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The map label for this gene is pbpE [H]

Identifier: 116329053

GI number: 116329053

Start: 2911721

End: 2912929

Strand: Direct

Name: pbpE [H]

Synonym: LBL_2460

Alternate gene names: 116329053

Gene position: 2911721-2912929 (Clockwise)

Preceding gene: 116329052

Following gene: 116329055

Centisome position: 80.56

GC content: 41.11

Gene sequence:

>1209_bases
TTGAAATCCGTCATATTGAAACAGTCTTTTCGAAAAATGAACATGACCCGTAAATTCAAATTGATCTCCCTCTTTTTTGT
GGTTTGGTTTATTGTAACGTGCAGTCCGGTAGGTCATAAAATAGTGGATAGGGAAAAAAGGATACACGATCATCTTTTGA
AGCGCGCAGGAAAGAATGATTGCCCCGGTATACAATATTCGGTAACGACTTCGAAAGGCCTGATTTATAGTTCAAGTGTG
GGATCAGCGGATATAGAAGGAAATGTACCTTTGGCTAAGGACTCACAAATGATGCTCCATTCTATGACGAAAACCTTTAC
GGCGGCGGCTGTTCTCCGATTGATAGATAAGGGAAAATTGTCTCTCGACGATCCTGCACGCAAATATCTACCGTATATAC
CCTACGATGAGCGGGTAACGATCCGAAATTTATTGTCGCAAACCTCCGGTATTCCTGATCCGATTCCTTTAAGATGGGTT
CATACCGCAAAAGAGGACGATTCGTTCGACGAGAACCGAATACTCCGCGAAATCTTGGAAGGACATTCCAAACTGAATTT
CGAACCGGGAAAAAAATACGCCTATTCCAACATATCCTATTGGCTTCTAGGCAAGATTGTGGAAAAGGTATCCGGCGTTC
CCTATAAAGAATATATGATTTCCGAAATATTCAAAAAATTAAATATTTCGGATTCTGAGATGGGATTTTTGATTCCAACC
GGAACGAAGCACGTAAAAGGATATTTAAGAAAATTCTCTTTCTTCAATCTATTGAAAATTTTTTTACTGGATTCCAAGTT
CTTCGGCAAATACGAAGGGGATTGGTTGCATGTCCGAGATCATTATCTAAACGGCCCGCCTTTCGGGGGAATCGTCTCGA
ATGCCGAATCGGTAAGCGTTTTTTTAAGGGATCAGCTAAGGAACGATTCCGTTCTTTTTTCTAAAGATACAAAGGATTTG
TTTTATCAGCAACAAAACGACAACACTGGAAAACCCGTGGAAATGAGTTTGGGTTGGCACATCCGATCTTTGAACGGGAA
TAGGTATTATTTCAAAGAAGGTGGCGGAGCCGGTTTCCATAGCGAAATGAGGATTTACCCCGAACTAAGGATAGCAACCG
TCGCGATTTCCAACAATACCGAATTCAACACTCGAGATTTTTTAAACGAAACAGATCCTGAATTTTTTTCGAGTGAAACT
CCCCGGTGA

Upstream 100 bases:

>100_bases
ATCTGAAAAAAAGCAAGCTTGTTCTATTTCCCGAAGCGAAACATGCAATTCACATGGAAAAACCGGAAGAACTTTCCTTG
GAAATCAACCGTTATCTCAA

Downstream 100 bases:

>100_bases
TCGTCTCTTTAGATCCCGTCGAGCGACAATAGAAGCGAGACGCTGAGTTTCTTCGAGCGACAATAGATTCCCTATGTTTC
TTGAACATAAGACAGTTCCG

Product: penicillin binding protein/Beta-lactamase class C protein

Products: NA

Alternate protein names: PBP 4*; PBP 4A; Penicillin-binding protein E [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKSVILKQSFRKMNMTRKFKLISLFFVVWFIVTCSPVGHKIVDREKRIHDHLLKRAGKNDCPGIQYSVTTSKGLIYSSSV
GSADIEGNVPLAKDSQMMLHSMTKTFTAAAVLRLIDKGKLSLDDPARKYLPYIPYDERVTIRNLLSQTSGIPDPIPLRWV
HTAKEDDSFDENRILREILEGHSKLNFEPGKKYAYSNISYWLLGKIVEKVSGVPYKEYMISEIFKKLNISDSEMGFLIPT
GTKHVKGYLRKFSFFNLLKIFLLDSKFFGKYEGDWLHVRDHYLNGPPFGGIVSNAESVSVFLRDQLRNDSVLFSKDTKDL
FYQQQNDNTGKPVEMSLGWHIRSLNGNRYYFKEGGGAGFHSEMRIYPELRIATVAISNNTEFNTRDFLNETDPEFFSSET
PR

Sequences:

>Translated_402_residues
MKSVILKQSFRKMNMTRKFKLISLFFVVWFIVTCSPVGHKIVDREKRIHDHLLKRAGKNDCPGIQYSVTTSKGLIYSSSV
GSADIEGNVPLAKDSQMMLHSMTKTFTAAAVLRLIDKGKLSLDDPARKYLPYIPYDERVTIRNLLSQTSGIPDPIPLRWV
HTAKEDDSFDENRILREILEGHSKLNFEPGKKYAYSNISYWLLGKIVEKVSGVPYKEYMISEIFKKLNISDSEMGFLIPT
GTKHVKGYLRKFSFFNLLKIFLLDSKFFGKYEGDWLHVRDHYLNGPPFGGIVSNAESVSVFLRDQLRNDSVLFSKDTKDL
FYQQQNDNTGKPVEMSLGWHIRSLNGNRYYFKEGGGAGFHSEMRIYPELRIATVAISNNTEFNTRDFLNETDPEFFSSET
PR
>Mature_402_residues
MKSVILKQSFRKMNMTRKFKLISLFFVVWFIVTCSPVGHKIVDREKRIHDHLLKRAGKNDCPGIQYSVTTSKGLIYSSSV
GSADIEGNVPLAKDSQMMLHSMTKTFTAAAVLRLIDKGKLSLDDPARKYLPYIPYDERVTIRNLLSQTSGIPDPIPLRWV
HTAKEDDSFDENRILREILEGHSKLNFEPGKKYAYSNISYWLLGKIVEKVSGVPYKEYMISEIFKKLNISDSEMGFLIPT
GTKHVKGYLRKFSFFNLLKIFLLDSKFFGKYEGDWLHVRDHYLNGPPFGGIVSNAESVSVFLRDQLRNDSVLFSKDTKDL
FYQQQNDNTGKPVEMSLGWHIRSLNGNRYYFKEGGGAGFHSEMRIYPELRIATVAISNNTEFNTRDFLNETDPEFFSSET
PR

Specific function: Probably involved in peptidoglycan modification during cortex synthesis [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=368, Percent_Identity=24.4565217391304, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=390, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17550934, Length=207, Percent_Identity=28.5024154589372, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565630, Length=185, Percent_Identity=30.8108108108108, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR021860 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF11954 DUF3471 [H]

EC number: NA

Molecular weight: Translated: 46185; Mature: 46185

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVILKQSFRKMNMTRKFKLISLFFVVWFIVTCSPVGHKIVDREKRIHDHLLKRAGKND
CCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
CPGIQYSVTTSKGLIYSSSVGSADIEGNVPLAKDSQMMLHSMTKTFTAAAVLRLIDKGKL
CCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
SLDDPARKYLPYIPYDERVTIRNLLSQTSGIPDPIPLRWVHTAKEDDSFDENRILREILE
CCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHH
GHSKLNFEPGKKYAYSNISYWLLGKIVEKVSGVPYKEYMISEIFKKLNISDSEMGFLIPT
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEECC
GTKHVKGYLRKFSFFNLLKIFLLDSKFFGKYEGDWLHVRDHYLNGPPFGGIVSNAESVSV
CCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCCCCCCHHCCCHHHHH
FLRDQLRNDSVLFSKDTKDLFYQQQNDNTGKPVEMSLGWHIRSLNGNRYYFKEGGGAGFH
HHHHHCCCCCEEEECCCHHHHEECCCCCCCCCEEEECCEEEEECCCCEEEEECCCCCCCC
SEMRIYPELRIATVAISNNTEFNTRDFLNETDPEFFSSETPR
CCEEECCCEEEEEEEEECCCCCCHHHHCCCCCCHHHCCCCCC
>Mature Secondary Structure
MKSVILKQSFRKMNMTRKFKLISLFFVVWFIVTCSPVGHKIVDREKRIHDHLLKRAGKND
CCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
CPGIQYSVTTSKGLIYSSSVGSADIEGNVPLAKDSQMMLHSMTKTFTAAAVLRLIDKGKL
CCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
SLDDPARKYLPYIPYDERVTIRNLLSQTSGIPDPIPLRWVHTAKEDDSFDENRILREILE
CCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHH
GHSKLNFEPGKKYAYSNISYWLLGKIVEKVSGVPYKEYMISEIFKKLNISDSEMGFLIPT
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEECC
GTKHVKGYLRKFSFFNLLKIFLLDSKFFGKYEGDWLHVRDHYLNGPPFGGIVSNAESVSV
CCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCCCCCCHHCCCHHHHH
FLRDQLRNDSVLFSKDTKDLFYQQQNDNTGKPVEMSLGWHIRSLNGNRYYFKEGGGAGFH
HHHHHCCCCCEEEECCCHHHHEECCCCCCCCCEEEECCEEEEECCCCEEEEECCCCCCCC
SEMRIYPELRIATVAISNNTEFNTRDFLNETDPEFFSSETPR
CCEEECCCEEEEEEEEECCCCCCHHHHCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491712; 9384377 [H]