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The map label for this gene is hisC

Identifier: 116328833

GI number: 116328833

Start: 2604526

End: 2605629

Strand: Direct

Name: hisC

Synonym: LBL_2212

Alternate gene names: 116328833

Gene position: 2604526-2605629 (Clockwise)

Preceding gene: 116328831

Following gene: 116328837

Centisome position: 72.06

GC content: 43.66

Gene sequence:

>1104_bases
ATGATTCAATTTCAACCCGTTCTTGGATCCCTTAAAAGCTACGAAGCGGGAAAACCGATAGAACTCGTAGTCAGAGAATT
CGGAATCGATCCGGATCAGATTATCAAACTCGGTTCGAACGAAAATCCTTTCGGCTGCGCACAACCCGTCGTAGAAGCCG
TTCAGAAAGCGGCTTCGAAAATGCCCTACTATCCTGACGATTCTTACTTGGAATTGAAAACCGCACTCGCTTCCAAGTTC
GACTTAACTCCCGATCGGATCATTTTAGGTAACGGAAGTGATCAAGTTTTGGATTTTGCCTGTAGATGCGTATTGGGACC
CGGTGATTCGATTCTCATCAACCGAATCACTTTTGCAATGTATAGGATCTACGCGCTCCAATGTGGTGCAAAGGTTCATT
CCACGGAAACCGTTTTGCATGATCTGAACGCATTTTTAGATCTCGCAAAATCAATCCGTCCTAAGATCATCTTCCTTTGC
ACCCCGTCCAATCCGATTGGAGACGCTCTTTTCAAATCCGACGTCTATGATTTTTTAAGACAAATTCCTTCGAACACGTT
AGTCGTCATAGATGCGGCCTATATGGAATTCGGGAAAAAAAAGGATTCGAACACCTTCATTTCCGCCAAAGAAGTTACGG
ATCTTTTCCCGAACGTTTTTTATACGGGAACCTTTTCGAAAGCTTACGGACTCGGAGGAATGAGGATCGGATACGGAATC
GGAAGCAAGGAACTAATTTCCAATTTATATAAAATGCGTCCACCTTTCAACGTCGCCAACCTTTCCGCACTCGCCGCGAC
CGAGGCCCTTAAAAACGAATCTCACGTGGAATCGTATTTGGATAACAATCTGAAAGAGATGAAACGATATGAAAAATTCG
CCGCCGAGCAAAGCGTCGAATTCATCGATTCCTACGCGAATTTCATTACATTTTTTGCAAGAAAACGGGGAAAATCCTCC
ACGGAAATCTCCCAGTCTCTTTTAAAACAGGGAATTATCCTCAGGAATTTGAGGAGTTACGACTTGAATGCAATTCGAAT
CACGATTGGAAAACCACAACAAAATGACCGGGTTCTAACCGCTTTGAATCAAGAATTCAGCTGA

Upstream 100 bases:

>100_bases
AATTGAGAATATAACGAACCGAAAACATTTTTCAGAAATCGGCGCGAATTTATTCTTAAATCGATTTTCAAAATTTTTCC
GAAAAAAAGCATGGGAAGAG

Downstream 100 bases:

>100_bases
AGCGAACGCCTTTCTATGGATCGGCGTTCAGGAAATCATTACACTTTAGTTTTTTATTCGACCAAACTTTCTTACAGCGC
GTCCCAAAAACCCAGTTTAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MIQFQPVLGSLKSYEAGKPIELVVREFGIDPDQIIKLGSNENPFGCAQPVVEAVQKAASKMPYYPDDSYLELKTALASKF
DLTPDRIILGNGSDQVLDFACRCVLGPGDSILINRITFAMYRIYALQCGAKVHSTETVLHDLNAFLDLAKSIRPKIIFLC
TPSNPIGDALFKSDVYDFLRQIPSNTLVVIDAAYMEFGKKKDSNTFISAKEVTDLFPNVFYTGTFSKAYGLGGMRIGYGI
GSKELISNLYKMRPPFNVANLSALAATEALKNESHVESYLDNNLKEMKRYEKFAAEQSVEFIDSYANFITFFARKRGKSS
TEISQSLLKQGIILRNLRSYDLNAIRITIGKPQQNDRVLTALNQEFS

Sequences:

>Translated_367_residues
MIQFQPVLGSLKSYEAGKPIELVVREFGIDPDQIIKLGSNENPFGCAQPVVEAVQKAASKMPYYPDDSYLELKTALASKF
DLTPDRIILGNGSDQVLDFACRCVLGPGDSILINRITFAMYRIYALQCGAKVHSTETVLHDLNAFLDLAKSIRPKIIFLC
TPSNPIGDALFKSDVYDFLRQIPSNTLVVIDAAYMEFGKKKDSNTFISAKEVTDLFPNVFYTGTFSKAYGLGGMRIGYGI
GSKELISNLYKMRPPFNVANLSALAATEALKNESHVESYLDNNLKEMKRYEKFAAEQSVEFIDSYANFITFFARKRGKSS
TEISQSLLKQGIILRNLRSYDLNAIRITIGKPQQNDRVLTALNQEFS
>Mature_367_residues
MIQFQPVLGSLKSYEAGKPIELVVREFGIDPDQIIKLGSNENPFGCAQPVVEAVQKAASKMPYYPDDSYLELKTALASKF
DLTPDRIILGNGSDQVLDFACRCVLGPGDSILINRITFAMYRIYALQCGAKVHSTETVLHDLNAFLDLAKSIRPKIIFLC
TPSNPIGDALFKSDVYDFLRQIPSNTLVVIDAAYMEFGKKKDSNTFISAKEVTDLFPNVFYTGTFSKAYGLGGMRIGYGI
GSKELISNLYKMRPPFNVANLSALAATEALKNESHVESYLDNNLKEMKRYEKFAAEQSVEFIDSYANFITFFARKRGKSS
TEISQSLLKQGIILRNLRSYDLNAIRITIGKPQQNDRVLTALNQEFS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=300, Percent_Identity=27.6666666666667, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322075, Length=370, Percent_Identity=28.1081081081081, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_LEPBJ (Q04QW8)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801460.1
- ProteinModelPortal:   Q04QW8
- STRING:   Q04QW8
- GeneID:   4411422
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2219
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- ProtClustDB:   PRK02731
- BioCyc:   LBOR355277:LBJ_2219-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40952; Mature: 40952

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQFQPVLGSLKSYEAGKPIELVVREFGIDPDQIIKLGSNENPFGCAQPVVEAVQKAASK
CCEECHHHHHHHCCCCCCCHHHHHHHHCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHC
MPYYPDDSYLELKTALASKFDLTPDRIILGNGSDQVLDFACRCVLGPGDSILINRITFAM
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHEECCCCHHHHHHHHHHH
YRIYALQCGAKVHSTETVLHDLNAFLDLAKSIRPKIIFLCTPSNPIGDALFKSDVYDFLR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
QIPSNTLVVIDAAYMEFGKKKDSNTFISAKEVTDLFPNVFYTGTFSKAYGLGGMRIGYGI
HCCCCCEEEEEHHHHHHCCCCCCCCEEEHHHHHHHCCCCEEECCCHHHHCCCCEEEECCC
GSKELISNLYKMRPPFNVANLSALAATEALKNESHVESYLDNNLKEMKRYEKFAAEQSVE
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FIDSYANFITFFARKRGKSSTEISQSLLKQGIILRNLRSYDLNAIRITIGKPQQNDRVLT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCHHHH
ALNQEFS
HHCCCCC
>Mature Secondary Structure
MIQFQPVLGSLKSYEAGKPIELVVREFGIDPDQIIKLGSNENPFGCAQPVVEAVQKAASK
CCEECHHHHHHHCCCCCCCHHHHHHHHCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHC
MPYYPDDSYLELKTALASKFDLTPDRIILGNGSDQVLDFACRCVLGPGDSILINRITFAM
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHEECCCCHHHHHHHHHHH
YRIYALQCGAKVHSTETVLHDLNAFLDLAKSIRPKIIFLCTPSNPIGDALFKSDVYDFLR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
QIPSNTLVVIDAAYMEFGKKKDSNTFISAKEVTDLFPNVFYTGTFSKAYGLGGMRIGYGI
HCCCCCEEEEEHHHHHHCCCCCCCCEEEHHHHHHHCCCCEEECCCHHHHCCCCEEEECCC
GSKELISNLYKMRPPFNVANLSALAATEALKNESHVESYLDNNLKEMKRYEKFAAEQSVE
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FIDSYANFITFFARKRGKSSTEISQSLLKQGIILRNLRSYDLNAIRITIGKPQQNDRVLT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCHHHH
ALNQEFS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA