| Definition | Leptospira borgpetersenii serovar Hardjo-bovis JB197 chromosome 2, complete sequence. |
|---|---|
| Accession | NC_008511 |
| Length | 299,762 |
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The map label for this gene is meaA [H]
Identifier: 116332504
GI number: 116332504
Start: 65997
End: 68009
Strand: Reverse
Name: meaA [H]
Synonym: LBJ_4062
Alternate gene names: 116332504
Gene position: 68009-65997 (Counterclockwise)
Preceding gene: 116332516
Following gene: 116332503
Centisome position: 22.69
GC content: 45.85
Gene sequence:
>2013_bases ATGGAAAATAAAAATCATATCCTATACGACAAATCCGGCAAACCCTCTAAAGAACCTGCTTGGATTTTCAGAACGTATGC GGGGCACACAAACGCGAGAGAATCTAACGAACTTTTTAGAAAAAATCTATCCAAAGGACAAACGGGTCTTTCCATCGCCT TCGACTTGGCAACCCAGTGCGGTTATAGTTCCGATCATGCTATCGCAAAACCGGAAATCGGGAAGGTCGGCGTTCCGATC AACACTCTGGAAGATTTTAGAATCCTTTTCAATCAAATTCCGATCGAAGAGATGAACACTTCGATGACGATCAACGGGAC CTCGATGTATCTTTTGTCCCTTTACGTCGCCCTCGCCCAGGAACGCGGAGTAGACGTTGCCCTTCTTCAAGGAACCACTC AGAACGACATCATTAAAGAATACCTCGCAAGGGGGACATACATCTTTCCTCCCGCACAATCGATCCGAGTCATCGTCGAT ATGTACGAATATTGTCTGAAAAACATTCCGAAATGGAACCCTTCCAACATTTGTTCGTATCACCTGCAGGAAGCCGGAGC GACACCCGTGCAGGAACTTGCGTTCGCACTCGCGACCGCAATGGCAATTCTCGACGCGATCAAGGAAAGAAATTGTTTCA CCGCCGAAGAGTTCGAACAATGTGTGGGAAGAATTTCATTCTTCGTAAACGCGGGTATTCGTTTTGTAGAAGAGATGTGC AAGATGCGCGCCTTTACGGAAATGTGGGACGAGATTACGAAAGATCGTTATCAAGTGAAACAGGAGAAATACCGCCGTTT CCGTTACGGGGTTCAGGTGAATTCTCTCGGTCTCACCGAAGAACAACCAGAAAACAACGCATGGAGAATTCTCATAGAAG CGTTAGGCGTCACCATGAGCCGCGATGCACGTTGCAGAGCGCTTCAGCTTCCCGCTTGGAACGAAGCTCTTTCCCTTCCA AGACCTTGGGACCAACAATGGTCTTTGAGATTGCAGCAGGTTCTCGCATATGAAACTGATCTTCTCGAATATCCGGACCT ATTCGAAGGTTCTAAAGTCGTCGAAAGTAAAGTAAAAGAACTCAAAGTAGAAGCTTACAAAGAAATTCAAAAGATACTTG ATATGGGCGGAGCGGTCAAAGCAATCGAAAACGGTTATATGAAATCTCAGCTCGTCAAGTCCCAAGCGGAACGTCTTACT AAGATCAACAACAATGAACTCATCATCGTTGGTAAAAACAAATGGACCGAGGGAACTCCTTCCCCACTCATGACCGATCA AGACGGAGGAATTTTTAAAGTGGATCCTAAATCCGCAGAAGAAACCTTAGAAGTACTTGCAAAAGTAAAATCGACAAGAG ACGCAAACAAAGTCAAAGAGGCTCTCTCTCAACTTGAAGCGGATGCGAAAGCCGGTAAAAATCTAATGTACGCTTCCATC GAATGTGCAAAAACAGGAATTTCAACCGGCGAATGGGCGGACGTTCTCAGATCCGTCTTCGGAGAATATAGACCTGCCAC CGGTGTAGAAGGACAAAAACTCAATCTTGAAACCGACAAAGTGATCCGAGTAAGGGGAAAAGTGGAAGCGTTTTTCAAAG CGAACGGTTCCAGACCTAAAATCGTGGTCGGCAAACCGGGGCTAGACGGTCACTCTAACGGTGCGGAGATGATAGCCGTT TCCGCAAAACACGCCGGATTTGACGTGATTTATTCCGGAATTCGTTTAACACCCGAGGAGATCGTTCAAACCGCGGTGGA AGAAAATGCGGACGTGATCGGAGTTTCGATTCTTTCCGGTTCTCATTTAGAACTTGCGGAACAGATTTTCAACGAACTAA AACACTACAAAGCGGATATCCCTGTGGTCTTTGGGGGAATCATCCCTTCGAACGACTTTGACTCTCTGACTAAACTCGGA GTCAAAGCAATCTTCACTCCAAAAGACTACGATCTAATGGACGTGATGGAAAGAATCATCGATATCATTTCTCAGACGAT AAAAGCCGCATAA
Upstream 100 bases:
>100_bases TAGGGTTTTTGCGGAAATCAGAGCAAGGATAAAAATTTGGGTGAAATTCTACCAACACATTTTGAAGTATCAATGAGAAC CTCGAATCGGGACAAAATTC
Downstream 100 bases:
>100_bases CGCGGTTTGACGGGTATGCCGTGAAACATCGCAAAGAAGATCTCGCGAAACTCATCGAAGGAGCACGCGAAGGGGAAAAA TTTCCCCTCGCGAAGCTCAT
Product: methylmalonyl-CoA mutase
Products: succinyl-CoA
Alternate protein names: NA
Number of amino acids: Translated: 670; Mature: 670
Protein sequence:
>670_residues MENKNHILYDKSGKPSKEPAWIFRTYAGHTNARESNELFRKNLSKGQTGLSIAFDLATQCGYSSDHAIAKPEIGKVGVPI NTLEDFRILFNQIPIEEMNTSMTINGTSMYLLSLYVALAQERGVDVALLQGTTQNDIIKEYLARGTYIFPPAQSIRVIVD MYEYCLKNIPKWNPSNICSYHLQEAGATPVQELAFALATAMAILDAIKERNCFTAEEFEQCVGRISFFVNAGIRFVEEMC KMRAFTEMWDEITKDRYQVKQEKYRRFRYGVQVNSLGLTEEQPENNAWRILIEALGVTMSRDARCRALQLPAWNEALSLP RPWDQQWSLRLQQVLAYETDLLEYPDLFEGSKVVESKVKELKVEAYKEIQKILDMGGAVKAIENGYMKSQLVKSQAERLT KINNNELIIVGKNKWTEGTPSPLMTDQDGGIFKVDPKSAEETLEVLAKVKSTRDANKVKEALSQLEADAKAGKNLMYASI ECAKTGISTGEWADVLRSVFGEYRPATGVEGQKLNLETDKVIRVRGKVEAFFKANGSRPKIVVGKPGLDGHSNGAEMIAV SAKHAGFDVIYSGIRLTPEEIVQTAVEENADVIGVSILSGSHLELAEQIFNELKHYKADIPVVFGGIIPSNDFDSLTKLG VKAIFTPKDYDLMDVMERIIDIISQTIKAA
Sequences:
>Translated_670_residues MENKNHILYDKSGKPSKEPAWIFRTYAGHTNARESNELFRKNLSKGQTGLSIAFDLATQCGYSSDHAIAKPEIGKVGVPI NTLEDFRILFNQIPIEEMNTSMTINGTSMYLLSLYVALAQERGVDVALLQGTTQNDIIKEYLARGTYIFPPAQSIRVIVD MYEYCLKNIPKWNPSNICSYHLQEAGATPVQELAFALATAMAILDAIKERNCFTAEEFEQCVGRISFFVNAGIRFVEEMC KMRAFTEMWDEITKDRYQVKQEKYRRFRYGVQVNSLGLTEEQPENNAWRILIEALGVTMSRDARCRALQLPAWNEALSLP RPWDQQWSLRLQQVLAYETDLLEYPDLFEGSKVVESKVKELKVEAYKEIQKILDMGGAVKAIENGYMKSQLVKSQAERLT KINNNELIIVGKNKWTEGTPSPLMTDQDGGIFKVDPKSAEETLEVLAKVKSTRDANKVKEALSQLEADAKAGKNLMYASI ECAKTGISTGEWADVLRSVFGEYRPATGVEGQKLNLETDKVIRVRGKVEAFFKANGSRPKIVVGKPGLDGHSNGAEMIAV SAKHAGFDVIYSGIRLTPEEIVQTAVEENADVIGVSILSGSHLELAEQIFNELKHYKADIPVVFGGIIPSNDFDSLTKLG VKAIFTPKDYDLMDVMERIIDIISQTIKAA >Mature_670_residues MENKNHILYDKSGKPSKEPAWIFRTYAGHTNARESNELFRKNLSKGQTGLSIAFDLATQCGYSSDHAIAKPEIGKVGVPI NTLEDFRILFNQIPIEEMNTSMTINGTSMYLLSLYVALAQERGVDVALLQGTTQNDIIKEYLARGTYIFPPAQSIRVIVD MYEYCLKNIPKWNPSNICSYHLQEAGATPVQELAFALATAMAILDAIKERNCFTAEEFEQCVGRISFFVNAGIRFVEEMC KMRAFTEMWDEITKDRYQVKQEKYRRFRYGVQVNSLGLTEEQPENNAWRILIEALGVTMSRDARCRALQLPAWNEALSLP RPWDQQWSLRLQQVLAYETDLLEYPDLFEGSKVVESKVKELKVEAYKEIQKILDMGGAVKAIENGYMKSQLVKSQAERLT KINNNELIIVGKNKWTEGTPSPLMTDQDGGIFKVDPKSAEETLEVLAKVKSTRDANKVKEALSQLEADAKAGKNLMYASI ECAKTGISTGEWADVLRSVFGEYRPATGVEGQKLNLETDKVIRVRGKVEAFFKANGSRPKIVVGKPGLDGHSNGAEMIAV SAKHAGFDVIYSGIRLTPEEIVQTAVEENADVIGVSILSGSHLELAEQIFNELKHYKADIPVVFGGIIPSNDFDSLTKLG VKAIFTPKDYDLMDVMERIIDIISQTIKAA
Specific function: Required for the assimilation of methanol and ethanol [H]
COG id: COG1884
COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 B12-binding domain [H]
Homologues:
Organism=Homo sapiens, GI156105689, Length=634, Percent_Identity=34.384858044164, Blast_Score=376, Evalue=1e-104, Organism=Escherichia coli, GI1789284, Length=657, Percent_Identity=35.4642313546423, Blast_Score=382, Evalue=1e-107, Organism=Caenorhabditis elegans, GI25144500, Length=635, Percent_Identity=35.748031496063, Blast_Score=388, Evalue=1e-108,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006159 - InterPro: IPR016176 - InterPro: IPR014348 - InterPro: IPR006158 - InterPro: IPR006099 - InterPro: IPR006098 [H]
Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]
EC number: 5.4.99.2
Molecular weight: Translated: 74938; Mature: 74938
Theoretical pI: Translated: 5.53; Mature: 5.53
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MENKNHILYDKSGKPSKEPAWIFRTYAGHTNARESNELFRKNLSKGQTGLSIAFDLATQC CCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHC GYSSDHAIAKPEIGKVGVPINTLEDFRILFNQIPIEEMNTSMTINGTSMYLLSLYVALAQ CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCEEEECCHHHHHHHHHHHHHH ERGVDVALLQGTTQNDIIKEYLARGTYIFPPAQSIRVIVDMYEYCLKNIPKWNPSNICSY HCCCEEEEECCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH HLQEAGATPVQELAFALATAMAILDAIKERNCFTAEEFEQCVGRISFFVNAGIRFVEEMC HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH KMRAFTEMWDEITKDRYQVKQEKYRRFRYGVQVNSLGLTEEQPENNAWRILIEALGVTMS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHCCCCC RDARCRALQLPAWNEALSLPRPWDQQWSLRLQQVLAYETDLLEYPDLFEGSKVVESKVKE CCCCCEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH LKVEAYKEIQKILDMGGAVKAIENGYMKSQLVKSQAERLTKINNNELIIVGKNKWTEGTP HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC SPLMTDQDGGIFKVDPKSAEETLEVLAKVKSTRDANKVKEALSQLEADAKAGKNLMYASI CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEH ECAKTGISTGEWADVLRSVFGEYRPATGVEGQKLNLETDKVIRVRGKVEAFFKANGSRPK HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEHHHEEEEEECCCCCCE IVVGKPGLDGHSNGAEMIAVSAKHAGFDVIYSGIRLTPEEIVQTAVEENADVIGVSILSG EEEECCCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECC SHLELAEQIFNELKHYKADIPVVFGGIIPSNDFDSLTKLGVKAIFTPKDYDLMDVMERII CHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCEEEECCCCCCHHHHHHHHH DIISQTIKAA HHHHHHHHCC >Mature Secondary Structure MENKNHILYDKSGKPSKEPAWIFRTYAGHTNARESNELFRKNLSKGQTGLSIAFDLATQC CCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHC GYSSDHAIAKPEIGKVGVPINTLEDFRILFNQIPIEEMNTSMTINGTSMYLLSLYVALAQ CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCEEEECCHHHHHHHHHHHHHH ERGVDVALLQGTTQNDIIKEYLARGTYIFPPAQSIRVIVDMYEYCLKNIPKWNPSNICSY HCCCEEEEECCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH HLQEAGATPVQELAFALATAMAILDAIKERNCFTAEEFEQCVGRISFFVNAGIRFVEEMC HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH KMRAFTEMWDEITKDRYQVKQEKYRRFRYGVQVNSLGLTEEQPENNAWRILIEALGVTMS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHCCCCC RDARCRALQLPAWNEALSLPRPWDQQWSLRLQQVLAYETDLLEYPDLFEGSKVVESKVKE CCCCCEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH LKVEAYKEIQKILDMGGAVKAIENGYMKSQLVKSQAERLTKINNNELIIVGKNKWTEGTP HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC SPLMTDQDGGIFKVDPKSAEETLEVLAKVKSTRDANKVKEALSQLEADAKAGKNLMYASI CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEH ECAKTGISTGEWADVLRSVFGEYRPATGVEGQKLNLETDKVIRVRGKVEAFFKANGSRPK HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEHHHEEEEEECCCCCCE IVVGKPGLDGHSNGAEMIAVSAKHAGFDVIYSGIRLTPEEIVQTAVEENADVIGVSILSG EEEECCCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECC SHLELAEQIFNELKHYKADIPVVFGGIIPSNDFDSLTKLGVKAIFTPKDYDLMDVMERII CHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCEEEECCCCCCHHHHHHHHH DIISQTIKAA HHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (R)-methylmalonyl-CoA
Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8868443 [H]