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The map label for this gene is folP [H]

Identifier: 116329524

GI number: 116329524

Start: 3570854

End: 3571696

Strand: Direct

Name: folP [H]

Synonym: LBL_2999

Alternate gene names: 116329524

Gene position: 3570854-3571696 (Clockwise)

Preceding gene: 116329519

Following gene: 116329525

Centisome position: 98.79

GC content: 39.74

Gene sequence:

>843_bases
ATGGAAAGTAAGTATGATTTGAATTCTGGGATTTATTTCCCTACGATCTTCGGAGTGTTAAACATTACCGAGGATTCGTT
TTCAGACGGAGGAAAATATCTCACTCTGAAAGCTTCTTCCGAAAAAGCAGACTCCCTTCTGATTCAAGGTGCAAGTGTAG
TCGATATTGGCGCTCAGTCTTCCAACATTCAGGCAAATCTAGTCGGCTCCGAAATCGAATGGATGAGAATGAAAGATCTT
ATACCAGACTTACTCGCAAAGGGAGTCCGCATTTCTGTGGATTCATTTCAGCCCGAAGTAATCGCAAATTCTTTGGATGC
CGGTGTGGAATTTATCAACCATATTCGTGGATTTGTGGATAAAGAATCCGTTCGAGAAGTTTCAAAATACGCAGGAACAA
ATCGAAAGTTTATCGTGATGTATTCTCATAATCATGCGAATCGTCCCGACACGCAATCTTATCTGACTTCACAAAATGTG
ATTTTCGAGATCGTAAAATTCTTTCGAGAAAGAAAAAAGGTTTTATTAAACGAAGGGATTACTCAGGAACAGTTGATTTT
CGATCCTGGTATGGGTTTTTTCTTAAGCCCCGATTTTCAAGTGAGCTTTGAAGTTTTGAGAAGGATTCAGACTCTCAAGG
AAGAATTTTCTCCAATGATGGTTTCGGTTACGAAAAAGTCCTTTTTGGGGAATGCGCTCGGGGGTTTGAAAGTAAATGAA
CGGGAGATTGCCACTGTGGTTGCGGAACTTTATCTTTCCATTCAAAACGTGGAATATATACGAACTCACGAGCCGAAAAA
TTTGAAACAGGCTTTAGAAATTTGGAATTTACTTCGTTCATGA

Upstream 100 bases:

>100_bases
ACGCATGAATCGCTCCGAAAAGAAAGTAGAAGAGTTGCCGTTTTTAGTTTAATTCCAGAATCTCTTTTAGAGTATCGGTT
TTGTATCCGAGTTTTTAAAG

Downstream 100 bases:

>100_bases
CATCGTTTACGGAGTCAAGGACGCTACAGTACGCACTAGAACCACCAAGCCACGGATTTTGTTCCGACATCCAAAGCATC
ATCGAGTCTTACTCGCTGAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: Dihydropteroate pyrophosphorylase type I; Dihydropteroate synthase type I; DHPS [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MESKYDLNSGIYFPTIFGVLNITEDSFSDGGKYLTLKASSEKADSLLIQGASVVDIGAQSSNIQANLVGSEIEWMRMKDL
IPDLLAKGVRISVDSFQPEVIANSLDAGVEFINHIRGFVDKESVREVSKYAGTNRKFIVMYSHNHANRPDTQSYLTSQNV
IFEIVKFFRERKKVLLNEGITQEQLIFDPGMGFFLSPDFQVSFEVLRRIQTLKEEFSPMMVSVTKKSFLGNALGGLKVNE
REIATVVAELYLSIQNVEYIRTHEPKNLKQALEIWNLLRS

Sequences:

>Translated_280_residues
MESKYDLNSGIYFPTIFGVLNITEDSFSDGGKYLTLKASSEKADSLLIQGASVVDIGAQSSNIQANLVGSEIEWMRMKDL
IPDLLAKGVRISVDSFQPEVIANSLDAGVEFINHIRGFVDKESVREVSKYAGTNRKFIVMYSHNHANRPDTQSYLTSQNV
IFEIVKFFRERKKVLLNEGITQEQLIFDPGMGFFLSPDFQVSFEVLRRIQTLKEEFSPMMVSVTKKSFLGNALGGLKVNE
REIATVVAELYLSIQNVEYIRTHEPKNLKQALEIWNLLRS
>Mature_280_residues
MESKYDLNSGIYFPTIFGVLNITEDSFSDGGKYLTLKASSEKADSLLIQGASVVDIGAQSSNIQANLVGSEIEWMRMKDL
IPDLLAKGVRISVDSFQPEVIANSLDAGVEFINHIRGFVDKESVREVSKYAGTNRKFIVMYSHNHANRPDTQSYLTSQNV
IFEIVKFFRERKKVLLNEGITQEQLIFDPGMGFFLSPDFQVSFEVLRRIQTLKEEFSPMMVSVTKKSFLGNALGGLKVNE
REIATVVAELYLSIQNVEYIRTHEPKNLKQALEIWNLLRS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. The type II enzyme is stable whereas type I DHPS loses its activity rapidly. Implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=265, Percent_Identity=27.5471698113208, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31646; Mature: 31646

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKYDLNSGIYFPTIFGVLNITEDSFSDGGKYLTLKASSEKADSLLIQGASVVDIGAQS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCEEEECCCC
SNIQANLVGSEIEWMRMKDLIPDLLAKGVRISVDSFQPEVIANSLDAGVEFINHIRGFVD
CCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
KESVREVSKYAGTNRKFIVMYSHNHANRPDTQSYLTSQNVIFEIVKFFRERKKVLLNEGI
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TQEQLIFDPGMGFFLSPDFQVSFEVLRRIQTLKEEFSPMMVSVTKKSFLGNALGGLKVNE
CHHHEEECCCCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECH
REIATVVAELYLSIQNVEYIRTHEPKNLKQALEIWNLLRS
HHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESKYDLNSGIYFPTIFGVLNITEDSFSDGGKYLTLKASSEKADSLLIQGASVVDIGAQS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCEEEECCCC
SNIQANLVGSEIEWMRMKDLIPDLLAKGVRISVDSFQPEVIANSLDAGVEFINHIRGFVD
CCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
KESVREVSKYAGTNRKFIVMYSHNHANRPDTQSYLTSQNVIFEIVKFFRERKKVLLNEGI
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TQEQLIFDPGMGFFLSPDFQVSFEVLRRIQTLKEEFSPMMVSVTKKSFLGNALGGLKVNE
CHHHEEECCCCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECH
REIATVVAELYLSIQNVEYIRTHEPKNLKQALEIWNLLRS
HHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2163027 [H]