Click here to switch to the map view.

The map label for this gene is htpX

Identifier: 116332599

GI number: 116332599

Start: 198163

End: 199050

Strand: Reverse

Name: htpX

Synonym: LBJ_4171

Alternate gene names: 116332599

Gene position: 199050-198163 (Counterclockwise)

Preceding gene: 116332600

Following gene: 116332598

Centisome position: 66.4

GC content: 44.14

Gene sequence:

>888_bases
ATGTGGTTTAAACGAATTGGGTTATTTTTACTGACCAATATTCTAGTAGTTGTAACGATTTCGATCGTTACGAGCGTGCT
TGGAATCGGTCCATATTTGGATGCAAACGGACTTAATCTGAGTTCCTTAGTTATCTTCTGTTTTCTCTGGGGTATGGGAG
GTGCGTTTGTATCTCTACTTCTCTCCAAGTTTATGGCTAAGATGATGATGGGAGTGCAGATCATCGATCCTAGATCTGCG
TCCGGTGCTGAAAGAGAATTGTATTCTAGAGTAGAAAGACTTGCAAGAGCGGCAAACCTTCCGATGCCCGAAGTGGGAAT
TTATCATTCTCCGGAAGTAAATGCATTTGCGACCGGACCTTCCAAGTCCAGTTCTCTTGTTGCGGTATCTAGCGGTTTAC
TTCAGGTGATGGACAACGCGGAAGTGGAAGGTGTTCTCGCGCACGAGTTGGCGCACGTTGCAAACGGAGACATGGTGACA
ATGACTCTGATTCAGGGTATTGTTAACGCTTTTGTAATGTTCTTTTCAAGGATCATCAGTTACGCTTTGAGTACGATGGT
TAAAGACGAAATGCAATACACAGTACGTCTGATTTCCAATATCGTCTTAAGCATTCTGTTCAGTATTCTCGGATCGATCG
TAGTCGCGTATTTCTCAAGAACCAGGGAATACCGTGCGGATGCAGGCGGAGCAAAACTCGTAGGACGTCAGAATATGATT
GCGGCTCTTGAAAAACTAAGACGTACATTTGACGCACCTGAGGATGAAAGGGGCAAGGAAGCTCTTGCTACAATGAAAAT
ATCCGGACATAACAAATGGATGGCCCTATTTTCAACTCACCCTCCTTTAGAAGCGAGAATTGCGGCTCTAAAGAACTCAG
GATATTAA

Upstream 100 bases:

>100_bases
CAATAGGATTTTTAACGTCGTCCGTAGATTGATTGCACTTATTGTTAGTTCATAAAATTCAATCTGCTTCCTATGGGGCG
CAAGATAAGGAGAAACTAAA

Downstream 100 bases:

>100_bases
GAACTGTTTTCAAAAGGAAGACCATTCCGAGCAATCGGGATTTTTGGAACGAATGCTAAAATTCGTTTAAAATGGAAACT
TCAAAATAAGCCCGGTTTTG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGLNLSSLVIFCFLWGMGGAFVSLLLSKFMAKMMMGVQIIDPRSA
SGAERELYSRVERLARAANLPMPEVGIYHSPEVNAFATGPSKSSSLVAVSSGLLQVMDNAEVEGVLAHELAHVANGDMVT
MTLIQGIVNAFVMFFSRIISYALSTMVKDEMQYTVRLISNIVLSILFSILGSIVVAYFSRTREYRADAGGAKLVGRQNMI
AALEKLRRTFDAPEDERGKEALATMKISGHNKWMALFSTHPPLEARIAALKNSGY

Sequences:

>Translated_295_residues
MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGLNLSSLVIFCFLWGMGGAFVSLLLSKFMAKMMMGVQIIDPRSA
SGAERELYSRVERLARAANLPMPEVGIYHSPEVNAFATGPSKSSSLVAVSSGLLQVMDNAEVEGVLAHELAHVANGDMVT
MTLIQGIVNAFVMFFSRIISYALSTMVKDEMQYTVRLISNIVLSILFSILGSIVVAYFSRTREYRADAGGAKLVGRQNMI
AALEKLRRTFDAPEDERGKEALATMKISGHNKWMALFSTHPPLEARIAALKNSGY
>Mature_295_residues
MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGLNLSSLVIFCFLWGMGGAFVSLLLSKFMAKMMMGVQIIDPRSA
SGAERELYSRVERLARAANLPMPEVGIYHSPEVNAFATGPSKSSSLVAVSSGLLQVMDNAEVEGVLAHELAHVANGDMVT
MTLIQGIVNAFVMFFSRIISYALSTMVKDEMQYTVRLISNIVLSILFSILGSIVVAYFSRTREYRADAGGAKLVGRQNMI
AALEKLRRTFDAPEDERGKEALATMKISGHNKWMALFSTHPPLEARIAALKNSGY

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=301, Percent_Identity=46.5116279069767, Blast_Score=243, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_LEPBJ (Q04NG2)

Other databases:

- EMBL:   CP000351
- RefSeq:   YP_802316.1
- ProteinModelPortal:   Q04NG2
- SMR:   Q04NG2
- STRING:   Q04NG2
- GeneID:   4412334
- GenomeReviews:   CP000351_GR
- KEGG:   lbj:LBJ_4171
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   NRFLTAN
- PhylomeDB:   Q04NG2
- ProtClustDB:   PRK05457
- BioCyc:   LBOR355277:LBJ_4171-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32234; Mature: 32234

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 149-149

Signals:

None

Transmembrane regions:

HASH(0x101fedd8)-; HASH(0x12ac9b5c)-; HASH(0x12ac9bc8)-; HASH(0x1235828c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGLNLSSLVIFCFLWGMGGAFVSLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSKFMAKMMMGVQIIDPRSASGAERELYSRVERLARAANLPMPEVGIYHSPEVNAFATGP
HHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCC
SKSSSLVAVSSGLLQVMDNAEVEGVLAHELAHVANGDMVTMTLIQGIVNAFVMFFSRIIS
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YALSTMVKDEMQYTVRLISNIVLSILFSILGSIVVAYFSRTREYRADAGGAKLVGRQNMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHH
AALEKLRRTFDAPEDERGKEALATMKISGHNKWMALFSTHPPLEARIAALKNSGY
HHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCEEEEECCCCCHHHHHHHHHCCCH
>Mature Secondary Structure
MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGLNLSSLVIFCFLWGMGGAFVSLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSKFMAKMMMGVQIIDPRSASGAERELYSRVERLARAANLPMPEVGIYHSPEVNAFATGP
HHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCC
SKSSSLVAVSSGLLQVMDNAEVEGVLAHELAHVANGDMVTMTLIQGIVNAFVMFFSRIIS
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YALSTMVKDEMQYTVRLISNIVLSILFSILGSIVVAYFSRTREYRADAGGAKLVGRQNMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHH
AALEKLRRTFDAPEDERGKEALATMKISGHNKWMALFSTHPPLEARIAALKNSGY
HHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCEEEEECCCCCHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA