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The map label for this gene is sahH

Identifier: 116332525

GI number: 116332525

Start: 100475

End: 101785

Strand: Direct

Name: sahH

Synonym: LBJ_4089

Alternate gene names: 116332525

Gene position: 100475-101785 (Clockwise)

Preceding gene: 116332524

Following gene: 116332526

Centisome position: 33.52

GC content: 46.15

Gene sequence:

>1311_bases
ATGTCCGCAACAACACAAGAAAAAGGTTTAAACTATAAAGTAAAGGATCTTTCCCAAGCTGAGTGGGGAAGGCAGGAGAT
CATCCTGGCAGAAAAAGAAATGCCCGGTCTTATGGCGTTAAGACAGGAATACAAAGGTAAAAAACCTTTGGCGGGTGCAA
GAATTGCCGGATCTCTTCACATGACGATTCAGACCGCGGTTTTGATCGAAACCCTGACGGAATTGGGAGCGGAGGTTCGC
TGGTCTTCTTGTAATATCTTTTCAACTCAAGATCATGCCGCCGCTGCGATCGCTAAGGCCGGGGTTCCCGTTTTTGCATG
GAAAGGAGAAACCGAAGAGGAATACTGGTGGTGTATCGAACAAACCCTTTTCTTCGGAGACAAAGGACCGAACATGATAC
TCGATGACGGAGGAGATCTCACTGCTTACGTTCACGAGAAGTATCCTAAATTGTTAAGCGAAATTCGTGGTATTTCCGAA
GAAACGACCACAGGTGTCAAGAGTCTTTACAAGTTACTCAAAAAGGGGGAATTGAAAGTCCCCGCGTTCAACGTAAACGA
TTCTGTTACCAAGTCTAAGTTTGACAACCTCTACGGATGTCGCGAATCTCTCGCGGACGGAATCAAAAGAGCGACCGACG
TTATGCTCGCAGGTAAAGTGGCTCTCGTTTGCGGTTTTGGAGACGTAGGTAAAGGGTCCGCCGCTTCTCTTCGTAATTTC
GGCGCAAGAGTGATCGTAACCGAAATCGATCCGATTTGCGCTCTTCAAGCTTCTATGGAAGGTTATCAGGTTCTTCGTGT
GGAAGACATTATCGAACAGGTGGACATCGTAGTAACCGCGACCGGGAACGACGATATCATCACTCTCGAACACATGAAAG
CGATGAAAGACGGTGCGATCCTCTGTAACATCGGACACTTCGATACCGAAATCCAAATGTCCAGATTAAATTCCGAAAAA
GGCGTAACCAAAAAAGAAATTAAACCTCAGGTGGACAAATACACTTTCCCTGACGGTAAATCCATCGTCGTTCTCGCAGA
AGGACGTCTTGTAAACTTAGGTTGTGCGACCGGTCACCCTTCGTTCGTAATGTCCTGTTCATTTACCAATCAGGTATTGG
CTCAGATCGAACTTTACAACAACAAATATGAACTCGGGGTCTACACCCTTCCGAAACATTTGGATGAGAAAGTGGCTGCT
CTTCATCTCGAACAGTTGGGGGTTCGTTTAACAAAACTGAACCAGAAACAAGCCGACTATTTGGGAGTTCCGCTCAACGG
ACCTTTCAAGCCGGAGAACTATAGATATTAA

Upstream 100 bases:

>100_bases
TGGAACTTTCTGGTTTTAGGGTCGGTTCTTACGAGGAGTTTGATACGGGTAACGTTTTCAAAATTTTGATCATTCAAGCA
AAGAAAAAGGAGGACTAAAA

Downstream 100 bases:

>100_bases
TCTACAAGCCTTTCCAAGTGCGGACTTCGAACTTTACGGTTCGTTTGTCCGTCTCGGAAGGATCGGACTTTTCGAATGGC
TTATGTTGTCACAGAACCTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSATTQEKGLNYKVKDLSQAEWGRQEIILAEKEMPGLMALRQEYKGKKPLAGARIAGSLHMTIQTAVLIETLTELGAEVR
WSSCNIFSTQDHAAAAIAKAGVPVFAWKGETEEEYWWCIEQTLFFGDKGPNMILDDGGDLTAYVHEKYPKLLSEIRGISE
ETTTGVKSLYKLLKKGELKVPAFNVNDSVTKSKFDNLYGCRESLADGIKRATDVMLAGKVALVCGFGDVGKGSAASLRNF
GARVIVTEIDPICALQASMEGYQVLRVEDIIEQVDIVVTATGNDDIITLEHMKAMKDGAILCNIGHFDTEIQMSRLNSEK
GVTKKEIKPQVDKYTFPDGKSIVVLAEGRLVNLGCATGHPSFVMSCSFTNQVLAQIELYNNKYELGVYTLPKHLDEKVAA
LHLEQLGVRLTKLNQKQADYLGVPLNGPFKPENYRY

Sequences:

>Translated_436_residues
MSATTQEKGLNYKVKDLSQAEWGRQEIILAEKEMPGLMALRQEYKGKKPLAGARIAGSLHMTIQTAVLIETLTELGAEVR
WSSCNIFSTQDHAAAAIAKAGVPVFAWKGETEEEYWWCIEQTLFFGDKGPNMILDDGGDLTAYVHEKYPKLLSEIRGISE
ETTTGVKSLYKLLKKGELKVPAFNVNDSVTKSKFDNLYGCRESLADGIKRATDVMLAGKVALVCGFGDVGKGSAASLRNF
GARVIVTEIDPICALQASMEGYQVLRVEDIIEQVDIVVTATGNDDIITLEHMKAMKDGAILCNIGHFDTEIQMSRLNSEK
GVTKKEIKPQVDKYTFPDGKSIVVLAEGRLVNLGCATGHPSFVMSCSFTNQVLAQIELYNNKYELGVYTLPKHLDEKVAA
LHLEQLGVRLTKLNQKQADYLGVPLNGPFKPENYRY
>Mature_435_residues
SATTQEKGLNYKVKDLSQAEWGRQEIILAEKEMPGLMALRQEYKGKKPLAGARIAGSLHMTIQTAVLIETLTELGAEVRW
SSCNIFSTQDHAAAAIAKAGVPVFAWKGETEEEYWWCIEQTLFFGDKGPNMILDDGGDLTAYVHEKYPKLLSEIRGISEE
TTTGVKSLYKLLKKGELKVPAFNVNDSVTKSKFDNLYGCRESLADGIKRATDVMLAGKVALVCGFGDVGKGSAASLRNFG
ARVIVTEIDPICALQASMEGYQVLRVEDIIEQVDIVVTATGNDDIITLEHMKAMKDGAILCNIGHFDTEIQMSRLNSEKG
VTKKEIKPQVDKYTFPDGKSIVVLAEGRLVNLGCATGHPSFVMSCSFTNQVLAQIELYNNKYELGVYTLPKHLDEKVAAL
HLEQLGVRLTKLNQKQADYLGVPLNGPFKPENYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=429, Percent_Identity=68.5314685314685, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI239937451, Length=405, Percent_Identity=69.6296296296296, Blast_Score=563, Evalue=1e-161,
Organism=Homo sapiens, GI24308043, Length=429, Percent_Identity=55.4778554778555, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI298286489, Length=429, Percent_Identity=55.4778554778555, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI195539337, Length=429, Percent_Identity=55.4778554778555, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI195539349, Length=429, Percent_Identity=55.4778554778555, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI21361647, Length=436, Percent_Identity=55.7339449541284, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17506425, Length=432, Percent_Identity=69.6759259259259, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6320882, Length=456, Percent_Identity=65.1315789473684, Blast_Score=569, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24642172, Length=429, Percent_Identity=69.2307692307692, Blast_Score=594, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24656245, Length=422, Percent_Identity=53.7914691943128, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45553387, Length=430, Percent_Identity=52.5581395348837, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45553385, Length=429, Percent_Identity=52.4475524475524, Blast_Score=459, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_LEPBJ (Q04NN6)

Other databases:

- EMBL:   CP000351
- RefSeq:   YP_802242.1
- ProteinModelPortal:   Q04NN6
- SMR:   Q04NN6
- STRING:   Q04NN6
- GeneID:   4412366
- GenomeReviews:   CP000351_GR
- KEGG:   lbj:LBJ_4089
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q04NN6
- ProtClustDB:   PRK05476
- BioCyc:   LBOR355277:LBJ_4089-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 48097; Mature: 47966

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 62-62 BINDING 136-136 BINDING 161-161 BINDING 191-191 BINDING 195-195 BINDING 196-196 BINDING 248-248 BINDING 283-283 BINDING 352-352

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATTQEKGLNYKVKDLSQAEWGRQEIILAEKEMPGLMALRQEYKGKKPLAGARIAGSLH
CCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEECEEE
MTIQTAVLIETLTELGAEVRWSSCNIFSTQDHAAAAIAKAGVPVFAWKGETEEEYWWCIE
EHHHHHHHHHHHHHHCCEEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCCCHHHEEEE
QTLFFGDKGPNMILDDGGDLTAYVHEKYPKLLSEIRGISEETTTGVKSLYKLLKKGELKV
HHEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEC
PAFNVNDSVTKSKFDNLYGCRESLADGIKRATDVMLAGKVALVCGFGDVGKGSAASLRNF
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECCCCCCCCHHHHHHC
GARVIVTEIDPICALQASMEGYQVLRVEDIIEQVDIVVTATGNDDIITLEHMKAMKDGAI
CCEEEEEECCCHHHHHHCCCCEEEEEHHHHHHHCEEEEEECCCCCEEEHHHHHHHCCCEE
LCNIGHFDTEIQMSRLNSEKGVTKKEIKPQVDKYTFPDGKSIVVLAEGRLVNLGCATGHP
EEEECCCCCCHHHHHCCCCCCCCHHHCCCCCCCEECCCCCEEEEEECCEEEEEEECCCCC
SFVMSCSFTNQVLAQIELYNNKYELGVYTLPKHLDEKVAALHLEQLGVRLTKLNQKQADY
CEEEEECHHHHHHHHEEEECCEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHCCCCCCCE
LGVPLNGPFKPENYRY
EECCCCCCCCCCCCCC
>Mature Secondary Structure 
SATTQEKGLNYKVKDLSQAEWGRQEIILAEKEMPGLMALRQEYKGKKPLAGARIAGSLH
CCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEECEEE
MTIQTAVLIETLTELGAEVRWSSCNIFSTQDHAAAAIAKAGVPVFAWKGETEEEYWWCIE
EHHHHHHHHHHHHHHCCEEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCCCHHHEEEE
QTLFFGDKGPNMILDDGGDLTAYVHEKYPKLLSEIRGISEETTTGVKSLYKLLKKGELKV
HHEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEC
PAFNVNDSVTKSKFDNLYGCRESLADGIKRATDVMLAGKVALVCGFGDVGKGSAASLRNF
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECCCCCCCCHHHHHHC
GARVIVTEIDPICALQASMEGYQVLRVEDIIEQVDIVVTATGNDDIITLEHMKAMKDGAI
CCEEEEEECCCHHHHHHCCCCEEEEEHHHHHHHCEEEEEECCCCCEEEHHHHHHHCCCEE
LCNIGHFDTEIQMSRLNSEKGVTKKEIKPQVDKYTFPDGKSIVVLAEGRLVNLGCATGHP
EEEECCCCCCHHHHHCCCCCCCCHHHCCCCCCCEECCCCCEEEEEECCEEEEEEECCCCC
SFVMSCSFTNQVLAQIELYNNKYELGVYTLPKHLDEKVAALHLEQLGVRLTKLNQKQADY
CEEEEECHHHHHHHHEEEECCEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHCCCCCCCE
LGVPLNGPFKPENYRY
EECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA