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The map label for this gene is metH [H]

Identifier: 116332527

GI number: 116332527

Start: 102207

End: 105950

Strand: Direct

Name: metH [H]

Synonym: LBJ_4091

Alternate gene names: 116332527

Gene position: 102207-105950 (Clockwise)

Preceding gene: 116332526

Following gene: 116332528

Centisome position: 34.1

GC content: 45.41

Gene sequence:

>3744_bases
ATGACTTATAAAGTTCAGAACTATACCAATCGTTCATCCCAGGAATTGTTAGGGCTCCTCGAAAAACAAATCTTAGTCAT
AGACGGGGCAATGGGAACGATGATCCAAAGATTCCTTCTCACCGAAGACGACTTCAGAGGGGAGGTTCTCAAAAACCATC
CGCATCCTCTCAAGGGGAACAACGAACTTCTTTGTTTGACAAGACCGGACGTAATTGAAGCGATTCACATTAAATTTTTG
GAAGCGGGAGCCAATATTTTAGAAACAAATACGTTCAGCTCGAATCAGGTTTCTCAAGGCGATTATAAAACGGAGTTTCT
CGTCGCGGATTTGAACAAGGCTGCGGTTCAATGCGCGCGTAACGCGATTGAAAAGTTTAAAAGGACAAATCGCCACCATC
CATGTTTTCTAGCCGGCGCGATCGGGCCTACGACTCGTACTGCGACACTTTCTCCGGATGTAAACAATCCTGCGTTTCGT
GCGGTGACTTTCGAAGATTTGGTTGCGACTTTTTACGAACAAGCACGCGCTCTTGTGGAAGCGGGGGTGGATCTGCTTCT
TCCCGAAACGAATATCGATACTTTGAATCTGAAGGCGGCAATCTTTGCGATCGAACAAGTATTCGAGGATCTTCAAGTTC
GAATTCCTGTGTGTCTTTCCGTAACGATCACAGACGCTTCGGGAAGGACTCTTTCCGGACAAACCGTGGAGGCATTTTAC
AATTCCATTGCACACTGTAAGCCTCTTTCGGTGGGAATCAATTGTGCGCTTGGTGCGGACGAAATGCGTCCTTATATCGA
GGAACTTGCGAGAATTTCATCCTGCTATATCAGTTGTTATCCGAATGCGGGATTGCCGAACGCGTTCGGAGGTTACGACC
AGACTCCGGAGGAATTCGGAGCTTATATTCAAGAGTTTGCAAGTTCTGGCTGGTTGAACATTACGGGCGGATGTTGCGGG
ACCACTCCCGAACATATCGCCGCTGCCACAAAAGCGGTCCAAGGGAAAAAGCCAAGAATACTTCCTCAGATCGAAGAAAT
CACAAGACTTTCTGGATTGGAGCCGTTGAACGTCACCTCTGATAAAGGATTTTTGCTCGTAGGGGAAAGAACCAACGTTA
CCGGATCTCCTAAATTCAAAAAGCTCATCATCGAAGGAAATTTCGAAGAAGCGGTTTCTGTTGCGTTACAACAAGTGGAA
GCGGGAGCGAATATCATCGATATCAATTTCGATGAAGCGCTGTTAGACGGCGAGGCATCGATGAGACATTTCCTAAATCT
CATCGCGGGCGAACCGGATATCGCAAAAGTTCCGTTCATGATCGATTCTTCCAAATGGAGCGTTCTGGAGGAAGGTCTGA
AATGTATTCAGGGAAAACCGATTGTAAATTCCATTTCTCTCAAAGAAGGAGAGGAAAAATTTTTAGAACACGCTCGTAAA
ATTCAAAGATACGGAGCTTCCGCGATCGTGATGGCATTTGACGAACGAGGACAAGCCGCGACCAAGGATGAGAAGGTTCG
TATTTGCAAAAGGGCATACGACCTTCTCGTAACGAAGGCGAATTTCAGTCCGACTGACATTATCTTTGATCCTAATATTC
TGACCGTGGCTACCGGGATTGAGGAACATAATAACTATGCAGTGGACTTTATAGAAGCTGTCCGTGAAATTAAAAAGTTT
TGTCCGGGTGCGAAAGTTTCGGGGGGGTTATCCAACGTATCTTTTTCCTTTAGAGGAAACAATCCCGTGAGAGAGGCGAT
GCACTCCGTTTTTTTATACCACGCGATACAAGCAGGGCTCGACATGGCAATCGTAAACGCAGGAATGCTTGCGGTCTATG
AAGAAATTTCGAAAGATTTATTAGAATATGTTGAAGATGTAATCCTAAATAGAAGACCAGACGCAACCGAACGTCTCGTG
GAATTTGCCGAAAGTATAAAATCCTCCGGGGACAAATCTGAAAAAAAAGGGGAAGCTTGGAGAGAAGGAACTACGGTCGA
GGAAAGGCTTTCGTACGCACTCGTCAAGGGAATCGTGGAGTATATCGATCAGGATACGGAAGAAGCCAGGCTCAAATACG
GACGTCCGTTAACCGTCATCGAAGGTCCTCTGATGGACGGAATGAAGATCGTGGGGGAATTATTCGGTGCCGGAAAGATG
TTTCTTCCCCAAGTGGTAAAAAGCGCTCGAGTCATGAAAAAATCCGTGGCCTATCTTCTTCCTTTTATGGAAGAAGAGAA
AAATCAATCGGAGGATGTGGCTGCCCGTCCTAAGTTTTTGATCGCGACCGTAAAAGGAGACGTTCACGATATAGGAAAGA
ACATCGTCGGAGTCGTTCTTGCATGTAATAACTACGAAGTGATCGATCTAGGCGTGATGGTACCTTCCGATAAAATTTTG
GAAGAAGCAAGGAAACATAACGTGAATATCATCGGGCTTTCCGGGCTTATCACTCCTTCACTCGATGAGATGGTACACGT
GGCTTCCGAGATGAAACGAACCGGCTTCGAAATCCCTCTTTTGATCGGAGGAGCGACCACGAGTTCCGCGCACACTGCGG
TAAAAATCGCGCCCGTATATGATCCACCTGTAGTACATGTGGTGGACGCTTCTCGGGTTGTAAACGTGGTAAATCAGCTT
TTACATCCGGATTTAAACGAGGGGTATGCTCAAAAGATCAAAGAAGACCAAAAGACGGCTCGAGAGAATTATTTTAATAC
GAGGGCGGAAAGGAAATTAATTTCTTTGGAACAAGCCAGAGAGAATCGGGAAGAGATCGATTGGACGGCTGCGACAATCG
ATAAACCTTCTTTTACAGGAATACGGATTTTTGACGAAGAAATTTCTTTGGAAACGTTGATACCGTTTATTGATTGGACT
CCGTTTTTTACCGCCTGGGAACTCAAGGGAAGATATCCCGCGATTTTGGAAAGTGAAACTACTGGAAAACAGGCGAGAGA
ACTTTTCGCGGACGCGCAAAAACTCATGAAGACAATCGTGGACGGAAAACTTTTTAAGACGAAAGGAGTAATTGGAATTT
TTCCGGCAAATTCGGTCGGAGACGACATCGAAATCTATGAAAACGAAAACCGTTCTAAACTTCTCACAGTGTTTCATACA
CTTCGTCAACAGATTCAAAAAGAAGACTCATCGGAGCCGAATTATTGTTTGGCGGACTACATCGCTCCGAAGAATTCTGG
GAGGATCGATTATATAGGCGGATTTGCCGTTACCGCCGGACACGGAGTCGAGGAATTCGCGAAAGATTTCGAAAACCACC
AAGACGACTACAACTCGATTATGGCGAAGGCTTTAGGAGATCGTTTTGCGGAAGCTTTTGCGGAATACATGCATTACAAG
GTTCGAAAAGAATATTGGGGTTATGACAAGGATGAAAATCTTTCTCCCGAAGATCTAATCCGTGAAAAATACAGGGGGAT
TCGTCCGGCGGCGGGTTATCCGGCTTCTCCCGATCATACCGAAAAGAGAATTTTATTCGATTTATTGCAGGTTGAAAAAA
ATACAGGAATTACACTTACCGAACATTTTGCGATGTGGCCTGCAAGTTCGGTCAGCGGCCTCTACTTTGCGCATCCTAAA
TCAAAATATTTCGCGGTCGCAAAGATCAACCGAGATCAAATTGAAGAATACGCAAAACGAAAGGTAATGAGTGTCGAAGA
AGTCGAACGTTGGCTGGCTCCGAATCTTGCCTATGATCCTCTTGCGGTTTCGGTGGTCCGATAA

Upstream 100 bases:

>100_bases
ATAGACGTGAAAGTTCCTCTCAAAAAAGAGGGATGTATAAATCCGGAATATTAGGATTTAATGTTATATTATTTATTAGA
ATTATCAAAGAAGTTTGCTT

Downstream 100 bases:

>100_bases
AACTTCGAACCTAATTTCGATTCTATTCGTCTTATTAGAGTAGAAAATTATGGAACCGAACATTCCTAATCATTTTTTTG
TACACGATCACGGTCCGGTG

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS [H]

Number of amino acids: Translated: 1247; Mature: 1246

Protein sequence:

>1247_residues
MTYKVQNYTNRSSQELLGLLEKQILVIDGAMGTMIQRFLLTEDDFRGEVLKNHPHPLKGNNELLCLTRPDVIEAIHIKFL
EAGANILETNTFSSNQVSQGDYKTEFLVADLNKAAVQCARNAIEKFKRTNRHHPCFLAGAIGPTTRTATLSPDVNNPAFR
AVTFEDLVATFYEQARALVEAGVDLLLPETNIDTLNLKAAIFAIEQVFEDLQVRIPVCLSVTITDASGRTLSGQTVEAFY
NSIAHCKPLSVGINCALGADEMRPYIEELARISSCYISCYPNAGLPNAFGGYDQTPEEFGAYIQEFASSGWLNITGGCCG
TTPEHIAAATKAVQGKKPRILPQIEEITRLSGLEPLNVTSDKGFLLVGERTNVTGSPKFKKLIIEGNFEEAVSVALQQVE
AGANIIDINFDEALLDGEASMRHFLNLIAGEPDIAKVPFMIDSSKWSVLEEGLKCIQGKPIVNSISLKEGEEKFLEHARK
IQRYGASAIVMAFDERGQAATKDEKVRICKRAYDLLVTKANFSPTDIIFDPNILTVATGIEEHNNYAVDFIEAVREIKKF
CPGAKVSGGLSNVSFSFRGNNPVREAMHSVFLYHAIQAGLDMAIVNAGMLAVYEEISKDLLEYVEDVILNRRPDATERLV
EFAESIKSSGDKSEKKGEAWREGTTVEERLSYALVKGIVEYIDQDTEEARLKYGRPLTVIEGPLMDGMKIVGELFGAGKM
FLPQVVKSARVMKKSVAYLLPFMEEEKNQSEDVAARPKFLIATVKGDVHDIGKNIVGVVLACNNYEVIDLGVMVPSDKIL
EEARKHNVNIIGLSGLITPSLDEMVHVASEMKRTGFEIPLLIGGATTSSAHTAVKIAPVYDPPVVHVVDASRVVNVVNQL
LHPDLNEGYAQKIKEDQKTARENYFNTRAERKLISLEQARENREEIDWTAATIDKPSFTGIRIFDEEISLETLIPFIDWT
PFFTAWELKGRYPAILESETTGKQARELFADAQKLMKTIVDGKLFKTKGVIGIFPANSVGDDIEIYENENRSKLLTVFHT
LRQQIQKEDSSEPNYCLADYIAPKNSGRIDYIGGFAVTAGHGVEEFAKDFENHQDDYNSIMAKALGDRFAEAFAEYMHYK
VRKEYWGYDKDENLSPEDLIREKYRGIRPAAGYPASPDHTEKRILFDLLQVEKNTGITLTEHFAMWPASSVSGLYFAHPK
SKYFAVAKINRDQIEEYAKRKVMSVEEVERWLAPNLAYDPLAVSVVR

Sequences:

>Translated_1247_residues
MTYKVQNYTNRSSQELLGLLEKQILVIDGAMGTMIQRFLLTEDDFRGEVLKNHPHPLKGNNELLCLTRPDVIEAIHIKFL
EAGANILETNTFSSNQVSQGDYKTEFLVADLNKAAVQCARNAIEKFKRTNRHHPCFLAGAIGPTTRTATLSPDVNNPAFR
AVTFEDLVATFYEQARALVEAGVDLLLPETNIDTLNLKAAIFAIEQVFEDLQVRIPVCLSVTITDASGRTLSGQTVEAFY
NSIAHCKPLSVGINCALGADEMRPYIEELARISSCYISCYPNAGLPNAFGGYDQTPEEFGAYIQEFASSGWLNITGGCCG
TTPEHIAAATKAVQGKKPRILPQIEEITRLSGLEPLNVTSDKGFLLVGERTNVTGSPKFKKLIIEGNFEEAVSVALQQVE
AGANIIDINFDEALLDGEASMRHFLNLIAGEPDIAKVPFMIDSSKWSVLEEGLKCIQGKPIVNSISLKEGEEKFLEHARK
IQRYGASAIVMAFDERGQAATKDEKVRICKRAYDLLVTKANFSPTDIIFDPNILTVATGIEEHNNYAVDFIEAVREIKKF
CPGAKVSGGLSNVSFSFRGNNPVREAMHSVFLYHAIQAGLDMAIVNAGMLAVYEEISKDLLEYVEDVILNRRPDATERLV
EFAESIKSSGDKSEKKGEAWREGTTVEERLSYALVKGIVEYIDQDTEEARLKYGRPLTVIEGPLMDGMKIVGELFGAGKM
FLPQVVKSARVMKKSVAYLLPFMEEEKNQSEDVAARPKFLIATVKGDVHDIGKNIVGVVLACNNYEVIDLGVMVPSDKIL
EEARKHNVNIIGLSGLITPSLDEMVHVASEMKRTGFEIPLLIGGATTSSAHTAVKIAPVYDPPVVHVVDASRVVNVVNQL
LHPDLNEGYAQKIKEDQKTARENYFNTRAERKLISLEQARENREEIDWTAATIDKPSFTGIRIFDEEISLETLIPFIDWT
PFFTAWELKGRYPAILESETTGKQARELFADAQKLMKTIVDGKLFKTKGVIGIFPANSVGDDIEIYENENRSKLLTVFHT
LRQQIQKEDSSEPNYCLADYIAPKNSGRIDYIGGFAVTAGHGVEEFAKDFENHQDDYNSIMAKALGDRFAEAFAEYMHYK
VRKEYWGYDKDENLSPEDLIREKYRGIRPAAGYPASPDHTEKRILFDLLQVEKNTGITLTEHFAMWPASSVSGLYFAHPK
SKYFAVAKINRDQIEEYAKRKVMSVEEVERWLAPNLAYDPLAVSVVR
>Mature_1246_residues
TYKVQNYTNRSSQELLGLLEKQILVIDGAMGTMIQRFLLTEDDFRGEVLKNHPHPLKGNNELLCLTRPDVIEAIHIKFLE
AGANILETNTFSSNQVSQGDYKTEFLVADLNKAAVQCARNAIEKFKRTNRHHPCFLAGAIGPTTRTATLSPDVNNPAFRA
VTFEDLVATFYEQARALVEAGVDLLLPETNIDTLNLKAAIFAIEQVFEDLQVRIPVCLSVTITDASGRTLSGQTVEAFYN
SIAHCKPLSVGINCALGADEMRPYIEELARISSCYISCYPNAGLPNAFGGYDQTPEEFGAYIQEFASSGWLNITGGCCGT
TPEHIAAATKAVQGKKPRILPQIEEITRLSGLEPLNVTSDKGFLLVGERTNVTGSPKFKKLIIEGNFEEAVSVALQQVEA
GANIIDINFDEALLDGEASMRHFLNLIAGEPDIAKVPFMIDSSKWSVLEEGLKCIQGKPIVNSISLKEGEEKFLEHARKI
QRYGASAIVMAFDERGQAATKDEKVRICKRAYDLLVTKANFSPTDIIFDPNILTVATGIEEHNNYAVDFIEAVREIKKFC
PGAKVSGGLSNVSFSFRGNNPVREAMHSVFLYHAIQAGLDMAIVNAGMLAVYEEISKDLLEYVEDVILNRRPDATERLVE
FAESIKSSGDKSEKKGEAWREGTTVEERLSYALVKGIVEYIDQDTEEARLKYGRPLTVIEGPLMDGMKIVGELFGAGKMF
LPQVVKSARVMKKSVAYLLPFMEEEKNQSEDVAARPKFLIATVKGDVHDIGKNIVGVVLACNNYEVIDLGVMVPSDKILE
EARKHNVNIIGLSGLITPSLDEMVHVASEMKRTGFEIPLLIGGATTSSAHTAVKIAPVYDPPVVHVVDASRVVNVVNQLL
HPDLNEGYAQKIKEDQKTARENYFNTRAERKLISLEQARENREEIDWTAATIDKPSFTGIRIFDEEISLETLIPFIDWTP
FFTAWELKGRYPAILESETTGKQARELFADAQKLMKTIVDGKLFKTKGVIGIFPANSVGDDIEIYENENRSKLLTVFHTL
RQQIQKEDSSEPNYCLADYIAPKNSGRIDYIGGFAVTAGHGVEEFAKDFENHQDDYNSIMAKALGDRFAEAFAEYMHYKV
RKEYWGYDKDENLSPEDLIREKYRGIRPAAGYPASPDHTEKRILFDLLQVEKNTGITLTEHFAMWPASSVSGLYFAHPKS
KYFAVAKINRDQIEEYAKRKVMSVEEVERWLAPNLAYDPLAVSVVR

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1254, Percent_Identity=54.1467304625199, Blast_Score=1369, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1228, Percent_Identity=58.8762214983713, Blast_Score=1473, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535405, Length=1252, Percent_Identity=54.3130990415335, Blast_Score=1335, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 138804; Mature: 138672

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYKVQNYTNRSSQELLGLLEKQILVIDGAMGTMIQRFLLTEDDFRGEVLKNHPHPLKGN
CCEEECCCCCCCHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
NELLCLTRPDVIEAIHIKFLEAGANILETNTFSSNQVSQGDYKTEFLVADLNKAAVQCAR
CCEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
NAIEKFKRTNRHHPCFLAGAIGPTTRTATLSPDVNNPAFRAVTFEDLVATFYEQARALVE
HHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
AGVDLLLPETNIDTLNLKAAIFAIEQVFEDLQVRIPVCLSVTITDASGRTLSGQTVEAFY
CCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCEECCCHHHHHH
NSIAHCKPLSVGINCALGADEMRPYIEELARISSCYISCYPNAGLPNAFGGYDQTPEEFG
HHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHH
AYIQEFASSGWLNITGGCCGTTPEHIAAATKAVQGKKPRILPQIEEITRLSGLEPLNVTS
HHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCC
DKGFLLVGERTNVTGSPKFKKLIIEGNFEEAVSVALQQVEAGANIIDINFDEALLDGEAS
CCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCHHHHCCHHH
MRHFLNLIAGEPDIAKVPFMIDSSKWSVLEEGLKCIQGKPIVNSISLKEGEEKFLEHARK
HHHHHHHHCCCCCCEECCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
IQRYGASAIVMAFDERGQAATKDEKVRICKRAYDLLVTKANFSPTDIIFDPNILTVATGI
HHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEECCCEEEEEECC
EEHNNYAVDFIEAVREIKKFCPGAKVSGGLSNVSFSFRGNNPVREAMHSVFLYHAIQAGL
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
DMAIVNAGMLAVYEEISKDLLEYVEDVILNRRPDATERLVEFAESIKSSGDKSEKKGEAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCHHH
REGTTVEERLSYALVKGIVEYIDQDTEEARLKYGRPLTVIEGPLMDGMKIVGELFGAGKM
HCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHH
FLPQVVKSARVMKKSVAYLLPFMEEEKNQSEDVAARPKFLIATVKGDVHDIGKNIVGVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEECCCHHHHHHHHEEEEE
ACNNYEVIDLGVMVPSDKILEEARKHNVNIIGLSGLITPSLDEMVHVASEMKRTGFEIPL
EECCEEEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
LIGGATTSSAHTAVKIAPVYDPPVVHVVDASRVVNVVNQLLHPDLNEGYAQKIKEDQKTA
EEECCCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RENYFNTRAERKLISLEQARENREEIDWTAATIDKPSFTGIRIFDEEISLETLIPFIDWT
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHCCC
PFFTAWELKGRYPAILESETTGKQARELFADAQKLMKTIVDGKLFKTKGVIGIFPANSVG
CCCEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCC
DDIEIYENENRSKLLTVFHTLRQQIQKEDSSEPNYCLADYIAPKNSGRIDYIGGFAVTAG
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCEEEECC
HGVEEFAKDFENHQDDYNSIMAKALGDRFAEAFAEYMHYKVRKEYWGYDKDENLSPEDLI
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
REKYRGIRPAAGYPASPDHTEKRILFDLLQVEKNTGITLTEHFAMWPASSVSGLYFAHPK
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCEEEECCC
SKYFAVAKINRDQIEEYAKRKVMSVEEVERWLAPNLAYDPLAVSVVR
CCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TYKVQNYTNRSSQELLGLLEKQILVIDGAMGTMIQRFLLTEDDFRGEVLKNHPHPLKGN
CEEECCCCCCCHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
NELLCLTRPDVIEAIHIKFLEAGANILETNTFSSNQVSQGDYKTEFLVADLNKAAVQCAR
CCEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
NAIEKFKRTNRHHPCFLAGAIGPTTRTATLSPDVNNPAFRAVTFEDLVATFYEQARALVE
HHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
AGVDLLLPETNIDTLNLKAAIFAIEQVFEDLQVRIPVCLSVTITDASGRTLSGQTVEAFY
CCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCEECCCHHHHHH
NSIAHCKPLSVGINCALGADEMRPYIEELARISSCYISCYPNAGLPNAFGGYDQTPEEFG
HHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHH
AYIQEFASSGWLNITGGCCGTTPEHIAAATKAVQGKKPRILPQIEEITRLSGLEPLNVTS
HHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCC
DKGFLLVGERTNVTGSPKFKKLIIEGNFEEAVSVALQQVEAGANIIDINFDEALLDGEAS
CCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCHHHHCCHHH
MRHFLNLIAGEPDIAKVPFMIDSSKWSVLEEGLKCIQGKPIVNSISLKEGEEKFLEHARK
HHHHHHHHCCCCCCEECCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
IQRYGASAIVMAFDERGQAATKDEKVRICKRAYDLLVTKANFSPTDIIFDPNILTVATGI
HHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEECCCEEEEEECC
EEHNNYAVDFIEAVREIKKFCPGAKVSGGLSNVSFSFRGNNPVREAMHSVFLYHAIQAGL
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
DMAIVNAGMLAVYEEISKDLLEYVEDVILNRRPDATERLVEFAESIKSSGDKSEKKGEAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCHHH
REGTTVEERLSYALVKGIVEYIDQDTEEARLKYGRPLTVIEGPLMDGMKIVGELFGAGKM
HCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHH
FLPQVVKSARVMKKSVAYLLPFMEEEKNQSEDVAARPKFLIATVKGDVHDIGKNIVGVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEECCCHHHHHHHHEEEEE
ACNNYEVIDLGVMVPSDKILEEARKHNVNIIGLSGLITPSLDEMVHVASEMKRTGFEIPL
EECCEEEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
LIGGATTSSAHTAVKIAPVYDPPVVHVVDASRVVNVVNQLLHPDLNEGYAQKIKEDQKTA
EEECCCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RENYFNTRAERKLISLEQARENREEIDWTAATIDKPSFTGIRIFDEEISLETLIPFIDWT
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHCCC
PFFTAWELKGRYPAILESETTGKQARELFADAQKLMKTIVDGKLFKTKGVIGIFPANSVG
CCCEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCC
DDIEIYENENRSKLLTVFHTLRQQIQKEDSSEPNYCLADYIAPKNSGRIDYIGGFAVTAG
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCEEEECC
HGVEEFAKDFENHQDDYNSIMAKALGDRFAEAFAEYMHYKVRKEYWGYDKDENLSPEDLI
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
REKYRGIRPAAGYPASPDHTEKRILFDLLQVEKNTGITLTEHFAMWPASSVSGLYFAHPK
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCEEEECCC
SKYFAVAKINRDQIEEYAKRKVMSVEEVERWLAPNLAYDPLAVSVVR
CCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2185137; 2668277; 8369296; 8265357; 9278503; 1593636; 7992050; 8939751 [H]