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The map label for this gene is add [H]

Identifier: 116329055

GI number: 116329055

Start: 2915214

End: 2916527

Strand: Direct

Name: add [H]

Synonym: LBL_2462

Alternate gene names: 116329055

Gene position: 2915214-2916527 (Clockwise)

Preceding gene: 116329053

Following gene: 116329056

Centisome position: 80.65

GC content: 43.53

Gene sequence:

>1314_bases
GTGGCTTTAACTTTTGGGGAAATTCTAGACAGAATTCGGATCATCGACCGGGATGTTACCGAACTGAGTCGCCTAAAATC
CAGGCTTCCCGCAGATCGACCTTATTCGTCTTCTTTACAAATTTCCTTCGACAAACAGATCAACGAACTCTTAAACGAGA
GGGTCGGGCTCATGGAGCTCGAAATTATAGATCCACCTTCTTGGATTTTAGGGGTTCCACAAGAAACACCGGTTCCGATC
AAAGGACTTTTTCCATCCGGAGATTTATCCAAGGAAAAACCGGACGACCAAGACGTAATCAATTTCCTTCGGGAACTTCC
CAAAACGGAAATCCATCTCCATCTCGAAGCTTGCGTCAACAAAGACACGATGAAACGGTTGATGGCAAAGAACGGAATCA
GCGTAACGGACGAAGAGTTCGAAGCTAAATTCAACTTCAAAGATCTCAATGGATTTATTCAGGTATTTTTTTTCATCCAA
TCCCTCGTAAAAGAACCCGCCGATTTTTCATTTTTCGTGGGAAGTCTCTCGGAATATATGAGAGCCAACAACATCGTATA
TACGGAAGTATTTTTTGCTCCGTCGAAGTTCATTCAGAACGGGCTCGATTTCGAAGAAATGGTAAACTTTCTCGTAAATC
GCATCCGAGAGGAAAAGGAAAACGACGGAATCACCATACGATTGTTAGTCGATGTATCCCGTTCTTTCGGACCGGAAAAC
GCGATGAATAATTTGAACCGAGTTTTGAAACTCAGACATCCCGAGGTGATCGGGATCGGGTTAGGTGGCGCAGAGCTTAT
GGGACCTGCAAGAGATTACCAAGCCGTTTTCCAAAAGGCAAGAGAAGCAGGTTTGAGAGTGGTGGCACATTCCGGAGAAG
ACGACGGCCCTTGGGCAATCTGGGAAGCGGTGGAACTTCTCAAAGCTGAAAGGATAGGACACGGAACCTCCGCTATCCAA
GACCCAGAACTGGTAAAATATCTGAGGGAGAATCACATCCCTATTGAAATTTGTGTGACGTCTAATGTGTTCACCGGAAA
ATACGTCCGAAAAGAACAGAACCACCCCATTCGTTATTATTATGATCAGGGACTTCCTCTCAGCATCAACACGGACGATC
CGGAAATATTCAACGTAAATCTTACATACGAATATTATAAATTATGGAGATTCTTGGATTTTTCTTTGGATGAAATCGTG
GATCTAATCCGCCAGGGAGTTTTCGCTTCTTTTCATCCGAACAAAGAATCACTTTGGTCGGAAATGGAAAAAAAGATTCA
TCTTGTAAAAGCAAGATACGGTCTGAAACAATAA

Upstream 100 bases:

>100_bases
CCACTTTCTCTATATCAATTCCCCTTCCGGAATCCCCGTTCCTATACCTAAGTTTTGAATCAGAATTGAAATCTTTTCCC
AGAAAATATATTTTGCCTTA

Downstream 100 bases:

>100_bases
GATTTCCTTTTCGGACAAATATCTAATCCAAGCCGTTTTTCGATCATACATTTATTGAACCATGTTTGAGATGGTTCTAA
GTTAAATCTGAGAGCCTTTT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MALTFGEILDRIRIIDRDVTELSRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEIIDPPSWILGVPQETPVPI
KGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGISVTDEEFEAKFNFKDLNGFIQVFFFIQ
SLVKEPADFSFFVGSLSEYMRANNIVYTEVFFAPSKFIQNGLDFEEMVNFLVNRIREEKENDGITIRLLVDVSRSFGPEN
AMNNLNRVLKLRHPEVIGIGLGGAELMGPARDYQAVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHGTSAIQ
DPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPIRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIV
DLIRQGVFASFHPNKESLWSEMEKKIHLVKARYGLKQ

Sequences:

>Translated_437_residues
MALTFGEILDRIRIIDRDVTELSRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEIIDPPSWILGVPQETPVPI
KGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGISVTDEEFEAKFNFKDLNGFIQVFFFIQ
SLVKEPADFSFFVGSLSEYMRANNIVYTEVFFAPSKFIQNGLDFEEMVNFLVNRIREEKENDGITIRLLVDVSRSFGPEN
AMNNLNRVLKLRHPEVIGIGLGGAELMGPARDYQAVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHGTSAIQ
DPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPIRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIV
DLIRQGVFASFHPNKESLWSEMEKKIHLVKARYGLKQ
>Mature_436_residues
ALTFGEILDRIRIIDRDVTELSRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEIIDPPSWILGVPQETPVPIK
GLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGISVTDEEFEAKFNFKDLNGFIQVFFFIQS
LVKEPADFSFFVGSLSEYMRANNIVYTEVFFAPSKFIQNGLDFEEMVNFLVNRIREEKENDGITIRLLVDVSRSFGPENA
MNNLNRVLKLRHPEVIGIGLGGAELMGPARDYQAVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHGTSAIQD
PELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPIRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIVD
LIRQGVFASFHPNKESLWSEMEKKIHLVKARYGLKQ

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=339, Percent_Identity=24.7787610619469, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI61175224, Length=245, Percent_Identity=26.9387755102041, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787910, Length=289, Percent_Identity=31.1418685121107, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI115537133, Length=324, Percent_Identity=26.2345679012346, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32565969, Length=341, Percent_Identity=25.8064516129032, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538512, Length=341, Percent_Identity=25.8064516129032, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324188, Length=289, Percent_Identity=26.643598615917, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24645260, Length=326, Percent_Identity=26.0736196319018, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 50324; Mature: 50193

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00485 A_DEAMINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTFGEILDRIRIIDRDVTELSRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMEL
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEE
EIIDPPSWILGVPQETPVPIKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVN
EEECCCHHEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHCC
KDTMKRLMAKNGISVTDEEFEAKFNFKDLNGFIQVFFFIQSLVKEPADFSFFVGSLSEYM
HHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RANNIVYTEVFFAPSKFIQNGLDFEEMVNFLVNRIREEKENDGITIRLLVDVSRSFGPEN
HHCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHCCCCHH
AMNNLNRVLKLRHPEVIGIGLGGAELMGPARDYQAVFQKAREAGLRVVAHSGEDDGPWAI
HHHHHHHHHHCCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
WEAVELLKAERIGHGTSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPIRYY
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCEEEE
YDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIVDLIRQGVFASFHPNKESLWS
ECCCEEEEECCCCCEEEEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCHHHHHH
EMEKKIHLVKARYGLKQ
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALTFGEILDRIRIIDRDVTELSRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMEL
CCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEE
EIIDPPSWILGVPQETPVPIKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVN
EEECCCHHEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHCC
KDTMKRLMAKNGISVTDEEFEAKFNFKDLNGFIQVFFFIQSLVKEPADFSFFVGSLSEYM
HHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RANNIVYTEVFFAPSKFIQNGLDFEEMVNFLVNRIREEKENDGITIRLLVDVSRSFGPEN
HHCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHCCCCHH
AMNNLNRVLKLRHPEVIGIGLGGAELMGPARDYQAVFQKAREAGLRVVAHSGEDDGPWAI
HHHHHHHHHHCCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
WEAVELLKAERIGHGTSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPIRYY
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCEEEE
YDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIVDLIRQGVFASFHPNKESLWS
ECCCEEEEECCCCCEEEEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCHHHHHH
EMEKKIHLVKARYGLKQ
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA