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The map label for this gene is apt

Identifier: 116332598

GI number: 116332598

Start: 197430

End: 197963

Strand: Reverse

Name: apt

Synonym: LBJ_4170

Alternate gene names: 116332598

Gene position: 197963-197430 (Counterclockwise)

Preceding gene: 116332599

Following gene: 116332597

Centisome position: 66.04

GC content: 43.26

Gene sequence:

>534_bases
ATGTCTATTGTTAAATCTAAAATCAGAACCATACCTGATTATCCAAAACCTGGAATCTTGTTTCGCGATATTACTTCACT
TTTACTTGATCCGGAGGGACTTGCATTGACAATTGGAACGTTTGTCAATCGTTACCAAGATAAAGGAATCACAAAGGTAG
CCGGAATCGAAGCTAGGGGTTTCCTCACGGGAGCACCTCTTGCTTTTCAGCTCGGAGTCGGCTTTATTCCCATACGTAAA
AAAGGAAAATTACCTGCCGAAACCGTATCGGAAGAATACGACCTCGAATACGGAAAAGACGTGATCGAAATCCATAAGGA
CGCAGTCCAGCCGGGAGATAAAATTCTTCTGATGGACGATCTAATCGCAACCGGAGGTACTATGATCGCCGCAGTAAAAC
TTCTTAAAAAACTCGGAGCTCAAATCTACGAAGCTGGAGTCATCATTGATCTTCCGGATTTGGGTGGAAGTAAGAAACTT
CAGGAAAAGCTTGAGGTTCCGGTTTTCGCGATTTGCGAATTCGAAGGACATTAG

Upstream 100 bases:

>100_bases
GCCGGGCTTTTCTCTATTCTGAACAAAAAAGAATTGTTTGAAATGTCTCTGATTTTTTGAATAGAACCGGTAAATTAAAA
ACCTGGGATGTAACACCTAG

Downstream 100 bases:

>100_bases
AAAATTCTAAAATTCTTTTTGGAGGATTCATTGACGGCTATAGTATCTGGTTTTTTGGGGATCCGAATCGGTTTGAAATG
TACGGTTCGTTTTTTTTCGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQDKGITKVAGIEARGFLTGAPLAFQLGVGFIPIRK
KGKLPAETVSEEYDLEYGKDVIEIHKDAVQPGDKILLMDDLIATGGTMIAAVKLLKKLGAQIYEAGVIIDLPDLGGSKKL
QEKLEVPVFAICEFEGH

Sequences:

>Translated_177_residues
MSIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQDKGITKVAGIEARGFLTGAPLAFQLGVGFIPIRK
KGKLPAETVSEEYDLEYGKDVIEIHKDAVQPGDKILLMDDLIATGGTMIAAVKLLKKLGAQIYEAGVIIDLPDLGGSKKL
QEKLEVPVFAICEFEGH
>Mature_176_residues
SIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQDKGITKVAGIEARGFLTGAPLAFQLGVGFIPIRKK
GKLPAETVSEEYDLEYGKDVIEIHKDAVQPGDKILLMDDLIATGGTMIAAVKLLKKLGAQIYEAGVIIDLPDLGGSKKLQ
EKLEVPVFAICEFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=178, Percent_Identity=42.6966292134831, Blast_Score=151, Evalue=3e-37,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=44.53125, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI1786675, Length=177, Percent_Identity=58.1920903954802, Blast_Score=213, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=47.5, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=37.7906976744186, Blast_Score=107, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=172, Percent_Identity=36.046511627907, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136334, Length=167, Percent_Identity=43.1137724550898, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_LEPBJ (Q04NG3)

Other databases:

- EMBL:   CP000351
- RefSeq:   YP_802315.1
- ProteinModelPortal:   Q04NG3
- SMR:   Q04NG3
- STRING:   Q04NG3
- GeneID:   4412333
- GenomeReviews:   CP000351_GR
- KEGG:   lbj:LBJ_4170
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q04NG3
- ProtClustDB:   PRK02304
- BioCyc:   LBOR355277:LBJ_4170-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19222; Mature: 19091

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQDKGITKVAGIEARG
CCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCCCC
FLTGAPLAFQLGVGFIPIRKKGKLPAETVSEEYDLEYGKDVIEIHKDAVQPGDKILLMDD
CCCCCCEEEECCCCEEEECCCCCCCHHHHHHHCCHHCCHHHHHHHHHHCCCCCEEEEEHH
LIATGGTMIAAVKLLKKLGAQIYEAGVIIDLPDLGGSKKLQEKLEVPVFAICEFEGH
HHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCEEEEEEECCC
>Mature Secondary Structure 
SIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQDKGITKVAGIEARG
CHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCCCC
FLTGAPLAFQLGVGFIPIRKKGKLPAETVSEEYDLEYGKDVIEIHKDAVQPGDKILLMDD
CCCCCCEEEECCCCEEEECCCCCCCHHHHHHHCCHHCCHHHHHHHHHHCCCCCEEEEEHH
LIATGGTMIAAVKLLKKLGAQIYEAGVIIDLPDLGGSKKLQEKLEVPVFAICEFEGH
HHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA