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The map label for this gene is purC [H]

Identifier: 116328979

GI number: 116328979

Start: 2823824

End: 2824684

Strand: Reverse

Name: purC [H]

Synonym: LBL_2381

Alternate gene names: 116328979

Gene position: 2824684-2823824 (Counterclockwise)

Preceding gene: 116328980

Following gene: 116328978

Centisome position: 78.15

GC content: 43.09

Gene sequence:

>861_bases
ATGAATTTACCGACCTACAGAGGAAAAGTTAGGGACATCTATGATCTCGGTGATAGACTGATTCTTTCTTCTTCGGATCG
TATTTCCGCTTTCGACGTCGTATTTCCGCAGGCCGTGCCGAACAAAGGAAAGGTTCTGAATCGGATTTCCATTTCTTGGT
TTGAATTTTTTAAGAATATCCCCAATCATATTTTGGAAACGGATGTGAAGAATTTTCCTTCCCCTTTTCGAAGCCGTGAG
GAACTGGAGGGTAGGTCGGTTCTTGTAAAAAAGTGCAAACGGATCGATTATGAATGTGTGGTTCGTGGTTATATCGCGGG
TTCCGGTTGGAAGGAATATAAGAATGAGGGGACTCTTGCGGGCGTAAAACTTCCCGCGGGTTTGAAAGAATCCGAAAAAC
TACCCGAACCGGTTTTTACTCCCGCAGTCAAAAACGATCAAGGCCATGATGAGAATATTTCCGAAAAAGAAATGGAGAAT
CGGGTCGGAAAGGAACTGTTCGGGATTCTGAAAGAAAAATCGATTTCCATTTTTCTGCGCGCCTCTGAAGTGGTAGATAG
TGCGGGAATCATTCTTTGTGATACTAAATTCGAATTTGGAATTTTGGACGGACAAATCATTCTGATTGACGAACTTTTGA
CTCCGGATTCTTCCCGGTATTGGTCTGCGGATTCGTATTCTGTCGGAATTTCTCCTCCGAGTTTGGATAAACAGATTCTC
AGGAATTATCTGGAAACTACGAGTTGGAACAAGATGCCTCCTGCGCCTGATCTCCCGGCGGAACTTATCCAAGAGCTGAG
AGAAAAATATCAGAAGATAGAGGATCTCATTCTTTCATGTATATCGCAAAAATCCAAGTAG

Upstream 100 bases:

>100_bases
CCAAGGAAGGAGATATTCTCGTTTCTATGATGGAAGCCATTCTTGCACATTCGGACAGAGGCACGAATGATGACGATATC
GCTATGATGGTATTGAAACT

Downstream 100 bases:

>100_bases
TCCTCAAGGAGTCCGTTTTGGATCCGCAAGGAAGTACGGTAAAAAAAGTTCTCTCCGAAGTCGGAGAAAAATCCGTTCAA
GACGTGAGAGTTGGCAAGTA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNLPTYRGKVRDIYDLGDRLILSSSDRISAFDVVFPQAVPNKGKVLNRISISWFEFFKNIPNHILETDVKNFPSPFRSRE
ELEGRSVLVKKCKRIDYECVVRGYIAGSGWKEYKNEGTLAGVKLPAGLKESEKLPEPVFTPAVKNDQGHDENISEKEMEN
RVGKELFGILKEKSISIFLRASEVVDSAGIILCDTKFEFGILDGQIILIDELLTPDSSRYWSADSYSVGISPPSLDKQIL
RNYLETTSWNKMPPAPDLPAELIQELREKYQKIEDLILSCISQKSK

Sequences:

>Translated_286_residues
MNLPTYRGKVRDIYDLGDRLILSSSDRISAFDVVFPQAVPNKGKVLNRISISWFEFFKNIPNHILETDVKNFPSPFRSRE
ELEGRSVLVKKCKRIDYECVVRGYIAGSGWKEYKNEGTLAGVKLPAGLKESEKLPEPVFTPAVKNDQGHDENISEKEMEN
RVGKELFGILKEKSISIFLRASEVVDSAGIILCDTKFEFGILDGQIILIDELLTPDSSRYWSADSYSVGISPPSLDKQIL
RNYLETTSWNKMPPAPDLPAELIQELREKYQKIEDLILSCISQKSK
>Mature_286_residues
MNLPTYRGKVRDIYDLGDRLILSSSDRISAFDVVFPQAVPNKGKVLNRISISWFEFFKNIPNHILETDVKNFPSPFRSRE
ELEGRSVLVKKCKRIDYECVVRGYIAGSGWKEYKNEGTLAGVKLPAGLKESEKLPEPVFTPAVKNDQGHDENISEKEMEN
RVGKELFGILKEKSISIFLRASEVVDSAGIILCDTKFEFGILDGQIILIDELLTPDSSRYWSADSYSVGISPPSLDKQIL
RNYLETTSWNKMPPAPDLPAELIQELREKYQKIEDLILSCISQKSK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=224, Percent_Identity=31.25, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319326, Length=277, Percent_Identity=43.3212996389892, Blast_Score=221, Evalue=8e-59,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 32436; Mature: 32436

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPTYRGKVRDIYDLGDRLILSSSDRISAFDVVFPQAVPNKGKVLNRISISWFEFFKNI
CCCCCCCCHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
PNHILETDVKNFPSPFRSREELEGRSVLVKKCKRIDYECVVRGYIAGSGWKEYKNEGTLA
HHHHHHHHHHHCCCHHCCHHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCEE
GVKLPAGLKESEKLPEPVFTPAVKNDQGHDENISEKEMENRVGKELFGILKEKSISIFLR
EEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
ASEVVDSAGIILCDTKFEFGILDGQIILIDELLTPDSSRYWSADSYSVGISPPSLDKQIL
HHHHHCCCCEEEEECCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHH
RNYLETTSWNKMPPAPDLPAELIQELREKYQKIEDLILSCISQKSK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLPTYRGKVRDIYDLGDRLILSSSDRISAFDVVFPQAVPNKGKVLNRISISWFEFFKNI
CCCCCCCCHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
PNHILETDVKNFPSPFRSREELEGRSVLVKKCKRIDYECVVRGYIAGSGWKEYKNEGTLA
HHHHHHHHHHHCCCHHCCHHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCEE
GVKLPAGLKESEKLPEPVFTPAVKNDQGHDENISEKEMENRVGKELFGILKEKSISIFLR
EEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
ASEVVDSAGIILCDTKFEFGILDGQIILIDELLTPDSSRYWSADSYSVGISPPSLDKQIL
HHHHHCCCCEEEEECCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHH
RNYLETTSWNKMPPAPDLPAELIQELREKYQKIEDLILSCISQKSK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA