Click here to switch to the map view.

The map label for this gene is can [H]

Identifier: 116329080

GI number: 116329080

Start: 2956514

End: 2958739

Strand: Reverse

Name: can [H]

Synonym: LBL_2497

Alternate gene names: 116329080

Gene position: 2958739-2956514 (Counterclockwise)

Preceding gene: 116329081

Following gene: 116329079

Centisome position: 81.86

GC content: 40.75

Gene sequence:

>2226_bases
ATGAATATTTTATACTTTTTTCCTAACGTTTCTTGGAACGATTTGAGGCACGATCTTTCTTCTAGTATCGTCGTCTTTTT
GGTCGCTCTTCCTCTTTGTATCGGAGTTGCATTTGCATCAGGTACACCTATTGTTTCCGGTTTGATCAGTGGTATCGTGG
GGGGTATCGTAATTTCTCTGATCAGTAAATCGCCTCTATCCGTAAGCGGTCCCGCCATGGGACTTACGGTGATTGTCTTC
GATTCGATTCAAACATTAGGAAGTTTTAACGATTTTCTTTTCGCTTTTTGTTTGGCCGGAGTTTTACAAATCACATTAGG
TTTTTTGAAAGCGGGAATTCTAAGTAATTTTTTCCCGTCTTCGGTGATCAAGGGGATGTTAGCGGCAATCGGAGCGGTTT
TAATCTTAAAACAGATTCCACACGCAATCGGTTACGATATGGATTACGAAGGAGATATGGTCTTTTTTCAACAAGATCAG
GAGAATACTTTTTCGGAGATCCTGACCGCATTTCATCGTTTTACTCCCGGAGCAATCATACTATCTTCTGTTTCCTTAGC
TTTGATTTTGATCTGGGAAAAGCTGAAACTACATAAAAAACTCATAATTCATGGATCTTTAGTCGCGATTCTAGTTAGTG
TTTTGTTAAACGAAGTTTTTAAAACTTTCGAATTGGGTATCGCCGTAGGCTCGGAACATATGATCCAGCCGATTCAACTA
AACGGGATTACGGATTTTTTTCGGGGGAATTATTTCCCGAGTTTTTCTCAATGGAAGAATCAGGCAATTTATCTGACCGC
GATTAAGATTTGTCTGGTGATGAGTCTTGAAACCCTATTGAACCTGGATGCGATCGAAAAATTGGATCCTCAAAGAAGAA
TCGTCTCTAAAAACCGCGAGCTGATTGCCCAAGGAACCGGAAATTTATTCTCCGCGATTTTTGGCGGACTACCCATCACG
TCCGTAATCATTCGAAGTTCCACGAATTTACAAGCCGGAGCGAAGACTAGATTCTCCGCATTCCTACACGGCTTGTTGAT
TCTTTTATCTCTGATTCTGATCCCGACTTGGATCTCAAAAATCCCTTTGGCTTCTTTGGCGGCCGTACTTTTGGTCGTAG
GTTACAAACTTACGGATTATAAAATTCTCCAAACACAATATCGAAAAGGAATGGATCAATTTATTCCGTTCATCTCCACA
TTGATCGGAATCGTTTTCTCGGATGTTCTTATAGGAATCGGAATCGGTTGTTTATTTTCCGTGTTCTTTATCGTAAGAAG
GAATATTCTGAATCCTTACGAATTCAACAAAAAGGAAATGACTTACGGAGTCGAGGTAAGGATCGATCTTTCCGAAGACG
TGTCTTTTTTGAACAAATCGAGCATGTTGTACAAACTAGATAAGGTTCCGGATAACGCGCACTTGATCATAGACGGTTCC
AAGTCCAAATACATCGATCCGGACGTTTTGGAAATCATCGAAGACTTTAAGATCGTAGCCGAGTTCCGCAATATCAAAGT
GGAGATTATCGACGTGACTTCTACTTATCAGAAAGTCAAAAACAAACCCTTGGACCCGATCATCCAACAGGATTATCAAA
AACTTTTCGAGAACAATCGGATTTGGGTGGAAGAAAAACTTTTAAAAGACCCGAATTACTTTAAGAATCTCGCTTTAGGC
CAGACTCCGAAATATCTTCTCATATCGTGCTCCGACAGTAGAATTTCGGTCAACGAAATGACGGGTACAAACGCAGGCGA
ACTTTTTGTTCATAGAAACATCGCAAACCTGGTAATCGACACGGATATGAATCTGATGTCGGTTCTTCAATATTCCGTCG
AAGTTCTAAAAGTCAAACATATCGTCGTTTGTGGTCATTACGGTTGCGGCGGGGTCAAGGCGGCAATAGACGGTAAATAC
CACGGATTGATCGACGCTTGGCTTAGACATATCAAACAGGTTTACCGAATGAACCGAAAAGAACTTTCCGGAATTTTAGA
CGAGGATGAAAAACACAAAAAACTCGTAGAGTTAAACGTGAGAGAACAGGTTTATAACCTTTGTATGACTACGATCGTTC
AAAACGCGTGGAGTCAGGGAAACAATCTTCAGCTTCACGGCTGGGTGTACAATCTCAAAGAAGGTATCCTCCTGGATCTC
AACATAGATATAAACAAGGATTTTCGCGACTACGACATTTTTCGCTATAAATTCGAAACGAATTAA

Upstream 100 bases:

>100_bases
TCAATACTTTTCGGAAATAGAAAACCCACCTCCGGAAAACCTTTATCTCTCGATTTAACAATTTCGAAATTTTGGGGCCT
GACCCAAGGAGTCTGTCTAT

Downstream 100 bases:

>100_bases
TGTTCATATATGAAAAAGAACGCGATAAGACATTTACCGTTTAGAAAAAGGAGTAAATTCATATTTTTGAATATTCTAAC
AAGAAATTTATTTCGAAGGA

Product: bifunctional permease/carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MNILYFFPNVSWNDLRHDLSSSIVVFLVALPLCIGVAFASGTPIVSGLISGIVGGIVISLISKSPLSVSGPAMGLTVIVF
DSIQTLGSFNDFLFAFCLAGVLQITLGFLKAGILSNFFPSSVIKGMLAAIGAVLILKQIPHAIGYDMDYEGDMVFFQQDQ
ENTFSEILTAFHRFTPGAIILSSVSLALILIWEKLKLHKKLIIHGSLVAILVSVLLNEVFKTFELGIAVGSEHMIQPIQL
NGITDFFRGNYFPSFSQWKNQAIYLTAIKICLVMSLETLLNLDAIEKLDPQRRIVSKNRELIAQGTGNLFSAIFGGLPIT
SVIIRSSTNLQAGAKTRFSAFLHGLLILLSLILIPTWISKIPLASLAAVLLVVGYKLTDYKILQTQYRKGMDQFIPFIST
LIGIVFSDVLIGIGIGCLFSVFFIVRRNILNPYEFNKKEMTYGVEVRIDLSEDVSFLNKSSMLYKLDKVPDNAHLIIDGS
KSKYIDPDVLEIIEDFKIVAEFRNIKVEIIDVTSTYQKVKNKPLDPIIQQDYQKLFENNRIWVEEKLLKDPNYFKNLALG
QTPKYLLISCSDSRISVNEMTGTNAGELFVHRNIANLVIDTDMNLMSVLQYSVEVLKVKHIVVCGHYGCGGVKAAIDGKY
HGLIDAWLRHIKQVYRMNRKELSGILDEDEKHKKLVELNVREQVYNLCMTTIVQNAWSQGNNLQLHGWVYNLKEGILLDL
NIDINKDFRDYDIFRYKFETN

Sequences:

>Translated_741_residues
MNILYFFPNVSWNDLRHDLSSSIVVFLVALPLCIGVAFASGTPIVSGLISGIVGGIVISLISKSPLSVSGPAMGLTVIVF
DSIQTLGSFNDFLFAFCLAGVLQITLGFLKAGILSNFFPSSVIKGMLAAIGAVLILKQIPHAIGYDMDYEGDMVFFQQDQ
ENTFSEILTAFHRFTPGAIILSSVSLALILIWEKLKLHKKLIIHGSLVAILVSVLLNEVFKTFELGIAVGSEHMIQPIQL
NGITDFFRGNYFPSFSQWKNQAIYLTAIKICLVMSLETLLNLDAIEKLDPQRRIVSKNRELIAQGTGNLFSAIFGGLPIT
SVIIRSSTNLQAGAKTRFSAFLHGLLILLSLILIPTWISKIPLASLAAVLLVVGYKLTDYKILQTQYRKGMDQFIPFIST
LIGIVFSDVLIGIGIGCLFSVFFIVRRNILNPYEFNKKEMTYGVEVRIDLSEDVSFLNKSSMLYKLDKVPDNAHLIIDGS
KSKYIDPDVLEIIEDFKIVAEFRNIKVEIIDVTSTYQKVKNKPLDPIIQQDYQKLFENNRIWVEEKLLKDPNYFKNLALG
QTPKYLLISCSDSRISVNEMTGTNAGELFVHRNIANLVIDTDMNLMSVLQYSVEVLKVKHIVVCGHYGCGGVKAAIDGKY
HGLIDAWLRHIKQVYRMNRKELSGILDEDEKHKKLVELNVREQVYNLCMTTIVQNAWSQGNNLQLHGWVYNLKEGILLDL
NIDINKDFRDYDIFRYKFETN
>Mature_741_residues
MNILYFFPNVSWNDLRHDLSSSIVVFLVALPLCIGVAFASGTPIVSGLISGIVGGIVISLISKSPLSVSGPAMGLTVIVF
DSIQTLGSFNDFLFAFCLAGVLQITLGFLKAGILSNFFPSSVIKGMLAAIGAVLILKQIPHAIGYDMDYEGDMVFFQQDQ
ENTFSEILTAFHRFTPGAIILSSVSLALILIWEKLKLHKKLIIHGSLVAILVSVLLNEVFKTFELGIAVGSEHMIQPIQL
NGITDFFRGNYFPSFSQWKNQAIYLTAIKICLVMSLETLLNLDAIEKLDPQRRIVSKNRELIAQGTGNLFSAIFGGLPIT
SVIIRSSTNLQAGAKTRFSAFLHGLLILLSLILIPTWISKIPLASLAAVLLVVGYKLTDYKILQTQYRKGMDQFIPFIST
LIGIVFSDVLIGIGIGCLFSVFFIVRRNILNPYEFNKKEMTYGVEVRIDLSEDVSFLNKSSMLYKLDKVPDNAHLIIDGS
KSKYIDPDVLEIIEDFKIVAEFRNIKVEIIDVTSTYQKVKNKPLDPIIQQDYQKLFENNRIWVEEKLLKDPNYFKNLALG
QTPKYLLISCSDSRISVNEMTGTNAGELFVHRNIANLVIDTDMNLMSVLQYSVEVLKVKHIVVCGHYGCGGVKAAIDGKY
HGLIDAWLRHIKQVYRMNRKELSGILDEDEKHKKLVELNVREQVYNLCMTTIVQNAWSQGNNLQLHGWVYNLKEGILLDL
NIDINKDFRDYDIFRYKFETN

Specific function: Unknown

COG id: COG0659

COG function: function code P; Sulfate permease and related transporters (MFS superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=209, Percent_Identity=45.933014354067, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI87081859, Length=427, Percent_Identity=26.9320843091335, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1786534, Length=177, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324292, Length=193, Percent_Identity=30.5699481865285, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325260, Length=603, Percent_Identity=21.8905472636816, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24649801, Length=555, Percent_Identity=21.8018018018018, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI85815873, Length=463, Percent_Identity=22.6781857451404, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651449, Length=452, Percent_Identity=20.7964601769912, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922482, Length=511, Percent_Identity=21.9178082191781, Blast_Score=70, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 83156; Mature: 83156

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILYFFPNVSWNDLRHDLSSSIVVFLVALPLCIGVAFASGTPIVSGLISGIVGGIVISL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ISKSPLSVSGPAMGLTVIVFDSIQTLGSFNDFLFAFCLAGVLQITLGFLKAGILSNFFPS
HCCCCCCCCCCCCCEEEEEEHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SVIKGMLAAIGAVLILKQIPHAIGYDMDYEGDMVFFQQDQENTFSEILTAFHRFTPGAII
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHH
LSSVSLALILIWEKLKLHKKLIIHGSLVAILVSVLLNEVFKTFELGIAVGSEHMIQPIQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEE
NGITDFFRGNYFPSFSQWKNQAIYLTAIKICLVMSLETLLNLDAIEKLDPQRRIVSKNRE
CCCHHHHCCCCCCCHHHHCCCEEHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCCC
LIAQGTGNLFSAIFGGLPITSVIIRSSTNLQAGAKTRFSAFLHGLLILLSLILIPTWISK
EECCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IPLASLAAVLLVVGYKLTDYKILQTQYRKGMDQFIPFISTLIGIVFSDVLIGIGIGCLFS
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFFIVRRNILNPYEFNKKEMTYGVEVRIDLSEDVSFLNKSSMLYKLDKVPDNAHLIIDGS
HHHHHHHHCCCCCCCCCCCEEEEEEEEEECHHHHHHHCCCHHEEEEECCCCCCEEEEECC
KSKYIDPDVLEIIEDFKIVAEFRNIKVEIIDVTSTYQKVKNKPLDPIIQQDYQKLFENNR
CCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHCCC
IWVEEKLLKDPNYFKNLALGQTPKYLLISCSDSRISVNEMTGTNAGELFVHRNIANLVID
EEEHHHHHCCCCHHHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCEEEEECHHHEEEE
TDMNLMSVLQYSVEVLKVKHIVVCGHYGCGGVKAAIDGKYHGLIDAWLRHIKQVYRMNRK
CCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCHH
ELSGILDEDEKHKKLVELNVREQVYNLCMTTIVQNAWSQGNNLQLHGWVYNLKEGILLDL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEE
NIDINKDFRDYDIFRYKFETN
EEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MNILYFFPNVSWNDLRHDLSSSIVVFLVALPLCIGVAFASGTPIVSGLISGIVGGIVISL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ISKSPLSVSGPAMGLTVIVFDSIQTLGSFNDFLFAFCLAGVLQITLGFLKAGILSNFFPS
HCCCCCCCCCCCCCEEEEEEHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SVIKGMLAAIGAVLILKQIPHAIGYDMDYEGDMVFFQQDQENTFSEILTAFHRFTPGAII
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHH
LSSVSLALILIWEKLKLHKKLIIHGSLVAILVSVLLNEVFKTFELGIAVGSEHMIQPIQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEE
NGITDFFRGNYFPSFSQWKNQAIYLTAIKICLVMSLETLLNLDAIEKLDPQRRIVSKNRE
CCCHHHHCCCCCCCHHHHCCCEEHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCCC
LIAQGTGNLFSAIFGGLPITSVIIRSSTNLQAGAKTRFSAFLHGLLILLSLILIPTWISK
EECCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IPLASLAAVLLVVGYKLTDYKILQTQYRKGMDQFIPFISTLIGIVFSDVLIGIGIGCLFS
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFFIVRRNILNPYEFNKKEMTYGVEVRIDLSEDVSFLNKSSMLYKLDKVPDNAHLIIDGS
HHHHHHHHCCCCCCCCCCCEEEEEEEEEECHHHHHHHCCCHHEEEEECCCCCCEEEEECC
KSKYIDPDVLEIIEDFKIVAEFRNIKVEIIDVTSTYQKVKNKPLDPIIQQDYQKLFENNR
CCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHCCC
IWVEEKLLKDPNYFKNLALGQTPKYLLISCSDSRISVNEMTGTNAGELFVHRNIANLVID
EEEHHHHHCCCCHHHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCEEEEECHHHEEEE
TDMNLMSVLQYSVEVLKVKHIVVCGHYGCGGVKAAIDGKYHGLIDAWLRHIKQVYRMNRK
CCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCHH
ELSGILDEDEKHKKLVELNVREQVYNLCMTTIVQNAWSQGNNLQLHGWVYNLKEGILLDL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEE
NIDINKDFRDYDIFRYKFETN
EEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]