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The map label for this gene is fabB [H]

Identifier: 116328797

GI number: 116328797

Start: 2553714

End: 2555006

Strand: Direct

Name: fabB [H]

Synonym: LBL_2172

Alternate gene names: 116328797

Gene position: 2553714-2555006 (Clockwise)

Preceding gene: 116328795

Following gene: 116328798

Centisome position: 70.65

GC content: 46.09

Gene sequence:

>1293_bases
ATGGATAAAACGAACACCAATCATAATTCAAGAGTTGCTATTACTGGAATCGGAATCATCCTTCCGAATACGTATTCTGT
GGATATGTTTTGGAAAAATCTTTCCGAAGGGAATTCGCAGATAGATAAAATTACCCGGTTCCAGACCAACGACATGACCG
TAAAAGTCGCTGCGGAGATGAACGACTTCGACTGGAAAAAATTCCTACCTGATTTGGAAGAAAAACACGCAAAACGTTAC
AACCGGGAAACATTTGCGATTATGTCTGCGATGGCGGAAGCTCGAAAAGACGCAAAGTTAGAAAAGGACTCCGTGGATCC
GTCCAAAGTAGGTTTTATCGACTCTTCTTCGAGATCCTCTCTTGCCTGGTGGGAACACGCTTGGAAACTCTACCACAAAG
AAAAAAAACTGAATATCTTTGATCGTTACTCCGTTCTCACTTCGATGGCCTCCAATCCTACCAACCTTACGGCAATCTAC
GCAAACATTCAAGGATTTGTGACTACGATCACCGCCGCTTGCGTCGGTGGACATCACGCGATCAGCCTTTGTTATCAGGC
GATTCGAAAGGGAAGAGCGGAAGTGATGTATGCGGGAGGTCACGAGTTTCCTCTCCTAAAACCTCTGATCATGATGTATT
CCGATCCTGCGAGTTCGGTTATGTCTTCCGAAGAGAAAAATCCGAAGTCCGCGATCAAACCCTACGATCGCAATCGAGAC
GGTTTTATTCTAGGAGAAGGAGCGGCCGTTCTCTGCTTGGAAAGAATGGATCATGCCCTCGCCAGAGGTGCGAAAATTTA
CGCGGAAGTTTTAGGAACCTACAGTTACAACGAAGCAGACCACGCAATGAGAATGGATCTAACCGGTAAAAAAGCCGCGA
TCGGTTTAAATCGACTTTTGAGAATTAGCGGTCTCAAACTTGAAGATATCGATTATTTCTGCGGACACGGAACCGCGACG
ATCAACAACGATATGGCCGAAAGTCGCGCGCTCAACATTTTATACAATGGACTCGCTCGAAGTAAATGGGCTCCTCTTGG
TTCCATCAAACCGATTTTCGGTCATACGTTCGGAGCGGCGGGAATCATCAATGTCGCCGCAACCGCTCTAATGCTAAAAA
AACAAATCCTTTGTCCAACAATCAACCTCAAGGAGGTGGACCCGGAATGCGATCACGATCATATCACCGAAGGTGCAAGA
AAGGCTCGACTTAGAAACGCGATTTCGATGGCCTTTGCAATCGGAAGTCAGTCTTCTTTTGTTAGTCTCGCTGCACCTCC
GGATCTTCTTTAA

Upstream 100 bases:

>100_bases
CAGTAAATATAGATCTCATGGGATGAAGATCTTGTAACTTAAAGGTATCTCGTGGCGATAGAAAATCTGAATTTTAGGAC
AAGCGGTAAAATCAAAAAGT

Downstream 100 bases:

>100_bases
GGAAAGCAGGATGAGATTCGACAAATTGTATAAACAATACGATTATTTAAAAAAATTAAGATCGGTTCTTTATTACCAGG
GGGTAGTGACACATGAGATT

Product: 3-oxoacyl-[acyl-carrier protein] synthase

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: KS; Polyketide condensing enzyme [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDKTNTNHNSRVAITGIGIILPNTYSVDMFWKNLSEGNSQIDKITRFQTNDMTVKVAAEMNDFDWKKFLPDLEEKHAKRY
NRETFAIMSAMAEARKDAKLEKDSVDPSKVGFIDSSSRSSLAWWEHAWKLYHKEKKLNIFDRYSVLTSMASNPTNLTAIY
ANIQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLLKPLIMMYSDPASSVMSSEEKNPKSAIKPYDRNRD
GFILGEGAAVLCLERMDHALARGAKIYAEVLGTYSYNEADHAMRMDLTGKKAAIGLNRLLRISGLKLEDIDYFCGHGTAT
INNDMAESRALNILYNGLARSKWAPLGSIKPIFGHTFGAAGIINVAATALMLKKQILCPTINLKEVDPECDHDHITEGAR
KARLRNAISMAFAIGSQSSFVSLAAPPDLL

Sequences:

>Translated_430_residues
MDKTNTNHNSRVAITGIGIILPNTYSVDMFWKNLSEGNSQIDKITRFQTNDMTVKVAAEMNDFDWKKFLPDLEEKHAKRY
NRETFAIMSAMAEARKDAKLEKDSVDPSKVGFIDSSSRSSLAWWEHAWKLYHKEKKLNIFDRYSVLTSMASNPTNLTAIY
ANIQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLLKPLIMMYSDPASSVMSSEEKNPKSAIKPYDRNRD
GFILGEGAAVLCLERMDHALARGAKIYAEVLGTYSYNEADHAMRMDLTGKKAAIGLNRLLRISGLKLEDIDYFCGHGTAT
INNDMAESRALNILYNGLARSKWAPLGSIKPIFGHTFGAAGIINVAATALMLKKQILCPTINLKEVDPECDHDHITEGAR
KARLRNAISMAFAIGSQSSFVSLAAPPDLL
>Mature_430_residues
MDKTNTNHNSRVAITGIGIILPNTYSVDMFWKNLSEGNSQIDKITRFQTNDMTVKVAAEMNDFDWKKFLPDLEEKHAKRY
NRETFAIMSAMAEARKDAKLEKDSVDPSKVGFIDSSSRSSLAWWEHAWKLYHKEKKLNIFDRYSVLTSMASNPTNLTAIY
ANIQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLLKPLIMMYSDPASSVMSSEEKNPKSAIKPYDRNRD
GFILGEGAAVLCLERMDHALARGAKIYAEVLGTYSYNEADHAMRMDLTGKKAAIGLNRLLRISGLKLEDIDYFCGHGTAT
INNDMAESRALNILYNGLARSKWAPLGSIKPIFGHTFGAAGIINVAATALMLKKQILCPTINLKEVDPECDHDHITEGAR
KARLRNAISMAFAIGSQSSFVSLAAPPDLL

Specific function: Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces halstedii [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=433, Percent_Identity=29.0993071593533, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI41872631, Length=387, Percent_Identity=23.5142118863049, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787337, Length=393, Percent_Identity=32.0610687022901, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=25.8823529411765, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983541, Length=381, Percent_Identity=27.5590551181102, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983535, Length=225, Percent_Identity=29.7777777777778, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=382, Percent_Identity=21.9895287958115, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320904, Length=400, Percent_Identity=25.5, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=26.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221330659, Length=413, Percent_Identity=23.0024213075061, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19920632, Length=413, Percent_Identity=23.0024213075061, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: 2.3.1.41

Molecular weight: Translated: 47623; Mature: 47623

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTNTNHNSRVAITGIGIILPNTYSVDMFWKNLSEGNSQIDKITRFQTNDMTVKVAAEM
CCCCCCCCCCEEEEEEEEEEECCCEEHHHHHHHHCCCHHHHHHHHHEECCCEEEEEEECC
NDFDWKKFLPDLEEKHAKRYNRETFAIMSAMAEARKDAKLEKDSVDPSKVGFIDSSSRSS
CCCCHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCC
LAWWEHAWKLYHKEKKLNIFDRYSVLTSMASNPTNLTAIYANIQGFVTTITAACVGGHHA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCHHH
ISLCYQAIRKGRAEVMYAGGHEFPLLKPLIMMYSDPASSVMSSEEKNPKSAIKPYDRNRD
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHCCCCCCHHHCCCCCCCCC
GFILGEGAAVLCLERMDHALARGAKIYAEVLGTYSYNEADHAMRMDLTGKKAAIGLNRLL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHH
RISGLKLEDIDYFCGHGTATINNDMAESRALNILYNGLARSKWAPLGSIKPIFGHTFGAA
HHCCCEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHH
GIINVAATALMLKKQILCPTINLKEVDPECDHDHITEGARKARLRNAISMAFAIGSQSSF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCE
VSLAAPPDLL
EEECCCCCCC
>Mature Secondary Structure
MDKTNTNHNSRVAITGIGIILPNTYSVDMFWKNLSEGNSQIDKITRFQTNDMTVKVAAEM
CCCCCCCCCCEEEEEEEEEEECCCEEHHHHHHHHCCCHHHHHHHHHEECCCEEEEEEECC
NDFDWKKFLPDLEEKHAKRYNRETFAIMSAMAEARKDAKLEKDSVDPSKVGFIDSSSRSS
CCCCHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCC
LAWWEHAWKLYHKEKKLNIFDRYSVLTSMASNPTNLTAIYANIQGFVTTITAACVGGHHA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCHHH
ISLCYQAIRKGRAEVMYAGGHEFPLLKPLIMMYSDPASSVMSSEEKNPKSAIKPYDRNRD
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHCCCCCCHHHCCCCCCCCC
GFILGEGAAVLCLERMDHALARGAKIYAEVLGTYSYNEADHAMRMDLTGKKAAIGLNRLL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHH
RISGLKLEDIDYFCGHGTATINNDMAESRALNILYNGLARSKWAPLGSIKPIFGHTFGAA
HHCCCEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHH
GIINVAATALMLKKQILCPTINLKEVDPECDHDHITEGARKARLRNAISMAFAIGSQSSF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCE
VSLAAPPDLL
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8344517 [H]