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The map label for this gene is lysC [H]

Identifier: 116329118

GI number: 116329118

Start: 3008436

End: 3009653

Strand: Direct

Name: lysC [H]

Synonym: LBL_2541

Alternate gene names: 116329118

Gene position: 3008436-3009653 (Clockwise)

Preceding gene: 116329115

Following gene: 116329120

Centisome position: 83.23

GC content: 45.4

Gene sequence:

>1218_bases
ATGCCAAACATCATCGTTCAAAAATACGGCGGAACTTCCGTGGGAACCCCGGAAAGAATCCAGAACGTTGCAAGAAGAAT
CAAATCCTATCATGACAAGGGACAACAAATCGCCGTCGTGGTTTCCGCTATGGGACATACCACGGACGACCTCGTAGAAC
TCGCTGCAAAAATTTCCGCAAATCCTCCCAAACGGGAAATGGACATGCTCCTCTCTACCGGTGAGCAGATTTCCACAGCA
TTACTCGCTATGGCACTTTGGGAAATCGGAGTTCCGGCAACTTCTTTTACCGGTTCTCAAATCAAACTTTTAACCGACGG
AAATTTCTCTAATGCGAAAATCAAAATGATCGATCGATCTCGAATCGACGCGGCTTTGAATGAAGGCAAGGTAGCTATCA
TCGCGGGTTTCCAAGGAATCGACGAAGAAGAAAACATCACCACTCTGGGAAGAGGTGGTTCCGACACGTCGGCGGTAGCG
GTAGCGGCGGTTCTAGGCGCGAAAGAATGCGAAATTTACACCGACGTTGACGGAGTTTATACGGCCGATCCGAGAATCGT
TCCAAACGCAAAAAAACATACACAAATCACTTATGAAGAAATGCTCGAACTTGCAAGTTTAGGTGCGGGGGTCCTTCATT
CTAGAAGCGTAGAATTGGGAATGAATTACGATGTAGTTATACACGTCCGCTCCAGTTTCAACGAAAACCAAGGAACACTT
GTGATGAGCGAGGATAAAATTATGGAAAAATTAAAAGTCAGCGGAGTCACCGCAAAGAGTGATCAAGCACGAATCACCAT
TGCGGAAGTTCCCGACAAACCCGGTTTAGCGGCGAGACTTTTTGGAGAATTGAACTCCAAACATATTCTCGTGGATATGA
TTGTACAATCCTCTCCACATAACGGAATCAATACGATCTCATTTACGATTTCCAAAAAGGACGTTCTTCAAGCAAAACCG
ATTCTTCAAGGATTTTCAAAAACACATAACGCAAAGGAACCCGAAATCAACGAAAGTATTGCGATCGTTTCCGCGGTCGG
AGTGGGTATGAAATCTCACGTAGGAGTTGCGGCCGGAATGTTTCAGGCACTTGCGGACAATGGAATCAACATAGAGATGA
TCTCCACCTCTGAGATTAAAATCTCTTGTGTAATCCCCGAAGATCAGGCCAAAATTGCGATCAACAAAATCCATGACGTC
TTCGGACTTTCGGGATAA

Upstream 100 bases:

>100_bases
AAACCTTTCCTGAGAACAAAACCCTCTTTCCAAAATCGGAGAATCAAAATCGAATTCTCTTGATCCCTCGTCTTGAAAGA
AAAATATGACTGTTAAGGTT

Downstream 100 bases:

>100_bases
AGTCTTCGATTTATAGAACCATCGAAAACGGAATTTCTAAACTCGTCGAGAAATGTGGATGTTCCGCCGACTCCCTATGG
TCGTCGCGGCAGGTTTAGGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPNIIVQKYGGTSVGTPERIQNVARRIKSYHDKGQQIAVVVSAMGHTTDDLVELAAKISANPPKREMDMLLSTGEQISTA
LLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRSRIDAALNEGKVAIIAGFQGIDEEENITTLGRGGSDTSAVA
VAAVLGAKECEIYTDVDGVYTADPRIVPNAKKHTQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNENQGTL
VMSEDKIMEKLKVSGVTAKSDQARITIAEVPDKPGLAARLFGELNSKHILVDMIVQSSPHNGINTISFTISKKDVLQAKP
ILQGFSKTHNAKEPEINESIAIVSAVGVGMKSHVGVAAGMFQALADNGINIEMISTSEIKISCVIPEDQAKIAINKIHDV
FGLSG

Sequences:

>Translated_405_residues
MPNIIVQKYGGTSVGTPERIQNVARRIKSYHDKGQQIAVVVSAMGHTTDDLVELAAKISANPPKREMDMLLSTGEQISTA
LLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRSRIDAALNEGKVAIIAGFQGIDEEENITTLGRGGSDTSAVA
VAAVLGAKECEIYTDVDGVYTADPRIVPNAKKHTQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNENQGTL
VMSEDKIMEKLKVSGVTAKSDQARITIAEVPDKPGLAARLFGELNSKHILVDMIVQSSPHNGINTISFTISKKDVLQAKP
ILQGFSKTHNAKEPEINESIAIVSAVGVGMKSHVGVAAGMFQALADNGINIEMISTSEIKISCVIPEDQAKIAINKIHDV
FGLSG
>Mature_404_residues
PNIIVQKYGGTSVGTPERIQNVARRIKSYHDKGQQIAVVVSAMGHTTDDLVELAAKISANPPKREMDMLLSTGEQISTAL
LAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRSRIDAALNEGKVAIIAGFQGIDEEENITTLGRGGSDTSAVAV
AAVLGAKECEIYTDVDGVYTADPRIVPNAKKHTQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNENQGTLV
MSEDKIMEKLKVSGVTAKSDQARITIAEVPDKPGLAARLFGELNSKHILVDMIVQSSPHNGINTISFTISKKDVLQAKPI
LQGFSKTHNAKEPEINESIAIVSAVGVGMKSHVGVAAGMFQALADNGINIEMISTSEIKISCVIPEDQAKIAINKIHDVF
GLSG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=344, Percent_Identity=33.4302325581395, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790455, Length=353, Percent_Identity=29.7450424929178, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790376, Length=268, Percent_Identity=26.865671641791, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=379, Percent_Identity=28.4960422163588, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43303; Mature: 43172

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIIVQKYGGTSVGTPERIQNVARRIKSYHDKGQQIAVVVSAMGHTTDDLVELAAKISA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCC
NPPKREMDMLLSTGEQISTALLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRS
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHH
RIDAALNEGKVAIIAGFQGIDEEENITTLGRGGSDTSAVAVAAVLGAKECEIYTDVDGVY
HHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TADPRIVPNAKKHTQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNENQGTL
ECCCCCCCCCCHHCEECHHHHHHHHHCCCCHHCCCCEEECCCEEEEEEEECCCCCCCCEE
VMSEDKIMEKLKVSGVTAKSDQARITIAEVPDKPGLAARLFGELNSKHILVDMIVQSSPH
EEEHHHHHHHHHHCCCEECCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCC
NGINTISFTISKKDVLQAKPILQGFSKTHNAKEPEINESIAIVSAVGVGMKSHVGVAAGM
CCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHH
FQALADNGINIEMISTSEIKISCVIPEDQAKIAINKIHDVFGLSG
HHHHHCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PNIIVQKYGGTSVGTPERIQNVARRIKSYHDKGQQIAVVVSAMGHTTDDLVELAAKISA
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCC
NPPKREMDMLLSTGEQISTALLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRS
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHH
RIDAALNEGKVAIIAGFQGIDEEENITTLGRGGSDTSAVAVAAVLGAKECEIYTDVDGVY
HHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TADPRIVPNAKKHTQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNENQGTL
ECCCCCCCCCCHHCEECHHHHHHHHHCCCCHHCCCCEEECCCEEEEEEEECCCCCCCCEE
VMSEDKIMEKLKVSGVTAKSDQARITIAEVPDKPGLAARLFGELNSKHILVDMIVQSSPH
EEEHHHHHHHHHHCCCEECCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCC
NGINTISFTISKKDVLQAKPILQGFSKTHNAKEPEINESIAIVSAVGVGMKSHVGVAAGM
CCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHH
FQALADNGINIEMISTSEIKISCVIPEDQAKIAINKIHDVFGLSG
HHHHHCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]