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The map label for this gene is hisI [H]

Identifier: 116329039

GI number: 116329039

Start: 2895711

End: 2896274

Strand: Direct

Name: hisI [H]

Synonym: LBL_2445

Alternate gene names: 116329039

Gene position: 2895711-2896274 (Clockwise)

Preceding gene: 116329038

Following gene: 116329040

Centisome position: 80.11

GC content: 42.02

Gene sequence:

>564_bases
ATGAGTTCCCGCAAGATCACAATCCTAAAAGTTCAAGAATCGACTCAGTCGATTGCGTCCCTCTCTCAAATCTCAGAAGA
AGAATTATCTCGGTATCGAAACGGCCTTCCCAAAGGATTTAGAGAAGAAGTGGATTGCGACGAGGATACGATTTTATTTC
TGCATCCGGATTTTCCACCTTTGAATTTTGAAAAAATACGAGAACTCTTAATACCTCCCACAAACGAAATGATTCCTATC
GTAGCGATCGATGCTCAAAATCAGATTCTCATGCAGGCATTTGGAAATGAAGAAAGCCAAAGGCTGACTTTACAAACCGG
TTACGCACATTATTTCAGCCGATCCAGAAACCGGCTCTGGAAAAAAGGAGACACTTCGGGACATACGCAAAAAATTCTTC
AAATCTTGTCTCCACTCAACCGGTCTTTTTTGGTCTATCAAGTGGAGCAAAAAATTGCGGCGTGCCATGAAGGATACTAC
AGTTGTTTTTTTAGGGAAAGAATGCCAGGGGGCGAATGGAATCTGTTGCCGGTTTCGAGAAATTTTCTTCCAGAAAAGAA
CTGA

Upstream 100 bases:

>100_bases
ACAGACTTTTCCTCCTATAGACAAAGCCGTAGGATTTGATTGGACCGAAGACGGATTTTTAAAACTTTGGTTTTAGGAGT
TCCTACATTCCAAAAACGTC

Downstream 100 bases:

>100_bases
AATCGTACTCTGTCCCTAGATCTTCTTTGAAAGTTATTGAAGGAAATAAATTGGATTTATGAATATTAAGAAATTTTTGA
TTTTCTCCTGTCTACTAATC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSSRKITILKVQESTQSIASLSQISEEELSRYRNGLPKGFREEVDCDEDTILFLHPDFPPLNFEKIRELLIPPTNEMIPI
VAIDAQNQILMQAFGNEESQRLTLQTGYAHYFSRSRNRLWKKGDTSGHTQKILQILSPLNRSFLVYQVEQKIAACHEGYY
SCFFRERMPGGEWNLLPVSRNFLPEKN

Sequences:

>Translated_187_residues
MSSRKITILKVQESTQSIASLSQISEEELSRYRNGLPKGFREEVDCDEDTILFLHPDFPPLNFEKIRELLIPPTNEMIPI
VAIDAQNQILMQAFGNEESQRLTLQTGYAHYFSRSRNRLWKKGDTSGHTQKILQILSPLNRSFLVYQVEQKIAACHEGYY
SCFFRERMPGGEWNLLPVSRNFLPEKN
>Mature_186_residues
SSRKITILKVQESTQSIASLSQISEEELSRYRNGLPKGFREEVDCDEDTILFLHPDFPPLNFEKIRELLIPPTNEMIPIV
AIDAQNQILMQAFGNEESQRLTLQTGYAHYFSRSRNRLWKKGDTSGHTQKILQILSPLNRSFLVYQVEQKIAACHEGYYS
CFFRERMPGGEWNLLPVSRNFLPEKN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=32.6530612244898, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 21696; Mature: 21565

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKITILKVQESTQSIASLSQISEEELSRYRNGLPKGFREEVDCDEDTILFLHPDFPP
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEECCCCCC
LNFEKIRELLIPPTNEMIPIVAIDAQNQILMQAFGNEESQRLTLQTGYAHYFSRSRNRLW
CCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHH
KKGDTSGHTQKILQILSPLNRSFLVYQVEQKIAACHEGYYSCFFRERMPGGEWNLLPVSR
CCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
NFLPEKN
CCCCCCC
>Mature Secondary Structure 
SSRKITILKVQESTQSIASLSQISEEELSRYRNGLPKGFREEVDCDEDTILFLHPDFPP
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEECCCCCC
LNFEKIRELLIPPTNEMIPIVAIDAQNQILMQAFGNEESQRLTLQTGYAHYFSRSRNRLW
CCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHH
KKGDTSGHTQKILQILSPLNRSFLVYQVEQKIAACHEGYYSCFFRERMPGGEWNLLPVSR
CCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
NFLPEKN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA