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The map label for this gene is mprA [H]

Identifier: 116332459

GI number: 116332459

Start: 14693

End: 15385

Strand: Direct

Name: mprA [H]

Synonym: LBJ_4013

Alternate gene names: 116332459

Gene position: 14693-15385 (Clockwise)

Preceding gene: 116332458

Following gene: 116332460

Centisome position: 4.9

GC content: 44.59

Gene sequence:

>693_bases
ATGAGAGCCAAACTCTTGTTAGTCGAAGATGATCGTTCCCTCGGTGAGACTCTTCAAGAACGTCTGCAAAAAGAGGGATA
TGAAGTTTTTTGGACGGTTTCCGCGATTTTTGCGAAAAAGTTGGTCAAAGACGAAAAACCGCATCTGATTCTTTTGGATG
TGCGCTTGCCGGATGGAGACGGTTTTACGCTTGCGGAAGAACTCAAAAAAACGAAAGACTGTCCTCCGTTTCTGTTTCTA
ACCGCACAAGCGGGAGCGCCGGAAAGACTCAGAGGATTTGAACTCGGAGCGGAGGAATTCATTCCTAAGCCGTTTCATTT
AAAGGAACTTCTTCTTCGTGTTAAACACGTATTAGAATCTCATAAACATTCCATAGAAGAGACTAGATTTTTTTATAAGG
ACTATGTTTTGGATTTCCGGGGATTTCAGGTTAGGAAAGGATCGGAAGAATTCCCGCTTTCCAAAAGGGATTGTGCCCTA
CTCCACTTTCTCGTAACCGAAAGAAATCGGACGATCAGCCGTGCGGAAATACTGGATAAACTTTGGGGGGAAGAAAGTTT
TCCCACAAATAGGACGATAGACAATTCGATCGTAAGACTTAGGCATGCCTTTGGCAAGGAAGGGGAAAGGGTGATTCGAT
CCGTCAGGGGCGTCGGTTATCAATGGACCGGAGAAATCAAAGATGCCAAGTAA

Upstream 100 bases:

>100_bases
ATAATAAAGAAGTTGATGAAAAAAATGAAAGGCGATATGCGTATCGTTCCGCAAAAAATCGGTTTTAGAGTGGATCTGAA
TTTTCCGGGAGCGATCTGAA

Downstream 100 bases:

>100_bases
ACGATATTCGAACGCTATCAGCGGAGTCGCTCAGAAAATTCCTCCCGTATGGATGATGAGGCAGGCGGGCCGTTATCATA
AACACTACCAAACTCTCAGA

Product: two component regulatory system response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MRAKLLLVEDDRSLGETLQERLQKEGYEVFWTVSAIFAKKLVKDEKPHLILLDVRLPDGDGFTLAEELKKTKDCPPFLFL
TAQAGAPERLRGFELGAEEFIPKPFHLKELLLRVKHVLESHKHSIEETRFFYKDYVLDFRGFQVRKGSEEFPLSKRDCAL
LHFLVTERNRTISRAEILDKLWGEESFPTNRTIDNSIVRLRHAFGKEGERVIRSVRGVGYQWTGEIKDAK

Sequences:

>Translated_230_residues
MRAKLLLVEDDRSLGETLQERLQKEGYEVFWTVSAIFAKKLVKDEKPHLILLDVRLPDGDGFTLAEELKKTKDCPPFLFL
TAQAGAPERLRGFELGAEEFIPKPFHLKELLLRVKHVLESHKHSIEETRFFYKDYVLDFRGFQVRKGSEEFPLSKRDCAL
LHFLVTERNRTISRAEILDKLWGEESFPTNRTIDNSIVRLRHAFGKEGERVIRSVRGVGYQWTGEIKDAK
>Mature_230_residues
MRAKLLLVEDDRSLGETLQERLQKEGYEVFWTVSAIFAKKLVKDEKPHLILLDVRLPDGDGFTLAEELKKTKDCPPFLFL
TAQAGAPERLRGFELGAEEFIPKPFHLKELLLRVKHVLESHKHSIEETRFFYKDYVLDFRGFQVRKGSEEFPLSKRDCAL
LHFLVTERNRTISRAEILDKLWGEESFPTNRTIDNSIVRLRHAFGKEGERVIRSVRGVGYQWTGEIKDAK

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=33.0396475770925, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=30.7017543859649, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=30.2631578947368, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=29.1139240506329, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=30.7339449541284, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=31.5555555555556, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=30.7017543859649, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=28.8288288288288, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=26.4957264957265, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=28.4403669724771, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=30.0884955752212, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=23.8738738738739, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=23.394495412844, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=26.0869565217391, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=27.5862068965517, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26756; Mature: 26756

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKLLLVEDDRSLGETLQERLQKEGYEVFWTVSAIFAKKLVKDEKPHLILLDVRLPDGD
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCC
GFTLAEELKKTKDCPPFLFLTAQAGAPERLRGFELGAEEFIPKPFHLKELLLRVKHVLES
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHH
HKHSIEETRFFYKDYVLDFRGFQVRKGSEEFPLSKRDCALLHFLVTERNRTISRAEILDK
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
LWGEESFPTNRTIDNSIVRLRHAFGKEGERVIRSVRGVGYQWTGEIKDAK
HHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MRAKLLLVEDDRSLGETLQERLQKEGYEVFWTVSAIFAKKLVKDEKPHLILLDVRLPDGD
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCC
GFTLAEELKKTKDCPPFLFLTAQAGAPERLRGFELGAEEFIPKPFHLKELLLRVKHVLES
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHH
HKHSIEETRFFYKDYVLDFRGFQVRKGSEEFPLSKRDCALLHFLVTERNRTISRAEILDK
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
LWGEESFPTNRTIDNSIVRLRHAFGKEGERVIRSVRGVGYQWTGEIKDAK
HHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA