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The map label for this gene is frlA [H]

Identifier: 116328868

GI number: 116328868

Start: 2659035

End: 2660546

Strand: Direct

Name: frlA [H]

Synonym: LBL_2254

Alternate gene names: 116328868

Gene position: 2659035-2660546 (Clockwise)

Preceding gene: 116328865

Following gene: 116328869

Centisome position: 73.57

GC content: 40.61

Gene sequence:

>1512_bases
TTGTTTGCGAAAATGAGACTACCATGCTGTCAGAAAACGATGCAACTCAAAAGATCCCTCAATCTATTTGATTCCATATC
CCTCATGTTCAGCTCCATGGTAGGGCCGGGAATATTTATCACTACAGGCTATATCCTCCATCAAGTCCCAAATCCGAACA
TCGTTTTACTCGCTTGGATCTTAGGAGGCTTTCTTGCAGTTGCAGGTGCAATGTCTTATGCAAAATCCGCTTCTCTTTTT
CCGTATGCAGGAGGAGATTACGTCTATCTTAAGGAAGCATATTCACCGATTGTAGCATTTGCTAGTGGATGGCTTTCTCT
TTCGATTAATTTTTCCGCTTCAATATCTTTATCCGCATTAGCGTTTTCTAAATCGTTTTTTTCTTTGATCAATCCGTCCT
GGGATATTTATTTTTTTGAATTTCCGTTTTTGGGATTAACGATCTCGATCGGCACAGCGCAGATGCTGGCGATGGGCGCG
ATTTTTCTTTTTACGATCATCAACTTCTTTGGAATTTCTACGGCTTCCAGAATTCAGAACTTATTCACAAGTGTAAAAAT
TCTGGGCTTAGTAAGTTTTGTAATTCTGGGATTCATCATCGGAAATTACGATACGTCTCGTTTTCAGTCCTTCTCTCTAT
TACCATCGGGCCTAGGTGGAATGGAACTTTTACTTGCAGGAGTAATTCCTGTGACATACTCGTATCTGGGCTGGAATATG
ATCACTTATGTAGCCGAAGAAGTCAAAGATCCGGATAGGAATATCTACAAAGCCGTTTTGTATTCCTGCGCGTTAGTCAC
CATTCTCTATATTTTCATCAACTTCCTCTTTTTAAGTTCCGCGCCTATTTCCGAATTATCGGGAGATAAAATCGGAATCA
CCGCATCTTCCTTTTTATTCGGGCCAAAAGCTACGATTTTTATTACCGCATTTATTTGCTGGGCGTTCCTCGGATCGATT
TCCGCTTACATCATAGGAGGTTCGAGAATTTATTTCGCGATGGCGAGGGACGGATTCTTTTTTTCAAATATGGCCAAACT
ACATCCCAAGCATAAAAGTCCTTATATGTCCCTTCTTTTTCAGTGCGGATACGCTTGTTTATTCTGTTTCGTGAAAGAAA
TTGAAAGTCTTCTTTATTTAATCACTTGTTCCACTTTACTACTCGCAACGATTACTTCTTACACACCTATTCTTTTTGAA
AAAAAACACTACAAATTAAAGTTTAGAATTCCAGGATATCCTTATACAACTTACCTTTACATCGCTTCCAACGTCGGAAT
TATAGCGACTTTACTCTGGAACAAACCTACCGAAGCGTTTTGGGGAATCGGGTTTACCCTCCTTTCCGTTCCTATGTACT
ACTACTTTAAAGCGACACAAGCATCTGCGGTAAAAGTTTCCATTCCCCTCGATTCGGAGTCTTCAGAACTCTTAACAACC
AGCCTACTCCCCGAAAACGAACCGGTTCCCGTCGTCAGCGGAAATCGTAATCCAAGCAAATTCCCTTTTTGA

Upstream 100 bases:

>100_bases
TTTTAGCCAAAAGTTTTAGAAAAGTATGCTTATCCGTTTTCGTTTGGAAGAATAGATCTTAACACAATAAAATCCCAAAT
AACCTTAAACGGAAAAATCC

Downstream 100 bases:

>100_bases
AGATAAAGTATCAACTTAAACTTCATTCCGCTTTAGGAATCATTTCAATTCTCCTTTTGAGTTGTAAAATTTTTCTCCCT
ACTCTTCTGCCTCCGATTTC

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MFAKMRLPCCQKTMQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWILGGFLAVAGAMSYAKSASLF
PYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSALAFSKSFFSLINPSWDIYFFEFPFLGLTISIGTAQMLAMGA
IFLFTIINFFGISTASRIQNLFTSVKILGLVSFVILGFIIGNYDTSRFQSFSLLPSGLGGMELLLAGVIPVTYSYLGWNM
ITYVAEEVKDPDRNIYKAVLYSCALVTILYIFINFLFLSSAPISELSGDKIGITASSFLFGPKATIFITAFICWAFLGSI
SAYIIGGSRIYFAMARDGFFFSNMAKLHPKHKSPYMSLLFQCGYACLFCFVKEIESLLYLITCSTLLLATITSYTPILFE
KKHYKLKFRIPGYPYTTYLYIASNVGIIATLLWNKPTEAFWGIGFTLLSVPMYYYFKATQASAVKVSIPLDSESSELLTT
SLLPENEPVPVVSGNRNPSKFPF

Sequences:

>Translated_503_residues
MFAKMRLPCCQKTMQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWILGGFLAVAGAMSYAKSASLF
PYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSALAFSKSFFSLINPSWDIYFFEFPFLGLTISIGTAQMLAMGA
IFLFTIINFFGISTASRIQNLFTSVKILGLVSFVILGFIIGNYDTSRFQSFSLLPSGLGGMELLLAGVIPVTYSYLGWNM
ITYVAEEVKDPDRNIYKAVLYSCALVTILYIFINFLFLSSAPISELSGDKIGITASSFLFGPKATIFITAFICWAFLGSI
SAYIIGGSRIYFAMARDGFFFSNMAKLHPKHKSPYMSLLFQCGYACLFCFVKEIESLLYLITCSTLLLATITSYTPILFE
KKHYKLKFRIPGYPYTTYLYIASNVGIIATLLWNKPTEAFWGIGFTLLSVPMYYYFKATQASAVKVSIPLDSESSELLTT
SLLPENEPVPVVSGNRNPSKFPF
>Mature_503_residues
MFAKMRLPCCQKTMQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWILGGFLAVAGAMSYAKSASLF
PYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSALAFSKSFFSLINPSWDIYFFEFPFLGLTISIGTAQMLAMGA
IFLFTIINFFGISTASRIQNLFTSVKILGLVSFVILGFIIGNYDTSRFQSFSLLPSGLGGMELLLAGVIPVTYSYLGWNM
ITYVAEEVKDPDRNIYKAVLYSCALVTILYIFINFLFLSSAPISELSGDKIGITASSFLFGPKATIFITAFICWAFLGSI
SAYIIGGSRIYFAMARDGFFFSNMAKLHPKHKSPYMSLLFQCGYACLFCFVKEIESLLYLITCSTLLLATITSYTPILFE
KKHYKLKFRIPGYPYTTYLYIASNVGIIATLLWNKPTEAFWGIGFTLLSVPMYYYFKATQASAVKVSIPLDSESSELLTT
SLLPENEPVPVVSGNRNPSKFPF

Specific function: May be involved in fructoselysine transport [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=446, Percent_Identity=25.7847533632287, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI115648022, Length=446, Percent_Identity=25.7847533632287, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI71979932, Length=449, Percent_Identity=26.2806236080178, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI33286428, Length=458, Percent_Identity=25.9825327510917, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI186910308, Length=370, Percent_Identity=27.027027027027, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI186910306, Length=370, Percent_Identity=27.027027027027, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI186910304, Length=370, Percent_Identity=27.027027027027, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI187423910, Length=485, Percent_Identity=24.1237113402062, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI7657591, Length=485, Percent_Identity=24.1237113402062, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI9790235, Length=384, Percent_Identity=26.0416666666667, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI7657683, Length=459, Percent_Identity=25.0544662309368, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI258614003, Length=404, Percent_Identity=23.2673267326733, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI258614005, Length=404, Percent_Identity=23.2673267326733, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI258645169, Length=408, Percent_Identity=23.2843137254902, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4507047, Length=424, Percent_Identity=21.9339622641509, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI114326544, Length=407, Percent_Identity=22.1130221130221, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI114326550, Length=407, Percent_Identity=22.1130221130221, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI33286430, Length=235, Percent_Identity=26.8085106382979, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI71999149, Length=358, Percent_Identity=24.0223463687151, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI181337167, Length=414, Percent_Identity=23.1884057971014, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082250, Length=429, Percent_Identity=28.9044289044289, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87082023, Length=309, Percent_Identity=26.2135922330097, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081869, Length=366, Percent_Identity=24.3169398907104, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=354, Percent_Identity=25.4237288135593, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI32566699, Length=376, Percent_Identity=25.7978723404255, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17568033, Length=342, Percent_Identity=25.7309941520468, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71995382, Length=391, Percent_Identity=25.0639386189258, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71995388, Length=391, Percent_Identity=25.0639386189258, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71993915, Length=376, Percent_Identity=24.468085106383, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982612, Length=454, Percent_Identity=24.0088105726872, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71982608, Length=453, Percent_Identity=23.3995584988962, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17532491, Length=455, Percent_Identity=25.4945054945055, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193208714, Length=367, Percent_Identity=23.7057220708447, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI32566695, Length=367, Percent_Identity=23.7057220708447, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71990446, Length=372, Percent_Identity=22.0430107526882, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982623, Length=266, Percent_Identity=28.1954887218045, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17533459, Length=411, Percent_Identity=21.654501216545, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321492, Length=361, Percent_Identity=22.9916897506925, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221331183, Length=385, Percent_Identity=28.3116883116883, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17647653, Length=385, Percent_Identity=28.3116883116883, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24664379, Length=385, Percent_Identity=28.3116883116883, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI45550968, Length=494, Percent_Identity=23.6842105263158, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19921172, Length=494, Percent_Identity=23.6842105263158, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24651635, Length=454, Percent_Identity=24.8898678414097, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24651633, Length=454, Percent_Identity=24.8898678414097, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21357367, Length=457, Percent_Identity=26.0393873085339, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24641993, Length=390, Percent_Identity=23.0769230769231, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24641995, Length=390, Percent_Identity=23.0769230769231, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24667468, Length=412, Percent_Identity=27.4271844660194, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24668806, Length=403, Percent_Identity=23.8213399503722, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21356285, Length=403, Percent_Identity=23.8213399503722, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24668802, Length=403, Percent_Identity=23.8213399503722, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161077963, Length=390, Percent_Identity=24.8717948717949, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666159, Length=392, Percent_Identity=22.4489795918367, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221512776, Length=392, Percent_Identity=22.4489795918367, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281366235, Length=420, Percent_Identity=22.6190476190476, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007820, Length=420, Percent_Identity=22.6190476190476, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007818, Length=416, Percent_Identity=22.8365384615385, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI85725152, Length=416, Percent_Identity=22.8365384615385, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55705; Mature: 55705

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAKMRLPCCQKTMQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHEEECCCCCEEEEHHH
LGGFLAVAGAMSYAKSASLFPYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSAL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCEEEEEEEEECCEEHHHH
AFSKSFFSLINPSWDIYFFEFPFLGLTISIGTAQMLAMGAIFLFTIINFFGISTASRIQN
HHHHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LFTSVKILGLVSFVILGFIIGNYDTSRFQSFSLLPSGLGGMELLLAGVIPVTYSYLGWNM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITYVAEEVKDPDRNIYKAVLYSCALVTILYIFINFLFLSSAPISELSGDKIGITASSFLF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEHHHCC
GPKATIFITAFICWAFLGSISAYIIGGSRIYFAMARDGFFFSNMAKLHPKHKSPYMSLLF
CCCHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHH
QCGYACLFCFVKEIESLLYLITCSTLLLATITSYTPILFEKKHYKLKFRIPGYPYTTYLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCEEEEE
IASNVGIIATLLWNKPTEAFWGIGFTLLSVPMYYYFKATQASAVKVSIPLDSESSELLTT
EECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCHHHEE
SLLPENEPVPVVSGNRNPSKFPF
ECCCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MFAKMRLPCCQKTMQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHEEECCCCCEEEEHHH
LGGFLAVAGAMSYAKSASLFPYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSAL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCEEEEEEEEECCEEHHHH
AFSKSFFSLINPSWDIYFFEFPFLGLTISIGTAQMLAMGAIFLFTIINFFGISTASRIQN
HHHHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LFTSVKILGLVSFVILGFIIGNYDTSRFQSFSLLPSGLGGMELLLAGVIPVTYSYLGWNM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITYVAEEVKDPDRNIYKAVLYSCALVTILYIFINFLFLSSAPISELSGDKIGITASSFLF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEHHHCC
GPKATIFITAFICWAFLGSISAYIIGGSRIYFAMARDGFFFSNMAKLHPKHKSPYMSLLF
CCCHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHH
QCGYACLFCFVKEIESLLYLITCSTLLLATITSYTPILFEKKHYKLKFRIPGYPYTTYLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCEEEEE
IASNVGIIATLLWNKPTEAFWGIGFTLLSVPMYYYFKATQASAVKVSIPLDSESSELLTT
EECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCHHHEE
SLLPENEPVPVVSGNRNPSKFPF
ECCCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]