMVILVVFVYQVALSNPNWGAVFSGLVPTTKAFETSPTIGGMTPLSGSLGIIG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ATVMPHNLYLHSAVSQTREIDHNDEEDVARTLRFSTWDSNIQLSFAFIVNSLLLVMGVAV
EEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHH
FKSGAVQDPSFFGLFHALNDTSTLSNGILIGVAKTGVLSTLFAVALLASGQNSTITGTLT
HCCCCCCCCHHHHHHHHHCCCCHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEH
GQVIMEGFIHMRMPLWARRLITRLISVVPVLICVMITSGKGDLQEHEALNQLMNNSQVFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEE
AFALPFSMIPLLMMTDSRVEMGDRFKNSWAVKILGWISVIFLTYLNMTGLPNSITAFFGA
EEHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECC
NPSAGEVELAHIIAYMLVAVVLALLAWTVFELHKGNQRYELEMRSKAEAKEEA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11414327 [H]